Perirhinal input to neocortical layer 1 controls learning
Open accessPublished version of a preprint
Abstract
Memory consolidation in the neocortex: Information transfer between brain structures located in the medial-temporal lobe and the neocortex is essential for learning. However, the neuronal underpinnings of this transfer are unknown. Doron et al. found that neurons located in the deep layers of the perirhinal cortex exhibit increased firing after microstimulation upon learning (see the Perspective by Donato). Learning was associated with the emergence of a small population of neurons in layer 5 of the somatosensory cortex that increased bursting upon stimulation. This increase in bursting was accompanied by an increase in dendritic activity, and silencing the perirhinal cortex to layer 1 projection effectively disrupted learning and its physiological correlates. During learning, perirhinal inputs thus act as a gate for the enhancement of cortico-cortical inputs, which are necessary for stimulus detection and are strengthened during learning. Science , this issue p. eaaz3136 ; see also p. 1410
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The distal compartment gets signals from neuromodulatory sources, other cortical regions, and non-lemniscal thalamus.
“the distal compartment receives input from neuromodulatory centers [36], other cortical areas [37–39], and the non-lemniscal thalamus [40,41]”
From Testing circuit-level theories of consciousness in humans (2026) · cites this paper as [38]
RPT explains inattentional and change blindness, and why only a few visual items (held in WM) are reported after brief presentations with no cue.
“This explains, e.g., inattentional and change blindness, and why only a few visual items (held in WM) are reported after brief presentations with no cue.108”
From An integrative, multiscale view on neural theories of consciousness (2024) · cites this paper as [108]
The paper’s Abstract describes rodents learning to report electrical microstimulation of somatosensory cortex. Searches for inattentional blindness, change blindness, visual working memory, and uncued brief visual presentations found no passage addressing the claimed explanation. (LLM, conf=0.77)
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- Authors
- Doron, G., Shin, J. N., Takahashi, N., Drüke, M., Bocklisch, C., Skenderi, S., de Mont, L., Toumazou, M., Ledderose, J., Brecht, M., Naud, R., & Larkum, M. E.
- Affiliations
- Humboldt-Universität zu Berlin (DE)
- Institute for Biology, Humboldt-Universität zu Berlin, D-10117 Berlin, Germany.
- University of Ottawa (CA)
- Corresponding author
- Doron, Guy
- Larkum, Matthew E.
- ORCID
- Venue
- Science
- Published
- 2020-12-18
- Volume
- 370
- Issue
- 6523
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC7612443
- OpenAlex
- W3111294797
- Cited by
- 160
- References
- 65
- Citations by year
- 2026: 26 · 2025: 20 · 2024: 20 · 2023: 45 · 2022: 21 · 2021: 19 · 2020: 9
- FWCI
- 12.63
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Licence
- cc-by-nc-nd
- Locations
- Science (publishedVersion)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Canadian Institutes of Health Research
- Natural Sciences and Engineering Research Council of Canada
- Deutsche Forschungsgemeinschaft (EXC 257, SFB 1315)
- Horizon 2020 (785907/HBP SGA2, 670118/ERC ActiveCortex, 945539)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- perirhinal cortex, hippocampus-dependent learning, associative learning, layer 5 pyramidal neurons, dendritic excitability, burst firing, memory formation, hippocampal-neocortical interaction, memory retrieval
- MeSH terms
- Perirhinal Cortex, Animals, Dendrites, Hippocampus, Learning, Male, Mice, Inbred C57BL, Mice, Transgenic, Rats, Wistar, Pyramidal Cells, Neocortex, Optogenetics
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