Cited by 8503D Printing in Biomedical ResearchMicrofluidic and Capillary Electrophoresis ApplicationsTissue Engineering and Regenerative Medicine

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Organoids-on-a-chip

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Park, Sunghee Estelle, Georgescu, Andrei, Huh, Dongeun·2019·Science

DOI 10.1126/science.aaw7894PMC PMC7764943

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Abstract

Recent studies have demonstrated an array of stem cell–derived, self-organizing miniature organs, termed organoids, that replicate the key structural and functional characteristics of their in vivo counterparts. As organoid technology opens up new frontiers of research in biomedicine, there is an emerging need for innovative engineering approaches for the production, control, and analysis of organoids and their microenvironment. In this Review, we explore organ-on-a-chip technology as a platform to fulfill this need and examine how this technology may be leveraged to address major technical challenges in organoid research. We also discuss emerging opportunities and future obstacles for the development and application of organoid-on-a-chip technology.

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Authors: Park, S. E., Georgescu, A., & Huh, D.
Affiliations: University of Pennsylvania (US)
Corresponding author: Huh, Dongeun
ORCID: Park, Sunghee Estelle
Georgescu, Andrei
Huh, Dongeun
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2019-06-07
Volume: 364
Issue: 6444
Pages: 960-965
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.aaw7894
PMC: PMC7764943
OpenAlex: W2948870515
Cited by: 847
References: 65
Citations by year: 2026: 118 · 2025: 132 · 2024: 126 · 2023: 132 · 2022: 116 · 2021: 134 · 2020: 74 · 2019: 15
FWCI: 29.88
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
Locations: Science (publishedVersion, cc-by)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Science Foundation (CMMI:15-48571)
National Institutes of Health (1UG3TR002198-01, 1UC4DK104196-01, 1DP2HL127720-01)
Cancer Research Institute
Paul G. Allen Family Foundation
University of Pennsvlvania
Topics: Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
Physical Sciences › Engineering › Biomedical Engineering › Microfluidic and Capillary Electrophoresis Applications
Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
Keywords: organoids, organ-on-a-chip, organoid engineering
MeSH terms: Humans, Organoids, Cell Culture Techniques, Lab-On-A-Chip Devices

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