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Inhibition of Bruton tyrosine kinase in patients with severe COVID-19

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Roschewski, Mark, Lionakis, Michail S., Sharman, Jeff P., Roswarski, Joseph, Goy, Andre, Monticelli, M. Andrew, Roshon, Michael, Wrzesinski, Stephen H., Desai, Jigar V., Zarakas, Marissa A., Collen, Jacob, Rose, Keith M., Hamdy, Ahmed, Izumi, Raquel, Wright, George W., Chung, Kevin K., Baselga, Jose, Staudt, Louis M., Wilson, Wyndham H.·2020·Science Immunology

DOI 10.1126/sciimmunol.abd0110

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Abstract

Acalabrutinib targets activated BTK in macrophages and was associated with reduced inflammation and clinical improvement in COVID-19.

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“Although we have focused our model on macrophages, BTK is also known to control signaling in neutrophils (41), megakaryocytes (42), and platelets (43), which may also contribute to the immunopathology of severe COVID-19 and be kept in check by BTK inhibitors.”
Background
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See all 357

Authors: Roschewski, M., Lionakis, M. S., Sharman, J. P., Roswarski, J., Goy, A., Monticelli, M. A., Roshon, M., Wrzesinski, S. H., Desai, J. V., Zarakas, M. A., Collen, J., Rose, K. M., Hamdy, A., Izumi, R., Wright, G. W., Chung, K. K., Baselga, J., Staudt, L. M., & Wilson, W. H.
Venue: Science Immunology
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2020-06-26
Volume: 5
Issue: 48
ISSN: 2470-9468 (ISSN-L)
DOI: 10.1126/sciimmunol.abd0110
OpenAlex: W3034129242
Cited by: 357
References: 54
FWCI: 9.63
Type: journal article
Language: en
Open access: hybrid

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Inhibition of Bruton tyrosine kinase in patients with severe COVID-19

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