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Targeted sequencing reveals clonal genetic changes in the progression of early lung neoplasms and paired circulating DNA

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Somatic mutations, genome mosaicism, cancer and aging

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Wnt/β-catenin pathway activation in adrenocortical adenomas is frequently due to somatic CTNNB1-activating mutations, which are associated with larger and nonsecreting tumors: a study in cortisol-secreting and -nonsecreting tumors

Bonnet, S., Gaujoux, S., Launay, P., Baudry, C., Chokri, I., Ragazzon, B., Libé, R., René-Corail, F., Audebourg, A., Vacher-Lavenu, M.-C., et al. (2011) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jc.2010-1885 · Cited by 133 · see citing works

Synthetic vulnerabilities of mesenchymal subpopulations in pancreatic cancer

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Tumor-derived p53 mutants induce oncogenesis by transactivating growth-promoting genes

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Consumption of hot beverages and foods and the risk of esophageal cancer: a meta-analysis of observational studies

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Genomic Analysis of Uterine Lavage Fluid Detects Early Endometrial Cancers and Reveals a Prevalent Landscape of Driver Mutations in Women without Histopathologic Evidence of Cancer: A Prospective Cross-Sectional Study

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The Case for a Pre-Cancer Genome Atlas (PCGA)

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The tumour microenvironment creates a niche for the self-renewal of tumour-promoting macrophages in colon adenoma

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The Impact of Environmental and Endogenous Damage on Somatic Mutation Load in Human Skin Fibroblasts

Saini, N., Roberts, S. A., Klimczak, L. J., Chan, K., Grimm, S. A., Dai, S., Fargo, D. C., Boyer, J. C., Kaufmann, W. K., Taylor, J. A., et al. (2016) · PLOS Genetics · doi:10.1371/journal.pgen.1006385 · Cited by 94 · see citing works

DeTiN: overcoming tumor-in-normal contamination

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Inflammatory microenvironment in the initiation and progression of bladder cancer

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RADIA: RNA and DNA Integrated Analysis for Somatic Mutation Detection

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Consistent and Differential Genetic Aberrations between Esophageal Dysplasia and Squamous Cell Carcinoma Detected By Array Comparative Genomic Hybridization

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Molecular Profiling of Premalignant Lesions in Lung Squamous Cell Carcinomas Identifies Mechanisms Involved in Stepwise Carcinogenesis

Ooi, A. T., Gower, A. C., Zhang, K. X., Vick, J. L., Hong, L., Nagao, B., Wallace, W. D., Elashoff, D. A., Walser, T. C., Dubinett, S. M., et al. (2014) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-13-0372 · Cited by 81 · see citing works

p53 mutations in benign breast tissue.

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Identification of GRO1 as a Critical Determinant for Mutant p53 Gain of Function

Yan, W., & Chen, X. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m900994200 · Cited by 77 · see citing works

Role of tumor microenvironment in ovarian cancer pathobiology

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Analysis of chromosomal aberrations and recombination by allelic bias in RNA-Seq

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Polo-like kinase 4 transcription is activated via CRE and NRF1 elements, repressed by DREAM through CDE/CHR sites and deregulated by HPV E7 protein

Fischer, M., Quaas, M., Wintsche, A., Müller, G. A., & Engeland, K. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt849 · Cited by 62 · see citing works

Sun-Induced Nonsynonymous p53 Mutations Are Extensively Accumulated and Tolerated in Normal Appearing Human Skin

Ståhl, P. L., Stranneheim, H., Asplund, A., Berglund, L., Pontén, F., & Lundeberg, J. (2010) · Journal of Investigative Dermatology · doi:10.1038/jid.2010.302 · Cited by 56 · see citing works

A fast and accurate method to detect allelic genomic imbalances underlying mosaic rearrangements using SNP array data

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Wnt/β-catenin pathway deregulation in childhood adrenocortical tumors

Leal, L. F., Mermejo, L. M., Ramalho, L. Z., Martinelli, C. E., Yunes, J. A., Seidinger, A. L., Mastellaro, M. J., Cardinalli, I. A., Brandalise, S. R., Moreira, A. C., et al. (2011) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jc.2011-0363 · Cited by 55 · see citing works

Elucidating Genomic Characteristics of Lung Cancer Progression from In Situ to Invasive Adenocarcinoma

Vinayanuwattikun, C., Calvez‐Kelm, F. L., Abedi‐Ardekani, B., Zaridze, D. G., Mukeria, A., Voegele, C., Vallée, M., Purnomosari, D., Forey, N., Durand, G., et al. (2016) · Scientific Reports · doi:10.1038/srep31628 · Cited by 49 · see citing works

The landscape of somatic mutations in protein coding genes in apparently benign human tissues carries signatures of relaxed purifying selection

Yadav, V. K., DeGregori, J. V., & De, S. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw086 · Cited by 48 · see citing works

Detecting the Presence and Progression of Premalignant Lung Lesions via Airway Gene Expression

Beane, J., Mazzilli, S. A., Tassinari, A. M., et al. (2017) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-16-2540 · Cited by 46 · see citing works

Practicability of detecting somatic point mutation from RNA high throughput sequencing data

Sheng, Q., Zhao, S., Li, C.-I., Shyr, Y., & Guo, Y. P. (2016) · Genomics · doi:10.1016/j.ygeno.2016.03.006 · Cited by 42 · see citing works

The eSNV-detect: a computational system to identify expressed single nucleotide variants from transcriptome sequencing data

Tang, X., Baheti, S., Shameer, K., Thompson, K. J., Wills, Q. F., Niu, N., Holcomb, I. N., Boutet, S. C., Ramakrishnan, R., Kachergus, J. M., et al. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku1005 · Cited by 41 · see citing works

The clonal relationships between pre‐cancer and cancer revealed by ultra‐deep sequencing

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Integrated genomic and molecular characterization of cervical cancer

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Patterns of Somatically Acquired Amplifications and Deletions in Apparently Normal Tissues of Ovarian Cancer Patients

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Integrated genomic characterization of oesophageal carcinoma

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The central role of DNA damage in the ageing process

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ESMO recommendations on the use of circulating tumour DNA assays for patients with cancer: A report from the ESMO Precision Medicine Working Group

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The gut microbiome switches mutant p53 from tumour-suppressive to oncogenic

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Understanding the tumor microenvironment for effective immunotherapy

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Extensive heterogeneity in somatic mutation and selection in the human bladder

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Mechanisms of UV-induced mutations and skin cancer

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Convergent somatic mutations in metabolism genes in chronic liver disease

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Genomic copy number predicts esophageal cancer years before transformation

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Clonal Hematopoiesis: Mechanisms Driving Dominance of Stem Cell Clones

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