Cited by 8503D Printing in Biomedical ResearchMicrofluidic and Capillary Electrophoresis ApplicationsTissue Engineering and Regenerative Medicine

The DOI matches its Crossref record; 65 of the 65 references it cites were found in a registry or an index.

Organoids-on-a-chip

Open access

Park, Sunghee Estelle, Georgescu, Andrei, Huh, Dongeun·2019·Science

DOI 10.1126/science.aaw7894PMC PMC7764943

Open this paper in CoChat — free account Open PDF

Abstract

Recent studies have demonstrated an array of stem cell–derived, self-organizing miniature organs, termed organoids, that replicate the key structural and functional characteristics of their in vivo counterparts. As organoid technology opens up new frontiers of research in biomedicine, there is an emerging need for innovative engineering approaches for the production, control, and analysis of organoids and their microenvironment. In this Review, we explore organ-on-a-chip technology as a platform to fulfill this need and examine how this technology may be leveraged to address major technical challenges in organoid research. We also discuss emerging opportunities and future obstacles for the development and application of organoid-on-a-chip technology.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1126/science.aaw7894

Cites

65 of 65 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cerebral organoids model human brain development and microcephaly
Lancaster, M. A., Renner, M., Martin, C.-A., Wenzel, D., Bicknell, L. S., Hurles, M. E., Homfray, T., Penninger, J. M., Jackson, A. P., & Knoblich, J. A. (2013) · Nature · doi:10.1038/nature12517 · Cited by 5,372
Reconstituting organ-level lung functions on a chip
Huh, D., Matthews, B. D., Mammoto, A., Montoya-Zavala, M., Hsin, H. Y., & Ingber, D. E. (2010) · Science · doi:10.1126/science.1188302 · Cited by 4,250
Self-citation
Microfluidic organs-on-chips
Bhatia, S. N., & Ingber, D. E. (2014) · Nature Biotechnology · doi:10.1038/nbt.2989 · Cited by 3,305
Modeling Development and Disease with Organoids
Clevers, H. (2016) · Cell · doi:10.1016/j.cell.2016.05.082 · Cited by 3,196
Organogenesis in a dish: Modeling development and disease using organoid technologies
Lancaster, M. A., & Knoblich, J. A. (2014) · Science · doi:10.1126/science.1247125 · Cited by 2,931
Soft Lithography in Biology and Biochemistry
Whitesides, G. M., Ostuni, E., Takayama, S., Jiang, X., & Ingber, D. E. (2001) · Annual Review of Biomedical Engineering · doi:10.1146/annurev.bioeng.3.1.335 · Cited by 2,603
Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure
Qian, X., Nguyen, H. N., Song, M. M., Hadiono, C., Ogden, S. C., Hammack, C., Yao, B., Hamersky, G. R., Jacob, F., Zhong, C., et al. (2016) · Cell · doi:10.1016/j.cell.2016.04.032 · Cited by 2,127
From 3D cell culture to organs-on-chips
Huh, D., Hamilton, G. A., & Ingber, D. E. (2011) · Trends in Cell Biology · doi:10.1016/j.tcb.2011.09.005 · Cited by 1,834
Self-citation
Mechanical forces direct stem cell behaviour in development and regeneration
Vining, K. H., & Mooney, D. J. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.108 · Cited by 1,656
Three-dimensional bioprinting of thick vascularized tissues
Kolesky, D. B., Homan, K. A., Skylar-Scott, M. A., & Lewis, J. A. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1521342113 · Cited by 1,492

Show all 65 references

Sorted by citations

Items 101–200 of 850

Geometric engineering of organoid culture for enhanced organogenesis in a dish
Park, S. E., Kang, S., Paek, J., Georgescu, A., Chang, J., Yi, A. Y., Wilkins, B. J., Karakasheva, T. A., Hamilton, K. E., & Huh, D. (2022) · Nature Methods · doi:10.1038/s41592-022-01643-8 · Cited by 67
Self-citation
Recent Advances of Organ-on-a-Chip in Cancer Modeling Research
Liu, X., Su, Q., Zhang, X., Yang, W., Ning, J., Jia, K., Xin, J., Li, H., Yu, L., Liao, Y., et al. (2022) · Biosensors · doi:10.3390/bios12111045 · Cited by 71
Patient-Derived Organoids as a Model for Cancer Drug Discovery
Rae, C. J., Amato, F., & Braconi, C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22073483 · Cited by 74
Organoids and Colorectal Cancer
Barbáchano, A., Fernández‐Barral, A., Bustamante‐Madrid, P., Prieto, I., Rodríguez-Salas, N., Larriba, M. J., & Múñoz, A. (2021) · Cancers · doi:10.3390/cancers13112657 · Cited by 74
Organoids – New Models for Host–Helminth Interactions
Correa, M. A. D., Maizels, R. M., Grencis, R. K., & Berriman, M. (2019) · Trends in Parasitology · doi:10.1016/j.pt.2019.10.013 · Cited by 65
Human Brain Organoids-on-Chip: Advances, Challenges, and Perspectives for Preclinical Applications
Castiglione, H., Vigneron, P.-A., Baquerre, C., Yates, F., Rontard, J., & Honegger, T. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14112301 · Cited by 73
Microphysiological Systems: Next Generation Systems for Assessing Toxicity and Therapeutic Effects of Nanomaterials
Ashammakhi, N. A., Darabi, M. A., Çelebi‐Saltik, B., Tutar, R., Hartel, M. C., Lee, J., Hussein, S. M., Goudie, M. J., Cornelius, M. B., Dokmeci, M. R., et al. (2019) · Small Methods · doi:10.1002/smtd.201900589 · Cited by 67
Advanced Multi-Dimensional Cellular Models as Emerging Reality to Reproduce In Vitro the Human Body Complexity
Bassi, G., Grimaudo, M. A., Panseri, S., & Montesi, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22031195 · Cited by 69
A path to translation: How 3D patient tumor avatars enable next generation precision oncology
Bose, S., Barroso, M., Chheda, M. G., Clevers, H. C., Élez, E., Kaochar, S., Kopetz, S., Li, X., Meric‐Bernstam, F., Meyer, C. A., et al. (2022) · Cancer Cell · doi:10.1016/j.ccell.2022.09.017 · Cited by 63
Organoids/organs-on-a-chip: new frontiers of intestinal pathophysiological models
Wu, L., Ai, Y., Xie, R., Xiong, J., Wang, Y., & Liang, Q. (2023) · Lab on a Chip · doi:10.1039/d2lc00804a · Cited by 66
A scalable and sensitive steatosis chip with long-term perfusion of in situ differentiated HepaRG organoids
Teng, Y., Zhao, Z., Tasnim, F., Huang, X., & Yu, H. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.120904 · Cited by 62
Tumor organoid biobank-new platform for medical research
Xie, X., Li, X., & Song, W. (2023) · Scientific Reports · doi:10.1038/s41598-023-29065-2 · Cited by 70
Liquid marble-based digital microfluidics – fundamentals and applications
Ooi, C. H., Vadivelu, R. K., Jin, J., Sreejith, K. R., Singha, P., Nguyen, N., & Nguyen, N.-T. (2021) · Lab on a Chip · doi:10.1039/d0lc01290d · Cited by 62
Human Spinal Organoid-on-a-Chip to Model Nociceptive Circuitry for Pain Therapeutics Discovery
Ao, Z., Cai, H., Wu, Z., Krzesniak, J., Tian, C., Lai, Y. Y., Mackie, K., & Guo, F. (2021) · Analytical Chemistry · doi:10.1021/acs.analchem.1c04641 · Cited by 62
Advances in Microfluidic Technologies in Organoid Research
Liu, H., Gan, Z., Qin, X., Wang, Y., & Qin, J. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202302686 · Cited by 68
Organs-on-chip: The way forward
Mastrangeli, M., & Raaij, J. V. D. E. (2021) · Stem Cell Reports · doi:10.1016/j.stemcr.2021.06.015 · Cited by 64
Breaking the mold: 3D cell cultures reshaping the future of cancer research
Cordeiro, S. Z., Oliveira, B. B. P. P., Valente, R., Ferreira, D., Luz, A., Baptista, P. V., & Fernandes, A. R. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1507388 · Cited by 70
A low-cost 3D printed microfluidic bioreactor and imaging chamber for live-organoid imaging
Khan, I., Prabhakar, A., Delépine, C., Tsang, H. W. S., Pham, V. A., & Sur, M. (2021) · Biomicrofluidics · doi:10.1063/5.0041027 · Cited by 64
Biofabrication Strategies and Engineered In Vitro Systems for Vascular Mechanobiology
Pradhan, S., Banda, O. A., Farino, C. J., Sperduto, J. L., Keller, K. A., Taitano, R. A., & Slater, J. H. (2020) · Advanced Healthcare Materials · doi:10.1002/adhm.201901255 · Cited by 63
The frontier of live tissue imaging across space and time
Huang, Q., Garrett, A., Bose, S., Blocker, S. J., Rios, A. C., Clevers, H. C., & Shen, X. (2021) · Cell stem cell · doi:10.1016/j.stem.2021.02.010 · Cited by 60
Establishment of Colorectal Cancer Organoids in Microfluidic-Based System
Pinho, D., Santos, D. R. D., Vila, A., & Carvalho, S. (2021) · Micromachines · doi:10.3390/mi12050497 · Cited by 63
Intestinal Models for Personalized Medicine: from Conventional Models to Microfluidic Primary Intestine-on-a-chip
Li, X., Chen, M., Zhao, S., & Wang, X. (2021) · Stem Cell Reviews and Reports · doi:10.1007/s12015-021-10205-y · Cited by 62
Recent Advances in Microfluidic Platforms for Programming Cell‐Based Living Materials
Zhang, P., Shao, N., & Qin, L. (2021) · Advanced Materials · doi:10.1002/adma.202005944 · Cited by 61
A human cornea-on-a-chip for the study of epithelial wound healing by extracellular vesicles
Yu, Z., Hao, R., Du, J., Wu, X., Chen, X., Zhang, Y., Li, W. S., Gu, Z., & Yang, H. (2022) · iScience · doi:10.1016/j.isci.2022.104200 · Cited by 65
Advancing Tissue Decellularized Hydrogels for Engineering Human Organoids
Moura, B. S., Monteiro, M. V., Ferreira, L. P., Lavrador, P., Gaspar, V. M., & Mano, J. F. (2022) · Advanced Functional Materials · doi:10.1002/adfm.202202825 · Cited by 64
The role of organoids in cancer research
Fang, Z., Li, P., Du, F., Shang, L., & Li, L. (2023) · Experimental Hematology and Oncology · doi:10.1186/s40164-023-00433-y · Cited by 68
Gastrointestinal organs and organoids-on-a-chip: advances and translation into the clinics
Carvalho, M. R., Yan, L., Li, B., Zhang, C., He, Y., Reis, R. L., & Oliveira, J. M. (2023) · Biofabrication · doi:10.1088/1758-5090/acf8fb · Cited by 65
Real-time sensors for live monitoring of disease and drug analysis in microfluidic model of proximal tubule
Asif, A., Kim, K. H., Jabbar, F., Kim, S., & Choi, K. H. (2020) · Microfluidics and Nanofluidics · doi:10.1007/s10404-020-02347-1 · Cited by 59
Co-contamination and interaction of fungal toxins and other environmental toxins
Guo, H., Ji, J., Wang, J.-S., & Sun, X. (2020) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2020.06.021 · Cited by 58
Glioblastoma-on-a-chip construction and therapeutic applications
Xie, Z., Chen, M., Lian, J., Wang, H., & Ma, J. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1183059 · Cited by 64
Strategies to overcome the limitations of current organoid technology - engineered organoids
Fan, X., Hou, K., Liu, G., Shi, R., Wang, W., & Liang, G. (2025) · Journal of Tissue Engineering · doi:10.1177/20417314251319475 · Cited by 72
Environmental toxicology wars: Organ-on-a-chip for assessing the toxicity of environmental pollutants
Yang, S., Chen, Z., Cheng, Y., Liu, T., Yin, L., Pu, Y., & Liang, G. (2020) · Environmental Pollution · doi:10.1016/j.envpol.2020.115861 · Cited by 57
Brain-on-a-Chip: Characterizing the next generation of advanced in vitro platforms for modeling the central nervous system
Maoz, B. M. (2021) · APL Bioengineering · doi:10.1063/5.0055812 · Cited by 63
A Vascularised Tumouroid-on-A-Chip Model Verifies Synergistic Vasoprotective and Chemotherapeutic Effects
Hu, Z., Cao, Y., Galan, E. A., Hao, L., Zhao, H., Tang, J., Sang, G., Wang, H., Xu, B., & Ma, S. (2021) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.1c01099 · Cited by 58
Organoids revealed: morphological analysis of the profound next generation in-vitro model with artificial intelligence
Du, X., Chen, Z., Li, Q., Yang, S., Jiang, L., Yang, Y., Li, Y., & Gu, Z. (2023) · Bio-Design and Manufacturing · doi:10.1007/s42242-022-00226-y · Cited by 57
3D Bioprinting for Vascularization
Mir, A., Lee, E., Shih, W., Koljaka, S., Wang, A., Jorgensen, C., Hurr, R., Dave, A., Sudheendra, K., & Hibino, N. (2023) · Bioengineering · doi:10.3390/bioengineering10050606 · Cited by 61
Engineering next generation vascularized organoids
Werschler, N., Quintard, C., Nguyen, S., & Penninger, J. M. (2024) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2024.118529 · Cited by 63
Cancer organoids: A platform in basic and translational research
Ma, X., Wang, Q. L., Li, G., Li, H., Xu, S., & Pang, D. (2023) · Genes & Diseases · doi:10.1016/j.gendis.2023.02.052 · Cited by 62
Recent advances in integrated solid-state nanopore sensors
Rahman, M., Sampad, M. J. N., Hawkins, A. R., & Schmidt, H. (2021) · Lab on a Chip · doi:10.1039/d1lc00294e · Cited by 58
Advances in human organoids-on-chips in biomedical research
Wang, Y., & Qin, J. (2023) · Life Medicine · doi:10.1093/lifemedi/lnad007 · Cited by 58
Probing organoid metabolism using fluorescence lifetime imaging microscopy (FLIM): The next frontier of drug discovery and disease understanding
Barroso, M., Monaghan, M. G., Niesner, R. A., & Dmitriev, R. I. (2023) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2023.115081 · Cited by 60
Advanced lung organoids for respiratory system and pulmonary disease modeling
Joo, H., Min, S., & Cho, S. (2024) · Journal of Tissue Engineering · doi:10.1177/20417314241232502 · Cited by 66
Uncovering mutation-specific morphogenic phenotypes and paracrine-mediated vessel dysfunction in a biomimetic vascularized mammary duct platform
Kutys, M. L., Polacheck, W. J., Welch, M., Gagnon, K. A., Koorman, T., Kim, S., Li, L., McClatchey, A. I., & Chen, C. S. (2020) · Nature Communications · doi:10.1038/s41467-020-17102-x · Cited by 57
Screening Cancer Immunotherapy: When Engineering Approaches Meet Artificial Intelligence
Zhou, X., Qu, M., Tebon, P. J., Jiang, X., Wang, C., Xue, Y., Zhu, J., Zhang, S., Öklü, R., Sengupta, S., et al. (2020) · Advanced Science · doi:10.1002/advs.202001447 · Cited by 55
Oral Organoids: Progress and Challenges
Gao, X., Wu, Y., Liao, L., & Tian, W. (2021) · Journal of Dental Research · doi:10.1177/0022034520983808 · Cited by 56
Early invasion of the bladder wall by solitary bacteria protects UPEC from antibiotics and neutrophil swarms in an organoid model
Sharma, K., Thacker, V. V., Dhar, N., Cabrer, M. C., Dubois, A., Signorino‐Gelo, F., Mullenders, J., Knott, G. W., Clevers, H. C., & McKinney, J. D. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109351 · Cited by 60
Overview of Neural Tube Defects: Gene–Environment Interactions, Preventative Approaches and Future Perspectives
Isaković, J., Šimunić, I., Jagečić, D., Hribljan, V., & Mitrečić, D. (2022) · Biomedicines · doi:10.3390/biomedicines10050965 · Cited by 58
Structural Color Colloidal Photonic Crystals for Biomedical Applications
Zhang, W., Hu, Y., Feng, P., Li, Z., Zhang, H., Zhang, B., Xu, D., Qi, J., Wang, H., Xu, L., et al. (2024) · Advanced Science · doi:10.1002/advs.202403173 · Cited by 54
Progress in human liver organoids
Sun, L., & Hui, L. (2020) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjaa013 · Cited by 57
Microfluidic and Organ-on-a-Chip Approaches to Investigate Cellular and Microenvironmental Contributions to Cardiovascular Function and Pathology
Doherty, E. L., Aw, W. Y., Hickey, A. J., & Polacheck, W. J. (2021) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.624435 · Cited by 53
Spatial confinement toward creating artificial living systems
Shang, L., Ye, F., Li, M., & Zhao, Y. (2022) · Chemical Society Reviews · doi:10.1039/d1cs01025e · Cited by 54
Advancing Organoid Engineering for Tissue Regeneration and Biofunctional Reconstruction
Jin, H., Xue, Z., Liu, J., Ma, B., Yang, J., & Lei, L. (2024) · Biomaterials Research · doi:10.34133/bmr.0016 · Cited by 58
Generation of Skin Organoids: Potential Opportunities and Challenges
Sun, H., Zhang, Y., & Li, Y. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.709824 · Cited by 55
PBPK Modeling on Organs-on-Chips: An Overview of Recent Advancements
Yang, Y., Chen, Y., Wang, L., Xu, S., Fang, G., Guo, X., Chen, Z., & Gu, Z. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.900481 · Cited by 52
Organoid assessment technologies
Gu, Y., Zhang, W. C., Wu, X., Zhang, Y., Xu, K., & Su, J. (2023) · Clinical and Translational Medicine · doi:10.1002/ctm2.1499 · Cited by 53
From organoids to organoids-on-a-chip: Current applications and challenges in biomedical research
Liu, K., Chen, X., Fan, Z., Ren, F., Liu, J., & Hu, B. (2025) · Chinese Medical Journal · doi:10.1097/cm9.0000000000003535 · Cited by 59
Beyond PDMS and Membranes: New Materials for Organ-on-a-Chip Devices
Radisic, M., & Loskill, P. (2021) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.1c00831 · Cited by 56
Engineering Organ-on-a-Chip to Accelerate Translational Research
Ko, J., Park, D., Lee, S., Gümüşcü, B., & Jeon, N. L. (2022) · Micromachines · doi:10.3390/mi13081200 · Cited by 55
Precision Hydrogels for the Study of Cancer Cell Mechanobiology
Sievers, J., Mahajan, V., Welzel, P. B., Werner, C., & Taubenberger, A. V. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202202514 · Cited by 50
Engineering the 3D structure of organoids
Moss, S. P., Bakırcı, E., & Feinberg, A. W. (2024) · Stem Cell Reports · doi:10.1016/j.stemcr.2024.11.009 · Cited by 52
Human organotypic bioconstructs from organ-on-chip devices for human-predictive biological insights on drug candidates
Cavero, I., Guillon, J., & Holzgrefe, H. H. (2019) · Expert Opinion on Drug Safety · doi:10.1080/14740338.2019.1634689 · Cited by 50
Organoids and Microphysiological Systems: New Tools for Ophthalmic Drug Discovery
Bai, J., & Wang, C. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00407 · Cited by 51
Microfluidics as a Novel Tool for Biological and Toxicological Assays in Drug Discovery Processes: Focus on Microchip Electrophoresis
Caruso, G., Musso, N., Grasso, M., Costantino, A., Lazzarino, G., Tascedda, F., Gulisano, M., Lunte, S. M., & Caraci, F. (2020) · Micromachines · doi:10.3390/mi11060593 · Cited by 49
Human Organoids and Organs‐on‐Chips for Addressing COVID‐19 Challenges
Wang, Y., Wang, P., & Qin, J. (2022) · Advanced Science · doi:10.1002/advs.202105187 · Cited by 48
Applicability of organ-on-chip systems in toxicology and pharmacology
Schneider, M. R., Oelgeschläger, M., Burgdorf, T., van Meer, P. J. K., Theunissen, P. T., Kienhuis, A. S., Piersma, A. H., & Vandebriel, R. J. (2021) · Critical Reviews in Toxicology · doi:10.1080/10408444.2021.1953439 · Cited by 52
Vascularization of engineered organoids
Liu, H., Zhang, X., Liu, J., & Qin, J. (2023) · BMEMat · doi:10.1002/bmm2.12031 · Cited by 46
Advances in Multidimensional Cardiac Biosensing Technologies: From Electrophysiology to Mechanical Motion and Contractile Force
Wei, X., Zhuang, L., Li, H., He, C., Wan, H., Hu, N., & Wang, P. (2020) · Small · doi:10.1002/smll.202005828 · Cited by 49
Sensors-integrated organ-on-a-chip for biomedical applications
Chen, H., Luo, Z., Lin, X., Zhu, Y., & Zhao, Y. (2023) · Nano Research · doi:10.1007/s12274-023-5651-9 · Cited by 47
Complications and comorbidities associated with antineoplastic chemotherapy: Rethinking drug design and delivery for anticancer therapy
Mao, X., Wu, S., Huang, D., & Li, C. (2024) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2024.03.006 · Cited by 53
New Methodologies as Opportunities in the Study of Bacterial Biofilms, Including Food-Related Applications
Coppola, F., Fratianni, F., Bianco, V., Wang, Z., Pellegrini, M., Coppola, R., & Nazzaro, F. (2025) · Microorganisms · doi:10.3390/microorganisms13051062 · Cited by 49
Mimicry of Central-Peripheral Immunity in Alzheimer's Disease and Discovery of Neurodegenerative Roles in Neutrophil
Park, J., Baik, S. H., Mook‐Jung, I., Irimia, D., & Cho, H. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02231 · Cited by 46
Reconstructing the tumor architecture into organoids
Luo, Z., Zhou, X., Mandal, K., He, N., Wennerberg, W., Qu, M., Jiang, X., Sun, W., & Khademhosseini, A. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.113839 · Cited by 49
Aorta smooth muscle-on-a-chip reveals impaired mitochondrial dynamics as a therapeutic target for aortic aneurysm in bicuspid aortic valve disease
Abudupataer, M., Zhu, S., Yan, S., Xu, K., Zhang, J., Luo, S., Ma, W., Alam, M. F., Tang, Y., Huang, H., et al. (2021) · eLife · doi:10.7554/elife.69310 · Cited by 47
Bioengineered Co-culture of organoids to recapitulate host-microbe interactions
Kim, M. B., Hwangbo, S., Jang, S., & Jo, Y. K. (2022) · Materials Today Bio · doi:10.1016/j.mtbio.2022.100345 · Cited by 49
3D skin models along with skin-on-a-chip systems: A critical review
Sun, W., Liu, Z., Xu, J., Cheng, Y., Yin, R., Ma, L., Li, H., Qian, X. H., & Zhang, H. (2022) · Chinese Chemical Letters · doi:10.1016/j.cclet.2022.107819 · Cited by 46
Pancreatic islet organoids-on-a-chip: how far have we gone?
Yin, J., Meng, H., Lin, J., Ji, W., Xu, T., & Liu, H. (2022) · Journal of Nanobiotechnology · doi:10.1186/s12951-022-01518-2 · Cited by 48
A Pillar and Perfusion Plate Platform for Robust Human Organoid Culture and Analysis
Kang, S., Kimura, M., Shrestha, S., Lewis, P., Lee, S., Cai, Y., Joshi, P., Acharya, P., Liu, J., Yang, Y., et al. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202302502 · Cited by 44
In vitroinfection models to study fungal–host interactions
Last, A., Maurer, M., Mosig, A. S., Gresnigt, M. S., & Hube, B. (2021) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuab005 · Cited by 45
Flourishing tumor organoids: History, emerging technology, and application
Yang, Q., Li, M., Yang, X., Xiao, Z., Tong, X., Tuerdi, A., Li, S., & Lei, L. (2023) · Bioengineering & Translational Medicine · doi:10.1002/btm2.10559 · Cited by 46
Organoids in the oral and maxillofacial region: present and future
Wu, Y., Li, X., Liu, H., Yang, X. Y., Li, R., Zhao, H., & Shang, Z. (2024) · International Journal of Oral Science · doi:10.1038/s41368-024-00324-w · Cited by 49
Recent Updates on Research Models and Tools to Study Virus–Host Interactions at the Placenta
Lee, J. K., Oh, S. J., Park, H., & Shin, O. S. (2019) · Viruses · doi:10.3390/v12010005 · Cited by 46
Organs-on-a-chip as model systems for multifactorial musculoskeletal diseases
Arrigoni, C., Lopa, S., Candrian, C., & Moretti, M. (2020) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2019.12.006 · Cited by 47
Intestinal Organoid Culture in Polymer Film‐Based Microwell Arrays
Kakni, P., Hueber, R., Knoops, K., López‐Iglesias, C., Truckenmüller, R. K., Habibović, P., & Giselbrecht, S. (2020) · Advanced Biosystems · doi:10.1002/adbi.202000126 · Cited by 47
Recent advances in organoid engineering: A comprehensive review
Unagolla, J. M., & Jayasuriya, A. C. (2022) · Applied Materials Today · doi:10.1016/j.apmt.2022.101582 · Cited by 44
Microfluidic preparation of optical sensors for biomedical applications
Wang, Q., Wang, C., Yang, X., Wang, J., Zhang, Z., & Shang, L. (2023) · Smart Medicine · doi:10.1002/smmd.20220027 · Cited by 44
Microfluidic based human-on-a-chip: A revolutionary technology in scientific research
Syama, S., & Mohanan, P. V. (2021) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2021.02.049 · Cited by 46
Developmental angiocrine diversification of endothelial cells for organotypic regeneration
Gómez-Salinero, J. M., Itkin, T., & Rafii, S. (2021) · Developmental Cell · doi:10.1016/j.devcel.2021.10.020 · Cited by 46
Roles of cytochrome P450 enzymes in pharmacology and toxicology: Past, present, and future
Guengerich, F. P. (2022) · Advances in pharmacology · doi:10.1016/bs.apha.2021.12.001 · Cited by 45
Harnessing the power of artificial intelligence for human living organoid research
Wang, H., Li, X., You, X., & Zhao, G. (2024) · Bioactive Materials · doi:10.1016/j.bioactmat.2024.08.027 · Cited by 43
The role of physical cues in the development of stem cell-derived organoids
Tortorella, I., Argentati, C., Emiliani, C., Martino, S., & Morena, F. (2021) · European Biophysics Journal · doi:10.1007/s00249-021-01551-3 · Cited by 44
Cancer-on-a-chip for precision cancer medicine
Liu, L., Wang, H., Chen, R., Song, Y., Wei, W., Baek, D. S. H., Gillin, M., Kurabayashi, K., & Chen, W. (2025) · Lab on a Chip · doi:10.1039/d4lc01043d · Cited by 48
3D Bioprinting of Miniaturized Tissues Embedded in Self‐Assembled Nanoparticle‐Based Fibrillar Platforms
Bakht, S. M., Gómez‐Florit, M., Lamers, T., Reis, R. L., Domingues, R. M. A., & Gomes, M. E. (2021) · Advanced Functional Materials · doi:10.1002/adfm.202104245 · Cited by 46
Media portrayal of ethical and social issues in brain organoid research
Presley, A., Samsa, L. A., & Dubljević, V. (2022) · Philosophy Ethics and Humanities in Medicine · doi:10.1186/s13010-022-00119-z · Cited by 41
3D multicellular systems in disease modelling: From organoids to organ-on-chip
Goldrick, C., Guri, I., Herrera-Oropeza, G. E., O’Brien-Gore, C., Roy, E., Wojtynska, M., & Spagnoli, F. M. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1083175 · Cited by 44
Breast cancer organoids derived from patients: A platform for tailored drug screening
Tzeng, Y. T., Hsiao, J., Tseng, L., Hou, M., & Li, C. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115803 · Cited by 45
Engineered 3D ex vivo models to recapitulate the complex stromal and immune interactions within the tumor microenvironment
Ravi, K., Manoharan, T. J. M., Wang, K.-C., Pockaj, B. A., & Nikkhah, M. (2023) · Biomaterials · doi:10.1016/j.biomaterials.2023.122428 · Cited by 45
Micro/Nanorobots for Advanced Light‐Based Biosensing and Imaging
Neettiyath, A., & Pumera, M. (2024) · Advanced Functional Materials · doi:10.1002/adfm.202415875 · Cited by 44
Applications of the microphysiology systems database for experimental ADME-Tox and disease models
Schurdak, M. E., Vernetti, L. A., Bergenthal, L., Wolter, Q. K., Shun, T. Y., Karcher, S. C., Taylor, D. L., & Gough, A. (2020) · Lab on a Chip · doi:10.1039/c9lc01047e · Cited by 41
Low-cost rapid prototyping and assembly of an open microfluidic device for a 3D vascularized organ-on-a-chip
Li, Q., Niu, K., Wang, D., Xuan, L., & Wang, X. (2021) · Lab on a Chip · doi:10.1039/d1lc00767j · Cited by 41
Nerve‐on‐a‐Chip Derived Biomimicking Microfibers for Peripheral Nerve Regeneration
Yu, Y., Jin, B., Chen, J., Lou, C., Guo, J., Yang, C., & Zhao, Y. (2023) · Advanced Science · doi:10.1002/advs.202207536 · Cited by 39

Authors: Park, S. E., Georgescu, A., & Huh, D.
Affiliations: University of Pennsylvania (US)
Corresponding author: Huh, Dongeun
ORCID: Park, Sunghee Estelle
Georgescu, Andrei
Huh, Dongeun
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2019-06-07
Volume: 364
Issue: 6444
Pages: 960-965
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.aaw7894
PMC: PMC7764943
OpenAlex: W2948870515
Cited by: 847
References: 65
Citations by year: 2026: 118 · 2025: 132 · 2024: 126 · 2023: 132 · 2022: 116 · 2021: 134 · 2020: 74 · 2019: 15
FWCI: 29.88
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
Locations: Science (publishedVersion, cc-by)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Science Foundation (CMMI:15-48571)
National Institutes of Health (1UG3TR002198-01, 1UC4DK104196-01, 1DP2HL127720-01)
Cancer Research Institute
Paul G. Allen Family Foundation
University of Pennsvlvania
Topics: Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
Physical Sciences › Engineering › Biomedical Engineering › Microfluidic and Capillary Electrophoresis Applications
Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
Keywords: organoids, organ-on-a-chip, organoid engineering
MeSH terms: Humans, Organoids, Cell Culture Techniques, Lab-On-A-Chip Devices

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Organoids-on-a-chip

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks