Cited by 8503D Printing in Biomedical ResearchMicrofluidic and Capillary Electrophoresis ApplicationsTissue Engineering and Regenerative Medicine

The DOI matches its Crossref record; 65 of the 65 references it cites were found in a registry or an index.

Organoids-on-a-chip

Open access

Abstract

Recent studies have demonstrated an array of stem cell–derived, self-organizing miniature organs, termed organoids, that replicate the key structural and functional characteristics of their in vivo counterparts. As organoid technology opens up new frontiers of research in biomedicine, there is an emerging need for innovative engineering approaches for the production, control, and analysis of organoids and their microenvironment. In this Review, we explore organ-on-a-chip technology as a platform to fulfill this need and examine how this technology may be leveraged to address major technical challenges in organoid research. We also discuss emerging opportunities and future obstacles for the development and application of organoid-on-a-chip technology.

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Metadata

Authors
Park, S. E., Georgescu, A., & Huh, D.
Affiliations
University of Pennsylvania (US)
Corresponding author
Huh, Dongeun
Venue
Science
Published
2019-06-07
Volume
364
Issue
6444
Pages
960-965
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2948870515
Cited by
847
References
65
Citations by year
2026: 118 · 2025: 132 · 2024: 126 · 2023: 132 · 2022: 116 · 2021: 134 · 2020: 74 · 2019: 15
FWCI
29.88
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Science (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Science Foundation (CMMI:15-48571)
  • National Institutes of Health (1UG3TR002198-01, 1UC4DK104196-01, 1DP2HL127720-01)
  • Cancer Research Institute
  • Paul G. Allen Family Foundation
  • University of Pennsvlvania
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
  • Physical Sciences › Engineering › Biomedical Engineering › Microfluidic and Capillary Electrophoresis Applications
  • Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
Keywords
organoids, organ-on-a-chip, organoid engineering
MeSH terms
Humans, Organoids, Cell Culture Techniques, Lab-On-A-Chip Devices

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