Cited by 563Alzheimer's disease research and treatmentsSleep and Wakefulness ResearchDementia and Cognitive Impairment Research

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Disruption of the Sleep-Wake Cycle and Diurnal Fluctuation of β-Amyloid in Mice with Alzheimer’s Disease Pathology

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Roh, Jee Hoon, Huang, Yafei, Bero, Adam W., Kasten, Tom, Stewart, Floy R., Bateman, Randall J., Holtzman, David M.·2012·Science Translational Medicine

DOI 10.1126/scitranslmed.3004291PMC PMC3654377

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Decreased sleep and attenuation of circadian fluctuations in Aβ reflect amyloid-associated pathology in Alzheimer’s disease.

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Authors: Roh, J. H., Huang, Y., Bero, A. W., Kasten, T., Stewart, F. R., Bateman, R. J., & Holtzman, D. M.
Affiliations: Washington University in St. Louis (US)
Corresponding author: Holtzman, David M.
ORCID: Roh, Jee Hoon
Huang, Yafei
Bateman, Randall J.
Holtzman, David M.
Venue: Science Translational Medicine
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2012-09-05
Volume: 4
Issue: 150
Pages: 150ra122-150ra122
ISSN: 1946-6234 (ISSN-L)
1946-6242
DOI: 10.1126/scitranslmed.3004291
PMC: PMC3654377
OpenAlex: W2109053359
Cited by: 563
References: 51
Citations by year: 2026: 25 · 2025: 32 · 2024: 42 · 2023: 44 · 2022: 47 · 2021: 50 · 2020: 56 · 2019: 51 · 2018: 48 · 2017: 54 · 2016: 39 · 2015: 28 · 2014: 24 · 2013: 17 · 2012: 5
FWCI: 15.87
Type: journal article
Language: en
Open access: green
europepmc.org
Locations: Science Translational Medicine (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Aging (R01AG013956, K23AG03094604, P01AG026276-S1, P50AG005681, R37AG013956, AG13956, K23AG030946, P01AG026276)
National Institute of Neurological Disorders and Stroke (P30NS057105, R01NS065667, P01NS074969)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords: Alzheimer's disease, amyloid-beta, sleep-wake cycle, daily fluctuations, interstitial fluid, cerebrospinal fluid, APPswe/PS1ΔE9 mice, amyloid plaques, presenilin mutations, active immunization, sleep quality, aging
MeSH terms: Alzheimer Disease, Animals, Circadian Rhythm, Disease Models, Animal, Genes, Dominant, Hippocampus, Humans, Immunization, Lactates, Mice, Transgenic, Mutation, Sleep, Time Factors, Wakefulness, Amyloid beta-Peptides, Neostriatum, Extracellular Fluid, Mice, Presenilins

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Disruption of the Sleep-Wake Cycle and Diurnal Fluctuation of β-Amyloid in Mice with Alzheimer’s Disease Pathology

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