Cited by 759Ultrasound and Hyperthermia ApplicationsBarrier Structure and Function StudiesGlioma Diagnosis and Treatment

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Clinical trial of blood-brain barrier disruption by pulsed ultrasound

Carpentier, Alexandre, Canney, Michael, Vignot, Alexandre, Reina, Vincent, Beccaria, Kevin, Horodyckid, Catherine, Karachi, Carine, Leclercq, Delphine, Lafon, Cyril, Chapelon, Jean-Yves, Capelle, Laurent, Cornu, Philippe, Sanson, Marc, Hoang-Xuan, Khê, Delattre, Jean-Yves, Idbaih, Ahmed·2016·Science Translational Medicine

DOI 10.1126/scitranslmed.aaf6086

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Abstract

An implantable ultrasound device safely disrupts the blood-brain barrier in glioblastoma patients.

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Crossref · 10.1126/scitranslmed.aaf6086

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Authors: Carpentier, A., Canney, M., Vignot, A., Reina, V., Beccaria, K., Horodyckid, C., Karachi, C., Leclercq, D., Lafon, C., Chapelon, J.-Y., Capelle, L., Cornu, P., Sanson, M., Hoang-Xuan, K., Delattre, J.-Y., & Idbaih, A.
Affiliations: Sorbonne Université (FR)
Institut du Cerveau (FR)
Assistance Publique–Hôpitaux de Paris (AP-HP), Hôpitaux Universitaires La Pitié-Salpêtrière, Service de Neurochirurgie, F-75013 Paris, France.
Assistance Publique – Hôpitaux de Paris (FR)
Inserm (FR)
Centre National de la Recherche Scientifique (FR)
Sorbonne Universités, UPMC Univ Paris 06, UMR S 1127, F-75013 Paris, France.
Corresponding author: Carpentier, Alexandre
ORCID: Carpentier, Alexandre
Canney, Michael
Horodyckid, Catherine
Karachi, Carine
Leclercq, Delphine
Lafon, Cyril
Chapelon, Jean-Yves
Sanson, Marc
Venue: Science Translational Medicine
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2016-06-15
Volume: 8
Issue: 343
Pages: 343re2-343re2
ISSN: 1946-6234 (ISSN-L)
1946-6242
DOI: 10.1126/scitranslmed.aaf6086
OpenAlex: W2433010802
Cited by: 757
References: 36
Citations by year: 2026: 55 · 2025: 74 · 2024: 75 · 2023: 73 · 2022: 92 · 2021: 104 · 2020: 101 · 2019: 73 · 2018: 65 · 2017: 34 · 2016: 10
FWCI: 29.25
Type: journal article
Language: en
Open access: closed
Licence: www.sciencemag.org/about/science-licenses-journal-article-reuse (vor, 365 d)
Locations: Science Translational Medicine (publishedVersion)
PubMed (publishedVersion)
Funders: CarThera (#12109)
Investissements d'avenir (ANR-10-IAIHU-06)
Topics: Physical Sciences › Engineering › Biomedical Engineering › Ultrasound and Hyperthermia Applications
Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
Health Sciences › Medicine › Oncology › Glioma Diagnosis and Treatment
Keywords: blood-brain barrier disruption, pulsed ultrasound, recurrent glioblastoma, carboplatin, microbubbles, contrast-enhanced MRI
MeSH terms: Ultrasonic Waves, Blood-Brain Barrier, Brain, Female, Glioblastoma, Humans, Magnetic Resonance Imaging, Male, Carboplatin, Microbubbles

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