Clinical trial of blood-brain barrier disruption by pulsed ultrasound

Updated Response Assessment Criteria for High-Grade Gliomas: Response Assessment in Neuro-Oncology Working Group

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Accelerated Titration Designs for Phase I Clinical Trials in Oncology

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Temporary Disruption of the Blood–Brain Barrier by Use of Ultrasound and Microbubbles: Safety and Efficacy Evaluation in Rhesus Macaques

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Scanning ultrasound removes amyloid-β and restores memory in an Alzheimer’s disease mouse model

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Blood-brain barrier disruption with focused ultrasound enhances delivery of chemotherapeutic drugs for glioblastoma treatment.

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Amyloid-β plaque reduction, endogenous antibody delivery and glial activation by brain-targeted, transcranial focused ultrasound

Jordão, J. F., Thévenot, E., Markham-Coultes, K., Scarcelli, T., Weng, Y.-Q., Xhima, K., O'Reilly, M., Huang, Y., McLaurin, J., Hynynen, K., et al. (2013) · Experimental Neurology · doi:10.1016/j.expneurol.2013.05.008 · Cited by 326

Improved Anti-Tumor Effect of Liposomal Doxorubicin After Targeted Blood-Brain Barrier Disruption by MRI-Guided Focused Ultrasound in Rat Glioma

Treat, L. H., McDannold, N. J., Zhang, Y., Vykhodtseva, N. I., & Hynynen, K. (2012) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2012.04.015 · Cited by 296

Device-assisted strategies for drug delivery across the blood-brain barrier to treat glioblastoma

Mokarram, N., Case, A. G., Hossainy, N. N., Lyon, J. G., MacDonald, T. J., & Bellamkonda, R. V. (2025) · Communications Materials · doi:10.1038/s43246-024-00721-y · Cited by 54

Microbubble formulation influences inflammatory response to focused ultrasound exposure in the brain

McMahon, D., Lassus, A., Gaud, E., Jeannot, V., & Hynynen, K. (2020) · Scientific Reports · doi:10.1038/s41598-020-78657-9 · Cited by 52

Physical blood-brain barrier disruption induced by focused ultrasound does not overcome the transporter-mediated efflux of erlotinib

Goutal, S., Gerstenmayer, M., Auvity, S., Caillé, F., Mériaux, S., Buvat, I., Larrat, B., & Tournier, N. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2018.11.009 · Cited by 52

Focused ultrasound for safe and effective release of brain tumor biomarkers into the peripheral circulation

Zhu, L., Nazeri, A., Pacia, C. P., Yue, Y., & Chen, H. (2020) · PLoS ONE · doi:10.1371/journal.pone.0234182 · Cited by 52

Breaching the Blood–Brain Tumor Barrier for Tumor Therapy

Marcucci, F., Corti, A., & Ferreri, A. J. M. (2021) · Cancers · doi:10.3390/cancers13102391 · Cited by 51

Claudin-5-Binders Enhance Permeation of Solutes across the Blood-Brain Barrier in a Mammalian Model

Hashimoto, Y., Shirakura, K., Okada, Y., Takeda, H., Endo, K., Tamura, M., Watari, A., Sadamura, Y., Sawasaki, T., Doi, T., et al. (2017) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.117.243014 · Cited by 51

Localized delivery of therapeutic doxorubicin dose across the canine blood–brain barrier with hyperthermia and temperature sensitive liposomes

Bredlau, A. L., Motamarry, A., Chen, C., McCrackin, M. A., Helke, K. L., Armeson, K. E., Bynum, K., Broome, A., & Haemmerich, D. (2018) · Drug Delivery · doi:10.1080/10717544.2018.1461280 · Cited by 51

Convection-Enhanced Delivery in Malignant Gliomas: A Review of Toxicity and Efficacy

Shi, M., & Sanche, L. (2019) · Journal of Oncology · doi:10.1155/2019/9342796 · Cited by 51

Therapy of breast cancer brain metastases: challenges, emerging treatments and perspectives

Kotecki, N., Lefranc, F., Devriendt, D., & Awada, A. H. (2018) · Therapeutic Advances in Medical Oncology · doi:10.1177/1758835918780312 · Cited by 52

A review of bioeffects induced by focused ultrasound combined with microbubbles on the neurovascular unit

Chen, S., Nazeri, A., Baek, H., Ye, D., Yang, Y., Yuan, J., Rubin, J. B., & Chen, H. (2021) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x211046129 · Cited by 52

An Overview on the Physiopathology of the Blood–Brain Barrier and the Lipid-Based Nanocarriers for Central Nervous System Delivery

Susa, F., Arpicco, S., Pirri, C. F., & Limongi, T. (2024) · Pharmaceutics · doi:10.3390/pharmaceutics16070849 · Cited by 50

Blood-brain barrier disruption in humans using an implantable ultrasound device: quantification with MR images and correlation with local acoustic pressure

Asquier, N., Bouchoux, G., Canney, M. S., Martin, C., Law-Ye, B., Leclercq, D., Chapelon, J., Lafon, C., Idbaïh, A., & Carpentier, A. C. (2019) · Journal of neurosurgery · doi:10.3171/2018.9.jns182001 · Cited by 50

Transcranial Ultrasound Innovations Ready for Broad Clinical Application

Beisteiner, R., & Lozano, A. M. (2020) · Advanced Science · doi:10.1002/advs.202002026 · Cited by 51

Tyrosine Kinase Inhibitors for Glioblastoma Multiforme: Challenges and Opportunities for Drug Delivery

Brar, H. K., Jose, J., Wu, Z., & Sharma, M. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics15010059 · Cited by 50

The road ahead to successful BBB opening and drug-delivery with focused ultrasound

López‐Aguirre, M., Castillo-Ortiz, M., Viña-González, A., Blesa, J., & Pineda‐Pardo, J. A. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2024.07.006 · Cited by 49

Role of Resection in Glioblastoma Management

Youngblood, M. W., Stupp, R., & Sonabend, A. M. (2020) · Neurosurgery Clinics of North America · doi:10.1016/j.nec.2020.08.002 · Cited by 52

Glioblastoma Multiforme—A Look at the Past and a Glance at the Future

King, J. L., & Benhabbour, S. R. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13071053 · Cited by 49

Implementation of a Skull-Conformal Phased Array for Transcranial Focused Ultrasound Therapy

Adams, C., Jones, R. M., Yang, S. D., Kan, W. M., Leung, K., Zhou, Y., Lee, K. U., Huang, Y., & Hynynen, K. (2021) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2021.3077802 · Cited by 48

Blood-Spinal Cord Barrier: Its Role in Spinal Disorders and Emerging Therapeutic Strategies

Chopra, N., Menounos, S., Choi, J. P., Hansbro, P. M., Diwan, A. D., & Das, A. (2021) · NeuroSci · doi:10.3390/neurosci3010001 · Cited by 51

Magnetic microbubble mediated chemo-sonodynamic therapy using a combined magnetic-acoustic device

Beguin, E., Gray, M. D., Logan, K. A., Nesbitt, H., Sheng, Y., Kamila, S., Barnsley, L. C., Baù, L., McHale, A. P., Callan, J. F., et al. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2019.11.013 · Cited by 48

Incisionless targeted adeno-associated viral vector delivery to the brain by focused ultrasound-mediated intranasal administration

Ye, D., Yuan, J., Yang, Y., Yue, Y., Hu, Z., Fadera, S., & Chen, H. (2022) · EBioMedicine · doi:10.1016/j.ebiom.2022.104277 · Cited by 47

Sonodynamic Therapy on Intracranial Glioblastoma Xenografts Using Sinoporphyrin Sodium Delivered by Ultrasound with Microbubbles

Pi, Z., Huang, Y., Shen, Y., Zeng, X., Hu, Y., Chen, T., Li, C., Yu, H., Chen, S., & Chen, X. (2018) · Annals of Biomedical Engineering · doi:10.1007/s10439-018-02141-9 · Cited by 47

Oligonucleotide Therapeutics as a New Class of Drugs for Malignant Brain Tumors: Targeting mRNAs, Regulatory RNAs, Mutations, Combinations, and Beyond

Krichevsky, A. M., & Uhlmann, E. J. (2019) · Neurotherapeutics · doi:10.1007/s13311-018-00702-3 · Cited by 48

Effect of Ultrasound on the Vasculature and Extravasation of Nanoscale Particles Imaged in Real Time

Yemane, P. T., Åslund, A., Snipstad, S., Bjørkøy, A., Grendstad, K., Berg, S., Mørch, Y. A., TORP, S. H., Hansen, R., & Davies, C. D. L. (2019) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2019.07.683 · Cited by 47

Crossing the blood–brain barrier with graphene nanostructures

Tabish, T. A., & Narayan, R. J. (2021) · Materials Today · doi:10.1016/j.mattod.2021.08.013 · Cited by 47

Cavitation monitoring, treatment strategy, and acoustic simulations of focused ultrasound blood-brain barrier disruption in patients with glioblastoma

McDannold, N. J., Wen, P. Y., Reardon, D. A., Fletcher, S.-M. P., & Golby, A. J. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2024.06.036 · Cited by 46

A battery-free nanofluidic intracellular delivery patch for internal organs

Yin, D., Wang, P., Hao, Y., Yue, W. W., Jiang, X., Yao, K., Wang, Y., Hang, X., Xiao, A., Zhou, J., et al. (2025) · Nature · doi:10.1038/s41586-025-08943-x · Cited by 48

Ultrasound-assisted brain delivery of nanomedicines for brain tumor therapy: advance and prospect

Zhang, S., Zhang, S., Luo, S., Tang, P., Wan, M., Wu, D., & Gao, W. (2022) · Journal of Nanobiotechnology · doi:10.1186/s12951-022-01464-z · Cited by 46

Miniaturized therapeutic systems for ultrasound-modulated drug delivery to the central and peripheral nervous system

Zhu, P., Simon, I., Kokalari, I., Kohane, D. S., & Rwei, A. Y. (2024) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2024.115275 · Cited by 45

Translating ultrasound-mediated drug delivery technologies for CNS applications

Perolina, E., Meissner, S., Raos, B. J., Harland, B. C., Thakur, S. S., & Svirskis, D. M. (2024) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2024.115274 · Cited by 47

Advances in acoustic monitoring and control of focused ultrasound-mediated increases in blood-brain barrier permeability

Jones, R. M., & Hynynen, K. (2018) · British Journal of Radiology · doi:10.1259/bjr.20180601 · Cited by 46

Endothelial Cells, First Target of Drug Delivery Using Microbubble-Assisted Ultrasound

Presset, A., Bonneau, C., Sasaoka, K., Nadal‐Desbarats, L., Mitsuyoshi, T., Bouakaz, A., Kudo, N., Escoffre, J., & Sasaki, N. (2020) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2020.03.013 · Cited by 47

Ultrasonic technologies in imaging and drug delivery

Ho, Y.-J., Huang, C., Fan, C., Liu, H., & Yeh, C. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-03904-9 · Cited by 44

The Challenge of Gene Therapy for Neurological Diseases: Strategies and Tools to Achieve Efficient Delivery to the Central Nervous System

Piguet, F., Saint-Denis, T. D., Audouard, E., Beccaria, K., André, A., Wurtz, G., Schatz, R., Alves, S., Sevin, C., Zérah, M., et al. (2020) · Human Gene Therapy · doi:10.1089/hum.2020.105 · Cited by 47

A phase I clinical trial of sonodynamic therapy combined with temozolomide in the treatment of recurrent glioblastoma

Zha, B., Yang, J., Dang, Q., Li, P., Shi, S., Wu, J., Cui, H., Huangfu, L., Li, Y., Yang, D., et al. (2023) · Journal of Neuro-Oncology · doi:10.1007/s11060-023-04292-9 · Cited by 43

Mechanistic insights and the clinical prospects of targeted therapies for glioblastoma: a comprehensive review

Shen, Y., Thng, D. K. H., Wong, A. L. A., & Toh, T. B. (2024) · Experimental Hematology and Oncology · doi:10.1186/s40164-024-00512-8 · Cited by 47

Blood Brain Barrier‐Crossing Delivery of Felodipine Nanodrug Ameliorates Anxiety‐Like Behavior and Cognitive Impairment in Alzheimer's Disease

He, X., Peng, Y., Huang, S., Xiao, Z., Li, G., Zuo, Z., Zhang, L., Shuai, X., Zheng, H., & Hu, X. (2024) · Advanced Science · doi:10.1002/advs.202401731 · Cited by 43

Efficient Enhancement of Blood-Brain Barrier Permeability Using Acoustic Cluster Therapy (ACT)

Åslund, A., Snipstad, S., Healey, A., Kvåle, S., TORP, S. H., Sontum, P. C., Davies, C. D. L., & van Wamel, A. J. E. T. (2016) · Theranostics · doi:10.7150/thno.16577 · Cited by 43

Blood-brain barrier disruption with low-intensity pulsed ultrasound for the treatment of pediatric brain tumors: a review and perspectives

Beccaria, K., Canney, M. S., Bouchoux, G., Puget, S., Grill, J., & Carpentier, A. C. (2020) · Neurosurgical FOCUS · doi:10.3171/2019.10.focus19726 · Cited by 43

Sonopermeation Enhances Uptake and Therapeutic Effect of Free and Encapsulated Cabazitaxel

Snipstad, S., Mørch, Y. A., Sulheim, E., Åslund, A., Pedersen, A., Davies, C. D. L., Hansen, R., & Berg, S. (2021) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2020.12.026 · Cited by 46

Sonothrombolysis with Magnetically Targeted Microbubbles

Victor, M. D. S., Barnsley, L. C., Carugo, D., Owen, J., Coussios, C. C., & Stride, E. (2019) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2018.12.014 · Cited by 42

In Vivo Visualization of Brain Vasculature in Alzheimer's Disease Mice by High-Frequency Micro-Doppler Imaging

Li, H.-C., Chen, P., Cheng, H.-F., Kuo, Y., & Huang, C. (2019) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2019.2904702 · Cited by 44

Blood-brain barrier disruption and delivery of irinotecan in a rat model using a clinical transcranial MRI-guided focused ultrasound system

McDannold, N. J., Zhang, Y., Supko, J. G., Power, C., Sun, T., Vykhodtseva, N. I., Golby, A. J., & Reardon, D. A. (2020) · Scientific Reports · doi:10.1038/s41598-020-65617-6 · Cited by 42

Drug Release via Ultrasound-Activated Nanocarriers for Cancer Treatment: A Review

Refaai, K. A. A., AlSawaftah, N. A., Abuwatfa, W. H., & Husseini, G. A. (2024) · Pharmaceutics · doi:10.3390/pharmaceutics16111383 · Cited by 42

Ultrasound-induced biophysical effects in controlled drug delivery

Zhang, L., Lin, Z., Zeng, L., Zhang, F., Sun, L., Sun, S., Wang, P., Xu, M., Zhang, J., Liang, X., et al. (2021) · Science China Life Sciences · doi:10.1007/s11427-021-1971-x · Cited by 41

Targeted Delivery of Liposomal Temozolomide Enhanced Anti-Glioblastoma Efficacy through Ultrasound-Mediated Blood–Brain Barrier Opening

Song, Z., Huang, X., Wang, J., Cai, F., Zhao, P., & Yan, F. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13081270 · Cited by 41

Therapeutic antibodies – natural and pathological barriers and strategies to overcome them

Ojaimi, Y. A., Blin, T., Lamamy, J., Gracia, M., Pitiot, A., Denevault‐Sabourin, C., Joubert, N., Pouget, J., Gouilleux‐Gruart, V., Heuzé‐Vourc'h, N., et al. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.108022 · Cited by 43

Profiling of the immune landscape in murine glioblastoma following blood brain/tumor barrier disruption with MR image-guided focused ultrasound

Sheybani, N., Witter, A. R., Garrison, W. J., Miller, G. W., Price, R. J., & Bullock, T. N. J. (2021) · Journal of Neuro-Oncology · doi:10.1007/s11060-021-03887-4 · Cited by 41

SonoVue® vs. Sonazoid™ vs. Optison™: Which Bubble Is Best for Low-Intensity Sonoporation of Pancreatic Ductal Adenocarcinoma?

Kotopoulis, S., Popa, M. L., Safont, M. M., Murvold, E. T., Haugse, R., Langer, A., Dimcevski, G. G., Lam, C., Bjånes, T. K., Gilja, O. H., et al. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14010098 · Cited by 41

The new insight into the inflammatory response following focused ultrasound-mediated blood–brain barrier disruption

Choi, H. J., Han, M., Seo, H., Park, C. Y., Lee, E., & Park, J. Y. (2022) · Fluids and Barriers of the CNS · doi:10.1186/s12987-022-00402-3 · Cited by 42

Focused Ultrasound for Noninvasive, Focal Pharmacologic Neurointervention

Wang, J. B., Ianni, T. D., Vyas, D. B., Huang, Z., Park, S., Hosseini-Nassab, N., Aryal, M., & Airan, R. D. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00675 · Cited by 42

A sporadic Alzheimer's blood-brain barrier model for developing ultrasound-mediated delivery of Aducanumab and anti-Tau antibodies

Wasielewska, J. M., Chaves, J. C. S., Johnston, R. L., Milton, L. A., Hernández, D., Chen, L., Song, J. H., Lee, W., Leinenga, G., Nisbet, R. M., et al. (2022) · Theranostics · doi:10.7150/thno.72685 · Cited by 41

Fc-enhanced anti-CTLA-4, anti-PD-1, doxorubicin, and ultrasound-mediated blood–brain barrier opening: A novel combinatorial immunotherapy regimen for gliomas

Kim, K., Habashy, K. J., Gould, A., Zhao, J., Najem, H., Amidei, C., Saganty, R., Arrieta, V. A., Dmello, C., Chen, L., et al. (2024) · Neuro-Oncology · doi:10.1093/neuonc/noae135 · Cited by 39

Low-Intensity MR-Guided Focused Ultrasound Mediated Disruption of the Blood-Brain Barrier for Intracranial Metastatic Diseases

Meng, Y., Suppiah, S., Surendrakumar, S., Bigioni, L., & Lipsman, N. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00338 · Cited by 39

Therapeutic Effect of Cabazitaxel and Blood-Brain Barrier opening in a Patient-Derived Glioblastoma Model

Sulheim, E., Mørch, Y. A., Snipstad, S., Borgos, S. E., Miletić, H., Bjerkvig, R., Davies, C. D. L., & Åslund, A. (2019) · Nanotheranostics · doi:10.7150/ntno.31479 · Cited by 39

Focused Ultrasound Preconditioning for Augmented Nanoparticle Penetration and Efficacy in the Central Nervous System

Mead, B. P., Curley, C. T., Kim, N.-H., Negrón, K., Garrison, W. J., Song, J. S., Rao, D., Miller, G. W., Mandell, J. W., Purow, B. W., et al. (2019) · Small · doi:10.1002/smll.201903460 · Cited by 39

Gas-mediated cancer therapy combined with starvation therapy, ultrasound therapy, chemotherapy, radiotherapy, and photodynamic therapy: a review

Thakar, S. B., Ghorpade, P. N., Shaker, B., Lee, J., & Na, D. (2021) · Environmental Chemistry Letters · doi:10.1007/s10311-021-01218-7 · Cited by 39

Modelling Lipid-Coated Microbubbles in Focused Ultrasound Applications at Subresonance Frequencies

Gümmer, J., Schenke, S., & Denner, F. (2021) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2021.06.012 · Cited by 39

Current state of therapeutic focused ultrasound applications in neuro-oncology

Meng, Y., Pople, C. B., Budiansky, D., Li, D., Suppiah, S., Lim-Fat, M. J., Perry, J., Sahgal, A., & Lipsman, N. (2021) · Journal of Neuro-Oncology · doi:10.1007/s11060-021-03861-0 · Cited by 39

Synergistic therapy for orthotopic gliomas via biomimetic nanosonosensitizer-mediated sonodynamic therapy and ferroptosis

Zhu, M., Wu, P., Li, Y., Zhang, L., Zong, Y., & Wan, M. (2022) · Biomaterials Science · doi:10.1039/d2bm00562j · Cited by 40

Therapeutic Potentials of Localized Blood–Brain Barrier Disruption by Noninvasive Transcranial Focused Ultrasound: A Technical Review

Cammalleri, A., Croce, P., Lee, W., Yoon, K., & Yoo, S. (2020) · Journal of Clinical Neurophysiology · doi:10.1097/wnp.0000000000000488 · Cited by 38

Focused ultrasound combined with radiotherapy for malignant brain tumor: a preclinical and clinical study

Chen, K., Huang, C.-Y., Pai, P., Yang, W.-C., Tseng, C., Tsai, H., Li, J.-C., Chuang, C., Hsu, P., Lee, C., et al. (2023) · Journal of Neuro-Oncology · doi:10.1007/s11060-023-04517-x · Cited by 37

Localized Blood–Brain Barrier Opening in Ovine Model Using Image-Guided Transcranial Focused Ultrasound

Yoon, K., Lee, W., Chen, E., Lee, J. E., Croce, P., Cammalleri, A., Foley, L., Tsao, A. L., & Yoo, S. (2019) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2019.05.023 · Cited by 39

Focused Ultrasound in Neuroscience. State of the Art and Future Perspectives

Giammalva, G. R., Gagliardo, C., Marrone, S., Paolini, F., Gerardi, R. M., Umana, G. E., Yağmurlu, K., Chaurasia, B. K., Scalia, G., Midiri, F., et al. (2021) · Brain Sciences · doi:10.3390/brainsci11010084 · Cited by 38

Safety and efficacy of an anti-claudin-5 monoclonal antibody to increase blood–brain barrier permeability for drug delivery to the brain in a non-human primate

Tachibana, K., Hashimoto, Y., Shirakura, K., Okada, Y., Hirayama, R., Iwashita, Y., Nishino, I., Ago, Y., Takeda, H., Kuniyasu, H., et al. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.06.009 · Cited by 37

MR-guided focused ultrasound increases antibody delivery to nonenhancing high-grade glioma

Brighi, C., Reid, L. B., White, A. L., Genovesi, L. A., Kojic, M., Millar, A., Bruce, Z. C., Day, B. W., Rose, S., Whittaker, A. K., et al. (2020) · Neuro-Oncology Advances · doi:10.1093/noajnl/vdaa030 · Cited by 35

Transendothelial Perforations and the Sphere of Influence of Single-Site Sonoporation

Helfield, B. L., Chen, X., Watkins, S. C., & Villanueva, F. S. (2020) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2020.02.017 · Cited by 35

Leptomeningeal Carcinomatosis

Bhambhvani, H. P., Rodrigues, A. J., Umeh-Garcia, M. C., & Gephart, M. H. (2020) · Neurosurgery Clinics of North America · doi:10.1016/j.nec.2020.06.010 · Cited by 35

Electroporation-Based Therapy for Brain Tumors: A Review

Fang, Z. G., Chen, L., Moser, M., Zhang, W., Qin, Z., & Zhang, B. (2021) · Journal of Biomechanical Engineering · doi:10.1115/1.4051184 · Cited by 35

[18F]2-Fluoro-2-deoxy-sorbitol PET Imaging for Quantitative Monitoring of Enhanced Blood-Brain Barrier Permeability Induced by Focused Ultrasound

Hugon, G., Goutal, S., Dauba, A., Breuil, L., Larrat, B., Winkeler, A., Novell, A., & Tournier, N. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13111752 · Cited by 36

Advancements in Glioma Care: Focus on Emerging Neurosurgical Techniques

Simone, M. D., Conti, V., Palermo, G., Maria, L. D., & İaconetta, G. (2023) · Biomedicines · doi:10.3390/biomedicines12010008 · Cited by 34

Would Antioxidant-Loaded Nanoparticles Present an Effective Treatment for Ischemic Stroke?

Poellmann, M. J., Bu, J., & Hong, S. (2018) · Nanomedicine · doi:10.2217/nnm-2018-0084 · Cited by 34

Non-invasive ultrasonic modulation of visual evoked response by GABA delivery through the blood brain barrier

Constans, C., Ahnine, H., Santin, M. D., Lehéricy, S., Tanter, M., Pouget, P., & Aubry, J. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2019.12.006 · Cited by 34

Recent Strategies for Targeted Brain Drug Delivery

Ogawa, K., Kato, N., & Kawakami, S. (2020) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.c20-00041 · Cited by 34

Recent Trend of Ultrasound-Mediated Nanoparticle Delivery for Brain Imaging and Treatment

Jo, S., Sun, I., Ahn, C., Lee, S., & Kim, K. (2022) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.1c22803 · Cited by 34

Opportunities and challenges in delivering biologics for Alzheimer’s disease by low-intensity ultrasound

Chen, L., Cruz, E., Oikari, L. E., Padmanabhan, P., Song, J. H., & Götz, J. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114517 · Cited by 35

Harnessing Ultrasound for Targeting Drug Delivery to the Brain and Breaching the Blood–Brain Tumour Barrier

Barzegar‐Fallah, A., Gandhi, K., Rizwan, S. B., Slatter, T. L., & Reynolds, J. N. J. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14102231 · Cited by 36

Beyond the Walls of Troy: A Scoping Review on Pharmacological Strategies to Enhance Drug Delivery Across the Blood–Brain Barrier and Blood–Tumor Barrier

Pinkiewicz, M., Zaczyński, A., Walecki, J. M., & Zawadzki, M. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26157050 · Cited by 36

Probing the brain with molecular fMRI

Ghosh, S., Harvey, P., Simon, J. C., & Jasanoff, A. (2018) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2018.03.009 · Cited by 33

Ultrasound‐mediated nano‐sized drug delivery systems for cancer treatment: Multi‐scale and multi‐physics computational modeling

Kashkooli, F. M., Hornsby, T. K., Kolios, M. C., & Tavakkoli, J. (2023) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1913 · Cited by 33

MRI Monitoring and Quantification of Ultrasound-Mediated Delivery of Liposomes Dually Labeled with Gadolinium and Fluorophore through the Blood-Brain Barrier

Aryal, M., Papademetriou, I. T., Zhang, Y., Power, C., McDannold, N. J., & Porter, T. M. (2019) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2019.02.024 · Cited by 32

Histologic evaluation of activation of acute inflammatory response in a mouse model following ultrasound-mediated blood-brain barrier using different acoustic pressures and microbubble doses

Pascal‐Tenorio, A., Li, N., Lechtenberg, K. J., Rosenberg, J., Airan, R. D., James, M. L., Bouley, D. M., & Butts, K. (2020) · Nanotheranostics · doi:10.7150/ntno.49898 · Cited by 36

Multimodal neuro-nanotechnology: Challenging the existing paradigm in glioblastoma therapy

Kudruk, S., Forsyth, C. M., Dion, M. Z., Orbeck, J., Luo, J. R., Klein, R. S., Kim, A. H., Heimberger, A. B., Mirkin, C. A., Stegh, A. H., et al. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2306973121 · Cited by 32

Anticancer drug delivery by focused ultrasound-mediated blood-brain/tumor barrier disruption for glioma therapy: From benchside to bedside

Bérard, C., Truillet, C., Larrat, B., Dhermain, F. G., Estève, M., Corréard, F., & Novell, A. (2023) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2023.108518 · Cited by 32

Ultrasound‐Sensitive Intelligent Nanosystems: A Promising Strategy for the Treatment of Neurological Diseases

Pan, X., Huang, W., Nie, G., Wang, C., & Wang, H. (2023) · Advanced Materials · doi:10.1002/adma.202303180 · Cited by 31

Anatomical evidence for functional diversity in the mesencephalic locomotor region of primates

Sébille, S. B., Belaïd, H., Philippe, A.-C., André, A., Lau, B., François, C., Karachi, C., & Bardinet, É. (2016) · NeuroImage · doi:10.1016/j.neuroimage.2016.12.011 · Cited by 39

Broadband Ultrasonic Attenuation Estimation and Compensation With Passive Acoustic Mapping

Gray, M. D., & Coussios, C. C. (2018) · IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control · doi:10.1109/tuffc.2018.2866171 · Cited by 31

Closed-loop cavitation control for focused ultrasound-mediated blood–brain barrier opening by long-circulating microbubbles

Çavuşoğlu, M., Zhang, J., Ielacqua, G. D., Pellegrini, G., Signorell, R. D., Papachristodoulou, A., Brambilla, D., Roth, P., Weller, M., Rudin, M., et al. (2018) · Physics in Medicine and Biology · doi:10.1088/1361-6560/aafaa5 · Cited by 31

Open-Label Phase II Evaluation of Imatinib in Primary Inoperable or Incompletely Resected and Recurrent Glioblastoma

Sautter, L., Hofheinz, R., Tuettenberg, J., Grimm, M., Vajkoczy, P., Groden, C., Schmieder, K., Hochhaus, A., Wenz, F. K., & Giordano, F. A. (2019) · Oncology · doi:10.1159/000502483 · Cited by 33

Temporal Stability of Lipid-Shelled Microbubbles During Acoustically-Mediated Blood-Brain Barrier Opening

Pouliopoulos, A. N., Jimenez, D. A., Frank, A., Robertson, A. D., Zhang, L., Kline-Schoder, A. R., Bhaskar, V., Harpale, M., Caso, E., Papapanou, N., et al. (2020) · Frontiers in Physics · doi:10.3389/fphy.2020.00137 · Cited by 31

Sonoporation: Underlying Mechanisms and Applications in Cellular Regulation

Li, Y., Chen, Z., & Ge, S. (2021) · BIO Integration · doi:10.15212/bioi-2020-0028 · Cited by 31

The roles of thermal and mechanical stress in focused ultrasound-mediated immunomodulation and immunotherapy for central nervous system tumors

Kim, C., Lim, M. K., Woodworth, G. F., & Arvanitis, C. (2022) · Journal of Neuro-Oncology · doi:10.1007/s11060-022-03973-1 · Cited by 31

Drug Repurposing, a Fast-Track Approach to Develop Effective Treatments for Glioblastoma

Ntafoulis, I., Koolen, S. L. W., Leenstra, S., & Lamfers, M. L. M. (2022) · Cancers · doi:10.3390/cancers14153705 · Cited by 31

Medical Device Advances in the Treatment of Glioblastoma

Foo, C. Y., Munir, N., Kumaria, A., Akhtar, Q., Bullock, C. J., Narayanan, A., & Fu, R. Z. (2022) · Cancers · doi:10.3390/cancers14215341 · Cited by 32

Theranostic Attributes of Acoustic Cluster Therapy and Its Use for Enhancing the Effectiveness of Liposomal Doxorubicin Treatment of Human Triple Negative Breast Cancer in Mice

Bush, N., Healey, A., Shah, A., Box, G., Kirkin, V., Eccles, S. A., Sontum, P. C., Kotopoulis, S., Kvåle, S., van Wamel, A. J. E. T., et al. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00075 · Cited by 31

Listening in on the Microbubble Crowd: Advanced Acoustic Monitoring for Improved Control of Blood-Brain Barrier Opening with Focused Ultrasound

Gorick, C. M., Sheybani, N., Curley, C. T., & Price, R. J. (2018) · Theranostics · doi:10.7150/thno.26025 · Cited by 30

Ultrasound-Induced Blood-Brain-Barrier Opening Enhances Anticancer Efficacy in the Treatment of Glioblastoma: Current Status and Future Prospects

Deng, Z., Sheng, Z., & Yan, F. (2019) · Journal of Oncology · doi:10.1155/2019/2345203 · Cited by 30

Ribosomal protein S11 influences glioma response to TOP2 poisons

Awah, C. U., Chen, L., Bansal, M., Mahajan, A., Winter, J., Lad, M., Warnke, L., González-Buendía, E., Park, C., Zhang, D. Y., et al. (2020) · Oncogene · doi:10.1038/s41388-020-1342-0 · Cited by 30

Drug Delivery Strategies to Overcome the Blood–Brain Barrier (BBB)

Helms, H. C. C., Kristensen, M., Saaby, L., Fricker, G., & Brodin, B. (2020) · Handbook of experimental pharmacology · doi:10.1007/164_2020_403 · Cited by 30

Focused Ultrasound Stimulation as a Neuromodulatory Tool for Parkinson’s Disease: A Scoping Review

Lee, K. S., Clennell, B., Steward, T. G. J., Gialeli, A., Llana, O. C., & Whitcomb, D. J. (2022) · Brain Sciences · doi:10.3390/brainsci12020289 · Cited by 30

Safety and Feasibility of Repeated and Transient Blood–Brain Barrier Disruption by Pulsed Ultrasound in Patients with Recurrent Glioblastoma

Idbaïh, A., Canney, M. S., Belin, L., Desseaux, C., Vignot, A., Bouchoux, G., Asquier, N., Law-Ye, B., Leclercq, D., Bissery, A., et al. (2019) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-18-3643 · Cited by 367

Temporary disruption of the blood-brain barrier using an implantable ultrasound system for recurrent glioblastoma patients under IV carboplatin chemotherapy: initial phase 1/2a clinical trial observations

Carpentier, A. C., Canney, M. S., Vignot, A., Horodyckid, C., Goldwirt, L., Leclercq, D., Delattre, J., Chapelon, J., & Idbaïh, A. (2015) · Journal of Therapeutic Ultrasound · doi:10.1186/2050-5736-3-s1-o14 · Cited by 11

A phase I/IIa study to evaluate the safety and efficacy of blood-brain barrier (BBB) opening with the SonoCloud-9 implantable ultrasound device in recurrent glioblastoma patients receiving IV carboplatin.

Idbaïh, A., Ducray, F., Stupp, R., Baize, N., Chinot, O. L., Groot, J. F. D., Guyotat, J., Sonabend, A. M., Meneï, P., Dufour, H., et al. (2021) · Journal of Clinical Oncology · doi:10.1200/jco.2021.39.15_suppl.2049 · Cited by 11

News in brief

(2016) · The Lancet Neurology · doi:10.1016/s1474-4422(16)30136-3

OS07.3.A Phase 1/2 clinical trial of blood-brain barrier opening with the SonoCloud-9 implantable ultrasound device in recurrent glioblastoma patients receiving IV carboplatin

Idbaïh, A., Sonabend, A. M., Stupp, R., Chinot, O. L., Dufour, H., Ducray, F., Meneï, P., de Groot, J., Desseaux, C., & Carpentier, A. C. (2022) · Neuro-Oncology · doi:10.1093/neuonc/noac174.048 · Cited by 2