Clinical trial of blood-brain barrier disruption by pulsed ultrasound

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Accelerated Titration Designs for Phase I Clinical Trials in Oncology

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Blood-brain barrier disruption with focused ultrasound enhances delivery of chemotherapeutic drugs for glioblastoma treatment.

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Amyloid-β plaque reduction, endogenous antibody delivery and glial activation by brain-targeted, transcranial focused ultrasound

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Improved Anti-Tumor Effect of Liposomal Doxorubicin After Targeted Blood-Brain Barrier Disruption by MRI-Guided Focused Ultrasound in Rat Glioma

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CAR-T cells for pediatric brain tumors: Present and future

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Blood-brain barrier derangement after electrical brain stimulation

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Light Induces Opening of Vascular Barrier for Precise Nanoparticle DeliveryPreprint

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Deep Learning Enables Reduced Gadolinium Dose for Contrast-Enhanced Blood-Brain Barrier OpeningPreprint

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Dietary Plant Diversity Predicts Early Life Microbiome MaturationPreprint

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Ultrasound-induced blood–brain barrier opening and selenium-nanoparticle injection lower seizure activity: A mouse model of temporal lobe epilepsy

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From barrier to bridge: a scoping review on the methods, clinical efficacy, and safety of blood–brain barrier disruption in treating high-grade glioma

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Epitranscriptomic circuits wiring the tumor microenvironment: A pharmacodynamic framework for clinical translation

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Adaptive Ultrasound Focusing Through the Cranial Bone for Non-invasive Treatment of Brain Disorders

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Future challenges of contrast media in radiology

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Breaking Barriers With Sound: Focused Ultrasound in the Brain

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Recent Advances about Local Gene Delivery by Ultrasound

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Computational sensitivity evaluation of ultrasound neuromodulation resolution to brain tissue sound speed with robust beamforming

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A Metric and Method for Calculating Energy-Preserving Spatiotemporal Cavitation Dose: Cavitational Radiated Energy Density (CRED)

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Neurosurgical Implant-Based Strategy for Brain Cancer Therapy

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A Study of Cavitation Simulation by Focused Ultrasound Stimulation

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Evaluating drug delivery enhancement following ultrasound treatment

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Treating early dementia: Drug targeting and circumventing the blood-brain barrier

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Applications of noncoding RNAs in brain cancer patients

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Gene Therapy for Neurological Disorders

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Enhancing oxime efficacy into brain using ultrasound to counteract nerve agent exposure

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Protamine-1 encoded recombinant adeno-associated virus for enhanced brain magnetic resonance imaging

Xie, K., Yuan, Y., Jiang, M., Chen, D., Chen, S., & Zhou, X. H. (2025) · Magnetic Resonance Letters · doi:10.1016/j.mrl.2025.200222 · Cited by 1

Focused ultrasound combined with drug-loaded microbubbles suppresses ictal spikes in kainic acid-induced epileptic animals

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Advances in Pharmacological Strategies for Brain Tumors: Molecular Insights and Therapeutic Innovations

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Effect of Ultrasound Combined with Microbubbles on Blood Perfusion in Invasive Breast Cancer—A Prospective Clinical Trial

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Current state and future of clinical-focused ultrasound devices in neuro-oncology

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STING agonism in brain tumours: mechanisms, challenges, and therapeutic advances

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Therapeutic modulation of the blood–brain barrier in brain tumors: a systematic review of clinical and translational approaches

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Focused ultrasound opens the blood–brain barrier and reveals an age-dependent dissociation between resting cerebral blood flow and neurovascular coupling

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Optimized ultrasound neurostimulation of ventromedial prefrontal cortex reverses depression behaviours and normalizes brain metabolism

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Focused ultrasound–induced blood–brain barrier modulation for drug delivery in recurrent glioblastoma: A systematic review

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Focused ultrasound in epilepsy

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Repurposing Alzheimer’s and ovarian cancer drugs as sonosensitizers for glioblastoma via a positive-unlabeled learning and 3D bioprinting-based new approach methodology (NAM)

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Drug discovery

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Ultrasound as a treatment modality for neurological diseases

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Brain tumours: Non-invasive techniques to treat invasive pathologies

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Increasing BBB Permeability via Focused Ultrasound and Microbubbles: Current Methods in Preclinical Research

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The dark matter of diffuse intrinsic pontine gliomas: an update

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Temporal Evolutional Acoustic Pattern Generated by a 3D Printed Fresnel Lens-Focused Transducer

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Evaluation of the Uncertainty of Passive Cavitation Measurements for Blood–Brain Barrier Disruption Monitoring

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Real-Time Visualization of a Focused Ultrasound Beam Using Ultrasonic Backscatter for Monitoring of Mechanical-Based Therapies

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Passing across the blood-brain barrier in glioblastoma multiforme (GBM)

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Local Administration of Therapies and Drug Delivery Strategies for the Treatment of Gliomas

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Des innovations aux transferts cliniques et commerciaux : 100 ans après leur découverte, les ultrasons médicaux vivent leur seconde révolution

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Medical Technology Innovation and Entrepreneurship in Neurosurgery

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Engineered Materials for Probing and Perturbing Brain Chemistry

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Recent Advances in Brain Tumour Therapy Using Electrospun Nanofibres

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Breaking Barriers:The Past, Present and Future of Focused Ultrasound and Diffuse Intrinsic Pontine Glioma

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Proof of Concept of an Affordable, Compact and Transcranial Submillimeter Accurate Ultrasound-Based Tracking System

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Editorial: Bubbles, Droplets and Micelles for Acoustically-Mediated Drug/Gene Delivery

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Ultrasound Mediated Microbubbles Destruction Assists Dual Delivery of Beta-amyloid Antibody and NSCs to Restore Neural Function in Transgenic Mice of Alzheimer’s DiseasePreprint

Zhu, Q., Cui, H., Liao, Y., Guan, X., He, Y., Rong, Y., Zhang, Y., Li, C., Liu, Z., & Xu, Y. (2020) · doi:10.21203/rs.3.rs-27241/v1 · Cited by 1

Design of a therapeutic ultrasound array for small volume blood-brain barrier opening in macaquesPreprint

Manuel, T. J., Phipps, M. A., & Caskey, C. F. (2022) · doi:10.36227/techrxiv.20427975 · Cited by 1

Engineering Regionally-Activated Drugs for NeurosciencePreprint

Huang, Z., Mitrofan, A., Nouraein, S., Horak, C., Seo, J. P., Harb, M., Jin, R., & Szablowski, J. O. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.10.12.562069 · Cited by 1

Ultrasound Induced Blood-brain Barrier Opening on Rodents : from Nanoparticles Delivery to a Therapy for Alzheimer’s Disease

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Development, Characterization, and Implementation of a System for Focused Ultrasound-Mediated Blood-Brain Barrier Opening In Mice

Valdez, M. A. (2017) · UA Campus Repository (The University of Arizona)

Targeting Astrocytes With Viral Gene Therapy for Alzheimer’s Disease

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The potential of enhancement of the EPR effect by modulation of microvascular permeability by the combination of ultrasound and microbubbles

Suzuki, R., Omata, D., Unga, J., Osaki, T., & Maruyama, K. (2018) · Drug Delivery System · doi:10.2745/dds.33.115

Principles of Neuropharmacodynamics: As Applied to Neuro-Oncology

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Can we overcome the most significant barrier to treatment of neurodegenerative disorders?

Allen, C. J. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2019.05.014

Gene and nucleic acid delivery and theranostics with lipid bubbles and ultrasound

Endo‐Takahashi, Y., Maruyama, K., & Negishi, Y. (2019) · Drug Delivery System · doi:10.2745/dds.34.116

Dinaciclib Inhibits Glioblastoma Multiforme Cell Growth and Selects for a Brain Tumour Initiating Cell Population

Stover, M. (2019) · Scholarship at UWindsor (University of Windsor)

Current situation of drug reviews and future expectations on drugs for central nervous diseases

Honma, N., Miura, Y., Ishige, C., Ozawa, K., Sekiguchi, H., & Kato, N. (2019) · Drug Delivery System · doi:10.2745/dds.34.385

Quantitative analysis of the focused ultrasound-induced blood-brain barrier opening with applications in neurodegenerative disorders

Karakatsani, M. E. (2020) · doi:10.7916/d8-gvqg-2009

Development of a Sonically Powered Biodegradable Nanogenerator for Bone Regeneration

Patel, A. (2019) · OpenCommons - UConn (University of Connecticut)

Planning Framework for Robot-assisted Blood-Brain Barrier Opening with Focused Ultrasound

Thomas, G., Barbé, L., Larrat, B., Agou, P., Vappou, J., & Nageotte, F. P. (2020) · Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) · doi:10.1109/embc44109.2020.9175849

Spatio-temporal characterization of causal electrophysiological activity stimulated by single pulse focused ultrasound: An ex vivo study on hippocampal brain slicesPreprint

Castellanos, I. M. S., Dossi, E., Vion‐Bailly, J., Salette, L., Chapelon, J., Carpentier, A. C., Huberfeld, G., & N’Djin, W. A. (2021) · arXiv (Cornell University) · doi:10.48550/arxiv.2101.06935

The mechanical potential of ultrasound on nervous tissue

O’Reilly, M. A., & Hynynen, K. (2021) · The Journal of the Acoustical Society of America · doi:10.1121/10.0005066

Strategies for Improving the Efficiency of Nanomaterials

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m6A function and tumor microenvironment infiltration characteristics in gliomaPreprint

Yang, A., Wang, X., Shang, C., Hu, Y., Chen, P., & Hong, Y. (2021) · Research Square · doi:10.21203/rs.3.rs-1142715/v1

Devemos usar beta-bloqueadores para diminuir a progressão dos gliomas como em outras neoplasias (e.g., de mama, ovário e próstata)?

Plauto, L. L. D. C., & de Resende, R. M. (2022) · Avanços em Medicina · doi:10.52329/avanmed.45

Inter-Bubble Interactions in Ultrasonically Excited Microbubble Clusters

Haghi, H., & Kolios, M. C. (2021) · doi:10.32920/ryerson.14661777

Industry Update: 1–30 June 2016

Steinbach, O. C. (2016) · Therapeutic Delivery · doi:10.4155/tde-2016-0048

Biophysical and Clinical Perspectives on Blood-Brain Barrier Permeability Enhancement by Ultrasound and Microbubbles for Targeted Drug Delivery

McMahon, D., & Hynynen, K. (2022) · AAPS advances in the pharmaceutical sciences series · doi:10.1007/978-3-030-88773-5_19

Optimization of Blood-Brain Barrier Opening with Focused Ultrasound: The Animal Perspective

Konofagou, E. E. (2022) · AAPS advances in the pharmaceutical sciences series · doi:10.1007/978-3-030-88773-5_20

Design of a therapeutic ultrasound array for small volume blood-brain barrier opening in macaquesPreprint

Manuel, T. J., Phipps, M. A., & Caskey, C. F. (2022) · doi:10.36227/techrxiv.20427975.v1

Strategies to Improve Delivery of Bioactive Agents

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Exploiting modulation of the Blood-Brain and Blood-Tumor Barrier permeability by Translational Focused Ultrasound for therapeutic delivery to CNS metastases

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Vessel Rupture Thresholds for Vessel–Bubble Interactions Using an Earthworm Vasculature Model

Lopez, A., Osborn, J., Irwin, R., Khismatullin, D. B., Clement, G. T., & Myers, M. R. (2023) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2022.12.011

Drug discovery: Standing on the shoulders of giants

Miller, S. M., Moos, W. H., Munk, B. H., Munk, S. A., Hart, C. P., & Spellmeyer, D. C. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-824304-6.00001-8

Perspective: Focused-Ultrasound Guided Neuropeptide Delivery as a Novel Therapeutic Approach in Psychiatry

Karthikeyan, M., Shrivastava, A., & Neff, A. (2023) · Seeds of Science · doi:10.53975/ykha-lrmn

An overview of current drug delivery strategies for glioblastoma treatment and barriers to progress

Duskey, J. T., Cook, A. B., Costabile, G., Tosi, G., & Schlich, M. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-99873-4.00029-3

Focused Ultrasound for Ablation in Neurosurgery — Present Use and Future Directions

Yoh, N. T., Tazhibi, M., Englander, Z. K., Wu, C., & Baltuch, G. H. (2022) · Applied Radiation Oncology · doi:10.37549/aro1329

Novel Approaches to Bypassing the Blood-Brain Barrier for Drug Delivery to Brain Tumors

Kannan, S., Putra, M. A. R., Antwi, D. A., & Cheng, V. W. T. (2024) · Interdisciplinary cancer research · doi:10.1007/16833_2024_224

Resistance of breast cancer brain metastasis to trastuzumab therapy

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Los retos futuros de los medios de contraste en Radiología

Alvarez-Hornia, E., Carnelli, C., Gutierrez, P. A., Sánchez, R. G., & Quesada, J. M. (2024) · Radiología · doi:10.1016/j.rx.2024.05.012

Next Frontiers in Surgical Management

Bono, B., Barbieri, E. M., Pessina, F., & Riva, M. (2024) · Springer eBooks · doi:10.1007/978-3-031-59341-3_5

Theranostic nanomaterials for intervention of the blood–brain barrier

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