The Cellular Basis of GABA B -Mediated Interhemispheric Inhibition
Abstract
Interhemispheric inhibition is thought to mediate cortical rivalry between the two hemispheres through callosal input. The long-lasting form of this inhibition is believed to operate via γ-aminobutyric acid type B (GABA(B)) receptors, but the process is poorly understood at the cellular level. We found that the firing of layer 5 pyramidal neurons in rat somatosensory cortex due to contralateral sensory stimulation was inhibited for hundreds of milliseconds when paired with ipsilateral stimulation. The inhibition acted directly on apical dendrites via layer 1 interneurons but was silent in the absence of pyramidal cell firing, relying on metabotropic inhibition of active dendritic currents recruited during neuronal activity. The results not only reveal the microcircuitry underlying interhemispheric inhibition but also demonstrate the importance of active dendritic properties for cortical output.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
RCs may provide supplementary inhibitory control required to balance the potentially higher excitability in human dendrites and modulate interactions between long-range excitatory connections arriving to layer 1 and backpropagating action potentials.
“Thus, RCs may provide supplementary inhibitory control required to balance the potentially higher excitability in human dendrites8 and modulate interactions between long range excitatory connections arriving to layer 1 and backpropagating action potentials suggested to participate in interhemispheric modulation45.”
From Transcriptomic and morphophysiological evidence for a specialized human cortical GABAergic cell type (2018) · cites this paper as [45]
Cites
Petilla terminology: nomenclature of features of GABAergic interneurons of the cerebral cortex
The Petilla Interneuron Nomenclature Group (PING) (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2402 · Cited by 1,491 · see citing works
Interhemispheric inhibition of the human motor cortex.
Ferbert, A., Priori, A., Rothwell, J. C., Day, B. L., Colebatch, J. G., & MARSDEN, C. D. (1992) · The Journal of Physiology · doi:10.1113/jphysiol.1992.sp019243 · Cited by 1,490 · see citing works
Channelrhodopsin-2-assisted circuit mapping of long-range callosal projections
Petreanu, L., Huber, D., Sobczyk, A., & Svoboda, K. (2007) · Nature Neuroscience · doi:10.1038/nn1891 · Cited by 930 · see citing works
Molecular Structure and Physiological Functions of GABA B Receptors
Bettler, B., Kaupmann, K., Mosbacher, J., & Gassmann, M. (2004) · Physiological Reviews · doi:10.1152/physrev.00036.2003 · Cited by 927 · see citing works
Bloom, J. S., & Hynd, G. W. (2005) · Neuropsychology Review · doi:10.1007/s11065-005-6252-y · Cited by 591 · see citing works
Hilgetag, C. C., Théoret, H., & Pascual‐Leone, Á. (2001) · Nature Neuroscience · doi:10.1038/nn0901-953 · Cited by 583 · see citing works
Dendritic organization of sensory input to cortical neurons in vivo
Jia, H., Rochefort, N. L., Chen, X., & Konnerth, A. (2010) · Nature · doi:10.1038/nature08947 · Cited by 508 · see citing works
Horizontal Propagation of Visual Activity in the Synaptic Integration Field of Area 17 Neurons
Bringuier, V., Chavane, F., Glaeser, L., & Frégnac, Y. (1999) · Science · doi:10.1126/science.283.5402.695 · Cited by 507 · see citing works
Heilman, K. M., & Valenstein, E. (1972) · Neurology · doi:10.1212/wnl.22.6.660 · Cited by 447 · see citing works
Forty-five years of split-brain research and still going strong
Gazzaniga, M. S. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1723 · Cited by 442 · see citing works
Membrane Potential and Firing Rate in Cat Primary Visual Cortex
Carandini, M., & Ferster, D. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-01-00470.2000 · Cited by 413 · see citing works
General Organization of Callosal Connections in the Cerebral Cortex
Innocenti, G. M. (1986) · Cerebral cortex · doi:10.1007/978-1-4613-2149-1_9 · Cited by 394 · see citing works
In vivo dendritic calcium dynamics in deep-layer cortical pyramidal neurons
Helmchen, F., Svoboda, K., Denk, W. T., & Tank, D. W. (1999) · Nature Neuroscience · doi:10.1038/14788 · Cited by 380 · see citing works
Dendritic encoding of sensory stimuli controlled by deep cortical interneurons
Murayama, M., Pérez-Garci, E., Nevian, T., Bock, T., Senn, W., & Larkum, M. E. (2009) · Nature · doi:10.1038/nature07663 · Cited by 369 · see citing works
Self-citationTop-down Dendritic Input Increases the Gain of Layer 5 Pyramidal Neurons
Larkum, M. E. (2004) · Cerebral Cortex · doi:10.1093/cercor/bhh065 · Cited by 366 · see citing works
Self-citationIdentified sources and targets of slow inhibition in the neocortex
Tamás, G., Simon, A. L., & Szabadics, J. (2003) · Science · doi:10.1126/science.1082053 · Cited by 359 · see citing works
Direct hyperpolarizing action of baclofen on hippocampal pyramidal cells
Newberry, N. R., & Nicoll, R. A. (1984) · Nature · doi:10.1038/308450a0 · Cited by 337 · see citing works
Mechanisms and consequences of action potential burst firing in rat neocortical pyramidal neurons
Williams, S. R., & Stuart, G. J. (1999) · The Journal of Physiology · doi:10.1111/j.1469-7793.1999.00467.x · Cited by 298 · see citing works
Repetitive TMS of the motor cortex improves ipsilateral sequential simple finger movements
Kobayashi, M., Hutchinson, S., Théoret, H., Gottfried Schlaug, A., & Pascual‐Leone, Á. (2004) · Neurology · doi:10.1212/wnl.62.1.91 · Cited by 268 · see citing works
Pérez‐Garci, E., Gassmann, M., Bettler, B., & Larkum, M. E. (2006) · Neuron · doi:10.1016/j.neuron.2006.04.019 · Cited by 262 · see citing works
Self-citationTransient Suppression of Ipsilateral Primary Somatosensory Cortex during Tactile Finger Stimulation
Hlushchuk, Y., & Hari, R. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.5536-05.2006 · Cited by 243 · see citing works
EFFECTS OF TRANSCALLOSAL VOLLEYS ON PYRAMIDAL TRACT CELL ACTIVITY OF CAT
Asanuma, H., & Okuda, O. (1962) · Journal of Neurophysiology · doi:10.1152/jn.1962.25.2.198 · Cited by 208 · see citing works
Bimanual coordination and interhemispheric interaction
Gerloff, C. P., & Andres, F. G. (2002) · Acta Psychologica · doi:10.1016/s0001-6918(02)00032-x · Cited by 202 · see citing works
Synaptic interactions of late-spiking neocortical neurons in layer 1
Chu, Z., Galarreta, M., & Hestrin, S. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-01-00096.2003 · Cited by 172 · see citing works
Interhemispheric control of manual motor activity
Geffen, G. M., Jones, D. L., & Geffen, L. B. (1994) · Behavioural Brain Research · doi:10.1016/0166-4328(94)90125-2 · Cited by 163 · see citing works
Seyal, M., Ro, T., & Rafal, R. D. (1995) · Annals of Neurology · doi:10.1002/ana.410380221 · Cited by 158 · see citing works
Modified activation of somatosensory cortical network in patients with right-hemisphere stroke
Forss, N., Hietanen, M., Salonen, O. L. M., & Hari, R. (1999) · Brain · doi:10.1093/brain/122.10.1889 · Cited by 148 · see citing works
Brecht, M., & Sakmann, B. J. (2002) · The Journal of Physiology · doi:10.1113/jphysiol.2001.012334 · Cited by 137 · see citing works
Wozny, C., & Williams, S. R. (2011) · Cerebral Cortex · doi:10.1093/cercor/bhq257 · Cited by 129 · see citing works
López‐Bendito, G., Shigemoto, R., Kulik, Á., Paulsen, O., Fairén, A. G., & Luján, R. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.02032.x · Cited by 113 · see citing works
Transcallosally mediated inhibition of interneurons within human primary motor cortex
Schnitzler, A., Kessler, K. R., & Benecke, R. (1996) · Experimental Brain Research · doi:10.1007/bf00227944 · Cited by 96 · see citing works
Murayama, M., Pérez‐Garci, E., Lüscher, H., & Larkum, M. E. (2007) · Journal of Neurophysiology · doi:10.1152/jn.00082.2007 · Cited by 91 · see citing works
Self-citationInhibitory control of excitable dendrites in neocortex
Kim, H. G., Beierlein, M., & Connors, B. W. (1995) · Journal of Neurophysiology · doi:10.1152/jn.1995.74.4.1810 · Cited by 81 · see citing works
Interhemispheric balance of overt attention: a theta burst stimulation study
Cazzoli, D., Wurtz, P., Müri, R. M., Hess, C. W., & Nyffeler, T. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06665.x · Cited by 78 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits
Tremblay, R., Lee, S., & Rudy, B. (2016) · Neuron · doi:10.1016/j.neuron.2016.06.033 · Cited by 2,033 · see citing works
Diaschisis: past, present, future
Carrera, E., & Tononi, G. (2014) · Brain · doi:10.1093/brain/awu101 · Cited by 824 · see citing works
A cellular mechanism for cortical associations: an organizing principle for the cerebral cortex
Larkum, M. (2013) · Trends in Neurosciences · doi:10.1016/j.tins.2012.11.006 · Cited by 755 · see citing works
Self-citationZiemann, U., Reis, J., Schwenkreis, P., Rosanova, M., Strafella, A. P., Badawy, R. A. B., & Müller‐Dahlhaus, F. (2014) · Clinical Neurophysiology · doi:10.1016/j.clinph.2014.08.028 · Cited by 678 · see citing works
Dendritic integration: 60 years of progress
Stuart, G. J., & Spruston, N. (2015) · Nature Neuroscience · doi:10.1038/nn.4157 · Cited by 489 · see citing works
Active properties of neocortical pyramidal neuron dendrites
Major, G., Larkum, M. E., & Schiller, J. (2013) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-062111-150343 · Cited by 443 · see citing works
Self-citationActive cortical dendrites modulate perception
Takahashi, N., Oertner, T. G., Hegemann, P., & Larkum, M. E. (2016) · Science · doi:10.1126/science.aah6066 · Cited by 419 · see citing works
Self-citationSomatostatin-expressing neurons in cortical networks
Urban-Ciecko, J., & Barth, A. L. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2016.53 · Cited by 374 · see citing works
The organization of two new cortical interneuronal circuits
Jiang, X., Wang, G., Lee, A. J., Stornetta, R. L., & Zhu, J. J. (2013) · Nature Neuroscience · doi:10.1038/nn.3305 · Cited by 338 · see citing works
Spontaneous and Therapeutic-Induced Mechanisms of Functional Recovery After Stroke
Cassidy, J. M., & Cramer, S. C. (2017) · Translational Stroke Research · doi:10.1007/s12975-016-0467-5 · Cited by 292 · see citing works
Transcriptomic and morphophysiological evidence for a specialized human cortical GABAergic cell type
Boldog, E., Bakken, T. E., Hodge, R. D., Novotny, M., Aevermann, B. D., Baka, J., Bordé, S., Close, J. L., Diez-Fuertes, F., Ding, S.-L., et al. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0205-2 · Cited by 291 · see citing works
Dendritic channelopathies contribute to neocortical and sensory hyperexcitability in Fmr1−/y mice
Zhang, Y., Bonnan, A., Bony, G., Férézou, I., Pietropaolo, S., Ginger, M. R., Sans, N., Rossier, J., Oostra, B. A., LeMasson, G., et al. (2014) · Nature Neuroscience · doi:10.1038/nn.3864 · Cited by 227 · see citing works
Principles Governing the Operation of Synaptic Inhibition in Dendrites
Gidon, A., & Segev, I. (2012) · Neuron · doi:10.1016/j.neuron.2012.05.015 · Cited by 224 · see citing works
Learning-Related Plasticity in Dendrite-Targeting Layer 1 Interneurons
Abs, E., Poorthuis, R. B., Apelblat, D., Muhammad, K., Pardi, M. B., Enke, L., Kushinsky, D., Pu, D.-L., Eizinger, M. F., Conzelmann, K., et al. (2018) · Neuron · doi:10.1016/j.neuron.2018.09.001 · Cited by 212 · see citing works
Thalamic control of layer 1 circuits in prefrontal cortex
Cruikshank, S. J., Ahmed, O. J., Stevens, T. R., Patrick, S. L., Gonzalez, A. N., Elmaleh, M., & Connors, B. W. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.3231-12.2012 · Cited by 212 · see citing works
Interneuron Types as Attractors and Controllers
Fishell, G., & Kepecs, Á. (2019) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-070918-050421 · Cited by 197 · see citing works
Anatomy and physiology of the thick-tufted layer 5 pyramidal neuron
Ramaswamy, S., & Markram, H. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00233 · Cited by 186 · see citing works
Four Unique Interneuron Populations Reside in Neocortical Layer 1
Schuman, B., Machold, R. P., Hashikawa, Y., Fuzik, J., Fishell, G. J., & Rudy, B. (2019) · The Journal of Neuroscience · doi:10.1523/jneurosci.1613-18.2018 · Cited by 184 · see citing works
“Although the precise composition of L1 INs has been difficult to establish (Table 1), there is evidence that they are direct targets of L1 projections and are important for processing long-range inputs (Letzkus et al., 2011; Cruikshank et al., 2012; Palmer et al., 2012; Ibrahim et al., 2016).”
BackgroundThe Diversity of Cortical Inhibitory Synapses
Kubota, Y., Karube, F., Nomura, M., & Kawaguchi, Y. (2016) · Frontiers in Neural Circuits · doi:10.3389/fncir.2016.00027 · Cited by 180 · see citing works
Untangling GABAergic wiring in the cortical microcircuit
Kubota, Y. (2014) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2013.10.003 · Cited by 172 · see citing works
Membrane Potential Dynamics of Neocortical Projection Neurons Driving Target-Specific Signals
Yamashita, T., Pala, A., Pedrido, L., Kremer, Y., Welker, E., & Petersen, C. C. H. (2013) · Neuron · doi:10.1016/j.neuron.2013.10.059 · Cited by 172 · see citing works
Neuronal circuits in barrel cortex for whisker sensory perception
Staiger, J. F., & Petersen, C. C. H. (2021) · Physiological Reviews · doi:10.1152/physrev.00019.2019 · Cited by 165 · see citing works
Engagement of Pulvino-cortical Feedforward and Feedback Pathways in Cognitive Computations
Jaramillo, J., Mejías, J. F., & Wang, X. (2018) · Neuron · doi:10.1016/j.neuron.2018.11.023 · Cited by 160 · see citing works
Theta burst stimulation reduces disability during the activities of daily living in spatial neglect
Cazzoli, D., Müri, R. M., Schumacher, R., von Arx, S., Chaves, S., Gutbrod, K., Bohlhalter, S., Bauer, D., Vanbellingen, T., Bertschi, M., et al. (2012) · Brain · doi:10.1093/brain/aws182 · Cited by 161 · see citing works
Perirhinal input to neocortical layer 1 controls learning
Doron, G., Shin, J. N., Takahashi, N., Drüke, M., Bocklisch, C., Skenderi, S., de Mont, L., Toumazou, M., Ledderose, J., Brecht, M., et al. (2020) · Science · doi:10.1126/science.aaz3136 · Cited by 160 · see citing works
Self-citationFan, L. Z., Kheifets, S., Böhm, U. L., Wu, H., Piatkevich, K. D., Xie, M. E., Parot, V., Ha, Y., Evans, K. E., Boyden, E. S., et al. (2020) · Cell · doi:10.1016/j.cell.2020.01.001 · Cited by 155 · see citing works
Diversity of layer 5 projection neurons in the mouse motor cortex
Oswald, M. J., Tantirigama, M. L. S., Sonntag, I., Hughes, S. M., & Empson, R. M. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00174 · Cited by 155 · see citing works
Neocortical Layer 1: an elegant solution to top-down and bottom-up integration
Schuman, B., Dellal, S., Prönneke, A., Machold, R., & Rudy, B. (2021) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-100520-012117 · Cited by 148 · see citing works
The Neurobiological Grounding of Persistent Stuttering: from Structure to Function
Neef, N. E., Anwander, A., & Friederici, A. D. (2015) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-015-0579-4 · Cited by 146 · see citing works
Tejeda, H. A., Wu, J., Kornspun, A. R., Pignatelli, M., Kashtelyan, V., Krashes, M. J., Lowell, B. B., Carlezon, W. A., & Bonci, A. (2017) · Neuron · doi:10.1016/j.neuron.2016.12.005 · Cited by 134 · see citing works
A Laminar Organization for Selective Cortico-Cortical Communication
D’Souza, R. D., & Burkhalter, A. (2017) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2017.00071 · Cited by 138 · see citing works
Mediodorsal and Ventromedial Thalamus Engage Distinct L1 Circuits in the Prefrontal Cortex
Anastasiades, P. G., Collins, D. P., & Carter, A. G. (2020) · Neuron · doi:10.1016/j.neuron.2020.10.031 · Cited by 135 · see citing works
Transcranial magnetic stimulation (TMS) inhibits cortical dendrites
Murphy, S. C., Palmer, L. M., Nyffeler, T., Müri, R. M., & Larkum, M. E. (2016) · eLife · doi:10.7554/elife.13598 · Cited by 136 · see citing works
Self-citationNeocortical Somatostatin Neurons Reversibly Silence Excitatory Transmission via GABAb Receptors
Urban‐Ciećko, J., Fanselow, E. E., & Barth, A. L. (2015) · Current Biology · doi:10.1016/j.cub.2015.01.035 · Cited by 126 · see citing works
Inhibitory Circuits in Cortical Layer 5
Naka, A., & Adesnik, H. (2016) · Frontiers in Neural Circuits · doi:10.3389/fncir.2016.00035 · Cited by 130 · see citing works
Ding, J., Hou, G. G., Nemzer, B. V., Xiong, S., Dubat, A., & Feng, H. (2017) · Food Chemistry · doi:10.1016/j.foodchem.2017.09.128 · Cited by 129 · see citing works
Functional integration across oscillation frequencies by cross‐frequency phase synchronization
Palva, J. M., & Palva, S. (2017) · European Journal of Neuroscience · doi:10.1111/ejn.13767 · Cited by 131 · see citing works
Inhibitory Gating of Input Comparison in the CA1 Microcircuit
Milstein, A. D., Bloss, E. B., Apostolides, P. F., Vaidya, S. P., Dilly, G. A., Zemelman, B. V., & Magee, J. C. (2015) · Neuron · doi:10.1016/j.neuron.2015.08.025 · Cited by 126 · see citing works
Spatiotemporal specificity in cholinergic control of neocortical function
Muñoz, W., & Rudy, B. (2014) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2014.02.015 · Cited by 122 · see citing works
A Dendritic Substrate for the Cholinergic Control of Neocortical Output Neurons
Williams, S. R., & Fletcher, L. N. (2018) · Neuron · doi:10.1016/j.neuron.2018.11.035 · Cited by 125 · see citing works
An integrative, multiscale view on neural theories of consciousness
Storm, J. F., Klink, P. C., Aru, J., Senn, W., Goebel, R., Pigorini, A., Avanzini, P., Vanduffel, W., Roelfsema, P. R., Massimini, M., et al. (2024) · Neuron · doi:10.1016/j.neuron.2024.02.004 · Cited by 114 · see citing works
“126 DIT hypothesizes firstly that the basal compartment of these neurons receives predominantly feedfor-ward information that relates to the specific cognitive or sensory feature being processed in the column the L5 pyramidal neuron.”
Self-citationVariable Dendritic Integration in Hippocampal CA3 Pyramidal Neurons
Makara, J. K., & Magee, J. C. (2013) · Neuron · doi:10.1016/j.neuron.2013.10.033 · Cited by 114 · see citing works
Sensory inputs control the integration of neurogliaform interneurons into cortical circuits
De Marco García, N. V., Priya, R., Tuncdemir, S. N., Fishell, G., & Karayannis, T. (2015) · Nature Neuroscience · doi:10.1038/nn.3946 · Cited by 117 · see citing works
Ding, J., ULANOV, A. V., Dong, M., Yang, T., Nemzer, B. V., Xiong, S., Zhao, S., & Feng, H. (2017) · Ultrasonics Sonochemistry · doi:10.1016/j.ultsonch.2017.08.029 · Cited by 113 · see citing works
Carson, R. G. (2020) · The Journal of Physiology · doi:10.1113/jp279793 · Cited by 111 · see citing works
Inhibitory interneurons in visual cortical plasticity
van Versendaal, D., & Levelt, C. N. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2264-4 · Cited by 102 · see citing works
The Contribution of the Corpus Callosum to Language Lateralization
Hinkley, L. B. N., Marco, E. J., Brown, E. G., Bukshpun, P., Gold, J., Hill, S. S., Findlay, A. M., Jeremy, R. J., Wakahiro, M. L. J., Barkovich, A. J., et al. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.3850-14.2016 · Cited by 103 · see citing works
Inhibitory Modulation of Orbitofrontal Cortex on Medial Prefrontal Cortex–Amygdala Information Flow
Chang, C., & Grace, A. A. (2016) · Cerebral Cortex · doi:10.1093/cercor/bhw342 · Cited by 105 · see citing works
Theta burst stimulation in neglect after stroke: functional outcome and response variability origins
Nyffeler, T., Vanbellingen, T., Kaufmann, B. C., Pflugshaupt, T., Bauer, D., Frey, J. N., Chechlacz, M., Bohlhalter, S., Müri, R. M., Nef, T., et al. (2019) · Brain · doi:10.1093/brain/awz029 · Cited by 97 · see citing works
Grienberger, C., Chen, X., & Konnerth, A. (2014) · Trends in Neurosciences · doi:10.1016/j.tins.2014.11.002 · Cited by 97 · see citing works
Bachmann, T., & Hudetz, A. G. (2014) · Frontiers in Psychology · doi:10.3389/fpsyg.2014.00940 · Cited by 104 · see citing works
Hakon, J., Quattromani, M. J., Sjölund, C., Tomasevic, G., Carey, L. M., Lee, J., Ruscher, K., Wieloch, T. W., & Bauer, A. Q. (2017) · NeuroImage Clinical · doi:10.1016/j.nicl.2017.11.022 · Cited by 97 · see citing works
Ding, J., Johnson, J., Chu, Y. F., & Feng, H. (2019) · Food Chemistry · doi:10.1016/j.foodchem.2018.12.136 · Cited by 95 · see citing works
Lee, A. J., Wang, G., Jiang, X., Johnson, S. M., Hoang, E. T., Lanté, F., Stornetta, R. L., Beenhakker, M. P., Shen, Y., & Julius Zhu, J. (2015) · Cerebral Cortex · doi:10.1093/cercor/bhu020 · Cited by 94 · see citing works
Malina, K. C.-K., Tsivourakis, E., Kushinsky, D., Apelblat, D., Shtiglitz, S., Zohar, E., Sokoletsky, M., Tasaka, G., Mizrahi, A., Lampl, I., et al. (2021) · Neuron · doi:10.1016/j.neuron.2021.05.001 · Cited by 99 · see citing works
Ding, J., Yang, T., Feng, H., Dong, M., Slavin, M., Xiong, S., & Zhao, S. (2016) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5b04859 · Cited by 88 · see citing works
Histed, M. H., & Maunsell, J. H. R. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1318750111 · Cited by 84 · see citing works
Activity-Dependent Modulation of Layer 1 Inhibitory Neocortical Circuits by Acetylcholine
Brombas, A., Fletcher, L. N., & Williams, S. R. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.4470-13.2014 · Cited by 88 · see citing works
Inhibitory Regulation of Dendritic Activity in vivo
Palmer, L. M., Murayama, M., & Larkum, M. E. (2012) · Frontiers in Neural Circuits · doi:10.3389/fncir.2012.00026 · Cited by 82 · see citing works
Self-citationThe functional characterization of callosal connections
Innocenti, G. M., Schmidt, K. E., Milleret, C., Mara Fabri, C., Knyazeva, M. G., Battaglia‐Mayer, A., Aboitiz, F., Ptito, M., Caleo, M., Marzi, C. A., et al. (2021) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2021.102186 · Cited by 81 · see citing works
GABA-A Receptor Inhibition of Local Calcium Signaling in Spines and Dendrites
Marlin, J. J., & Carter, A. G. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.0869-13.2014 · Cited by 75 · see citing works
Dembrow, N. C., Zemelman, B. V., & Johnston, D. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.4673-14.2015 · Cited by 75 · see citing works
Functional diversity of supragranular GABAergic neurons in the barrel cortex
Gentet, L. J. (2012) · Frontiers in Neural Circuits · doi:10.3389/fncir.2012.00052 · Cited by 76 · see citing works
Antagonism of the 5-HT 6 receptor – Preclinical rationale for the treatment of Alzheimer's disease
de Jong, I. E. M., & Mørk, A. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.07.010 · Cited by 76 · see citing works
Apical drive-A cellular mechanism of dreaming?
Aru, J., Siclari, F., Phillips, W. A., & Storm, J. F. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.09.018 · Cited by 74 · see citing works
Naskar, S., Qi, J., Pereira, F., Gerfen, C. R., & Lee, S. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.108774 · Cited by 72 · see citing works
Rapid Neuromodulation of Layer 1 Interneurons in Human Neocortex
Poorthuis, R. B., Muhammad, K., Wang, M., Verhoog, M. B., Junek, S., Wrana, A., Mansvelder, H. D., & Letzkus, J. J. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.03.111 · Cited by 70 · see citing works
Pérez‐Garci, E., Larkum, M. E., & Nevian, T. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2012.245464 · Cited by 66 · see citing works
Self-citationDendritic calcium spikes are clearly detectable at the cortical surface
Suzuki, M., & Larkum, M. E. (2017) · Nature Communications · doi:10.1038/s41467-017-00282-4 · Cited by 70 · see citing works
Self-citationSynaptic and cellular organization of layer 1 of the developing rat somatosensory cortex
Muralidhar, S., Wang, Y., & Markram, H. (2014) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2013.00052 · Cited by 67 · see citing works
Helboe, L., Egebjerg, J., & de Jong, I. E. M. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.09.064 · Cited by 66 · see citing works
The contribution of synaptic location to inhibitory gain control in pyramidal cells
Pouille, F., Watkinson, O., Scanziani, M., & Trevelyan, A. J. (2013) · Physiological Reports · doi:10.1002/phy2.67 · Cited by 65 · see citing works
Sublinear integration underlies binocular processing in primary visual cortex
Longordo, F., To, M., Ikeda, K., & Stuart, G. J. (2013) · Nature Neuroscience · doi:10.1038/nn.3394 · Cited by 63 · see citing works
Cognitive functions of intracellular mechanisms for contextual amplification
Phillips, W. A. (2017) · Brain and Cognition · doi:10.1016/j.bandc.2015.09.005 · Cited by 62 · see citing works
Griffen, T. C. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00091 · Cited by 62 · see citing works
Scheyltjens, I., & Arckens, L. (2016) · Neural Plasticity · doi:10.1155/2016/8723623 · Cited by 60 · see citing works
GABAB receptors: modulation of thalamocortical dynamics and synaptic plasticity
Sanchez-Vives, M. V., Barbero‐Castillo, A., Pérez‐Zabalza, M., & Reig, R. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.03.011 · Cited by 61 · see citing works
Impact of functional synapse clusters on neuronal response selectivity
Ujfalussy, B. B., & Makara, J. K. (2020) · Nature Communications · doi:10.1038/s41467-020-15147-6 · Cited by 58 · see citing works
Ibrahim, L. A., Huang, S., Fernández-Otero, M., Sherer, M., Qiu, Y., Vemuri, S., Xu, Q., Machold, R. P., Pouchelon, G., Rudy, B., et al. (2021) · Neuron · doi:10.1016/j.neuron.2021.08.004 · Cited by 60 · see citing works
Neural mechanisms of economic choices in mice
Kuwabara, M., Kang, N., Holy, T. E., & Padoa-Schioppa, C. (2020) · eLife · doi:10.7554/elife.49669 · Cited by 56 · see citing works
Craig, M. T., Mayne, E. W., Bettler, B., Paulsen, O., & McBain, C. J. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2012.248088 · Cited by 56 · see citing works
Modulation of cortical circuits by top-down processing and arousal state in health and disease
Batista‐Brito, R., Zagha, E., Ratliff, J. M., & Vinck, M. A. (2018) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2018.06.008 · Cited by 57 · see citing works
Neurogliaform cortical interneurons derive from cells in the preoptic area
Niquille, M., Limoni, G., Markopoulos, F., Cadilhac, C., Prados, J., Holtmaat, A., & Dayer, A. (2018) · eLife · doi:10.7554/elife.32017 · Cited by 55 · see citing works
Dendritic Excitability and Gain Control in Recurrent Cortical Microcircuits
Hay, E., & Segev, I. (2014) · Cerebral Cortex · doi:10.1093/cercor/bhu200 · Cited by 52 · see citing works
Spalletti, C., Alia, C., Lai, S., Panarese, A., Conti, S., Micera, S., & Caleo, M. (2017) · eLife · doi:10.7554/elife.28662 · Cited by 53 · see citing works
Науменко, Н. В., Потороко, И. Ю., & Kalinina, I. V. (2022) · Ultrasonics Sonochemistry · doi:10.1016/j.ultsonch.2022.106000 · Cited by 54 · see citing works
Dendritic integration in pyramidal neurons during network activity and disease
Palmer, L. M. (2013) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2013.09.010 · Cited by 52 · see citing works
Self-citationBarbero‐Castillo, A., Mateos‐Aparicio, P., Porta, L. D., Camassa, A., Perez-Mendez, L., & Sanchez-Vives, M. V. (2021) · Journal of Neuroscience · doi:10.1523/jneurosci.1837-20.2021 · Cited by 53 · see citing works
Craig, M. T., & McBain, C. (2013) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2013.10.002 · Cited by 56 · see citing works
The yin and yang of cortical layer 1
Larkum, M. E. (2013) · Nature Neuroscience · doi:10.1038/nn.3317 · Cited by 50 · see citing works
Self-citationBehavioral consequences of GABAergic neuronal diversity
Lovett-Barron, M., & Losonczy, A. (2013) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2013.11.002 · Cited by 48 · see citing works
Sublinear binocular integration preserves orientation selectivity in mouse visual cortex
Zhao, X., Liu, M., & Cang, J. (2013) · Nature Communications · doi:10.1038/ncomms3088 · Cited by 48 · see citing works
Zangen, A., Zibman, S., Tendler, A., Barnea‐Ygael, N., Alyagon, U., Blumberger, D. M., Grammer, G. G., Shalev, H., Gulevsky, T., Vapnik, T., et al. (2023) · JCI Insight · doi:10.1172/jci.insight.165271 · Cited by 48 · see citing works
Mining the jewels of the cortex’s crowning mystery
Ibrahim, L. A., Schuman, B., Bandler, R. C., Rudy, B., & Fishell, G. (2020) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2020.04.005 · Cited by 48 · see citing works
Principles of GABAergic signaling in developing cortical network dynamics
Kirmse, K., & Zhang, C. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110568 · Cited by 46 · see citing works
Optogenetic Approaches to Target Specific Neural Circuits in Post-stroke Recovery
Cheng, M., Aswendt, M., & Steinberg, G. K. (2015) · Neurotherapeutics · doi:10.1007/s13311-015-0411-5 · Cited by 43 · see citing works
Development of cortical motor circuits between childhood and adulthood: A navigated TMS‐HdEEG study
Määttä, S., Könönen, M., Kallioniemi, E., Lakka, T. A., Lintu, N., Lindi, V., Ferreri, F., Ponzo, D., & Säïsänen, L. (2017) · Human Brain Mapping · doi:10.1002/hbm.23545 · Cited by 45 · see citing works
Pharmacological mechanisms of interhemispheric signal propagation: a TMS-EEG study
Hui, J., Zomorrodi, R., Lioumis, P., Salavati, B., Rajji, T. K., Chen, R. E., Blumberger, D. M., & Daskalakis, Z. J. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-019-0468-7 · Cited by 42 · see citing works
Layer-specific regulation of cortical neurons by interhemispheric inhibition
Palmer, L. M., Schulz, J. M., & Larkum, M. E. (2013) · Communicative & Integrative Biology · doi:10.4161/cib.23545 · Cited by 44 · see citing works
Self-citationDegro, C. E., Kulik, Á., Booker, S. A., & Vida, I. (2015) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2015.00006 · Cited by 43 · see citing works
- Authors
- Palmer, L. M., Schulz, J. M., Murphy, S. C., Ledergerber, D., Murayama, M., & Larkum, M. E.
- Affiliations
- University of Bern (CH)
- RIKEN Center for Brain Science (JP)
- Corresponding author
- Larkum, Matthew E.
- ORCID
- Venue
- Science
- Published
- 2012-02-24
- Volume
- 335
- Issue
- 6071
- Pages
- 989-993
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2031248308
- Cited by
- 284
- References
- 34
- Citations by year
- 2026: 9 · 2025: 9 · 2024: 11 · 2023: 14 · 2022: 9 · 2021: 26 · 2020: 35 · 2019: 25 · 2018: 26 · 2017: 24 · 2016: 20 · 2015: 15 · 2014: 21 · 2013: 27 · 2012: 13
- FWCI
- 9.98
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Keywords
- interhemispheric inhibition, GABAB receptors, corpus callosum, layer 5 pyramidal neurons, somatosensory cortex, dendritic inhibition, layer 1 interneurons, paired stimulation, cortical microcircuitry, active dendrites
- MeSH terms
- Action Potentials, Animals, Calcium, Corpus Callosum, Dendrites, Electric Stimulation, Hindlimb, Interneurons, Neural Inhibition, Somatosensory Cortex, Rats, Wistar, Pyramidal Cells, Receptors, GABA-B, Patch-Clamp Techniques, Rats, Cerebrum
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review