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Organoids-on-a-chip
Open accessAbstract
Recent studies have demonstrated an array of stem cell–derived, self-organizing miniature organs, termed organoids, that replicate the key structural and functional characteristics of their in vivo counterparts. As organoid technology opens up new frontiers of research in biomedicine, there is an emerging need for innovative engineering approaches for the production, control, and analysis of organoids and their microenvironment. In this Review, we explore organ-on-a-chip technology as a platform to fulfill this need and examine how this technology may be leveraged to address major technical challenges in organoid research. We also discuss emerging opportunities and future obstacles for the development and application of organoid-on-a-chip technology.
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“human small intestinal organoids were used to form self-evolving tissue constructs by a concept called bioprinting-assisted tissue emergence (BATE), where centimeter-scale intestinal tissues were printed sequentially to mimic boundaries in the gastrointestinal tract98.”
From Organoids (2022) · cites this paper as [98]
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Metadata
- Authors
- Park, S. E., Georgescu, A., & Huh, D.
- Affiliations
- University of Pennsylvania (US)
- Corresponding author
- Huh, Dongeun
- Venue
- Science
- Published
- 2019-06-07
- Volume
- 364
- Issue
- 6444
- Pages
- 960-965
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC7764943
- OpenAlex
- W2948870515
- Cited by
- 847
- References
- 65
- Citations by year
- 2026: 118 · 2025: 132 · 2024: 126 · 2023: 132 · 2022: 116 · 2021: 134 · 2020: 74 · 2019: 15
- FWCI
- 29.88
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by
- Locations
- Science (publishedVersion, cc-by)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Science Foundation (CMMI:15-48571)
- National Institutes of Health (1UG3TR002198-01, 1UC4DK104196-01, 1DP2HL127720-01)
- Cancer Research Institute
- Paul G. Allen Family Foundation
- University of Pennsvlvania
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Physical Sciences › Engineering › Biomedical Engineering › Microfluidic and Capillary Electrophoresis Applications
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Keywords
- organoids, organ-on-a-chip, organoid engineering
- MeSH terms
- Humans, Organoids, Cell Culture Techniques, Lab-On-A-Chip Devices
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