Cited by 465Gut microbiota and healthProbiotics and Fermented FoodsOral microbiology and periodontitis research

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Cancer and the gut microbiota: An unexpected link

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Zitvogel, Laurence, Galluzzi, Lorenzo, Viaud, Sophie, Vétizou, Marie, Daillère, Romain, Merad, Miriam, Kroemer, Guido·2015·Science Translational Medicine

DOI 10.1126/scitranslmed.3010473PMC PMC4690201

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Abstract

Gut microbiota and its interactions with the host immune system play a role in oncogenesis and can alter the effectiveness of anticancer agents.

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Role of the gut microbiota in immunity and inflammatory disease
Kamada, N., Seo, S.-U., Chen, G. Y., & Núñez, G. (2013) · Nature reviews. Immunology · doi:10.1038/nri3430 · Cited by 2,256
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Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome
Yoshimoto, S., Loo, T. M., Atarashi, K., Kanda, H., Sato, S., Oyadomari, S., Iwakura, Y., Oshima, K., Morita, H., Hattori, M., et al. (2013) · Nature · doi:10.1038/nature12347 · Cited by 2,219
The Intestinal Microbiota Modulates the Anticancer Immune Effects of Cyclophosphamide
Viaud, S., Saccheri, F., Mignot, G., Yamazaki, T., Daillère, R., Hannani, D., Enot, D. P., Pfirschke, C., Engblom, C., Pittet, M. J., et al. (2013) · Science · doi:10.1126/science.1240537 · Cited by 2,050
Self-citation
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Schwabe, R. F., & Jobin, C. (2013) · Nature Reviews Cancer · doi:10.1038/nrc3610 · Cited by 1,689
Reciprocal interactions of the intestinal microbiota and immune system
Maynard, C. L., Elson, C. O., Hatton, R. D., & Weaver, C. T. (2012) · Nature · doi:10.1038/nature11551 · Cited by 1,598 · cited 2×
“A detailed description of the intestinal immune system is beyond the scope of this article and can be found in (2).”
Background
Promotion of Hepatocellular Carcinoma by the Intestinal Microbiota and TLR4
Dapito, D. H., Mencin, A., Gwak, G.-Y., Pradere, J.-P., Jang, M.-K., Mederacke, I., Caviglia, J. M., Khiabanian, H., Adeyemi, A., Bataller, R., et al. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.02.007 · Cited by 1,346
Alleviating Cancer Drug Toxicity by Inhibiting a Bacterial Enzyme
Wallace, B. D., Wang, H., Lane, K. T., Scott, J. E., Orans, J., Koo, J. S., Venkatesh, M., Jobin, C., Yeh, L.-A., Mani, S., et al. (2010) · Science · doi:10.1126/science.1191175 · Cited by 1,080

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“Among all tumors, GC is arguably the most intensely affected by gut bacteria owing to their spatial proximity, and their associations with the gut microbiome have been intensively investigated [93,94].”
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Authors: Zitvogel, L., Galluzzi, L., Viaud, S., Vétizou, M., Daillère, R., Merad, M., & Kroemer, G.
Affiliations: Inserm (FR)
Department of Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Corresponding author: Zitvogel, Laurence
Galluzzi, Lorenzo
ORCID: Zitvogel, Laurence
Galluzzi, Lorenzo
Vétizou, Marie
Daillère, Romain
Kroemer, Guido
Venue: Science Translational Medicine
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2015-01-21
Volume: 7
Issue: 271
Pages: 271ps1-271ps1
ISSN: 1946-6234 (ISSN-L)
1946-6242
DOI: 10.1126/scitranslmed.3010473
PMC: PMC4690201
OpenAlex: W2164536401
Cited by: 465
References: 32
Citations by year: 2026: 21 · 2025: 31 · 2024: 35 · 2023: 37 · 2022: 42 · 2021: 62 · 2020: 64 · 2019: 48 · 2018: 46 · 2017: 36 · 2016: 28 · 2015: 15
FWCI: 4.04
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.sciencemag.org/about/science-licenses-journal-article-reuse (vor, 365 d)
Locations: Science Translational Medicine (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: Association pour la Recherche sur le Cancer (ARC)
European Commission (ArtForce)
European Research Council (ERC)
Agence Nationale de la Recherche (ANR)
AXA Chair for Longevity Research
Fondation pour la Recherche Medicale (FRM)
Ligue contre le Cancer
Fondation de France
Institut National du Cancer (INCa)
Canceropole Ile-de-France
Fondation Bettencourt-Schueller
LabEx Immuno-Oncology
Site de Recherche Integree sur le Cancer (SIRIC)
Stratified Oncology Cell DNA Repair and Tumor Immune Elimination (SOCRATE)
SIRIC Cancer Research and Personalized Medicine (CARPEM)
Paris Alliance of Cancer Research Institutes (PACRI)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
Keywords: gut microbiota, cancer, carcinogenesis, tumor progression, host-microbe interactions, intestinal epithelium, host immune system, environmental factors, cancer therapy, microbiome manipulation
MeSH terms: Antineoplastic Agents, Humans, Neoplasms, Gastrointestinal Tract, Carcinogenesis, Microbiota, Dysbiosis

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Cancer and the gut microbiota: An unexpected link

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