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NAD + repletion improves muscle function in muscular dystrophy and counters global PARylation
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NAD + treatment can reverse the functional decline in degenerating muscles.
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“Treatment with NR also improved muscle stem cell functions by regulating mitochondrial metabolism in a mouse model of muscular dystrophy197,198.”
From NAD+ metabolism and its roles in cellular processes during ageing (2021) · cites this paper as [197]
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Metadata
- Authors
- Ryu, D., Zhang, H., Ropelle, E. R., Sorrentino, V., Mázala, D. A. G., Mouchiroud, L., Marshall, P. L., Campbell, M. D., Ali, A. S., Knowels, G. M., Bellemin, S., Iyer, S. R., Wang, X., Gariani, K., Sauve, A. A., Cantó, C., Conley, K. E., Walter, L., Lovering, R. M., Chin, E. R., Jasmin, B. J., Marcinek, D. J., Menzies, K. J., & Auwerx, J.
- Affiliations
- École Polytechnique Fédérale de Lausanne (CH)
- Universidade Estadual de Campinas (UNICAMP) (BR)
- University of Maryland, College Park (US)
- University of Ottawa (CA)
- University of Washington (US)
- Lyon 1 Université (FR)
- University of Maryland, Baltimore (US)
- Weill Cornell Medicine (US)
- Nestlé Institute of Health Sciences, 1015 Lausanne, Switzerland.
- Corresponding author
- Ryu, Dongryeol
- Zhang, Hongbo
- Ropelle, Eduardo R.
- Menzies, Keir J.
- Auwerx, Johan
- ORCID
- Ryu, Dongryeol
- Zhang, Hongbo
- Ropelle, Eduardo R.
- Sorrentino, Vincenzo
- Mázala, Davi A. G.
- Mouchiroud, Laurent
- Campbell, Matthew D.
- Wang, Xu
- Gariani, Karim
- Sauve, Anthony A.
- Cantó, Carles
- Conley, Kevin E.
- Walter, Ludivine
- Lovering, Richard M.
- Chin, Eva R.
- Jasmin, Bernard J.
- Marcinek, David J.
- Menzies, Keir J.
- Auwerx, Johan
- Venue
- Science Translational Medicine
- Published
- 2016-10-19
- Volume
- 8
- Issue
- 361
- Pages
- 361ra139-361ra139
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC5535761
- OpenAlex
- W2537034621
- Cited by
- 256
- References
- 61
- Citations by year
- 2026: 8 · 2025: 16 · 2024: 19 · 2023: 32 · 2022: 28 · 2021: 48 · 2020: 26 · 2019: 29 · 2018: 31 · 2017: 15 · 2016: 3
- FWCI
- 15.11
- Type
- journal article
- Language
- en
- Open access
- green
- pure.amsterdamumc.nl
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion, other-oa)
- Archive ouverte UNIGE (University of Geneva) (publishedVersion, other-oa)
- PubMed Central (acceptedVersion)
- National University of Singapore (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
- Funders
- Heart and Stroke Foundation of Canada
- NIH (R01AG043930)
- Krebsforschung Schweiz/Swiss Cancer League (KFS-3082-02-2013)
- Systems X (SySX.ch 2013/153)
- Swiss National Science Foundation (310030B-160318)
- Horizon 2020 (665667)
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Molecular Research
- Keywords
- muscular dystrophy, muscle function, poly(ADP-ribosyl)ation, poly(ADP-ribose), poly(ADP-ribose) polymerase, NAD+ metabolism, neuromuscular degeneration, nicotinamide N-methyltransferase
- MeSH terms
- Poly ADP Ribosylation, Adenosine Diphosphate, Animals, Cell Line, Fibrosis, Inflammation, Male, Mice, Inbred C57BL, Mice, Transgenic, Muscular Diseases, Muscular Dystrophies, NAD, Nitrosamines, RNA, Messenger, Tyramine, Cytokines, Caenorhabditis elegans, Muscle, Skeletal, Gene Expression Profiling, Mice, Nicotinamide Phosphoribosyltransferase
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