Organoids-on-a-chip

Cerebral organoids model human brain development and microcephaly

Lancaster, M. A., Renner, M., Martin, C.-A., Wenzel, D., Bicknell, L. S., Hurles, M. E., Homfray, T., Penninger, J. M., Jackson, A. P., & Knoblich, J. A. (2013) · Nature · doi:10.1038/nature12517 · Cited by 5,372

Reconstituting organ-level lung functions on a chip

Huh, D., Matthews, B. D., Mammoto, A., Montoya-Zavala, M., Hsin, H. Y., & Ingber, D. E. (2010) · Science · doi:10.1126/science.1188302 · Cited by 4,250

Microfluidic organs-on-chips

Bhatia, S. N., & Ingber, D. E. (2014) · Nature Biotechnology · doi:10.1038/nbt.2989 · Cited by 3,305

Modeling Development and Disease with Organoids

Clevers, H. (2016) · Cell · doi:10.1016/j.cell.2016.05.082 · Cited by 3,196

Organogenesis in a dish: Modeling development and disease using organoid technologies

Lancaster, M. A., & Knoblich, J. A. (2014) · Science · doi:10.1126/science.1247125 · Cited by 2,931

Soft Lithography in Biology and Biochemistry

Whitesides, G. M., Ostuni, E., Takayama, S., Jiang, X., & Ingber, D. E. (2001) · Annual Review of Biomedical Engineering · doi:10.1146/annurev.bioeng.3.1.335 · Cited by 2,603

Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure

Qian, X., Nguyen, H. N., Song, M. M., Hadiono, C., Ogden, S. C., Hammack, C., Yao, B., Hamersky, G. R., Jacob, F., Zhong, C., et al. (2016) · Cell · doi:10.1016/j.cell.2016.04.032 · Cited by 2,127

From 3D cell culture to organs-on-chips

Huh, D., Hamilton, G. A., & Ingber, D. E. (2011) · Trends in Cell Biology · doi:10.1016/j.tcb.2011.09.005 · Cited by 1,834

Mechanical forces direct stem cell behaviour in development and regeneration

Vining, K. H., & Mooney, D. J. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.108 · Cited by 1,656

Three-dimensional bioprinting of thick vascularized tissues

Kolesky, D. B., Homan, K. A., Skylar-Scott, M. A., & Lewis, J. A. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1521342113 · Cited by 1,492

Engineering organoids

Hofer, M., & Lutolf, M. P. (2021) · Nature Reviews Materials · doi:10.1038/s41578-021-00279-y · Cited by 1,184

Organs-on-chips: into the next decade

Low, L. A., Mummery, C., Berridge, B. R., Austin, C. P., & Tagle, D. A. (2021) · Nature Reviews Drug Discovery · doi:10.1038/s41573-020-0079-3 · Cited by 1,029

Organoids

Zhao, Z., Chen, X., Dowbaj, A. M., Sljukic, A., Bratlie, K., Lin, L., Fong, E. L. S., Balachander, G. M., Chen, Z., Soragni, A., et al. (2022) · Nature Reviews Methods Primers · doi:10.1038/s43586-022-00174-y · Cited by 1,082

Organ-on-a-Chip: A New Paradigm for Drug Development

Ma, C., Peng, Y., Li, H., & Chen, W. (2020) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2020.11.009 · Cited by 612

Organoid and Spheroid Tumor Models: Techniques and Applications

Gunti, S., Hoke, A. T. K., Vu, K., & London, N. R. (2021) · Cancers · doi:10.3390/cancers13040874 · Cited by 525

Organoids by design

Takebe, T., & Wells, J. M. (2019) · Science · doi:10.1126/science.aaw7567 · Cited by 417

Brain organoids for the study of human neurobiology at the interface of in vitro and in vivo

Chiaradia, I., & Lancaster, M. A. (2020) · Nature Neuroscience · doi:10.1038/s41593-020-00730-3 · Cited by 360

Modeling neoplastic disease with spheroids and organoids

Zanoni, M., Cortesi, M., Zamagni, A., Arienti, C., Pignatta, S., & Tesei, A. (2020) · Journal of Hematology & Oncology · doi:10.1186/s13045-020-00931-0 · Cited by 280

An Update on Adipose‐Derived Stem Cells for Regenerative Medicine: Where Challenge Meets Opportunity

Qin, Y., Ge, G., Yang, P., Wang, L., Qiao, Y., Pan, G., Yang, H., Bai, J., Cui, W., & Geng, D. (2023) · Advanced Science · doi:10.1002/advs.202207334 · Cited by 278

Tumor-on-a-chip: from bioinspired design to biomedical application

Liu, X., Fang, J., Huang, S., Wu, X., Xie, X., Wang, J., Liu, F., Zhang, M., Peng, Z., & Hu, N. (2021) · Microsystems & Nanoengineering · doi:10.1038/s41378-021-00277-8 · Cited by 246

Emerging organoid models: leaping forward in cancer research

Fan, H., Demirci, U., & Chen, P. (2019) · Journal of Hematology & Oncology · doi:10.1186/s13045-019-0832-4 · Cited by 199

Electrochemical Sensing Directions for Next-Generation Healthcare: Trends, Challenges, and Frontiers

Hernández-Rodríguez, J. F., Rojas, D., & Escarpa, A. (2020) · Analytical Chemistry · doi:10.1021/acs.analchem.0c04378 · Cited by 202

An Automated Organoid Platform with Inter-organoid Homogeneity and Inter-patient Heterogeneity

Jiang, S., Zhao, H., Zhang, W., Wang, J., Liu, Y., Cao, Y., Zheng, H., Hu, Z., Wang, S., Zhu, Y., et al. (2020) · Cell Reports Medicine · doi:10.1016/j.xcrm.2020.100161 · Cited by 188

Intelligent Microfluidics: The Convergence of Machine Learning and Microfluidics in Materials Science and Biomedicine

Galan, E. A., Zhao, H., Wang, X., Dai, Q., Huck, W. T. S., & Ma, S. (2020) · Matter · doi:10.1016/j.matt.2020.08.034 · Cited by 194

Microfluidic Organ-on-A-chip: A Guide to Biomaterial Choice and Fabrication

Cao, U. M. N., Zhang, Y., Chen, J., Sayson, D., Pillai, S., & Tran, S. D. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043232 · Cited by 193

Patient-Derived Organoids in Precision Medicine: Drug Screening, Organoid-on-a-Chip and Living Organoid Biobank

Zhou, Z., Cong, L., & Cong, X. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.762184 · Cited by 189

Tumor organoids: synergistic applications, current challenges, and future prospects in cancer therapy

Qu, J., Kalyani, F. S., Liu, L., Cheng, T., & Chen, L. (2021) · 癌症：英文版 · doi:10.1002/cac2.12224 · Cited by 173

Review on the Vascularization of Organoids and Organoids-on-a-Chip

Zhao, X., Xu, Z., Xiao, L., Shi, T., Xiao, H., Wang, Y., Li, Y., Xue, F., & Zeng, W. (2021) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.637048 · Cited by 167

Gastrointestinal tract modeling using organoids engineered with cellular and microbiota niches

Min, S., Kim, S., & Cho, S. (2020) · Experimental & Molecular Medicine · doi:10.1038/s12276-020-0386-0 · Cited by 151

Cell Culture in Microfluidic Droplets

Sart, S., Ronteix, G., Jain, S., Amselem, G., & Baroud, C. N. (2022) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00666 · Cited by 154

Recapitulating Pancreatic Tumor Microenvironment through Synergistic Use of Patient Organoids and Organ‐on‐a‐Chip Vasculature

Lai, B. F. L., Lu, R. X. Z., Hu, Y., Davenport Huyer, L., Dou, W., Wang, E. Y., Radulovich, N., Tsao, M. S., Sun, Y., & Radisic, M. (2020) · Advanced Functional Materials · doi:10.1002/adfm.202000545 · Cited by 142

Drug Toxicity Evaluation Based on Organ-on-a-chip Technology: A Review

Cong, Y., Han, X., Wang, Y., Chen, Z., Lu, Y., Liu, T., Wu, Z., Jin, Y., Luo, Y., & Zhang, X. (2020) · Micromachines · doi:10.3390/mi11040381 · Cited by 140

Patient-derived organoid (PDO) platforms to facilitate clinical decision making

Liu, L., Yu, L., Li, Z., Li, W., & Huang, W. (2021) · Journal of Translational Medicine · doi:10.1186/s12967-020-02677-2 · Cited by 145

Is Target-Based Drug Discovery Efficient? Discovery and “Off-Target” Mechanisms of All Drugs

Sadri, A. (2023) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.2c01737 · Cited by 149

An Organoid for Woven Bone

Akiva, A., Melke, J., Ansari, S., Liv, N., van der Meijden, R., van Erp, M., Zhao, F., Stout, M., Nijhuis, W. H., de Heus, C., et al. (2021) · Advanced Functional Materials · doi:10.1002/adfm.202010524 · Cited by 138

Insight into Mechanobiology: How Stem Cells Feel Mechanical Forces and Orchestrate Biological Functions

Argentati, C., Morena, F., Tortorella, I., Bazzucchi, M., Porcellati, S., Emiliani, C., & Martino, S. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20215337 · Cited by 143

Liver Organoids: Recent Developments, Limitations and Potential

Harrison, S. P., Baumgarten, S., Verma, R., Lunov, O., Dejneka, A., & Sullivan, G. J. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.574047 · Cited by 152

Human organoids-on-chips for biomedical research and applications

Wang, H., Ning, X., Zhao, F. H., Zhao, H., & Li, D. (2024) · Theranostics · doi:10.7150/thno.90492 · Cited by 148

DNA Nanolithography Enables a Highly Ordered Recognition Interface in a Microfluidic Chip for the Efficient Capture and Release of Circulating Tumor Cells

Zhang, J., Lin, B., Wu, L., Huang, M., Li, X., Zhang, H., Song, J. T., Wang, W., Zhao, G., Song, Y., et al. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.202005974 · Cited by 132

Cell spheroids as a versatile research platform: formation mechanisms, high throughput production, characterization and applications

Decarli, M. C., do Amaral, R. L. F., dos Santos, D. P., Tofani, L. B., Katayama, E. T., Rezende, R. A., da Silva, J. V. L., Swiech, K., Suazo, C. A. T., Mota, C., et al. (2021) · Biofabrication · doi:10.1088/1758-5090/abe6f2 · Cited by 138

Advanced Strategies for 3D Bioprinting of Tissue and Organ Analogs Using Alginate Hydrogel Bioinks

Gao, Q., Kim, B.-S., & Gao, G. (2021) · Marine Drugs · doi:10.3390/md19120708 · Cited by 134

Biomimetic hydrogel supports initiation and growth of patient-derived breast tumor organoids

Prince, E., Cruickshank, J., Ba-Alawi, W., Hodgson, K., Haight, J., Tobin, C., Wakeman, A., Avoulov, A., Topolskaia, V., Elliott, M. J., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-28788-6 · Cited by 135

Microfluidic Organ-on-a-Chip System for Disease Modeling and Drug Development

Li, Z., Hui, J., Yang, P., & Mao, H. (2022) · Biosensors · doi:10.3390/bios12060370 · Cited by 135

Advancing models of neural development with biomaterials

Roth, J. G., Huang, M. S., Li, T. L., Feig, V. R., Jiang, Y., Cui, B., Greely, H. T., Bao, Z., Pașca, S. P., & Heilshorn, S. C. (2021) · Nature reviews. Neuroscience · doi:10.1038/s41583-021-00496-y · Cited by 122

Microfluidic Arrays of Breast Tumor Spheroids for Drug Screening and Personalized Cancer Therapies

Prince, E., Kheiri, S., Wang, Y., Xu, F., Cruickshank, J., Topolskaia, V., Tao, H., Young, E. W. K., McGuigan, A. P., Cescon, D. W., et al. (2022) · Advanced Healthcare Materials · doi:10.1002/adhm.202101085 · Cited by 121

Organoids-on-a-chip: microfluidic technology enables culture of organoids with enhanced tissue function and potential for disease modeling

Papamichail, L., Koch, L. S., Veerman, D., Broersen, K., & van der Meer, A. D. (2025) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2025.1515340 · Cited by 120

Emerging technologies and their impact on regulatory science

Anklam, E., Bahl, M. I., Ball, R., Beger, R. D., Cohen, J. E., Fitzpatrick, S., Girard, P., Halamoda‐Kenzaoui, B., Hinton, D., Hirose, A., et al. (2021) · Experimental Biology and Medicine · doi:10.1177/15353702211052280 · Cited by 134

Controlled magnesium ion delivery system for in situ bone tissue engineering

Yuan, Z., Wan, Z., Gao, C., Wang, Y., Huang, J., & Cai, Q. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.08.036 · Cited by 119

Human biomimetic liver microphysiology systems in drug development and precision medicine

Gough, A., Soto-Gutierrez, A., Vernetti, L., Ebrahimkhani, M. R., Stern, A. M., & Taylor, D. L. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-020-00386-1 · Cited by 117

Trends in Droplet Microfluidics: From Droplet Generation to Biomedical Applications

Chen, Z., Kheiri, S., Young, E. W. K., & Kumacheva, E. (2022) · Langmuir · doi:10.1021/acs.langmuir.2c00491 · Cited by 116

Organoids and organs-on-chips: Recent advances, applications in drug development, and regulatory challenges

Zhou, L., Huang, J., Li, C., Gu, Q., Li, G., Li, Z. A., Xu, J., Zhou, J., & Tuan, R. S. (2025) · Med · doi:10.1016/j.medj.2025.100667 · Cited by 126

Modeling human nonalcoholic fatty liver disease (NAFLD) with an organoids-on-a-chip system

Wang, Y., Wang, H., Deng, P., Tao, T., Liu, H., Wu, S., Chen, W., & Qin, J. (2020) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.0c00682 · Cited by 109

Electrophysiological Analysis of Brain Organoids: Current Approaches and Advancements

Passaro, A. P., & Stice, S. L. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.622137 · Cited by 120

Gene Environment Interactions in the Etiology of Neural Tube Defects

Finnell, R. H., Caiaffa, C. D., Kim, S., Lei, Y., Steele, J., Cao, X., Tukeman, G. L., Lin, Y. L., Cabrera, R. M., & Wlodarczyk, B. J. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.659612 · Cited by 114

Polymer Hydrogels to Guide Organotypic and Organoid Cultures

Magno, V., Meinhardt, A., & Werner, C. (2020) · Advanced Functional Materials · doi:10.1002/adfm.202000097 · Cited by 110

Translating complexity and heterogeneity of pancreatic tumor: 3D in vitro to in vivo models

Heinrich, M. A., Mostafa, A. M. R. H., Morton, J. P., Hawinkels, L. J. A. C., & Prakash, J. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.04.018 · Cited by 115

Immunotherapy discovery on tumor organoid-on-a-chip platforms that recapitulate the tumor microenvironment

Zhang, J., Tavakoli, H., Ma, L., Li, X., Han, L., & Li, X. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114365 · Cited by 110

Advances in microfluidic in vitro systems for neurological disease modeling

Holloway, P. M., Willaime‐Morawek, S., Siow, R. C. M., Barber, M., Owens, R. M., Sharma, A. D., Rowan, W. C., Hill, E. J., & Zagnoni, M. (2021) · Journal of Neuroscience Research · doi:10.1002/jnr.24794 · Cited by 101

Recent advances in lung-on-a-chip models

Francis, I., Shrestha, J., Paudel, K. R., Hansbro, P. M., Warkiani, M. E., & Saha, S. C. (2022) · Drug Discovery Today · doi:10.1016/j.drudis.2022.06.004 · Cited by 118

Engineering Human Brain Assembloids by Microfluidics

Zhu, Y., Zhang, X., Sun, L., Wang, Y., & Zhao, Y. (2023) · Advanced Materials · doi:10.1002/adma.202210083 · Cited by 109

Roadmap on emerging concepts in the physical biology of bacterial biofilms: from surface sensing to community formation

Wong, G. C. L., Antani, J. D., Lele, P. P., Chen, J., Nan, B., Kühn, M. J., Persat, A., Bru, J.-L., Høyland‐Kroghsbo, N. M., Siryaporn, A., et al. (2021) · Physical Biology · doi:10.1088/1478-3975/abdc0e · Cited by 93

Generation of neural organoids for spinal-cord regeneration via the direct reprogramming of human astrocytes

Jin-hong, X., Shi, F., Deng, S., Li, H., Lin, X., Huang, Y., Chung, S., Shu, Y., & Shao, Z. (2022) · Nature Biomedical Engineering · doi:10.1038/s41551-022-00963-6 · Cited by 103

Vascular organoids: unveiling advantages, applications, challenges, and disease modelling strategies

Naderi‐Meshkin, H., Cornelius, V. A., Eleftheriadou, M., Potel, K. N., Setyaningsih, W. A. W., & Margariti, A. (2023) · Stem Cell Research & Therapy · doi:10.1186/s13287-023-03521-2 · Cited by 101

Biosensors integrated 3D organoid/organ-on-a-chip system: A real-time biomechanical, biophysical, and biochemical monitoring and characterization

Liu, S., Kumari, S., He, H., Mishra, P., Singh, B. N., Singh, D., Liu, S., Srivastava, P., & Li, C. (2023) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2023.115285 · Cited by 103

Advances in microphysiological blood-brain barrier (BBB) models towards drug delivery

Lee, C. S., & Leong, K. W. (2020) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2020.06.009 · Cited by 96

Automated evaluation of tumor spheroid behavior in 3D culture using deep learning-based recognition

Chen, Z., Ma, N., Sun, X., Li, Q., Zeng, Y., Chen, F., Sun, S., Xu, J., Zhang, J., Ye, H., et al. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.120770 · Cited by 96

Organ-on-a-chip technology for the study of the female reproductive system

Young, R. E., & Huh, D. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.03.010 · Cited by 99

Methodological aspects and pharmacological applications of three-dimensional cancer cell cultures and organoids

Foglietta, F., Canaparo, R., Muccioli, G., Terreno, E., & Serpe, L. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.117784 · Cited by 101

Organ-on-a-chip technology for nanoparticle research

Kang, S., Park, S. E., & Huh, D. (2021) · Nano Convergence · doi:10.1186/s40580-021-00270-x · Cited by 101

Human microphysiological systems for drug development

Roth, A., & 2019, M.-W. B. (2021) · Science · doi:10.1126/science.abc3734 · Cited by 94

Alveolar wars: The rise of in vitro models to understand human lung alveolar maintenance, regeneration, and disease

Evans, K. V., & Lee, J. (2020) · Stem Cells Translational Medicine · doi:10.1002/sctm.19-0433 · Cited by 96

Organ-on-Chip Approaches for Intestinal 3D In Vitro Modeling

Pimenta, J. M., Ribeiro, R. D. C., Almeida, R., Costa, P. F., da Silva, M. A., & Pereira, B. (2021) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2021.08.015 · Cited by 94

3D cancer models: One step closer to in vitro human studies

Manduca, N., Maccafeo, E., Maria, R. D., Sistigu, A., & Musella, M. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1175503 · Cited by 103

Past, Present, and Future of Brain Organoid Technology.

Koo, B., Choi, B., Park, H., & Yoon, K. (2019) · Europe PMC (PubMed Central) · doi:10.14348/molcells.2019.0162 · Cited by 93

Mechanomaterials: A Rational Deployment of Forces and Geometries in Programming Functional Materials

Cai, P., Wang, C., Gao, H., & Chen, X. (2021) · Advanced Materials · doi:10.1002/adma.202007977 · Cited by 91

Patient‐Specific Organoid and Organ‐on‐a‐Chip: 3D Cell‐Culture Meets 3D Printing and Numerical Simulation

Zheng, F., Xiao, Y., Liu, H., Fan, Y., & Dao, M. (2021) · Advanced Biology · doi:10.1002/adbi.202000024 · Cited by 96

From Organ-on-a-Chip to Human-on-a-Chip: A Review of Research Progress and Latest Applications

Huang, Y., Liu, T., Huang, Q., & Wang, Y. (2024) · ACS Sensors · doi:10.1021/acssensors.4c00004 · Cited by 97

Tubular human brain organoids to model microglia-mediated neuroinflammation

Ao, Z., Cai, H., Wu, Z., Song, S., Karahan, H., Kim, B., Lu, H.-C., Kim, J., Mackie, K., & Guo, F. (2021) · Lab on a Chip · doi:10.1039/d1lc00030f · Cited by 87

Microphysiological Systems: Design, Fabrication, and Applications

Wang, K., Man, K., Liu, J., Liu, Y., Chen, Q., Zhou, Y., & Yang, Y. S. (2020) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.9b01667 · Cited by 86

Advancing Drug Discovery for Neurological Disorders Using iPSC-Derived Neural Organoids

Costamagna, G., Comi, G. P., & Corti, S. P. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052659 · Cited by 91

Microfluidic high-throughput 3D cell culture

Ko, J., Park, D., Lee, J., Jung, S., Baek, K., Sung, K. E., Lee, J., & Jeon, N. L. (2024) · Nature Reviews Bioengineering · doi:10.1038/s44222-024-00163-8 · Cited by 88

Culture and analysis of kidney tubuloids and perfused tubuloid cells-on-a-chip

Gijzen, L., Yengej, F. A. Y., Schutgens, F., Vormann, M. K., Ammerlaan, C. M. E., Nicolas, A., Kurek, D., Vulto, P., Rookmaaker, M. B., Lanz, H. L., et al. (2021) · Nature Protocols · doi:10.1038/s41596-020-00479-w · Cited by 85

Exposure to cadmium induces neuroinflammation and impairs ciliogenesis in hESC-derived 3D cerebral organoids

Huang, Y., Dai, Y., Li, M., Guo, L., Cao, C., Huang, Y.-T., Ma, R., Qiu, S., Su, X., Zhong, K., et al. (2021) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2021.149043 · Cited by 85

Organoids and organs-on-chips: insights into predicting the efficacy of systemic treatment in colorectal cancer

Zhu, J., Ji, L., Chen, Y., Li, H., Huang, M., Dai, Z., Wang, J., Xiang, D., Fu, G., Lei, Z., et al. (2023) · Cell Death Discovery · doi:10.1038/s41420-023-01354-9 · Cited by 92

Revolutionizing Disease Modeling: The Emergence of Organoids in Cellular Systems

Silva-Pedrosa, R., Salgado, A. J., & Ferreira, P. E. (2023) · Cells · doi:10.3390/cells12060930 · Cited by 84

Modeling better in vitro models for the prediction of nanoparticle toxicity: a review

Cao, Y., Li, S., & Chen, J. (2020) · Toxicology Mechanisms and Methods · doi:10.1080/15376516.2020.1828521 · Cited by 83

Immunocompetent cancer-on-chip models to assess immuno-oncology therapy

Maulana, T. I., Kromidas, E., Wallstabe, L., Cipriano, M., Alb, M., Zaupa, C., Hudecek, M., Fogal, B., & Loskill, P. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.03.015 · Cited by 86

Middle-out methods for spatiotemporal tissue engineering of organoids

Blatchley, M. R., & Anseth, K. S. (2023) · Nature Reviews Bioengineering · doi:10.1038/s44222-023-00039-3 · Cited by 85

Standardization of organoid culture in cancer research

Zhou, C., Wu, Y., Wang, Z., Liu, Y., Yu, J., Wang, W., Chen, S., Wu, W., Wang, J., Qian, G., et al. (2023) · Cancer Medicine · doi:10.1002/cam4.5943 · Cited by 87

Construction of tumor organoids and their application to cancer research and therapy

Lv, J., Du, X., Wang, M., Su, J., Wei, Y., & Xu, C. (2024) · Theranostics · doi:10.7150/thno.91362 · Cited by 90

Bone/cartilage organoid on-chip: Construction strategy and application

Hu, Y., Zhang, H., Wang, S., Cao, L., Zhou, F., Jing, Y., & Su, J. (2023) · Bioactive Materials · doi:10.1016/j.bioactmat.2023.01.016 · Cited by 87

Applications of human organoids in the personalized treatment for digestive diseases

Wang, Q., Guo, F., Jin, Y., & Ma, Y. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01194-6 · Cited by 87

Enabling peristalsis of human colon tumor organoids on microfluidic chips

Fang, G., Lu, H., Al-Nakashli, R., Chapman, R., Zhang, Y., Ju, L. A., Lin, G., Stenzel, M. H., & Jin, D. (2022) · Biofabrication · doi:10.1088/1758-5090/ac2ef9 · Cited by 77

Understanding Immune‐Driven Brain Aging by Human Brain Organoid Microphysiological Analysis Platform

Ao, Z., Song, S., Tian, C., Cai, H., Li, X., Miao, Y., Wu, Z., Krzesniak, J., Ning, B., Gu, M., et al. (2022) · Advanced Science · doi:10.1002/advs.202200475 · Cited by 77

Recent Advances in Organ‐on‐Chips Integrated with Bioprinting Technologies for Drug Screening

Rezaei, N. T., Kumar, H., Liu, H., Lee, S. S., Park, S. S., & Kim, K. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202203172 · Cited by 81

Advances in development and application of human organoids

Shankaran, A., Prasad, K., Chaudhari, S., Brand, A. M., & Satyamoorthy, K. (2021) · 3 Biotech · doi:10.1007/s13205-021-02815-7 · Cited by 77

High resolution microfluidic assay and probabilistic modeling reveal cooperation between T cells in tumor killing

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