Cited by 228Autism Spectrum Disorder ResearchGenetics and Neurodevelopmental DisordersBioinformatics and Genomic Networks

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Protein Interactome Reveals Converging Molecular Pathways Among Autism Disorders

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Sakai, Yasunari, Shaw, Chad A., Dawson, Brian C., Dugas, Diana V., Al-Mohtaseb, Zaina, Hill, David E., Zoghbi, Huda Y.·2011·Science Translational Medicine

DOI 10.1126/scitranslmed.3002166PMC PMC3169432

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Abstract

We developed an autism protein interaction network that provides a framework for studying autism pathogenesis and reveals shared molecular pathways among distinct autism spectrum disorders.

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RETRACTED: Enhanced Polyubiquitination of Shank3 and NMDA Receptor in a Mouse Model of Autism
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Authors: Sakai, Y., Shaw, C. A., Dawson, B. C., Dugas, D. V., Al-Mohtaseb, Z., Hill, D. E., & Zoghbi, H. Y.
Affiliations: Howard Hughes Medical Institute (US)
Baylor College of Medicine (US)
Harvard University (US)
Corresponding author: Shaw, Chad A.
Zoghbi, Huda Y.
ORCID: Sakai, Yasunari
Shaw, Chad A.
Dugas, Diana V.
Al-Mohtaseb, Zaina
Hill, David E.
Zoghbi, Huda Y.
Venue: Science Translational Medicine
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2011-06-08
Volume: 3
Issue: 86
Pages: 86ra49-86ra49
ISSN: 1946-6234 (ISSN-L)
1946-6242
DOI: 10.1126/scitranslmed.3002166
PMC: PMC3169432
OpenAlex: W2126924893
Cited by: 226
References: 55
Citations by year: 2026: 2 · 2025: 9 · 2024: 11 · 2023: 12 · 2022: 15 · 2021: 12 · 2020: 15 · 2019: 12 · 2018: 7 · 2017: 11 · 2016: 18 · 2015: 16 · 2014: 23 · 2013: 26 · 2012: 32
FWCI: 13.96
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Science Translational Medicine (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: Howard Hughes Medical Institute
Japan Society for the Promotion of Science (23810025)
National Institute of Neurological Disorders and Stroke (R01NS057819)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioinformatics and Genomic Networks
Keywords: autism spectrum disorder, protein-protein interaction network, shank, TSC1, copy number variation, de novo deletion, Xq28 duplication, PKM2, filamin A, idiopathic autism, syndromic autism, molecular pathways
MeSH terms: Animals, Brain, Cell Line, Child Development Disorders, Pervasive, Humans, Infant, Newborn, Nerve Tissue Proteins, Two-Hybrid System Techniques, Protein Interaction Mapping, Immunoprecipitation, Mice

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Protein Interactome Reveals Converging Molecular Pathways Among Autism Disorders

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