Disruption of the Sleep-Wake Cycle and Diurnal Fluctuation of β-Amyloid in Mice with Alzheimer’s Disease Pathology

The diagnosis of dementia due to Alzheimer's disease: Recommendations from the National Institute on Aging‐Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

McKhann, G. M., Knopman, D. S., Chertkow, H., Hyman, B. T., Jack, C. R., Kawas, C. H., Klunk, W. E., Koroshetz, W. J., Manly, J. J., Mayeux, R., et al. (2011) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2011.03.005 · Cited by 18,657

The Mouse Brain in Stereotaxic Coordinates

Paxinos, G. (2001) · Cited by 12,859

Toward defining the preclinical stages of Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease

Sperling, R. A., Aisen, P. S., Beckett, L. A., Bennett, D. A., Craft, S., Fagan, A. M., Iwatsubo, T., Jack, C. R., Kaye, J., Montine, T. J., et al. (2011) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2011.03.003 · Cited by 7,155

Alzheimer's Disease: Genes, Proteins, and Therapy

Selkoe, D. J. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.741 · Cited by 6,063

The memory function of sleep

Diekelmann, S., & Born, J. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2762 · Cited by 3,760

Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse

Schenk, D., Barbour, R., Dunn, W., Gordon, G., Grajeda, H., Guido, T., Hu, K., Huang, J., Johnson-Wood, K., Khan, K., et al. (1999) · Nature · doi:10.1038/22124 · Cited by 3,160

Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization.

Pellerin, L., & Magistretti, P. J. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.22.10625 · Cited by 2,927

APP Processing and Synaptic Function

Kamenetz, F., Tomita, T., Hsieh, H., Seabrook, G., Borchelt, D., Iwatsubo, T., Sisodia, S., & Malinow, R. (2003) · Neuron · doi:10.1016/s0896-6273(03)00124-7 · Cited by 1,644

Amyloid-β Dynamics Are Regulated by Orexin and the Sleep-Wake Cycle

Kang, J.-E., Lim, M. M., Bateman, R. J., Lee, J. J., Smyth, L. P., Cirrito, J. R., Fujiki, N., Nishino, S., & Holtzman, D. M. (2009) · Science · doi:10.1126/science.1180962 · Cited by 1,565

Alzheimer’s Disease: The Challenge of the Second Century

Holtzman, D. M., Morris, J. C., & Goate, A. M. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002369 · Cited by 1,424

Is the glymphatic system the missing link between sleep impairments and neurological disorders? Examining the implications and uncertainties

Christensen, J., Yamakawa, G. R., Shultz, S. R., & Mychasiuk, R. (2020) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2020.101917 · Cited by 110

Circadian Rhythm Sleep–Wake Disorders in Older Adults

Kim, J. H., Elkhadem, A. R., & Duffy, J. F. (2022) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2022.02.003 · Cited by 111

Anti-tau antibody administration increases plasma tau in transgenic mice and patients with tauopathy

Yanamandra, K., Patel, T. K., Jiang, H., Schindler, S., Ulrich, J. D., Boxer, A. L., Miller, B. L., Kerwin, D. R., Gallardo, G., Stewart, F., et al. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aal2029 · Cited by 100

Transient dynamics of Aβ contribute to toxicity in Alzheimer’s disease

Hubin, E., van Nuland, N. A. J., Broersen, K., & Pauwels, K. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1634-z · Cited by 102

Effects of acute sleep loss on diurnal plasma dynamics of CNS health biomarkers in young men

Benedict, C., Blennow, K., Zetterberg, H., & Cedernaes, J. (2020) · Neurology · doi:10.1212/wnl.0000000000008866 · Cited by 100

An Update on Dual Orexin Receptor Antagonists and Their Potential Role in Insomnia Therapeutics

Janto, K., Prichard, J. R., & Pusalavidyasagar, S. S. (2018) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.7282 · Cited by 98

Local Sleep and Alzheimer’s Disease Pathophysiology

Mander, B. A. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.525970 · Cited by 97

Chronic Sleep Deprivation Exacerbates Learning-Memory Disability and Alzheimer’s Disease-Like Pathologies in AβPPswe/PS1ΔE9 Mice

Qiu, H., Zhong, R., Liu, H., Zhang, F., Li, S., & Le, W. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-150774 · Cited by 100

Sleep, Cognition and Dementia

Porter, V. R., Buxton, W. G., & Avidan, A. Y. (2015) · Current Psychiatry Reports · doi:10.1007/s11920-015-0631-8 · Cited by 94

Impaired Glymphatic System Actions in Obstructive Sleep Apnea Adults

Roy, B., Nunez, A., Aysola, R., Kang, D. W., Vacas, S., & Kumar, R. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.884234 · Cited by 96

The impact of neurovascular, blood-brain barrier, and glymphatic dysfunction in neurodegenerative and metabolic diseases

(2020) · International Review of Neurobiology · doi:10.1016/bs.irn.2020.02.006 · Cited by 87

Circadian Rhythm Sleep-Wake Disorders in Older Adults

Kim, J. H., & Duffy, J. F. (2017) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2017.09.004 · Cited by 96

Translational profiling of hypocretin neurons identifies candidate molecules for sleep regulationPreprint

Dalal, J. S., Roh, J. H., Maloney, S. E., Akuffo, A., Shah, S., Yuan, H., Wamsley, B., Jones, W. B., Strong, C. D. G., Gray, P. A., et al. (2013) · Genes & Development · doi:10.1101/gad.207654.112 · Cited by 92

Simultaneous Fe 2+ /Fe 3+ imaging shows Fe 3+ over Fe 2+ enrichment in Alzheimer’s disease mouse brain

Wu, Y., Torabi, S.-F., Lake, R. J., Hong, S., Yu, Z., Wu, P., Yang, Z., Nelson, K., Guo, W., Pawel, G. T., et al. (2023) · Science Advances · doi:10.1126/sciadv.ade7622 · Cited by 91

Dietary Patterns, Physical Activity, Sleep, and Risk for Dementia and Cognitive Decline

Zhao, C., Noble, J. M., Marder, K. S., Hartman, J. S., Gu, Y., & Scarmeas, N. (2018) · Current Nutrition Reports · doi:10.1007/s13668-018-0247-9 · Cited by 92

Altered glymphatic enhancement of cerebrospinal fluid tracer in individuals with chronic poor sleep quality

Eide, P. K., Pripp, A. H., Berge, B., Hrubos‐Strøm, H., Ringstad, G. A., & Valnes, L. M. (2022) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x221090747 · Cited by 94

Can sleep apnea cause Alzheimer's disease?

Pan, W., & Kastin, A. J. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.10.019 · Cited by 91

Golgi defects enhance APP amyloidogenic processing in Alzheimer's disease

Joshi, G. S., & Wang, Y. (2014) · BioEssays · doi:10.1002/bies.201400116 · Cited by 93

Impact of sleep disturbances on neurodegeneration: Insight from studies in animal models

Owen, J. E., & Veasey, S. C. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.104820 · Cited by 91

Acute Sleep Deprivation Increases Serum Levels of Neuron-Specific Enolase (NSE) and S100 Calcium Binding Protein B (S-100B) in Healthy Young Men

Benedict, C., Cedernaes, J., Giedraitis, V., Nilsson, E. K., Hogenkamp, P. S., Vågesjö, E., Massena, S., Pettersson, U., Christoffersson, G., Phillipson, M., et al. (2014) · Sleep · doi:10.5665/sleep.3336 · Cited by 86

Sleep and EEG Power Spectral Analysis in Three Transgenic Mouse Models of Alzheimer’s Disease: APP/PS1, 3xTgAD, and Tg2576

Kent, B. A., Strittmatter, S. M., & Nygaard, H. B. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-180260 · Cited by 95

Slow-wave sleep affects synucleinopathy and regulates proteostatic processes in mouse models of Parkinson’s disease

Morawska, M. M., Moreira, C. G., Ginde, V. R., Valko, P. O., Weiß, T., Büchele, F., Imbach, L., Masneuf, S., Kollarik, S., Prymaczok, N. C., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abe7099 · Cited by 85

Disruption of normal circadian clock function in a mouse model of tauopathy

Stevanovic, K. D., Yunus, A., Joly‐Amado, A., Gordon, M. N., Morgan, D., Gulick, D., & Gamsby, J. J. (2017) · Experimental Neurology · doi:10.1016/j.expneurol.2017.04.015 · Cited by 91

Alteration in sleep architecture and electroencephalogram as an early sign of Alzheimer's disease preceding the disease pathology and cognitive decline

Zhang, F., Zhong, R., Li, S., Fu, Z., Wang, R., Wang, T., Huang, Z., & Le, W. (2019) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2018.12.004 · Cited by 85

Consequences of Metabolic Disruption in Alzheimer's Disease Pathology

Ryu, J. C., Zimmer, E. R., Rosa‐Neto, P., & Yoon, S. O. (2019) · Neurotherapeutics · doi:10.1007/s13311-019-00755-y · Cited by 87

Excessive daytime sleepiness and fatigue in neurological disorders

Maestri, M., Romigi, A., Schirru, A., Fabbrini, M., Gori, S., Bonuccelli, U., & Bonanni, E. (2019) · Sleep And Breathing · doi:10.1007/s11325-019-01921-4 · Cited by 83

Orexin signaling regulates both the hippocampal clock and the circadian oscillation of Alzheimer’s disease-risk genes

Ma, Z., Jiang, W., & Zhang, E. E. (2016) · Scientific Reports · doi:10.1038/srep36035 · Cited by 79

Alzheimer’s disease: Neurotransmitters of the sleep-wake cycle

Erum, J. V., Dam, D. V., & Deyn, P. P. D. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.07.019 · Cited by 87

Excessive daytime sleepiness and napping in cognitively normal adults: associations with subsequent amyloid deposition measured by PiB PET

Spira, A. P., An, Y., Wu, M. N., Owusu, J. T., Simonsick, E. M., Bilgel, M., Ferrucci, L., Wong, D. F., & Resnick, S. M. (2018) · SLEEP · doi:10.1093/sleep/zsy152 · Cited by 87

Circadian regulation of membrane physiology in neural oscillators throughout the brain

Paul, J. R., Davis, J. A., Goode, L. K., Becker, B., Fusilier, A. R., Meador-Woodruff, A., & Gamble, K. L. (2019) · European Journal of Neuroscience · doi:10.1111/ejn.14343 · Cited by 81

Adaptive Immunity: New Aspects of Pathogenesis Underlying Neurodegeneration in Glaucoma and Optic Neuropathy

Jiang, S., Kametani, M., & Chen, D. F. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00065 · Cited by 77

Evidence of association between sleep quality and APOE ε4 in healthy older adults

Drogos, L. L., Gill, S. J., Tyndall, A. V., Raneri, J. K., Parboosingh, J. S., Naef, A. C., Guild, K. D., Eskes, G. A., Hanly, P. J., & Poulin, M. J. (2016) · Neurology · doi:10.1212/wnl.0000000000003255 · Cited by 79

Sleep and Neurodegeneration

Pillai, J. A., & Leverenz, J. B. (2017) · CHEST Journal · doi:10.1016/j.chest.2017.01.002 · Cited by 85

Early Failure of the Default‐Mode Network and the Pathogenesis of Alzheimer's Disease

Šimić, G., Leko, M. B., Borovečki, F., & Hof, P. R. (2014) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12260 · Cited by 75

Consequences of Circadian Disruption on Neurologic Health

Videnović, A., & Zee, P. C. (2015) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2015.08.004 · Cited by 75

Lost in translation: Inconvenient truths on the utility of mouse models in Alzheimer’s disease research

Granzotto, A., Vissel, B., & Sensi, S. L. (2024) · eLife · doi:10.7554/elife.90633 · Cited by 71

Sleep as a Therapeutic Target in the Aging Brain

Bah, T. M., Goodman, J. R., & Iliff, J. J. (2019) · Neurotherapeutics · doi:10.1007/s13311-019-00769-6 · Cited by 76

Actigraphic Sleep Duration and Fragmentation in Older Women: Associations With Performance Across Cognitive Domains

Spira, A. P., Stone, K. L., Redline, S. S., Ensrud, K. E., Ancoli‐Israel, S., Cauley, J. A., & Yaffe, K. S. (2017) · SLEEP · doi:10.1093/sleep/zsx073 · Cited by 74

Melatonin: A potential nighttime guardian against Alzheimer’s

Zhang, Z., Xue, P., Bendlin, B. B., Zetterberg, H., Felice, F. G. D., Tan, X. W., & Benedict, C. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02691-6 · Cited by 76

Orexin and Alzheimer’s Disease

Liguori, C. (2016) · Current topics in behavioral neurosciences · doi:10.1007/7854_2016_50 · Cited by 74

Cerebrospinal Fluid Amyloid-β Levels are Increased in Patients with Insomnia

Chen, D., Wang, J., Zhang, L., Wang, Y., & Gao, C. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-170032 · Cited by 75

CNS-Draining Meningeal Lymphatic Vasculature: Roles, Conundrums and Future Challenges

das Neves, S. P., Delivanoglou, N., & Mesquita, S. D. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.655052 · Cited by 71

Glymphatic Dysfunction: A Bridge Between Sleep Disturbance and Mood Disorders

Yan, T., Qiu, Y., Yu, X., & Yang, L. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.658340 · Cited by 76

Subcortical Neuronal Correlates of Sleep in Neurodegenerative Diseases

Oh, J. Y., Walsh, C. M., Ranasinghe, K. G., Mladinov, M., Pereira, F. L., Petersen, C., Falgàs, N., Yack, L. M., LaMore, T., Nasar, R. T., et al. (2022) · JAMA Neurology · doi:10.1001/jamaneurol.2022.0429 · Cited by 72

Associations Between β-Amyloid Kinetics and the β-Amyloid Diurnal Pattern in the Central Nervous System

Lucey, B. P., Mawuenyega, K. G., Patterson, B. W., Elbert, D. L., Ovod, V., Kasten, T. P., Morris, J. C., & Bateman, R. J. (2016) · JAMA Neurology · doi:10.1001/jamaneurol.2016.4202 · Cited by 73

Sleep and its regulation: An emerging pathogenic and treatment frontier in Alzheimer’s disease

Kent, B. A., Feldman, H., & Nygaard, H. B. (2020) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2020.101902 · Cited by 72

Disturbances of sleep quality, timing and structure and their relationship with other neuropsychiatric symptoms in Alzheimer’s disease and schizophrenia: Insights from studies in patient populations and animal models

Winsky‐Sommerer, R., de Oliveira, P., Loomis, S., Wafford, K. A., Dijk, D., & Gilmour, G. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.09.027 · Cited by 69

Sleep deficits in mild cognitive impairment are related to increased levels of plasma amyloid-β and cortical thinning

Sanchez-Espinosa, M. P., Atienza, M., & Cantero, J. L. (2014) · NeuroImage · doi:10.1016/j.neuroimage.2014.05.027 · Cited by 70

Subjective sleep quality and daytime sleepiness in late midlife and their association with age-related changes in cognition

Waller, K. L., Mortensen, E. L., Avlund, K., Osler, M., Fagerlund, B., Lauritzen, M., & Jennum, P. (2015) · Sleep Medicine · doi:10.1016/j.sleep.2015.01.004 · Cited by 71

APOE-ε4 synergizes with sleep disruption to accelerate Aβ deposition and Aβ-associated tau seeding and spreading

Wang, C., Nambiar, A., Strickland, M. R., Lee, C., Parhizkar, S., Moore, A., Musiek, E. S., Ulrich, J. D., & Holtzman, D. M. (2023) · Journal of Clinical Investigation · doi:10.1172/jci169131 · Cited by 70

Alzheimer's Disease and Sleep–Wake Disturbances: Amyloid, Astrocytes, and Animal Models

Vanderheyden, W. M., Lim, M. M., Musiek, E. S., & Gerstner, J. R. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.1135-17.2017 · Cited by 64

Connections Between Insomnia and Cognitive Aging

Sexton, C. E., Sykara, K., Karageorgiou, E., Zitser, J., Rosa, T. D., Yaffe, K. S., & Leng, Y. (2019) · Neuroscience Bulletin · doi:10.1007/s12264-019-00401-9 · Cited by 67

Sleep and hippocampal neurogenesis: Implications for Alzheimer’s disease

Kent, B. A., & Mistlberger, R. E. (2017) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2017.02.004 · Cited by 64

Brain Stimulation for Improving Sleep and Memory

Malkani, R. G., & Zee, P. C. (2020) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2019.11.002 · Cited by 68

The Bidirectional Relationship Between Sleep and Inflammation Links Traumatic Brain Injury and Alzheimer’s Disease

Green, T. R. F., Ortiz, J. B., Wonnacott, S., Williams, R. J., & Rowe, R. K. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00894 · Cited by 68

Proteostasis failure exacerbates neuronal circuit dysfunction and sleep impairments in Alzheimer’s disease

Morrone, C. D., Raghuraman, R., Hussaini, S. A., & Yu, W. H. (2023) · Molecular Neurodegeneration · doi:10.1186/s13024-023-00617-4 · Cited by 68

Long-term dasatinib plus quercetin effects on aging outcomes and inflammation in nonhuman primates: implications for senolytic clinical trial design

Ruggiero, A. D., Vemuri, R., Blawas, M., Long, M., DeStephanis, D., Williams, A. G., Chen, H., Justice, J. N., Macauley, S. L., Day, S. M., et al. (2023) · GeroScience · doi:10.1007/s11357-023-00830-5 · Cited by 69

Sleep–wake regulation and the hallmarks of the pathogenesis of Alzheimer’s disease

Egroo, M. V., Narbutas, J., Chylinski, D., González, P. V., Maquet, P., Salmon, É., Bastin, C., Collette, F., & Vandewalle, G. (2019) · SLEEP · doi:10.1093/sleep/zsz017 · Cited by 66

Suvorexant ameliorates cognitive impairments and pathology in APP/PS1 transgenic mice

Zhou, F., Yan, X., Wang, C., He, Y., Li, Y., Zhang, J., Wang, Z.-J., Cai, H.-Y., Qi, J., & Wu, M. (2020) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2020.02.020 · Cited by 61

The role of slow wave sleep in the development of dementia and its potential for preventative interventions

Wunderlin, M., Züst, M. A., Fehér, K. D., Klöppel, S., & Nissen, C. (2020) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2020.111178 · Cited by 63

The Role of Nrf2 and PPARγ in the Improvement of Oxidative Stress in Hypertension and Cardiovascular Diseases

Dovinová, I., Kvandová, M., Bališ, P., Gresová, L., Majzúnová, M., Horáková, Ľ., CHAN, J., & Barančı́k, M. (2020) · Physiological Research · doi:10.33549/physiolres.934612 · Cited by 60

Role of Sleep Disturbance in the Trajectory of Alzheimer’s Disease

Kang, D. W., Lee, C. U., & Lim, H. K. (2017) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.2017.15.2.89 · Cited by 61

Sleep and circadian rhythm disruption and stress intersect in Alzheimer's disease

Phan, T., & Malkani, R. G. (2018) · Neurobiology of Stress · doi:10.1016/j.ynstr.2018.10.001 · Cited by 66

Sleep, 24-Hour Activity Rhythms, and Subsequent Amyloid-β Pathology

Ho, P. T. N., Hoepel, S. J. W., Rodríguez‐Ayllón, M., Luik, A. I., Vernooij, M. W., & Neitzel, J. (2024) · JAMA Neurology · doi:10.1001/jamaneurol.2024.1755 · Cited by 65

Sleep-Wake Cycle Dysfunction in the TgCRND8 Mouse Model of Alzheimer’s Disease: From Early to Advanced Pathological Stages

Colby-Milley, J., Cavanagh, C., Jego, S., Breitner, J. C. S., Quirion, R., & Adamantidis, A. (2015) · PLoS ONE · doi:10.1371/journal.pone.0130177 · Cited by 61

Chronic sleep fragmentation exacerbates amyloid β deposition in Alzheimer’s disease model mice

Minakawa, E. N., Miyazaki, K., Maruo, K., Yagihara, H., Fujita, H., Wada, K., & Nagai, Y. (2017) · Neuroscience Letters · doi:10.1016/j.neulet.2017.05.054 · Cited by 62

Slow-Wave Sleep and MRI Markers of Brain Aging in a Community-Based Sample

Baril, A., Beiser, A., Mysliwiec, V., Sanchez, E., DeCarli, C. S., Redline, S. S., Gottlieb, D. J., Maillard, P., Romero, J. R., Satizábal, C. L., et al. (2020) · Neurology · doi:10.1212/wnl.0000000000011377 · Cited by 59

Neural Consequences of Chronic Short Sleep: Reversible or Lasting?

Zhao, Z., Zhao, X., & Veasey, S. C. (2017) · Frontiers in Neurology · doi:10.3389/fneur.2017.00235 · Cited by 59

Disorders of Body Weight, Sleep and Circadian Rhythm as Manifestations of Hypothalamic Dysfunction in Alzheimer’s Disease

Hiller, A. J., & Ishii, M. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00471 · Cited by 59

Regulation of Melatonin and Neurotransmission in Alzheimer’s Disease

Roy, J., Tsui, K. C., Ng, J., Fung, M., & Lim, L. W. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22136841 · Cited by 55

Sleep changes without medial temporal lobe or brain cortical changes in community‐dwelling individuals with subjective cognitive decline

Lauriola, M., Esposito, R., Pizzi, S. D., de Zambotti, M., Londrillo, F., Kramer, J. H., Rabinovici, G. D., & Tartaro, A. (2016) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2016.11.006 · Cited by 58

Disturbed sleep and diabetes: A potential nexus of dementia risk

Holingue, C., Wennberg, A. M. V., Berger, S., Polotsky, V. Y., & Spira, A. P. (2018) · Metabolism · doi:10.1016/j.metabol.2018.01.021 · Cited by 58

Sleep spindle abnormalities related to Alzheimer's disease: a systematic mini-review

Weng, Y.-Y., Lei, X., & Yu, J. (2020) · Sleep Medicine · doi:10.1016/j.sleep.2020.07.044 · Cited by 62

Aging, circadian disruption and neurodegeneration: Interesting interplay

Verma, A. K., Singh, S., & Rizvi, S. I. (2023) · Experimental Gerontology · doi:10.1016/j.exger.2022.112076 · Cited by 55

Napping characteristics and cognitive performance in older adults

Owusu, J. T., Wennberg, A. M. V., Holingue, C., Tzuang, M., Abeson, K., & Spira, A. P. (2018) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.4991 · Cited by 56

Genetic Risk of Alzheimer's Disease and Sleep Duration in Non‐Demented Elders

Leng, Y., Ackley, S. F., Glymour, M. M., Yaffe, K. S., & Brenowitz, W. D. (2020) · Annals of Neurology · doi:10.1002/ana.25910 · Cited by 56

Diurnal Patterns of Soluble Amyloid Precursor Protein Metabolites in the Human Central Nervous System

Zakaria, J. A. D., Kasten, T. P., Huang, Y., Benzinger, T. L. S., Sigurdson, W. C., Ovod, V., Morris, J. C., & Bateman, R. J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0089998 · Cited by 57

Interacting influences of aging and Alzheimer's disease on circadian rhythms

Duncan, M. J. (2019) · European Journal of Neuroscience · doi:10.1111/ejn.14358 · Cited by 55

Hypocretin and brain β-amyloid peptide interactions in cognitive disorders and narcolepsy

Dauvilliers, Y. A., Lehmann, S., Jaussent, I., & Gabelle, A. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00119 · Cited by 56

The Blood-Brain Barrier

Pan, W., & Kastin, A. J. (2016) · The Neuroscientist · doi:10.1177/1073858416639005 · Cited by 58

Chronic Sleep Restriction Induces Cognitive Deficits and Cortical Beta‐Amyloid Deposition in Mice via BACE 1‐Antisense Activation

Zhao, H., Wu, H., He, J., Zhuang, J., Liu, Z., Huang, L., & Zhao, Z. (2017) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12667 · Cited by 54

The Independent Associations of Physical Activity and Sleep with Cognitive Function in Older Adults

Falck, R. S., Best, J. R., Davis, J. C., & Liu-Ambrose, T. Y. L. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-170936 · Cited by 57

Tau and β-Amyloid Burden Predict Actigraphy-Measured and Self-Reported Impairment and Misperception of Human Sleep

Winer, J. R., Morehouse, A. B., Fenton, L. E., Harrison, T. M., Ayangma, L., Reed, M. E., Kumar, S., Baker, S. L., Jagust, W. J., & Walker, M. P. (2021) · Journal of Neuroscience · doi:10.1523/jneurosci.0353-21.2021 · Cited by 59

Neuroinflammation and Tau Interact with Amyloid in Predicting Sleep Problems in Aging Independently of Atrophy

Fjell, A. M., Idland, A., Sala‐Llonch, R., Watne, L. O., Borza, T., Brækhus, A., Lona, T., Zetterberg, H., Blennow, K., Wyller, T. B., et al. (2017) · Cerebral Cortex · doi:10.1093/cercor/bhx157 · Cited by 57

Thermodynamics in Neurodegenerative Diseases: Interplay Between Canonical WNT/Beta-Catenin Pathway–PPAR Gamma, Energy Metabolism and Circadian Rhythms

Vallée, A., Lecarpentier, Y., Guillevin, R., & Vallée, J.-N. (2018) · NeuroMolecular Medicine · doi:10.1007/s12017-018-8486-x · Cited by 54

Circadian and Brain State Modulation of Network Hyperexcitability in Alzheimer’s Disease

Brown, R., Lam, A. D., Gonzalez‐Sulser, A., Ying, A., Jones, M., Chou, R. C.-C., Tzioras, M., Jordan, C. Y., Jedrasiak-Cape, I., Hemonnot-Girard, A.-L., et al. (2018) · eNeuro · doi:10.1523/eneuro.0426-17.2018 · Cited by 51

Sleep deprivation accelerates the progression of alzheimer’s disease by influencing Aβ-related metabolism

Chen, L., Huang, J., Yang, L., Zeng, X., Zhang, Y. P., Wang, X., Chen, M., Li, X., Zhang, Y., & Zhang, M. (2017) · Neuroscience Letters · doi:10.1016/j.neulet.2017.04.047 · Cited by 51

Short-term exposure to dim light at night disrupts rhythmic behaviors and causes neurodegeneration in fly models of tauopathy and Alzheimer's disease

Kim, M., Subramanian, M., Cho, Y.-H., Kim, G.-H., Lee, E., & Park, J. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.12.021 · Cited by 51

Association of β-Amyloid Burden With Sleep Dysfunction and Cognitive Impairment in Elderly Individuals With Cognitive Disorders

You, J. C., Jones, E., Cross, D. E., Lyon, A. C., Kang, H., Newberg, A. B., & Lippa, C. F. (2019) · JAMA Network Open · doi:10.1001/jamanetworkopen.2019.13383 · Cited by 54

Impaired Hippocampal-Cortical Interactions during Sleep in a Mouse Model of Alzheimer’s Disease

Cushing, S. D., Skelin, I., Moseley, S. C., Stimmell, A. C., Dixon, J. R., Melilli, A. S., Molina, L. A., McNaughton, B. L., & Wilber, A. A. (2020) · Current Biology · doi:10.1016/j.cub.2020.04.087 · Cited by 51

Is sleep disruption a risk factor for Alzheimer's disease?

Macedo, A. C., Balouch, S., & Tabet, N. (2017) · Journal of Alzheimer’s Disease · doi:10.3233/jad-161287 · Cited by 49

Sleep deficiency promotes Alzheimer's disease development and progression

Lv, Y.-N., Cui, Y., Zhang, B., & Huang, S.-M. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.1053942 · Cited by 54

Brain Inflammation Connects Cognitive and Non-Cognitive Symptoms in Alzheimer’s Disease

Sellés, M. C., Oliveira, M. M., & Ferreira, S. T. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-179925 · Cited by 51

Revisiting Preclinical Observations of Several Histamine H3 Receptor Antagonists/Inverse Agonists in Cognitive Impairment, Anxiety, Depression, and Sleep–Wake Cycle Disorder

Alhusaini, M., Eissa, N., Saad, A. K., Beiram, R., & Sadek, B. S. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.861094 · Cited by 51

How amyloid, sleep and memory connect

Lucey, B. P., & Holtzman, D. M. (2015) · Nature Neuroscience · doi:10.1038/nn.4048 · Cited by 49

Sleep disturbances are key symptoms of very early stage Alzheimer disease with behavioral and psychological symptoms: a Japan multi‐center cross‐sectional study (J‐BIRD)

Kabeshita, Y., Adachi, H., Matsushita, M., Kanemoto, H., Sato, S., Suzuki, Y., Yoshiyama, K., Shimomura, T., Yoshida, T., Shimizu, H., et al. (2016) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.4470 · Cited by 49

The effects of phytochemicals on circadian rhythm and related diseases

Xu, T., & Lu, B. (2018) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2018.1493678 · Cited by 53

Frequency-dependent exacerbation of Alzheimer’s disease neuropathophysiology

Kastanenka, K. V., Calvo-Rodríguez, M., Hou, S. S., Zhou, H., Takeda, S., Arbel‐Ornath, M., Lariviere, A., Lee, Y. F., Kim, A., Hawkes, J. M., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-44964-z · Cited by 49

Dysfunction of circadian and sleep rhythms in the early stages of Alzheimer's disease

Rigat, L., Ouk, K., Kramer, A., & Priller, J. (2023) · Acta Physiologica · doi:10.1111/apha.13970 · Cited by 50

The role of synaptic activity in the regulation of amyloid beta levels in Alzheimer's disease

Cheng, X., Wu, J., Geng, M., & Xiong, J. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.11.021 · Cited by 51

O2‐05‐02: Potential role of the sleep‐wake cycle in the pathogenesis of Alzheimer's disease

Roh, J. H., Stewart, F. R., & Holtzman, D. M. (2012) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2012.05.649

P4‐081: Diurnal fluctuation of amyloid‐β in the brain interstitial fluid of young Tg2576 mice

Kang, J.-E., Cirrito, J. R., Lee, J. D., Fujiki, N., Nishino, S., & Holtzman, D. M. (2008) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2008.05.2146

Amyloid-β Dynamics Are Regulated by Orexin and the Sleep-Wake Cycle

Kang, J.-E., Lim, M. M., Bateman, R. J., Lee, J. J., Smyth, L. P., Cirrito, J. R., Fujiki, N., Nishino, S., & Holtzman, D. M. (2009) · Science · doi:10.1126/science.1180962 · Cited by 1,565

Amyloid-β diurnal pattern: possible role of sleep in Alzheimer's disease pathogenesis

Lucey, B. P., & Bateman, R. J. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.03.035 · Cited by 156

The sleep–wake Cycle and Alzheimer’s Disease: What do We know?

Lim, M. M., Gerstner, J. R., & Holtzman, D. M. (2014) · Neurodegenerative Disease Management · doi:10.2217/nmt.14.33 · Cited by 168