The DOI matches its Crossref record; 61 of the 61 references it cites were found in a registry or an index.
NAD + repletion improves muscle function in muscular dystrophy and counters global PARylation
Open accessAbstract
NAD + treatment can reverse the functional decline in degenerating muscles.
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“Treatment with NR also improved muscle stem cell functions by regulating mitochondrial metabolism in a mouse model of muscular dystrophy197,198.”
From NAD+ metabolism and its roles in cellular processes during ageing (2021) · cites this paper as [197]
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Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., Paulovich, A., Pomeroy, S. L., Golub, T. R., Lander, E. S., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506580102 · Cited by 53,625
Lagouge, M., Argmann, C., Gerhart-Hines, Z., Meziane, H., Lerin, C., Daussin, F., Messadeq, N., Milne, J., Lambert, P., Elliott, P., et al. (2006) · Cell · doi:10.1016/j.cell.2006.11.013 · Cited by 4,057
Self-citationGuidelines for the use and interpretation of assays for monitoring autophagy
Klionsky, D. J., Abdalla, F. C., Abeliovich, H., Abraham, R. T., Acevedo-Arozena, A., Adeli, K., Agholme, L., Agnello, M., Agostinis, P., Aguirre-Ghiso, J. A., et al. (2012) · Autophagy · doi:10.4161/auto.19496 · Cited by 3,996
Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase
Brunet, A., Sweeney, L. B., Sturgill, J. F., Chua, K. F., Greer, P. L., Lin, Y., Tran, H., Ross, S. E., Mostoslavsky, R., Cohen, H. Y., et al. (2004) · Science · doi:10.1126/science.1094637 · Cited by 3,239
Modulation of NF‐κB‐dependent transcription and cell survival by the SIRT1 deacetylase
Yeung, F., Hoberg, J. E., Ramsey, C. S., Keller, M. D., Jones, D. R., Frye, R. A., & Mayo, M. W. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600244 · Cited by 2,750
Muscle injury activates resident fibro/adipogenic progenitors that facilitate myogenesis
Joe, A. W. B., Yi, L., Natarajan, A., Le Grand, F., So, L., Wang, J., Rudnicki, M. A., & Rossi, F. M. V. (2010) · Nature Cell Biology · doi:10.1038/ncb2015 · Cited by 1,690
Cantó, C., Menzies, K. J., & Auwerx, J. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.05.023 · Cited by 1,648
Self-citationGomes, A. P., Price, N. L., Ling, A. J. Y., Moslehi, J. J., Montgomery, M. K., Rajman, L., White, J. P., Teodoro, J. S., Wrann, C. D., Hubbard, B. P., et al. (2013) · Cell · doi:10.1016/j.cell.2013.11.037 · Cited by 1,482
Yoshino, J., Mills, K. F., Yoon, M. J., & Imai, S.-I. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.08.014 · Cited by 1,340
Cellular and molecular mechanisms of muscle atrophy
Bonaldo, P., & Sandri, M. (2013) · Disease Models & Mechanisms · doi:10.1242/dmm.010389 · Cited by 1,284
Cited by
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NAD+ metabolism and its roles in cellular processes during ageing
Covarrubias, A. J., Perrone, R., Grozio, A., & Verdin, E. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-00313-x · Cited by 1,617
Kynurenines: Tryptophan’s metabolites in exercise, inflammation, and mental health
Cervenka, I., Agudelo, L. Z., & Ruas, J. L. (2017) · Science · doi:10.1126/science.aaf9794 · Cited by 1,382
NAD+ Intermediates: The Biology and Therapeutic Potential of NMN and NR
Yoshino, J., Baur, J. A., & Imai, S.-I. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2017.11.002 · Cited by 1,061
Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence
Rajman, L., Chwalek, K., & Sinclair, D. A. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.02.011 · Cited by 865
Mitochondria as a therapeutic target for common pathologies
Murphy, M. P., & Hartley, R. C. (2018) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2018.174 · Cited by 846
Metadata
- Authors
- Ryu, D., Zhang, H., Ropelle, E. R., Sorrentino, V., Mázala, D. A. G., Mouchiroud, L., Marshall, P. L., Campbell, M. D., Ali, A. S., Knowels, G. M., Bellemin, S., Iyer, S. R., Wang, X., Gariani, K., Sauve, A. A., Cantó, C., Conley, K. E., Walter, L., Lovering, R. M., Chin, E. R., Jasmin, B. J., Marcinek, D. J., Menzies, K. J., & Auwerx, J.
- Affiliations
- École Polytechnique Fédérale de Lausanne (CH)
- Universidade Estadual de Campinas (UNICAMP) (BR)
- University of Maryland, College Park (US)
- University of Ottawa (CA)
- University of Washington (US)
- Lyon 1 Université (FR)
- University of Maryland, Baltimore (US)
- Weill Cornell Medicine (US)
- Nestlé Institute of Health Sciences, 1015 Lausanne, Switzerland.
- Corresponding author
- Ryu, Dongryeol
- Zhang, Hongbo
- Ropelle, Eduardo R.
- Menzies, Keir J.
- Auwerx, Johan
- ORCID
- Ryu, Dongryeol
- Zhang, Hongbo
- Ropelle, Eduardo R.
- Sorrentino, Vincenzo
- Mázala, Davi A. G.
- Mouchiroud, Laurent
- Campbell, Matthew D.
- Wang, Xu
- Gariani, Karim
- Sauve, Anthony A.
- Cantó, Carles
- Conley, Kevin E.
- Walter, Ludivine
- Lovering, Richard M.
- Chin, Eva R.
- Jasmin, Bernard J.
- Marcinek, David J.
- Menzies, Keir J.
- Auwerx, Johan
- Venue
- Science Translational Medicine
- Published
- 2016-10-19
- Volume
- 8
- Issue
- 361
- Pages
- 361ra139-361ra139
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC5535761
- OpenAlex
- W2537034621
- Cited by
- 256
- References
- 61
- Citations by year
- 2026: 8 · 2025: 16 · 2024: 19 · 2023: 32 · 2022: 28 · 2021: 48 · 2020: 26 · 2019: 29 · 2018: 31 · 2017: 15 · 2016: 3
- FWCI
- 15.11
- Type
- journal article
- Language
- en
- Open access
- green
- pure.amsterdamumc.nl
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion, other-oa)
- Archive ouverte UNIGE (University of Geneva) (publishedVersion, other-oa)
- PubMed Central (acceptedVersion)
- National University of Singapore (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
- Funders
- Heart and Stroke Foundation of Canada
- NIH (R01AG043930)
- Krebsforschung Schweiz/Swiss Cancer League (KFS-3082-02-2013)
- Systems X (SySX.ch 2013/153)
- Swiss National Science Foundation (310030B-160318)
- Horizon 2020 (665667)
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Molecular Research
- Keywords
- muscular dystrophy, muscle function, poly(ADP-ribosyl)ation, poly(ADP-ribose), poly(ADP-ribose) polymerase, NAD+ metabolism, neuromuscular degeneration, nicotinamide N-methyltransferase
- MeSH terms
- Poly ADP Ribosylation, Adenosine Diphosphate, Animals, Cell Line, Fibrosis, Inflammation, Male, Mice, Inbred C57BL, Mice, Transgenic, Muscular Diseases, Muscular Dystrophies, NAD, Nitrosamines, RNA, Messenger, Tyramine, Cytokines, Caenorhabditis elegans, Muscle, Skeletal, Gene Expression Profiling, Mice, Nicotinamide Phosphoribosyltransferase
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