Cited by 284Neuroscience and Neuropharmacology ResearchNeural dynamics and brain functionVisual perception and processing mechanisms

The Cellular Basis of GABA B -Mediated Interhemispheric Inhibition

Palmer, Lucy M., Schulz, Jan M., Murphy, Sean C., Ledergerber, Debora, Murayama, Masanori, Larkum, Matthew E.·2012·Science

Abstract

Interhemispheric inhibition is thought to mediate cortical rivalry between the two hemispheres through callosal input. The long-lasting form of this inhibition is believed to operate via γ-aminobutyric acid type B (GABA(B)) receptors, but the process is poorly understood at the cellular level. We found that the firing of layer 5 pyramidal neurons in rat somatosensory cortex due to contralateral sensory stimulation was inhibited for hundreds of milliseconds when paired with ipsilateral stimulation. The inhibition acted directly on apical dendrites via layer 1 interneurons but was silent in the absence of pyramidal cell firing, relying on metabotropic inhibition of active dendritic currents recruited during neuronal activity. The results not only reveal the microcircuitry underlying interhemispheric inhibition but also demonstrate the importance of active dendritic properties for cortical output.

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Crossref · 10.1126/science.1217276

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  • RCs may provide supplementary inhibitory control required to balance the potentially higher excitability in human dendrites and modulate interactions between long-range excitatory connections arriving to layer 1 and backpropagating action potentials.

    “Thus, RCs may provide supplementary inhibitory control required to balance the potentially higher excitability in human dendrites8 and modulate interactions between long range excitatory connections arriving to layer 1 and backpropagating action potentials suggested to participate in interhemispheric modulation45.”

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Authors
Palmer, L. M., Schulz, J. M., Murphy, S. C., Ledergerber, D., Murayama, M., & Larkum, M. E.
Affiliations
  • University of Bern (CH)
  • RIKEN Center for Brain Science (JP)
Corresponding author
Larkum, Matthew E.
Venue
Science
Published
2012-02-24
Volume
335
Issue
6071
Pages
989-993
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2031248308
Cited by
284
References
34
Citations by year
2026: 9 · 2025: 9 · 2024: 11 · 2023: 14 · 2022: 9 · 2021: 26 · 2020: 35 · 2019: 25 · 2018: 26 · 2017: 24 · 2016: 20 · 2015: 15 · 2014: 21 · 2013: 27 · 2012: 13
FWCI
9.98
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
Keywords
interhemispheric inhibition, GABAB receptors, corpus callosum, layer 5 pyramidal neurons, somatosensory cortex, dendritic inhibition, layer 1 interneurons, paired stimulation, cortical microcircuitry, active dendrites
MeSH terms
Action Potentials, Animals, Calcium, Corpus Callosum, Dendrites, Electric Stimulation, Hindlimb, Interneurons, Neural Inhibition, Somatosensory Cortex, Rats, Wistar, Pyramidal Cells, Receptors, GABA-B, Patch-Clamp Techniques, Rats, Cerebrum

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