Organoids-on-a-chip

Cerebral organoids model human brain development and microcephaly

Lancaster, M. A., Renner, M., Martin, C.-A., Wenzel, D., Bicknell, L. S., Hurles, M. E., Homfray, T., Penninger, J. M., Jackson, A. P., & Knoblich, J. A. (2013) · Nature · doi:10.1038/nature12517 · Cited by 5,372

Reconstituting organ-level lung functions on a chip

Huh, D., Matthews, B. D., Mammoto, A., Montoya-Zavala, M., Hsin, H. Y., & Ingber, D. E. (2010) · Science · doi:10.1126/science.1188302 · Cited by 4,250

Microfluidic organs-on-chips

Bhatia, S. N., & Ingber, D. E. (2014) · Nature Biotechnology · doi:10.1038/nbt.2989 · Cited by 3,305

Modeling Development and Disease with Organoids

Clevers, H. (2016) · Cell · doi:10.1016/j.cell.2016.05.082 · Cited by 3,196

Organogenesis in a dish: Modeling development and disease using organoid technologies

Lancaster, M. A., & Knoblich, J. A. (2014) · Science · doi:10.1126/science.1247125 · Cited by 2,931

Soft Lithography in Biology and Biochemistry

Whitesides, G. M., Ostuni, E., Takayama, S., Jiang, X., & Ingber, D. E. (2001) · Annual Review of Biomedical Engineering · doi:10.1146/annurev.bioeng.3.1.335 · Cited by 2,603

Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure

Qian, X., Nguyen, H. N., Song, M. M., Hadiono, C., Ogden, S. C., Hammack, C., Yao, B., Hamersky, G. R., Jacob, F., Zhong, C., et al. (2016) · Cell · doi:10.1016/j.cell.2016.04.032 · Cited by 2,127

From 3D cell culture to organs-on-chips

Huh, D., Hamilton, G. A., & Ingber, D. E. (2011) · Trends in Cell Biology · doi:10.1016/j.tcb.2011.09.005 · Cited by 1,834

Mechanical forces direct stem cell behaviour in development and regeneration

Vining, K. H., & Mooney, D. J. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.108 · Cited by 1,656

Three-dimensional bioprinting of thick vascularized tissues

Kolesky, D. B., Homan, K. A., Skylar-Scott, M. A., & Lewis, J. A. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1521342113 · Cited by 1,492

A Biomimetic Cardiac Fibrosis-on-a-Chip as a Visible Disease Model for Evaluating Mesenchymal Stem Cell-Derived Exosome Therapy

Shang, Y., Sun, L., Gan, J., Xu, D., Zhao, Y., & Sun, L. (2023) · ACS Nano · doi:10.1021/acsnano.3c09368 · Cited by 17

Lab-on-a-chip: an advanced technology for the modernization of traditional Chinese medicine

Lu, Z., Yuan, Y., Han, Q., Wang, Y., & Liang, Q. (2024) · Chinese Medicine · doi:10.1186/s13020-024-00956-4 · Cited by 19

Stem cell-based therapies for fertility preservation in males: Current status and future prospects

Liu, H., Xie, Y., Deng, C., & Liu, G. (2020) · World Journal of Stem Cells · doi:10.4252/wjsc.v12.i10.1097 · Cited by 18

An Organ-on-a-Chip Modular Platform with Integrated Immunobiosensors for Monitoring the Extracellular Environment

Kanioura, A., Filippidou, M., Tsounidi, D., Petrou, P., Chatzandroulis, S., & Tserepi, A. (2025) · Micromachines · doi:10.3390/mi16070740 · Cited by 15

Highly reproducible and cost-effective one-pot organoid differentiation using a novel platform based on PF-127 triggered spheroid assembly

Zhang, X., Xie, G., Ma, H., Ding, S., Wu, Y., Fei, Y., Cheng, Q., Huang, Y., & Wang, Y. (2023) · Biofabrication · doi:10.1088/1758-5090/acee21 · Cited by 19

Operationalizing the Use of Biofabricated Tissue Models as Preclinical Screening Platforms for Drug Discovery and Development

Jung, O., Song, M. J., & Ferrer, M. (2021) · SLAS DISCOVERY · doi:10.1177/24725552211030903 · Cited by 16

Establishment of organoid models based on a nested array chip for fast and reproducible drug testing in colorectal cancer therapy

Cui, Y., Xiao, R., Zhou, Y., Liu, J., Wang, Y., Yang, X., Shen, Z., Liang, B., Shen, K., Li, Y., et al. (2022) · Bio-Design and Manufacturing · doi:10.1007/s42242-022-00206-2 · Cited by 16

Integration of Patient-Derived Organoids and Organ-on-Chip Systems: Investigating Colorectal Cancer Invasion within the Mechanical and GABAergic Tumor MicroenvironmentPreprint

Strelez, C., Perez, R. G., Chlystek, J. S., Cherry, C., Yoon, A. Y., Haliday, B., Shah, C. A., Ghaffarian, K., Sun, R., Jiang, H., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.09.14.557797 · Cited by 18

Musculoskeletal organoids: An emerging toolkit for establishing personalized models of musculoskeletal disorders and developing regenerative therapies

Liu, Y., Zhou, Z., Lu, G., Zhang, X., Shi, D., Tong, L., Chen, C., Tuan, R. S., & Li, Z. A. (2025) · Acta Biomaterialia · doi:10.1016/j.actbio.2025.05.037 · Cited by 16

Recent approaches of toxicity-related attributes of NMs: A systematic review

Chaudhari, N. B., Shinde, S., Havelikar, U. A., Desai, S. A., & Patel, V. P. (2025) · Nano Trends · doi:10.1016/j.nwnano.2025.100160 · Cited by 18

AI-integrated microfluidics for drug screening: From single cell to organ-on-a-chip

Yin, H., Li, Z., Shen, Z., Wang, S., Du, N., Cheng, S., Zhou, J., Li, Y., Jia, Y., & Li, Y. (2026) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2026.01.001 · Cited by 19

Organoids in drug development: from predictive models to regulatory integration

Song, X., Chen, X., Chen, Q., Wang, H., Zhang, T., Liao, M. Z., Liu, C., Yu, H., Hao, Y., Gu, G., et al. (2026) · Drug Discovery Today · doi:10.1016/j.drudis.2026.104608 · Cited by 20

Kidney organoids as a promising tool in nephrology

Wu, M., Hu, T., Zhu, P., Nasser, M. I., Shen, J., Sun, F., He, Q., & Zhao, M. (2021) · Genes & Diseases · doi:10.1016/j.gendis.2021.01.003 · Cited by 16

Progress and perspective of organoid technology in cancer-related translational medicine

Lin, Y., Jiang, L., He, Q., Yuan, M., & Cao, J. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.112869 · Cited by 18

Patient-derived organoids as a model for tumor research

Wang, J., Feng, X., Li, Z., Chen, Y., & Huang, W. (2022) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2022.03.004 · Cited by 15

Organoids in lung cancer: A teenager with infinite growth potential

Xu, Y., Xin, W., Yan, C., Shi, Y., Li, Y., Hu, Y., & Ying, K. (2022) · Lung Cancer · doi:10.1016/j.lungcan.2022.08.006 · Cited by 14

Bioengineering translational models of lymphoid tissues

Michaels, Y. S., Buchanan, C. F., Gjorevski, N., & Moisan, A. (2023) · Nature Reviews Bioengineering · doi:10.1038/s44222-023-00101-0 · Cited by 16

Modeling of the brain-lung axis using organoids in traumatic brain injury: an updated review

Kim, J.-T., Song, K., Han, S. W., Youn, D. H., Jung, H., Kim, K., Lee, H., Hong, J. Y., Cho, Y.-J., Kang, S., et al. (2024) · Cell & Bioscience · doi:10.1186/s13578-024-01252-2 · Cited by 16

Advances and Challenges of Bioassembly Strategies in Neurovascular In Vitro Modeling: An Overview of Current Technologies with a Focus on Three-Dimensional Bioprinting

Mancuso, S., Bhalerao, A., & Cucullo, L. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252011000 · Cited by 17

High Quality–Factor All–Dielectric Metacavity for Label–Free Biosensing

Zheng, Y., Sun, J., Ma, Y., Zhang, H., Cui, Z., Paschos, G. G., Song, X., Tao, Y., Savvidis, P. G., Kong, W., et al. (2024) · Advanced Science · doi:10.1002/advs.202410125 · Cited by 15

A microfluidics platform for simultaneous evaluation of sensitivity and side effects of anti-cancer drugs using a three-dimensional culture method

Kobayashi, Y., Hashizume, H., Takiguchi, S., Ji, J., Kawano, R., Koiwai, K., Yamamoto, H., Elbadawy, M., Omatsu, T., Abugomaa, A., et al. (2025) · Scientific Reports · doi:10.1038/s41598-024-84297-0 · Cited by 20

Exploring high-throughput drug sensitivity testing in neuroblastoma cell lines and patient-derived tumor organoids in the era of precision medicine

Langenberg, K. P. S., van Hooff, S. R., Koopmans, B., Strijker, J. G. M., Kholosy, W. M., Ober, K., Zwijnenburg, D. A., van der Hoek, J. J. F., Keller, K. M., Vernooij, L., et al. (2025) · European Journal of Cancer · doi:10.1016/j.ejca.2025.115275 · Cited by 18

Controlled Apoptosis of Stromal Cells to Engineer Human Microlivers

Chen, A. X., Chhabra, A., Song, H. G., Fleming, H. E., Chen, C. S., & Bhatia, S. N. (2020) · Advanced Functional Materials · doi:10.1002/adfm.201910442 · Cited by 15

A self-healing, antioxidative organoid-chip for cell sorting, capture and release-on-demand

Yuan, R., You, D., Wang, J., Chen, Z., & Ge, L. (2021) · Chemical Engineering Journal · doi:10.1016/j.cej.2021.129182 · Cited by 15

Live imaging approach of dynamic multicellular responses in ERK signaling during vertebrate tissue development

Hirashima, T. (2022) · Biochemical Journal · doi:10.1042/bcj20210557 · Cited by 12

Advancements in bone organoids: perspectives on construction methodologies and application strategies

Huang, S., Wu, Y., Zhao, H., Song, K., Liu, Y., Mao, J., & Li, Q. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2025.06.011 · Cited by 18

Innovative organ-on-a-chip platforms for exploring tumorigenesis and therapy in head and neck cancer

Lin, C., Zhang, Z., Yang, F. L., Gu, S., Zuo, J., Wu, Y. M., Zhang, J., Zhou, T., Zhang, Y., Chen, Z., et al. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-06824-5 · Cited by 14

Inner ear organoids: progress and outlook, with a focus on the vascularization

Moeinvaziri, F., Zarkesh, I., Pooyan, P., Nunez, D. A., & Baharvand, H. (2021) · FEBS Journal · doi:10.1111/febs.16146 · Cited by 18

Multicellular Modelling of Difficult-to-Treat Gastrointestinal Cancers: Current Possibilities and Challenges

Hakuno, S. K., Michiels, E., Kuhlemaijer, E. B., Rooman, I., Hawinkels, L. J. A. C., & Slingerland, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23063147 · Cited by 15

Operando NMR metabolomics of a microfluidic cell culture

Rogers, G., Barker, S. J., Sharma, M., Khakoo, S. I., & Utz, M. (2023) · Journal of Magnetic Resonance · doi:10.1016/j.jmr.2023.107405 · Cited by 14

Biotechnological advances and applications of human pluripotent stem cell-derived heart models

Muniyandi, P., O’Hern, C., Popa, M. A., & Aguirre, A. (2023) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1214431 · Cited by 14

Revealing the pathogenesis of gastric intestinal metaplasia based on the mucosoid air-liquid interface

Liu, S., Wen, H., Li, F., Xue, X., Sun, X., Li, F., Hu, R., Xi, H., Boccellato, F., Meyer, T. F., et al. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05276-7 · Cited by 14

Model Organoids: Integrated Frameworks for the Next Frontier of Healthcare Advancements

Bhattacharya, R., Bose, D., Kaur, T., Patel, R., Renuka, O., & Rodriguez, R. V. (2024) · Stem Cell Reviews and Reports · doi:10.1007/s12015-024-10814-3 · Cited by 15

Engineering the Future of Regenerative Medicines in Gut Health with Stem Cell-Derived Intestinal Organoids

Kumar, D., Gupta, S., Gupta, V., Tanwar, R., & Chandel, A. (2025) · Stem Cell Reviews and Reports · doi:10.1007/s12015-025-10893-w · Cited by 18

Integrating Engineering, Automation, and Intelligence to Catalyze the Biomedical Translation of Organoids

Ma, S., Zhao, H., & Galan, E. A. (2021) · Advanced Biology · doi:10.1002/adbi.202100535 · Cited by 14

Predicting flows through microfluidic circuits with fluid walls

Deroy, C., Stovall‐Kurtz, N., Nebuloni, F., Soitu, C., Cook, P. R., & Walsh, E. J. (2021) · Microsystems & Nanoengineering · doi:10.1038/s41378-021-00322-6 · Cited by 14

Multifunctional profiling of triple-negative breast cancer patient-derived tumoroids for disease modeling

Cromwell, E. F., Sirenko, O., Nikolov, E., Hammer, M., Brock, C. K., Matossian, M. D., Alzoubi, M. S., Collins‐Burow, B. M., & Burow, M. E. (2022) · SLAS DISCOVERY · doi:10.1016/j.slasd.2022.01.006 · Cited by 15

Instructive Hydrogels for Primary Tumor Cell Culture: Current Status and Outlook

Jia, Y., Wei, Z., Zhang, S., Yang, B., & Li, Y. (2022) · Advanced Healthcare Materials · doi:10.1002/adhm.202102479 · Cited by 13

The right tools for the job: the central role for next generation chemical probes and chemistry-based target deconvolution methods in phenotypic drug discovery

Jörg, M., & Madden, K. S. (2021) · RSC Medicinal Chemistry · doi:10.1039/d1md00022e · Cited by 14

A similarity scaling approach for organ-on-chip devices

Feng, J. J., & Hedtrich, S. (2022) · Lab on a Chip · doi:10.1039/d2lc00641c · Cited by 13

LEADS – a comprehensive human liver-on-a-chip for non-alcoholic steatohepatitis (NASH) drug testing

Balachander, G. M., Ng, I. C., Pai, R. R., Mitra, K., Tasnim, F., Lim, Y. S., Kwok, R., Song, Y., Yaw, L. P., Quah, C. B., et al. (2025) · Lab on a Chip · doi:10.1039/d5lc00221d · Cited by 16

Biomineralization empowers bone organoids

Zhu, M., Fan, Z., Chen, M., Xu, K., Jiang, Y., & Su, J. (2025) · Biomaterials · doi:10.1016/j.biomaterials.2025.123703 · Cited by 17

Organoids for disease modeling and treatment: state-of-the-art

Xu, M., Kong, D., Sun, S., Wang, Y., Su, G., Zhang, S., Yan, J., Han, Z., Li, J., & Zhang, L. (2026) · Experimental Hematology and Oncology · doi:10.1186/s40164-026-00743-x · Cited by 14

Advanced in vitro models for renal cell carcinoma therapy design

Mieville, V., Griffioen, A. W., Benamran, D. A., & Nowak-Sliwinska, P. M. (2023) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2023.188942 · Cited by 12

Transplantation of in vitro prefabricated adipose organoids attenuates skin fibrosis by restoring subcutaneous fat and inducing dermal adipogenesis

Quan, Y., Zhang, Y., Li, J., Lu, F., & Cai, J. (2023) · The FASEB Journal · doi:10.1096/fj.202202117r · Cited by 13

A Linkable, Polycarbonate Gut Microbiome‐Distal Tumor Chip Platform for Interrogating Cancer Promoting Mechanisms

Brasino, D. S. K., Speese, S. D., Schilling, K. J., Schutt, C. E., & Barton, M. C. (2024) · Advanced Science · doi:10.1002/advs.202309220 · Cited by 12

Interpretation of the past, present, and future of organoid technology: an updated bibliometric analysis from 2009 to 2024

Qu, B., Mu, Q., Bi, H., Chen, Y., Wang, Q., Ma, X., & Lu, L. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1433111 · Cited by 13

Recent advances in 3D models for multiparametric blood–brain barrier detection in microfluidic systems

Boncristiani, C., Gilio, A. D., Castro, F. D., Nardini, A., Palmisani, J., Vàzquez, R. M., de Gennaro, G., Fanizzi, F. P., Ciccarella, G., & Vergaro, V. (2025) · Journal of Materials Chemistry B · doi:10.1039/d4tb02499k · Cited by 14

Rhythm on a chip: circadian entrainment in vitro is the next frontier in body-on-a chip technology

Fustin, J., Li, M., Gao, X., Chen, Q., Cheng, T., & Stewart, A. G. (2019) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2019.09.005 · Cited by 13

New insight into air flow distribution in alveoli based on air- and saline-filled lungs

Dong, J., Yang, Y., & Zhu, Y. (2020) · Microfluidics and Nanofluidics · doi:10.1007/s10404-020-02377-9 · Cited by 13

Intestinal Organoids: A Model to Study the Role of Microbiota in the Colonic Tumor Microenvironment

Nalluri, H., Subramanian, S., & Staley, C. M. (2020) · Future Microbiology · doi:10.2217/fmb-2019-0345 · Cited by 13

Why Can Organoids Improve Current Organ-on-Chip Platforms?

Sokołowska, P., Żuchowska, A., & Brzózka, Z. (2022) · Organoids · doi:10.3390/organoids1010007 · Cited by 15

Organ-On-A-Chip Database Revealed—Achieving the Human Avatar in Silicon

Jiang, L., Li, Q., Liang, W., Du, X., Yang, Y., Zhang, Z., Xu, L., Zhang, J., Li, J., Chen, Z., et al. (2022) · Bioengineering · doi:10.3390/bioengineering9110685 · Cited by 15

Application of colloidal photonic crystals in study of organoids

Huang, K., Li, Q., Xue, Y., Wang, Q., Chen, Z., & Gu, Z. (2023) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2023.115075 · Cited by 13

Microphysiological systems as models for immunologically ‘cold’ tumors

Gaebler, D., Hachey, S. J., & Hughes, C. C. W. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1389012 · Cited by 14

Multiscale Construction, Evaluation, and Application of Organoids

Ma, W., Dong, Z., Zheng, Z., Bai, L., Zhang, X., & Su, J. (2025) · Advanced Science · doi:10.1002/advs.202508534 · Cited by 15

Scaling up stem cell production: harnessing the potential of microfluidic devices

Ding, L., Oh, S., Shrestha, J., Lam, A. T., Wang, Y., Radfar, P., & Warkiani, M. E. (2023) · Biotechnology Advances · doi:10.1016/j.biotechadv.2023.108271 · Cited by 13

Bridging systems biology and tissue engineering: Unleashing the full potential of complex 3D in vitro tissue models of disease

Cadavid, J. L., Li, N. T., & McGuigan, A. P. (2024) · Biophysics Reviews · doi:10.1063/5.0179125 · Cited by 11

An Engineered Anisotropic Skeletal Muscle Organoid‐on‐a‐Chip for Deciphering Muscle Response under Intermittent Hypoxia

Li, J., Zhang, W., Liu, A., Lu, Y., Yu, L., Liu, X., Sun, L., Zhao, B., Tong, X., Liu, T., et al. (2024) · Advanced Functional Materials · doi:10.1002/adfm.202401564 · Cited by 13

Gastrointestinal Cancer Patient Derived Organoids at the Frontier of Personalized Medicine and Drug Screening

Yang, Z., Yu, J. Q., & Wong, C. C. (2024) · Cells · doi:10.3390/cells13161312 · Cited by 12

How Insect Exocrine Glands Work

FOSTER, S. P., & Casas, J. (2024) · Annual Review of Entomology · doi:10.1146/annurev-ento-011624-013339 · Cited by 12

Sensor-combined organ-on-a-chip for pharmaceutical and medical sciences: from design and materials to typical biomedical applications

Liao, Y., Chai, D., Wang, Q., Wang, X., Yong, Q., Cheng, Z., Zhang, C., Zhang, D., Liu, B., Liu, R., et al. (2024) · Materials Horizons · doi:10.1039/d4mh01174k · Cited by 12

Musculoskeletal organoids-on-chip uncover muscle–bone communication under intermittent hypoxia

Tong, X., Liu, M., Li, J., Zhang, W., Hu, R. J., Yang, G., Deng, J., Li, Y., Li, X., & Liu, Y. (2025) · National Science Review · doi:10.1093/nsr/nwaf214 · Cited by 12

Balance between the cell viability and death in 3D

Debruyne, A. C., Okkelman, I. A., & Dmitriev, R. I. (2022) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2022.09.005 · Cited by 16

Exploring the Contribution of Thalamic and Hippocampal Input on Cortical Dynamics in a Brain-on-a-Chip Model

Brofiga, M., Pisano, M., Callegari, F., & Massobrio, P. (2021) · IEEE Transactions on Medical Robotics and Bionics · doi:10.1109/tmrb.2021.3072234 · Cited by 12

Alveolus Lung-on-a-Chip Platform: A Proposal

Campillo, N., Oliveira, V. R., & da Palma, R. K. (2021) · Chemosensors · doi:10.3390/chemosensors9090248 · Cited by 12

Intratracheal instillation of graphene oxide decreases anti‐virus responses and lipid contents via suppressing Toll‐like receptor 3 in mouse livers

Tang, X., Song, F., Zhao, W., Zhang, Z., & Cao, Y. (2022) · Journal of Applied Toxicology · doi:10.1002/jat.4359 · Cited by 12

Ins-ATP: Deep estimation of ATP for organoid based on high throughput microscope images

Bian, X., Chen, S., & Liu, W. (2025) · Methods · doi:10.1016/j.ymeth.2025.01.012 · Cited by 11

Patient-Derived Tumor Organoids to Model Cancer Cell Plasticity and Overcome Therapeutic Resistance

Coppo, R., & Inoue, M. (2025) · Cells · doi:10.3390/cells14181464 · Cited by 12

Application and challenges of tumor organoid technology in precision immunotherapy

Zhao, X., Gao, J., Liu, Y., Shi, Y., Zhang, M., Zhang, C., & Chen, J. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1723995 · Cited by 14

Modelling human liver microphysiology on a chip through a finite element based design approach

Menezes, P. D., Gadegaard, N., Jorge, R. N., & Pinto, S. I. S. (2021) · International Journal for Numerical Methods in Biomedical Engineering · doi:10.1002/cnm.3445 · Cited by 11

A 3D co-culture intestinal organoid system for exploring glucose metabolism

Nie, J., Liao, W., Zhang, Z., Zhang, M., Wen, Y., Çapanoğlu, E., Sarker, M. M. R., Zhu, R., & Zhao, C. (2022) · Current Research in Food Science · doi:10.1016/j.crfs.2022.11.021 · Cited by 11

Current trends and research topics regarding organoids: A bibliometric analysis of global research from 2000 to 2023

Wan, Y., Ding, J., Jia, Z., Hong, Y., Tian, G., Zheng, S., Pan, P., Wang, J., & Liang, H. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e32965 · Cited by 13

Printable and biocompatible hydrogels for residual-free and high-throughput printing patient-derived organoid biochips

Xie, D., Chen, B., Xue, Y., Sun, Z., Ning, B., Zhang, Z., Chi, J., Su, M., & Song, Y. (2024) · Science China Materials · doi:10.1007/s40843-024-2933-8 · Cited by 11

Novel organoids mode evaluating the food nutrition and safety: Current state and future prospects

Tan, F., Cui, P., Li, S., Tan, Y., & Ma, A. (2024) · Food Frontiers · doi:10.1002/fft2.451 · Cited by 11

Pluripotent stem cell‐derived organoids: A brief history of curiosity‐led discoveries

Lancaster, M. A. (2024) · BioEssays · doi:10.1002/bies.202400105 · Cited by 11

The promise of Synovial Joint-on-a-Chip in rheumatoid arthritis

Zhang, X., Su, R., Wang, H., Wu, R., Fan, Y., Bin, Z., Gao, C., & Wang, C. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1408501 · Cited by 11

A High-Throughput and Logarithm-Serial-Dilution Microfluidic Chip for Combinational Drug Screening on Tumor Organoids

Yan, X., Tan, D., Yu, L., Li, D., Huang, W., Huang, W., & Wu, H. (2024) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.4c00565 · Cited by 13

In silico modelling of organ-on-a-chip devices: an overview

Wang, Y., Marucci, L., & Homer, M. (2025) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2024.1520795 · Cited by 11

Application progress of bio-manufacturing technology in kidney organoids

Mao, R., Zhang, J., Qin, H., Liu, Y., Xing, Y., & Zeng, W. (2025) · Biofabrication · doi:10.1088/1758-5090/adb4a1 · Cited by 12

Compelling standardized and high-throughput micro-/millifluidic plates for biomedical research: from laboratory to market

Gu, L., Liu, P., Zhao, W. Y., Fan, Y., Wang, Y., & Chen, P. (2025) · MedMat. · doi:10.1097/mm9.0000000000000016 · Cited by 11

Developments and Applications of Liver-on-a-Chip Technology—Current Status and Future Prospects

Mugaanyi, J., Huang, J., Fang, J., Musinguzi, A., Lu, C., & Chen, Z. (2025) · Biomedicines · doi:10.3390/biomedicines13061272 · Cited by 11

Modeling colorectal cancers using multidimensional organoids

Sayed, I. M., El‐Hafeez, A. A. A., Maity, P. P., Das, S., & Ghosh, P. (2021) · Advances in cancer research · doi:10.1016/bs.acr.2021.02.005 · Cited by 11

Exploring the Role of Innate Lymphocytes in the Immune System of Bats and Virus-Host Interactions

Sia, W. R., Zheng, Y., Han, F., Chen, S., Ma, S., Wang, L., & Leeansyah, E. (2022) · Viruses · doi:10.3390/v14010150 · Cited by 15

Application of Organoids in Carcinogenesis Modeling and Tumor Vaccination

Wang, Z., Zhao, S., Lin, X., Chen, G., Kang, J., Ma, Z., Wang, Y., Li, Z., Xiao, X., He, A., et al. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.855996 · Cited by 13

Urological cancer organoids, patients' avatars for precision medicine: past, present and future

Chen, H., Zhang, W., Maskey, N., Yang, F., Zheng, Z., Li, C., Wang, R., Wu, P., Mao, S., Zhang, J., et al. (2022) · Cell & Bioscience · doi:10.1186/s13578-022-00866-8 · Cited by 15

Opportunities and challenges of hepatocellular carcinoma organoids for targeted drugs sensitivity screening

Xie, C., Gu, A., Khan, M. N., Yao, X., Chen, L., He, J., Yuan, F., Wang, P., Yang, Y., Wei, Y., et al. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2022.1105454 · Cited by 12

Shell engineering in soft alginate‐based capsules for culturing liver spheroids

Peng, X., Janićijević, Ž., Lemm, S., Laube, M., Pietzsch, J., Bachmann, M., & Baraban, L. (2023) · Biotechnology Journal · doi:10.1002/biot.202200365 · Cited by 11

A mini-panel PET scanner-based microfluidic radiobioassay system allowing high-throughput imaging of real-time cellular pharmacokinetics

Liu, Z., Zhang, P., Ji, H., Long, Y., Jing, B., Wan, L., Xi, D., An, R., & Lan, X. (2020) · Lab on a Chip · doi:10.1039/c9lc01066a · Cited by 11

Harnessing the power of microphysiological systems for COVID-19 research

Kleinstreuer, N., & Holmes, A. M. (2021) · Drug Discovery Today · doi:10.1016/j.drudis.2021.06.020 · Cited by 12

Airway Organoid Models as Pivotal Tools for Unraveling Molecular Mechanisms and Therapeutic Targets in Respiratory Diseases: A Literature Review

Jiang, S., Lin, B.-Q., Zhou, X., Li, M., Feng, Z., Qin, Y.-Y., Lin, S., Zhou, Z., Peng, Y., & Li, L. (2025) · Therapeutics and Clinical Risk Management · doi:10.2147/tcrm.s526727 · Cited by 10

Nanocomposite Hydrogel Bioinks for 3D Bioprinting of Tumor Models

Wang, Y., Duan, Y., Yang, B., & Li, Y. (2024) · Biomacromolecules · doi:10.1021/acs.biomac.4c00671 · Cited by 11

Establishment of nasal and olfactory epithelium organoids for unveiling mechanism of tissue regeneration and pathogenesis of nasal diseases

Liu, J., Zhang, Y. F., & Yu, Y. (2025) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-024-05557-w · Cited by 10

Bioengineering tools for next-generation neural organoids

O’Laughlin, R., Cheng, F., Song, H., & Ming, G. (2025) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2025.103011 · Cited by 12

Mechanical Forces in Tumor Growth and Treatment: Perspectives From Biology, Physics, Engineering, and Mathematical Modeling

Kashkooli, F. M., Mirala, F., Tehrani, M. H. H., Alirahimi, M., Souri, M., Golzaryan, A., Kar, S., & Soltani, M. (2025) · WIREs Mechanisms of Disease · doi:10.1002/wsbm.70000 · Cited by 12

Hypoxia and Multilineage Communication in 3D Organoids for Human Disease Modeling

Ehab, S., Gaser, O. A., & Dayem, A. A. (2025) · Biomimetics · doi:10.3390/biomimetics10090624 · Cited by 13

Engineering organoid microfluidic system for biomedical and health engineering: A review

Xing, Y., Liu, J., Guo, X., Liu, H., Zeng, W., Wang, Y., Zhang, C., Lu, Y., Dong, H., Ma, S., et al. (2020) · Chinese Journal of Chemical Engineering · doi:10.1016/j.cjche.2020.11.013 · Cited by 11

Complex in vitro 3D models of digestive system tumors to advance precision medicine and drug testing: Progress, challenges, and trends

Song, S., Li, B., Carvalho, M. R., Wang, H., Mao, D., Wei, J., Chen, W., Weng, Z.-H., Chen, Y., Deng, C., et al. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2022.108276 · Cited by 9

A proof-of-concept study poised to remodel the drug development process

Nahle, Z. A. (2022) · Frontiers in Medical Technology · doi:10.3389/fmedt.2022.1053588 · Cited by 11

Open multi-organ communication device for easy interrogation of tissue slices

Delong, L. M., & Ross, A. E. (2023) · Lab on a Chip · doi:10.1039/d3lc00115f · Cited by 10

Advances and applications of organoid-on-a-chip in disease modeling

Yang, Y., Sheng, J., Sheng, F., Liang, X., Ma, C., Chen, R., Wang, S., & Qian, X. (2025) · The Analyst · doi:10.1039/d5an00514k · Cited by 5

Organoids-on-a-chip: microfluidic technology enables culture of organoids with enhanced tissue function and potential for disease modeling

Papamichail, L., Koch, L. S., Veerman, D., Broersen, K., & van der Meer, A. D. (2025) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2025.1515340 · Cited by 120

Advances in human organoids-on-chips in biomedical research

Wang, Y., & Qin, J. (2023) · Life Medicine · doi:10.1093/lifemedi/lnad007 · Cited by 58

Recent advances and challenges in organoid-on-a-chip technology

Suhito, I. R., & Kim, T. P. (2022) · Organoid · doi:10.51335/organoid.2022.2.e4 · Cited by 21

Grand challenges in organoid and organ-on-a-chip technologies

Skardal, A. (2024) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2024.1366280 · Cited by 33