A CD36-initiated Signaling Cascade Mediates Inflammatory Effects of β-Amyloid
Open accessAbstract
beta-Amyloid accumulation is associated with pathologic changes in the brain in Alzheimer's disease and has recently been identified in plaques of another chronic inflammatory disorder, atherosclerosis. The class B scavenger receptor, CD36, mediates binding of fibrillar beta-amyloid to cells of the monocyte/macrophage lineage, including brain macrophages (microglia). In this study, we demonstrate that in microglia and other tissue macrophages, beta-amyloid initiates a CD36-dependent signaling cascade involving the Src kinase family members, Lyn and Fyn, and the mitogen-activated protein kinase, p44/42. Interruption of this signaling cascade, through targeted disruption of Src kinases downstream of CD36, inhibits macrophage inflammatory responses to beta-amyloid, including reactive oxygen and chemokine production, and results in decreased recruitment of microglia to sites of amyloid deposition in vivo. The finding that engagement of CD36 by beta-amyloid initiates a Src kinase-dependent production of inflammatory mediators in cells of the macrophage lineage reveals a novel receptor-mediated pro-inflammatory signaling pathway of potential therapeutic importance.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
CD36 mediates fAβ-induced signal cascade leading to production of ROS and chemokines.
“Furthermore, CD36 mediates fAβ-induced signal cascade which leads to the production of ROS and chemokines [366].”
From Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease (2020) · cites this paper as [366]
Cites
Atherosclerosis--an inflammatory disease
Ross, R. (1999) · New England Journal of Medicine · doi:10.1056/nejm199901143400207 · Cited by 21,725 · see citing works
Inflammation and Alzheimer’s disease
Akiyama, H. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00124-x · Cited by 4,514 · see citing works
Cellular functions regulated by Src family kinases.
Thomas, S. M., & Brugge, J. (1997) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.13.1.513 · Cited by 2,610 · see citing works
CD36 is a receptor for oxidized low density lipoprotein
Endemann, G., Stanton, L. W., Madden, K. S., Bryant, C. M., White, R. T., & Protter, A. A. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)50272-1 · Cited by 1,282 · see citing works
A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection
Suzuki, H. I., Kurihara, Y., Takeya, M., Kamada, N., Kataoka, M., Jishage, K., Ueda, O., Sakaguchi, H., Higashi, T., Suzuki, T., et al. (1997) · Nature · doi:10.1038/386292a0 · Cited by 1,226 · see citing works
Febbraio, M., Hajjar, D., & Silverstein, R. (2001) · Journal of Clinical Investigation · doi:10.1172/jci14006 · Cited by 1,171 · see citing works
Febbraio, M., Podrez, E. A., Smith, J. D., Hajjar, D. P., Hazen, S. L., Hoff, H. F., Sharma, K., & Silverstein, R. L. (2000) · Journal of Clinical Investigation · doi:10.1172/jci9259 · Cited by 1,037 · see citing works
Signals leading to apoptosis-dependent inhibition of neovascularization by thrombospondin-1
Jiménez, B., Volpert, O. V., Crawford, S. E., Febbraio, M., Silverstein, R. L., & Bouck, N. (2000) · Nature Medicine · doi:10.1038/71517 · Cited by 1,014 · see citing works
MICROGLIA AS MEDIATORS OF INFLAMMATORY AND DEGENERATIVE DISEASES
González-Scarano, F., & Baltuch, G. (1999) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.22.1.219 · Cited by 984 · see citing works
Scavenger receptor-mediated adhesion of microglia to β-amyloid fibrils
Khoury, J. E., Hickman, S. E., Thomas, C. A., Cao, L., Silverstein, S. C., & Loike, J. D. (1996) · Nature · doi:10.1038/382716a0 · Cited by 727 · see citing works
Self-citationCombs, C. K., Karlo, J. C., Kao, S.-C., & Landreth, G. E. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-04-01179.2001 · Cited by 721 · see citing works
Microglial response to amyloid plaques in APPsw transgenic mice.
Frautschy, S. A., Yang, F., Irrizarry, M., Hyman, B. T., Saido, T. C., Hsiao, K., & Cole, G. M. (1998) · Europe PMC (PubMed Central) · Cited by 592 · see citing works
Aging renders the brain vulnerable to amyloid β-protein neurotoxicity
Guela, C., Wu, C.-K., Saroff, D., Lorenzo, A., Yuan, M., & Yankner, B. A. (1998) · Nature Medicine · doi:10.1038/nm0798-827 · Cited by 520 · see citing works
The role of PPAR-γ in macrophage differentiation and cholesterol uptake
Moore, K. J., Rosen, E. D., Fitzgerald, M. L., Randow, F., Andersson, L. P., Altshuler, D., Milstone, D. S., Mortensen, R. M., Spiegelman, B. M., & Freeman, M. W. (2001) · Nature Medicine · doi:10.1038/83328 · Cited by 513 · see citing works
Self-citationCombs, C. K., Johnson, D. E., Karlo, J. C., Cannady, S. B., & Landreth, G. E. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-02-00558.2000 · Cited by 483 · see citing works
Podrez, E. A., Febbraio, M., Sheibani, N., Schmitt, D. C., Silverstein, R. L., Hajjar, D. P., Cohen, P. A., Frazier, W. A., Hoff, H. F., & Hazen, S. L. (2000) · Journal of Clinical Investigation · doi:10.1172/jci8574 · Cited by 455 · see citing works
Huang, M., Bolen, J. B., Barnwell, J. W., Shattil, S. J., & Brugge, J. S. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.17.7844 · Cited by 406 · see citing works
Coraci, I. S., Husemann, J., Berman, J. W., Hulette, C., Dufour, J. H., Campanella, G. K., Luster, A. D., Silverstein, S. C., & El Khoury, J. B. (2002) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)64354-4 · Cited by 398 · see citing works
Self-citationCombs, C. K., Johnson, D. E., Cannady, S. B., Lehman, T. M., & Landreth, G. E. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-03-00928.1999 · Cited by 349 · see citing works
Weldon, D. T., Rogers, S. D., Ghilardi, J. R., Finke, M. P., Cleary, J. P., O’Hare, E., Esler, W. P., Maggio, J. E., & Mantyh, P. W. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-06-02161.1998 · Cited by 348 · see citing works
Amyloid Fibrils Activate Tyrosine Kinase-Dependent Signaling and Superoxide Production in Microglia
McDonald, D. R., Brunden, K. R., & Landreth, G. E. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-07-02284.1997 · Cited by 308 · see citing works
McDonald, D. R., Bamberger, M. E., Combs, C. K., & Landreth, G. E. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-12-04451.1998 · Cited by 259 · see citing works
Divergent Response to LPS and Bacteria in CD14-Deficient Murine Macrophages
Moore, K. J., Andersson, L. P., Ingalls, R. R., Monks, B. G., Li, R., Arnaout, M. A., Golenbock, D. T., & Freeman, M. W. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.8.4272 · Cited by 226 · see citing works
Self-citationMicroglia, Scavenger Receptors, and the Pathogenesis of Alzheimer’s Disease
Khoury, J. B. E., Hickman, S., Thomas, C. A., Loike, J. D., & Silverstein, S. C. (1998) · Neurobiology of Aging · doi:10.1016/s0197-4580(98)00036-0 · Cited by 157 · see citing works
Role of macrophage scavenger receptors in diet-induced atherosclerosis in mice.
Sakaguchi, H., Takeya, M., Suzuki, H., Hakamata, H., Kodama, T., Horiuchi, S., Gordon, S., van der Laan, L. J. W., Kraal, G., Ishibashi, S., et al. (1998) · PubMed · Cited by 146 · see citing works
Meyer, G. R. Y. D., Cleen, D. M. M. D., Cooper, S., Knaapen, M., Jans, D. M., Martinet, W., Herman, A. G., Bult, H., & Kockx, M. M. (2002) · Circulation Research · doi:10.1161/01.res.0000020017.84398.61 · Cited by 139 · see citing works
Klein, A., Kowall, N. W., & Ferrante, R. J. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb07845.x · Cited by 114 · see citing works
Tyrosine phosphorylation systems in Alzheimer's disease pathology
Wood, J. G., & Zinsmeister, P. P. (1991) · Neuroscience Letters · doi:10.1016/0304-3940(91)90637-9 · Cited by 53 · see citing works
Tedgui, A., & Mallat, Z. (2002) · Circulation Research · doi:10.1161/01.res.0000023048.87638.92 · Cited by 21 · see citing works
Smits, H. A., Vos, N., Wat, J. W. Y., van der Bruggen, T., Verhoef, J., & Nottet, H. S. L. M. (2001) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(01)00254-5 · Cited by 19 · see citing works
Flagged first, then by citations
2 of the 32 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
The NALP3 inflammasome is involved in the innate immune response to amyloid-β
Halle, A., Hornung, V., Petzold, G. C., Stewart, C. R., Monks, B. G., Reinheckel, T., Fitzgerald, K. A., Latz, E., Moore, K. J., & Golenbock, D. T. (2008) · Nature Immunology · doi:10.1038/ni.1636 · Cited by 2,441 · see citing works
Self-citationNeurovascular regulation in the normal brain and in Alzheimer's disease
Iadecola, C. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1387 · Cited by 2,213 · see citing works
Stewart, C. R., Stuart, L. M., Wilkinson, K., van Gils, J. M., Deng, J., Halle, A., Rayner, K. J., Boyer, L., Zhong, R., Frazier, W. A., et al. (2010) · Nature Immunology · doi:10.1038/ni.1836 · Cited by 1,513 · see citing works
Self-citationCD36, a Scavenger Receptor Involved in Immunity, Metabolism, Angiogenesis, and Behavior
Silverstein, R. L., & Febbraio, M. (2009) · Science Signaling · doi:10.1126/scisignal.272re3 · Cited by 1,247 · see citing works
Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease
Guo, T., Zhang, D., Zeng, Y., Huang, T. Y., Xu, H., & Zhao, Y. (2020) · Molecular Neurodegeneration · doi:10.1186/s13024-020-00391-7 · Cited by 994 · see citing works
Autophagy‐based unconventional secretory pathway for extracellular delivery of IL‐1β
Dupont, N., Jiang, S., Pilli, M., Ornatowski, W., Bhattacharya, D., & Deretic, V. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.398 · Cited by 967 · see citing works
Sheedy, F. J., Grebe, A., Rayner, K. J., Kalantari, P., Ramkhelawon, B., Carpenter, S. B., Becker, C. E., Ediriweera, H. N., Mullick, A. E., Golenbock, D. T., et al. (2013) · Nature Immunology · doi:10.1038/ni.2639 · Cited by 935 · see citing works
Self-citationScavenger receptors in homeostasis and immunity
Canton, J., Neculai, D., & Grinstein, S. (2013) · Nature Reviews Immunology · doi:10.1038/nri3515 · Cited by 838 · see citing works
Cytokine networks in neuroinflammation
Becher, B., Spath, S., & Goverman, J. M. (2016) · Nature reviews. Immunology · doi:10.1038/nri.2016.123 · Cited by 681 · see citing works
Savelieff, M. G., Nam, G., Kang, J., Lee, H. J., Lee, M., & Lim, M. H. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00138 · Cited by 603 · see citing works
Microglia, neuroinflammation, and beta-amyloid protein in Alzheimer’s disease
Cai, Z., Hussain, M. D., & Yan, L.-J. (2014) · International Journal of Neuroscience · doi:10.3109/00207454.2013.833510 · Cited by 583 · see citing works
Scavenger Receptors in Atherosclerosis: Beyond Lipid Uptake
Moore, K. J., & Freeman, M. W. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000229218.97976.43 · Cited by 562 · see citing works
Self-citationCD36, a scavenger receptor implicated in atherosclerosis
Park, Y. M. (2014) · Experimental & Molecular Medicine · doi:10.1038/emm.2014.38 · Cited by 517 · see citing works
A CD36-dependent signaling cascade is necessary for macrophage foam cell formation
Rahaman, S. O., Lennon, D. J., Febbraio, M., Podrez, E. A., Hazen, S. L., & Silverstein, R. L. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.06.007 · Cited by 506 · see citing works
A Cell Surface Receptor Complex for Fibrillar β-Amyloid Mediates Microglial Activation
Bamberger, M. E., Harris, M. E., McDonald, D. R., Husemann, J., & Landreth, G. E. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-07-02665.2003 · Cited by 501 · see citing works
CD36 Mediates the Innate Host Response to β-Amyloid
El Khoury, J. B., Moore, K. J., Means, T. K., Leung, J., Terada, K., Toft, M., Freeman, M. W., & Luster, A. D. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20021546 · Cited by 483 · see citing works
Self-citationSynuclein activates microglia in a model of Parkinson's disease
Su, X., Maguire-Zeiss, K. A., Giuliano, R., Prifti, L., Venkatesh, K., & Federoff, H. J. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.04.006 · Cited by 474 · see citing works
Microglial Phagocytosis of Fibrillar β-Amyloid through a β1Integrin-Dependent Mechanism
Koenigsknecht-Talboo, J., & Landreth, G. E. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.2557-04.2004 · Cited by 444 · see citing works
Ursolic acid: An anti‐ and pro‐inflammatory triterpenoid
Ikeda, Y., Murakami, A., & Ohigashi, H. (2008) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200700389 · Cited by 417 · see citing works
Stuart, L. M., Deng, J., Silver, J. M., Takahashi, K., Tseng, A. A., Hennessy, E. J., Ezekowitz, R. A. B., & Moore, K. J. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200501113 · Cited by 417 · see citing works
Self-citationPhosphorylation of Tau by Fyn: Implications for Alzheimer's Disease
Lee, G. S., Thangavel, R., Sharma, V. M., Litersky, J. M., Bhaskar, K., Fang, S. M., Lana, H., Andreadis, A., Hoesen, G. W. V., & Ksiȩżak-Reding, H. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.4162-03.2004 · Cited by 414 · see citing works
Park, Y. M., Febbraio, M., & Silverstein, R. L. (2008) · Journal of Clinical Investigation · doi:10.1172/jci35535 · Cited by 407 · see citing works
Wan, E. Y., Yeap, X. Y., Dehn, S., Terry, R. L., Novak, M. L., Zhang, S., Iwata, S., Han, X., Homma, S., Drosatos, K., et al. (2013) · Circulation Research · doi:10.1161/circresaha.113.301198 · Cited by 385 · see citing works
Moore, K. J., Kunjathoor, V. V., Koehn, S. L., Manning, J. J., Tseng, A. A., Silver, J. M., McKee, M. L., & Freeman, M. W. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24061 · Cited by 371 · see citing works
Self-citationvan Gils, J. M., Derby, M. C., Fernandes, L. R., Ramkhelawon, B., Ray, T. D., Rayner, K. J., Parathath, S., Distel, E., Feig, J. L., Alvarez-Leite, J. I., et al. (2012) · Nature Immunology · doi:10.1038/ni.2205 · Cited by 365 · see citing works
Self-citationDoens, D., & Fernández, P. L. (2014) · Journal of Neuroinflammation · doi:10.1186/1742-2094-11-48 · Cited by 348 · see citing works
Salminen, A., Ojala, J. O., Kauppinen, A., Kaarniranta, K., & Suuronen, T. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2009.01.001 · Cited by 350 · see citing works
Biochemistry and cell biology of mammalian scavenger receptors
Murphy, J. E., Tedbury, P. R., Homer‐Vanniasinkam, S., Walker, J. H., & Ponnambalam, S. (2005) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2005.03.036 · Cited by 331 · see citing works
<scp>F</scp>yn inhibition rescues established memory and synapse loss in <scp>A</scp>lzheimer mice
Kaufman, A. C., Salazar, S. V., Haas, L. T., Yang, J., Kostylev, M. A., Jeng, A. T., Robinson, S. A., Gunther, E. C., van Dyck, C. H., Nygaard, H. B., et al. (2015) · Annals of Neurology · doi:10.1002/ana.24394 · Cited by 314 · see citing works
IFN-γ receptor signaling mediates spinal microglia activation driving neuropathic pain
Tsuda, M., Masuda, T., Kitano, J., Shimoyama, H., Tozaki‐Saitoh, H., & Inoue, K. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810420106 · Cited by 296 · see citing works
Alzheimer’s disease: pathological mechanisms and the beneficial role of melatonin
Rosales‐Corral, S., Acuña-Castroviejo, D., Coto‐Montes, A. M., Boga, J. A., Manchester, L. C., Fuentes‐Broto, L., Korkmaz, A., Ma, S., Tan, D. X., & Reiter, R. J. (2011) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2011.00937.x · Cited by 293 · see citing works
Pan, X.-D., Zhu, Y.-G., Lin, N., Zhang, J., Ye, Q.-Y., Huang, H.-P., & Chen, X.-C. (2011) · Molecular Neurodegeneration · doi:10.1186/1750-1326-6-45 · Cited by 292 · see citing works
Isenberg, J. S., Ridnour, L. A., Dimitry, J. M., Frazier, W. A., Wink, D. A., & Roberts, D. D. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m605040200 · Cited by 291 · see citing works
Amyloids — a functional coat for microorganisms
Gebbink, M. F. B. G., Claessen, D., Bouma, B., Dijkhuizen, L., & Wösten, H. A. B. (2005) · Nature Reviews Microbiology · doi:10.1038/nrmicro1127 · Cited by 287 · see citing works
Microglia and neuropathic pain
Inoue, K., & Tsuda, M. (2009) · Glia · doi:10.1002/glia.20871 · Cited by 291 · see citing works
Systemic inflammation during midlife and cognitive change over 20 years: The ARIC Study
Walker, K. A., Gottesman, R. F., Wu, A., Knopman, D. S., Gross, A. L., Mosley, T. H., Selvin, E., & Windham, B. G. (2019) · Neurology · doi:10.1212/wnl.0000000000007094 · Cited by 282 · see citing works
Manning, J. J., Moore, K. J., Seimon, T. A., Bell, S. A., Sharuk, M., Alvarez-Leite, J. I., de Winther, M. P. J., Tabas, I. A., & Freeman, M. W. (2008) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.176644 · Cited by 266 · see citing works
Self-citationCerebrovascular atherosclerosis correlates with Alzheimer pathology in neurodegenerative dementias
Yarchoan, M. M., Xie, S. X., Kling, M. A., Toledo, J. B., Wolk, D. A., Lee, E. B., Deerlin, V. M. V., Lee, V. M. Y., Trojanowski, J. Q., & Arnold, S. E. (2012) · Brain · doi:10.1093/brain/aws271 · Cited by 263 · see citing works
Fyn kinase regulates misfolded α-synuclein uptake and NLRP3 inflammasome activation in microglia
Panicker, N., Sarkar, S., Harischandra, D. S., Neal, M. P., Kam, T., Jin, H., Saminathan, H., Langley, M. R., Charli, A., Samidurai, M., et al. (2019) · The Journal of Experimental Medicine · doi:10.1084/jem.20182191 · Cited by 255 · see citing works
Amyloid-β Receptors: The Good, the Bad, and the Prion Protein
Jarosz-Griffiths, H. H., Noble, E., Rushworth, J. V., & Hooper, N. M. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.r115.702704 · Cited by 256 · see citing works
CD36: Implications in cardiovascular disease
Febbraio, M., & Silverstein, R. L. (2007) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2007.03.012 · Cited by 248 · see citing works
Microglial Aβ Receptors in Alzheimer’s Disease
Yu, Y., & Ye, R. D. (2015) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-014-0101-6 · Cited by 247 · see citing works
Tampakakis, E., Puckett, L. L., Tai, M., Stewart, C. R., Hickman, S. E., Moore, K. J., El Khoury, J., Means, T. K., Mylonakis, E. E., Colvin, R. A., et al. (2009) · Digital Access to Scholarship at Harvard (DASH) (Harvard University) · Cited by 246 · see citing works
Self-citationAmyloid β-Protein Toxicity and the Pathogenesis of Alzheimer Disease
Yankner, B. A., & Lu, T. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.r800018200 · Cited by 225 · see citing works
Arai, S., Kitada, K., Yamazaki, T., Takai, R., Zhang, X., Tsugawa, Y., Sugisawa, R., Matsumoto, A., Mori, M., Yoshihara, Y., et al. (2016) · Nature Medicine · doi:10.1038/nm.4012 · Cited by 226 · see citing works
The microglial phagocytic role with specific plaque types in the Alzheimer disease brain
D’Andrea, M. R., Cole, G. M., & Ard, M. D. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2003.12.026 · Cited by 215 · see citing works
Kuchibhotla, S., Vanegas, D., Kennedy, D. J., Guy, E. C., Nimako, G., Morton, R. E., & Febbraio, M. (2007) · Cardiovascular Research · doi:10.1093/cvr/cvm093 · Cited by 210 · see citing works
Apoptotic cell recognition receptors and scavenger receptors
Penberthy, K. K., & Ravichandran, K. S. (2015) · Immunological Reviews · doi:10.1111/imr.12376 · Cited by 202 · see citing works
Chen, K., Febbraio, M., Li, W., & Silverstein, R. L. (2008) · Circulation Research · doi:10.1161/circresaha.108.172064 · Cited by 202 · see citing works
Oxidized low density lipoprotein and innate immune receptors
Miller, Y. I., Chang, M.-K., Binder, C. J., Shaw, P. X., & Witztum, J. L. (2003) · Current Opinion in Lipidology · doi:10.1097/00041433-200310000-00004 · Cited by 200 · see citing works
Biochemical diversity of odor detection
Vogt, R. G. (2003) · Elsevier eBooks · doi:10.1016/b978-012107151-6/50016-5 · Cited by 202 · see citing works
Relationship Between Amyloid-β Deposition and Blood–Brain Barrier Dysfunction in Alzheimer’s Disease
Wang, D., Chen, F., Han, Z., Yin, Z., Ge, X., & Lei, P. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.695479 · Cited by 201 · see citing works
Cho, S., Park, E., Febbraio, M., Anrather, J., Park, L., Racchumi, G., Silverstein, R. L., & Iadecola, C. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.0035-05.2005 · Cited by 195 · see citing works
The Alzheimer’s Disease Amyloid-Beta Hypothesis in Cardiovascular Aging and Disease
Stakos, D. A., Stamatelopoulos, K., Bampatsias, D., Sachse, M., Zormpas, E., Vlachogiannis, N. I., Tual-Chalot, S., & Stellos, K. (2020) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2019.12.033 · Cited by 188 · see citing works
Microglial Scavenger Receptors and Their Roles in the Pathogenesis of Alzheimer's Disease
Wilkinson, K., & Khoury, J. B. E. (2012) · International Journal of Alzheimer s Disease · doi:10.1155/2012/489456 · Cited by 186 · see citing works
Baranova, I. N., Kurlander, R. J., Bocharov, A. V., Vishnyakova, T. G., Chen, Z., Remaley, A. T., Csákó, G., Patterson, A. P., & Eggerman, T. L. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.10.7147 · Cited by 184 · see citing works
Fu, H., Liu, B., Frost, J. L., Hong, S., Jin, M., Ostaszewski, B., Shankar, G. M., Costantino, I. M., Carroll, M. C., Mayadas, T. N., et al. (2012) · Glia · doi:10.1002/glia.22331 · Cited by 180 · see citing works
Molecular Basis of Pheromone Detection in Insects
Vogt, R. G. (2005) · Elsevier eBooks · doi:10.1016/b0-44-451924-6/00047-8 · Cited by 178 · see citing works
Tsuda, M., Ueno, H., Kataoka, A., Tozaki‐Saitoh, H., & Inoue, K. (2008) · Glia · doi:10.1002/glia.20623 · Cited by 168 · see citing works
Ghosh, A., Li, W., Febbraio, M., Espinola, R. G., McCrae, K. R., Cockrell, E., & Silverstein, R. L. (2008) · Journal of Clinical Investigation · doi:10.1172/jci34904 · Cited by 169 · see citing works
Panicker, N., Saminathan, H., Jin, H., Neal, M., Harischandra, D. S., Gordon, R., Kanthasamy, K. A., Lawana, V., Sarkar, S., Luo, J. D., et al. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.0302-15.2015 · Cited by 163 · see citing works
Molecular Mechanisms of Neuroinflammation in Aging and Alzheimer’s Disease Progression
Andronie-Cioară, F. L., Ardelean, A. I., Nistor-Cseppento, C. D., Jurcău, A., Jurcău, M. C., Pașcalău, N., & Marcu, F. M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24031869 · Cited by 164 · see citing works
Mannose-binding lectin enhances Toll-like receptors 2 and 6 signaling from the phagosome
Ip, W., Takahashi, K., Moore, K. J., Stuart, L. M., & Ezekowitz, R. A. B. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20071164 · Cited by 163 · see citing works
Self-citationMicroglia Demonstrate Age-Dependent Interaction with Amyloid-β Fibrils
Floden, A. M., & Combs, C. K. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-101014 · Cited by 160 · see citing works
Alzheimer’s Disease Pathogenesis: Role of Autophagy and Mitophagy Focusing in Microglia
Eshraghi, M., Adlimoghaddam, A., Mahmoodzadeh, A., Sharifzad, F., Yasavoli-Sharahi, H., Lorzadeh, S., Albensi, B. C., & Ghavami, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22073330 · Cited by 158 · see citing works
Fat taste and lipid metabolism in humans
Mattes, R. D. (2005) · Physiology & Behavior · doi:10.1016/j.physbeh.2005.08.058 · Cited by 158 · see citing works
Macrophages: An elusive yet emerging therapeutic target of atherosclerosis
Tiwari, R. L., Singh, V., & Barthwal, M. K. (2007) · Medicinal Research Reviews · doi:10.1002/med.20118 · Cited by 153 · see citing works
Miller, Y. I., Choi, S.-H., Fang, L., & Tsimikas, S. (2010) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-90-481-8622-8_8 · Cited by 155 · see citing works
The Important Interface Between Apolipoprotein E and Neuroinflammation in Alzheimer’s Disease
Kloske, C. M., & Wilcock, D. M. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00754 · Cited by 152 · see citing works
Casadevall, A., & Pirofski, L. (2006) · Advances in immunology · doi:10.1016/s0065-2776(06)91001-3 · Cited by 146 · see citing works
Jurcău, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111847 · Cited by 150 · see citing works
The impact of nanoparticle ligand density on dendritic-cell targeted vaccines
Bandyopadhyay, A., Fine, R. L., Demento, S., Bockenstedt, L. K., & Fahmy, T. M. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2010.12.054 · Cited by 141 · see citing works
The Neurovascular Unit Dysfunction in Alzheimer’s Disease
Soto-Rojas, L. O., Pacheco‐Herrero, M., Martínez-Gómez, P. A., Campa-Córdoba, B. B., Apátiga-Pérez, R., Villegas-Rojas, M. M., Harrington, C. R., de la Cruz, F., Garcés‐Ramírez, L., & Luna‐Muñoz, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22042022 · Cited by 140 · see citing works
Fibrillar Amyloid Protein Present in Atheroma Activates CD36 Signal Transduction
Medeiros, L. A., Khan, T., Khoury, J. B. E., Pham, C. L. L., Hatters, D. M., Howlett, G. J., Lopez, R., O’Brien, K. D., & Moore, K. J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m311735200 · Cited by 140 · see citing works
Self-citationInsulin-like actions of glucagon-like peptide-1: a dual receptor hypothesis
Tomás, E., & Habener, J. F. (2009) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2009.11.007 · Cited by 135 · see citing works
Woo, M., Yang, J., Beltran, C., & Cho, S. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.750018 · Cited by 136 · see citing works
The Lipoxygenases: Their Regulation and Implication in Alzheimer’s Disease
Czapski, G. A., Czubowicz, K., Strosznajder, J. B., & Strosznajder, R. P. (2015) · Neurochemical Research · doi:10.1007/s11064-015-1776-x · Cited by 133 · see citing works
Endothelial Cell Receptors in Tissue Lipid Uptake and Metabolism
Abumrad, N. A., Cabodevilla, A. G., Samovski, D., Pietka, T., Basu, D., & Goldberg, I. J. (2021) · Circulation Research · doi:10.1161/circresaha.120.318003 · Cited by 125 · see citing works
Chylomicron remnants are increased in the postprandial state in CD36 deficiency
Masuda, D., Hirano, K., Oku, H., Sandoval, J. C., Kawase, R., Yuasa‐Kawase, M., Yamashita, Y., Takada, M., Tsubakio‐Yamamoto, K., Tochino, Y., et al. (2008) · Journal of Lipid Research · doi:10.1194/jlr.p700032-jlr200 · Cited by 124 · see citing works
Phosphocholine as a pattern recognition ligand for CD36
Boullier, A., Friedman, P., Harkewicz, R., Hartvigsen, K., Green, S. R., Almazan, F., Dennis, E. A., Steinberg, D. H., Witztum, J. L., & Quehenberger, O. (2005) · Journal of Lipid Research · doi:10.1194/jlr.m400496-jlr200 · Cited by 123 · see citing works
CD36 and TLR Interactions in Inflammation and Phagocytosis: Implications for Malaria
Erdman, L. K., Cosı́o, G., Helmers, A. J., Gowda, D. C., Grinstein, S., & Kain, K. C. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901374 · Cited by 120 · see citing works
Manocha, G. D., & Combs, C. K. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-117 · Cited by 119 · see citing works
Chuang, P., Lin, Y.-J., Wu, M., Wing, L.-Y. C., Shoji, Y., & Tsai, S. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2010.090551 · Cited by 116 · see citing works
CD36 Signals to the Actin Cytoskeleton and Regulates Microglial Migration via a p130Cas Complex
Stuart, L. M., Bell, S. A., Stewart, C. R., Silver, J. M., Richard, J., Goss, J. L., Tseng, A. A., Zhang, A., Khoury, J. B. E., & Moore, K. J. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m702887200 · Cited by 115 · see citing works
Self-citationThrombospondin-1 CD47 Signalling: From Mechanisms to Medicine
Kale, A., Rogers, N. M., & Ghimire, K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22084062 · Cited by 114 · see citing works
Tau and src family tyrosine kinases
Lee, G. S. (2004) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2004.09.002 · Cited by 111 · see citing works
Microbial Phagocytic Receptors and Their Potential Involvement in Cytokine Induction in Macrophages
Fu, Y., & Harrison, R. E. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.662063 · Cited by 109 · see citing works
Baranova, I. N., Bocharov, A. V., Vishnyakova, T. G., Kurlander, R. J., Chen, Z., Fu, D., Arias, I. M., Csákó, G., Patterson, A. P., & Eggerman, T. L. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.007526 · Cited by 106 · see citing works
Du, X., Jiang, S., Zeng, X., Zhang, J., Pan, K., Zhou, J., Xie, Y., Kan, H., Song, W., Sun, Q., et al. (2018) · Toxicology Letters · doi:10.1016/j.toxlet.2018.03.022 · Cited by 105 · see citing works
Reed-Geaghan, E. G., Reed, Q. W., Cramer, P. E., & Landreth, G. E. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.2637-10.2010 · Cited by 104 · see citing works
Methionine oxidation induces amyloid fibril formation by full-length apolipoprotein A-I
Wong, Y. Q., Binger, K. J., Howlett, G. J., & Griffin, M. D. W. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0910136107 · Cited by 102 · see citing works
Möhle, L., Israël, N., Paarmann, K., Krohn, M., Pietkiewicz, S., Müller, A. J., Lavrik, I. N., Buguliskis, J. S., Schott, B. H., Schlüter, D., et al. (2016) · Acta Neuropathologica Communications · doi:10.1186/s40478-016-0293-8 · Cited by 101 · see citing works
Dual role of lipoproteins in endothelial cell dysfunction in atherosclerosis
Stancu, C. S., Toma, L., & Sima, A. V. (2012) · Cell and Tissue Research · doi:10.1007/s00441-012-1437-1 · Cited by 104 · see citing works
Tsuda, M., Tozaki‐Saitoh, H., Masuda, T., Toyomitsu, E., Tezuka, T., Yamamoto, T. S., & Inoue, K. (2007) · Glia · doi:10.1002/glia.20591 · Cited by 102 · see citing works
BACE1: More than just a β‐secretase
Taylor, H. A., Przemyłska, L., Clavane, E. M., & Meakin, P. J. (2022) · Obesity Reviews · doi:10.1111/obr.13430 · Cited by 102 · see citing works
Pennathur, S., Pasichnyk, K., Bahrami, N. M., Zeng, L., Febbraio, M., Yamaguchi, I., & Okamura, D. M. (2015) · American Journal Of Pathology · doi:10.1016/j.ajpath.2015.04.016 · Cited by 94 · see citing works
Li, Y., Gerbod-Giannone, M.-C., Seitz, H., Cui, D., Thorp, E. B., Tall, A. R., Matsushima, G. K., & Tabas, I. A. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m510579200 · Cited by 91 · see citing works
Wilkinson, K., Boyd, J. D., Glicksman, M. A., Moore, K. J., & Khoury, J. B. E. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.232116 · Cited by 90 · see citing works
Self-citationHo, G., Hashimoto, M., Adame, A., Izu, M., Alford, M., Thal, L., Hansen, L., & Masliah, E. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.06.016 · Cited by 98 · see citing works
Simone, R. D., Ajmone‐Cat, M. A., & Minghetti, L. (2004) · Molecular Neurobiology · doi:10.1385/mn:29:2:197 · Cited by 88 · see citing works
- Authors
- Moore, K. J., El Khoury, J., Medeiros, L. A., Terada, K., Geula, C., Luster, A. D., & Freeman, M. W.
- Affiliations
- Harvard University (US)
- Beth Israel Deaconess Medical Center (US)
- Corresponding author
- Freeman, Mason W.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2002-12
- Volume
- 277
- Issue
- 49
- Pages
- 47373-47379
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2106020004
- Cited by
- 327
- References
- 32
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 7 · 2023: 10 · 2022: 14 · 2021: 18 · 2020: 17 · 2019: 13 · 2018: 10 · 2017: 10 · 2016: 15 · 2015: 19 · 2014: 8 · 2013: 18 · 2012: 20
- FWCI
- 8.21
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (R01AG020255, R01AG20255-01)
- National Heart, Lung, and Blood Institute (R01 HL45098, R01HL045098)
- National Institute of Diabetes and Digestive and Kidney Diseases (P01-DK50305, P01DK050305)
- National Institute of Neurological Disorders and Stroke (NS41330-02, K08NS041330)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Keywords
- amyloid-beta, CD36, scavenger receptors, microglia, macrophages, Src kinase, Lyn kinase, Fyn, receptor signaling, neuroinflammation, reactive oxygen species, chemokine production, microglial recruitment, Alzheimer's disease, atherosclerosis, amyloid plaques
- MeSH terms
- Alleles, Animals, Brain, Crosses, Genetic, Female, Immunohistochemistry, Inflammation, Leukocytes, Mononuclear, Ligands, Macrophages, Mice, Inbred C57BL, Models, Biological, Phosphorylation, Precipitin Tests, Proto-Oncogene Proteins, Tyrosine, Blotting, Western, Signal Transduction, Amyloid beta-Peptides, Reactive Oxygen Species, Microglia, Mice, Knockout, CD36 Antigens, src-Family Kinases, Mitogen-Activated Protein Kinase 1, Mitogen-Activated Protein Kinases, Mitogen-Activated Protein Kinase 3, Proto-Oncogene Proteins c-fyn, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review