Clinical trial of blood-brain barrier disruption by pulsed ultrasound

Updated Response Assessment Criteria for High-Grade Gliomas: Response Assessment in Neuro-Oncology Working Group

Wen, P. Y., Macdonald, D. R., Reardon, D. A., Cloughesy, T. F., Sorensen, A. G., Galanis, E., DeGroot, J. F., Wick, W., Gilbert, M. R., Lassman, A. B., et al. (2010) · Journal of Clinical Oncology · doi:10.1200/jco.2009.26.3541 · Cited by 3,890

Carboplatin dosage: prospective evaluation of a simple formula based on renal function.

Calvert, H., Newell, D. R., Gumbrell, L. A., O’Reilly, S., Burnell, M., Boxall, F. E., Siddik, Z. H., Judson, I. R., Gore, M. E., & Wiltshaw, E. (1989) · Journal of Clinical Oncology · doi:10.1200/jco.1989.7.11.1748 · Cited by 1,862

Noninvasive MR Imaging–guided Focal Opening of the Blood-Brain Barrier in Rabbits

Hynynen, K., McDannold, N. J., Vykhodtseva, N. I., & Jolesz, F. A. (2001) · Radiology · doi:10.1148/radiol.2202001804 · Cited by 1,463

Direct brain infusion of glial cell line–derived neurotrophic factor in Parkinson disease

Gill, S. S., Patel, N. K., Hotton, G. R., O'Sullivan, K., McCarter, R., Bunnage, M., Brooks, D. J., Svendsen, C. N., & Heywood, P. (2003) · Nature Medicine · doi:10.1038/nm850 · Cited by 1,290

Accelerated Titration Designs for Phase I Clinical Trials in Oncology

Simon, R. M., Rubinstein, L., Arbuck, S. G., Christian, M. C., Freidlin, B., & Collins, J. M. (1997) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/89.15.1138 · Cited by 641

Temporary Disruption of the Blood–Brain Barrier by Use of Ultrasound and Microbubbles: Safety and Efficacy Evaluation in Rhesus Macaques

McDannold, N. J., Arvanitis, C., Vykhodtseva, N. I., & Livingstone, M. S. (2012) · Cancer Research · doi:10.1158/0008-5472.can-12-0128 · Cited by 600

Scanning ultrasound removes amyloid-β and restores memory in an Alzheimer’s disease mouse model

Leinenga, G., & Götz, J. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aaa2512 · Cited by 498

Blood-brain barrier disruption with focused ultrasound enhances delivery of chemotherapeutic drugs for glioblastoma treatment.

Liu, H.-L., Hua, M., Chen, P.-Y., Chu, P.-C., Pan, C.-H., Yang, H.-W., Huang, C.-Y., Wang, J.-J., Yen, T., & Wei, K.-C. (2010) · Radiology · doi:10.1148/radiol.10090699 · Cited by 387

Amyloid-β plaque reduction, endogenous antibody delivery and glial activation by brain-targeted, transcranial focused ultrasound

Jordão, J. F., Thévenot, E., Markham-Coultes, K., Scarcelli, T., Weng, Y.-Q., Xhima, K., O'Reilly, M., Huang, Y., McLaurin, J., Hynynen, K., et al. (2013) · Experimental Neurology · doi:10.1016/j.expneurol.2013.05.008 · Cited by 326

Improved Anti-Tumor Effect of Liposomal Doxorubicin After Targeted Blood-Brain Barrier Disruption by MRI-Guided Focused Ultrasound in Rat Glioma

Treat, L. H., McDannold, N. J., Zhang, Y., Vykhodtseva, N. I., & Hynynen, K. (2012) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2012.04.015 · Cited by 296

Recent advances in ultrasound-based diagnosis and therapy with micro- and nanometer-sized formulations

Güvener, N., Appold, L. C., Lorenzi, F. D., Golombek, S. K., Rizzo, L. Y., Lammers, T., & Kiessling, F. M. (2017) · Methods · doi:10.1016/j.ymeth.2017.05.018 · Cited by 100

Acoustic properties across the human skull

Riis, T. S., Webb, T. D., & Kubanek, J. (2021) · Ultrasonics · doi:10.1016/j.ultras.2021.106591 · Cited by 100

Ultrasound for the Brain: A Review of Physical and Engineering Principles, and Clinical Applications

Qiu, W., Bouakaz, A., Konofagou, E. E., & Zheng, H. (2020) · IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control · doi:10.1109/tuffc.2020.3019932 · Cited by 99

Feedback control of microbubble cavitation for ultrasound-mediated blood–brain barrier disruption in non-human primates under magnetic resonance guidance

Kamimura, H. A. S., Flament, J., Valette, J., Cafarelli, A., Badin, R. A., Hantraye, P., & Larrat, B. (2018) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x17753514 · Cited by 98

Ultrasound targeted CNS gene delivery for Parkinson's disease treatment

Fan, C.-H., Lin, C.-Y., Liu, H.-L., & Yeh, C.-K. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.07.004 · Cited by 97

Microbubbles and Nanobubbles with Ultrasound for Systemic Gene Delivery

Endo‐Takahashi, Y., & Negishi, Y. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12100964 · Cited by 97

Applications of Focused Ultrasound for the Treatment of Glioblastoma: A New Frontier

Hersh, A. M., Bhimreddy, M., Weber-Levine, C., Jiang, K., Alomari, S., Theodore, N., Manbachi, A., & Tyler, B. (2022) · Cancers · doi:10.3390/cancers14194920 · Cited by 97

Focused Ultrasound Strategies for Brain Tumor Therapy

Bunevičius, A., McDannold, N. J., & Golby, A. J. (2019) · Operative Neurosurgery · doi:10.1093/ons/opz374 · Cited by 101

Engineering challenges for brain tumor immunotherapy

Lyon, J. G., Mokarram, N., Saxena, T. K., Carroll, S. L., & Bellamkonda, R. V. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2017.06.006 · Cited by 102

Challenges in glioblastoma immunotherapy: mechanisms of resistance and therapeutic approaches to overcome them

Habashy, K. J., Mansour, R., Moussalem, C., Sawaya, R., & Massaad, M. J. (2022) · British Journal of Cancer · doi:10.1038/s41416-022-01864-w · Cited by 95

Evaluating the safety profile of focused ultrasound and microbubble-mediated treatments to increase blood-brain barrier permeability

McMahon, D., Poon, C., & Hynynen, K. (2019) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2019.1567490 · Cited by 95

Chemotherapy sensitization of glioblastoma by focused ultrasound-mediated delivery of therapeutic liposomes

Papachristodoulou, A., Signorell, R. D., Werner, B., Brambilla, D., Luciani, P., Çavuşoğlu, M., Grandjean, J., Silginer, M., Rudin, M., Martin, E., et al. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2018.12.009 · Cited by 93

How to Make Anticancer Drugs Cross the Blood–Brain Barrier to Treat Brain Metastases

Angeli, E., Nguyen, T. T., Janin, A., & Bousquet, G. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms21010022 · Cited by 93

Optical blood-brain-tumor barrier modulation expands therapeutic options for glioblastoma treatment

Cai, Q., Li, X., Xiong, H., Fan, H., Gao, X., Vemireddy, V., Margolis, R., Li, J., Ge, X., Giannotta, M., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-40579-1 · Cited by 95

Ultrasound Improves the Delivery and Therapeutic Effect of Nanoparticle-Stabilized Microbubbles in Breast Cancer Xenografts

Snipstad, S., Berg, S., Mørch, Y. A., Bjørkøy, A., Sulheim, E., Hansen, R., Grimstad, I. H., van Wamel, A. J. E. T., Maaland, A. F., TORP, S. H., et al. (2017) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2017.06.029 · Cited by 96

Rapid Short-pulse Ultrasound Delivers Drugs Uniformly across the Murine Blood-Brain Barrier with Negligible Disruption

Morse, S. V., Pouliopoulos, A. N., Chan, T. G., Copping, M. J., Lin, J., Long, N. J., & Choi, J. J. (2019) · Radiology · doi:10.1148/radiol.2019181625 · Cited by 91

Temporary blood–brain barrier disruption by low intensity pulsed ultrasound increases carboplatin delivery and efficacy in preclinical models of glioblastoma

Dréan, A., Lemaire, N., Bouchoux, G., Goldwirt, L., Canney, M. S., Goli, L., Bouzidi, A., Schmitt, C., Guehennec, J., Verreault, M., et al. (2019) · Journal of Neuro-Oncology · doi:10.1007/s11060-019-03204-0 · Cited by 90

Focused ultrasound mediated blood–brain barrier opening is safe and feasible in a murine pontine glioma model

Englander, Z. K., Wei, H.-J., Pouliopoulos, A. N., Bendau, E. V., Upadhyayula, P. S., Jan, C., Spinazzi, E. F., Yoh, N. T., Tazhibi, M., McQuillan, N., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-85180-y · Cited by 90

Ultrasound Contrast Imaging: Fundamentals and Emerging Technology

Yusefi, H., & Helfield, B. L. (2022) · Frontiers in Physics · doi:10.3389/fphy.2022.791145 · Cited by 90

Oncolytic Viro-Immunotherapy: An Emerging Option in the Treatment of Gliomas

Zeng, J., Li, X., Sander, M., Zhang, H., Yan, G., & Lin, Y. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.721830 · Cited by 89

Clinical Intervention Using Focused Ultrasound (FUS) Stimulation of the Brain in Diverse Neurological Disorders

Baek, H., Lockwood, D. S., Mason, E. J., Obusez, E. C., Poturalski, M. J., Rammo, R. A., Nagel, S. J., & Jones, S. E. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.880814 · Cited by 90

Updates in IDH-Wildtype Glioblastoma

Melhem, J. M., Detsky, J. S., Lim-Fat, M. J., & Perry, J. (2022) · Neurotherapeutics · doi:10.1007/s13311-022-01251-6 · Cited by 101

An Emerging Era: Conformable Ultrasound Electronics

Zhang, L., Du, W., Kim, J., Yu, C., & Dağdeviren, C. (2023) · Advanced Materials · doi:10.1002/adma.202307664 · Cited by 90

Current status and future perspectives of sonodynamic therapy in glioma treatment.

Wang, X., Jia, Y., Wang, P., Liu, Q., & Zheng, H. (2017) · Ultrasonics Sonochemistry · doi:10.1016/j.ultsonch.2017.02.020 · Cited by 86

Neuronavigation-guided focused ultrasound (NaviFUS) for transcranial blood-brain barrier opening in recurrent glioblastoma patients: clinical trial protocol

Chen, K., Lin, Y.-J., Chai, W., Lin, C.-J., Chen, P., Huang, C.-Y., Kuo, J. S., Liu, H.-L., & Wei, K. (2020) · Annals of Translational Medicine · doi:10.21037/atm-20-344 · Cited by 84

Inflammatory Mediators in Glioma Microenvironment Play a Dual Role in Gliomagenesis and Mesenchymal Stem Cell Homing: Implication for Cellular Therapy

Al‐kharboosh, R., ReFaey, K., Lara-Velazquez, M. A., Grewal, S. S., Imitola, J., & Quiñones-Hinojosa, A. (2020) · Mayo Clinic Proceedings Innovations Quality & Outcomes · doi:10.1016/j.mayocpiqo.2020.04.006 · Cited by 87

Recent Advances on Ultrasound Contrast Agents for Blood-Brain Barrier Opening with Focused Ultrasound

Dauba, A., Delalande, A., Kamimura, H. A. S., Conti, A., Larrat, B., Tsapis, N., & Novell, A. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12111125 · Cited by 83

Safety evaluation of a clinical focused ultrasound system for neuronavigation guided blood-brain barrier opening in non-human primates

Pouliopoulos, A. N., Kwon, N., Jensen, G., Meaney, A., Niimi, Y., Burgess, M. T., Ji, R., McLuckie, A. J., Muñoz, F., Kamimura, H. A. S., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-94188-3 · Cited by 85

Micro‐Nanocarriers Based Drug Delivery Technology for Blood‐Brain Barrier Crossing and Brain Tumor Targeting Therapy

Wang, L., Shi, Y., Jiang, J., Li, C., Zhang, H., Zhang, X., Jiang, T., Wang, L., Wang, Y., & Feng, L. (2022) · Small · doi:10.1002/smll.202203678 · Cited by 71

Highly Crystalline Multicolor Carbon Nanodots for Dual-Modal Imaging-Guided Photothermal Therapy of Glioma

Qian, M., Du, Y., Wang, S., Li, C., Jiang, H., Shi, W., Chen, J., Wang, Y., Wagner, E., & Huang, R. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b19716 · Cited by 82

Therapeutic Agent Delivery Across the Blood–Brain Barrier Using Focused Ultrasound

McMahon, D., O’Reilly, M. A., & Hynynen, K. (2021) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-062117-121238 · Cited by 83

Ultrasound Responsive Magnetic Mesoporous Silica Nanoparticle-Loaded Microbubbles for Efficient Gene Delivery

Du, M., Chen, Y., Tu, J., Liufu, C., Yu, J., Yuan, Z., Gong, X., & Chen, Z. (2020) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.0c00014 · Cited by 80

Potent Anti-seizure Effects of Locked Nucleic Acid Antagomirs Targeting miR-134 in Multiple Mouse and Rat Models of Epilepsy

Reschke, C. R., Silva, L. F. A., Norwood, B. A., Senthilkumar, K., Morris, G., Sanz‐Rodriguez, A., Conroy, R. M., Costard, L. S., Neubert, V., Bauer, S., et al. (2016) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2016.11.002 · Cited by 79

Established and Emerging Strategies for Drug Delivery Across the Blood-Brain Barrier in Brain Cancer

Parodi, A., Rudzińska, M., Deviatkin, A. A., Soond, S. M., Baldin, A. V., & Zamyatnin, A. A. (2019) · Pharmaceutics · doi:10.3390/pharmaceutics11050245 · Cited by 81

Lipid-based microbubbles and ultrasound for therapeutic application

Omata, D., Unga, J., Suzuki, R., & Maruyama, K. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.07.005 · Cited by 77

Focused ultrasound-mediated enhancement of blood-brain barrier permeability for brain tumor treatment: A systematic review of clinical trials

Zhu, H., Allwin, C., Bassous, M. G., & Pouliopoulos, A. N. (2024) · Journal of Neuro-Oncology · doi:10.1007/s11060-024-04795-z · Cited by 75

Ultrasound as a versatile tool for short- and long-term improvement and monitoring of brain function

Blackmore, D. G., Razansky, D., & Götz, J. (2023) · Neuron · doi:10.1016/j.neuron.2023.02.018 · Cited by 75

Ultrasound‐Triggered Enzymatic Gelation

Nele, V., Schutt, C. E., Wojciechowski, J. P., Kit‐Anan, W., Doutch, J., Armstrong, J. P. K., & Stevens, M. M. (2020) · Advanced Materials · doi:10.1002/adma.201905914 · Cited by 74

Blood–brain barrier opening by intracarotid artery hyperosmolar mannitol induces sterile inflammatory and innate immune responses

Burks, S. R., Kersch, C. N., Witko, J. A., Pagel, M. A., Sundby, M., Muldoon, L. L., Neuwelt, E. A., & Frank, J. A. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2021915118 · Cited by 76

Amelioration of the nigrostriatal pathway facilitated by ultrasound-mediated neurotrophic delivery in early Parkinson's disease

Karakatsani, M. E., Wang, S., Samiotaki, G., Kugelman, T., Olumolade, O., Acosta, C., Sun, T., Han, Y., Kamimura, H. A. S., Jackson-Lewis, V. R., et al. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2019.03.030 · Cited by 76

Pilot study of repeated blood-brain barrier disruption in patients with mild Alzheimer’s disease with an implantable ultrasound device

Epelbaum, S., Burgos, N., Canney, M., Matthews, D., Houot, M., Santin, M. D., Desseaux, C., Bouchoux, G., Stroer, S., Martin, C., et al. (2022) · Alzheimer's Research & Therapy · doi:10.1186/s13195-022-00981-1 · Cited by 72

Radiation Dose‐Enhancement Is a Potent Radiotherapeutic Effect of Rare‐Earth Composite Nanoscintillators in Preclinical Models of Glioblastoma

Bulin, A., Broekgaarden, M., Chaput, F., Baisamy, V., Garrevoet, J., Busser, B., Brückner, D., Youssef, A., Ravanat, J., Dujardin, C., et al. (2020) · Advanced Science · doi:10.1002/advs.202001675 · Cited by 74

Low-Intensity Continuous Ultrasound Therapies—A Systematic Review of Current State-of-the-Art and Future Perspectives

Uddin, S. M. Z., Komatsu, D. E., Motyka, T. M., & Petterson, S. C. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10122698 · Cited by 73

Focused Ultrasound Combined with Microbubbles in Central Nervous System Applications

Chen, K., Wei, K., & Liu, H. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13071084 · Cited by 77

Comprehensive review on ultrasound-responsive theranostic nanomaterials: mechanisms, structures and medical applications

Fateh, S. T., Moradi, L., Kohan, E., Hamblin, M. R., & Dezfuli, A. S. (2021) · Beilstein Journal of Nanotechnology · doi:10.3762/bjnano.12.64 · Cited by 73

Sonobiopsy for minimally invasive, spatiotemporally-controlled, and sensitive detection of glioblastoma-derived circulating tumor DNA

Pacia, C. P., Yuan, J., Yue, Y., Xu, L., Nazeri, A., Desai, R. R., Gach, H. M., Wang, X., Talcott, M., Chaudhuri, A. A., et al. (2021) · Theranostics · doi:10.7150/thno.65597 · Cited by 71

MicroRNA-Based Drugs for Brain Tumors

Anthiya, S., Griveau, A., Loussouarn, C., Baril, P., Garnett, M. C., Issartel, J., & Garcion, E. (2018) · Trends in cancer · doi:10.1016/j.trecan.2017.12.008 · Cited by 72

Metal-involved theranostics: An emerging strategy for fighting Alzheimer’s disease

Wang, X., Wang, X., & Guo, Z. (2018) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2018.03.010 · Cited by 72

Reverse engineering the ultrasound contrast agent

Borden, M. A., & Song, K.-H. (2018) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2018.10.004 · Cited by 71

Boosting RNAi therapy for orthotopic glioblastoma with nontoxic brain-targeting chimaeric polymersomes

Shi, Y., Jiang, Y., Cao, J., Yang, W., Zhang, J., Meng, F., & Zhong, Z. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2018.10.034 · Cited by 72

An Advanced In Situ Magnetic Resonance Imaging and Ultrasonic Theranostics Nanocomposite Platform: Crossing the Blood–Brain Barrier and Improving the Suppression of Glioblastoma Using Iron-Platinum Nanoparticles in Nanobubbles

Chan, M., Chen, W., Li, C., Fang, C., Chang, Y., Wei, D., Liu, R., & Hsiao, M. (2021) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.1c04990 · Cited by 70

Delivery of therapeutic oligonucleotides in nanoscale

Wu, L., Zhou, W., Lin, L., Chen, A., Feng, J. C., Qu, X., Zhang, H., & Yue, J. (2021) · Bioactive Materials · doi:10.1016/j.bioactmat.2021.05.038 · Cited by 72

Cyclic jetting enables microbubble-mediated drug delivery

Cattaneo, M., Guerriero, G., Shakya, G., Krattiger, L. A., Paganella, L. G., Narciso, M., & Supponen, O. (2025) · Nature Physics · doi:10.1038/s41567-025-02785-0 · Cited by 70

MiR-584-5p potentiates vincristine and radiation response by inducing spindle defects and DNA damage in medulloblastoma

Abdelfattah, N., Rajamanickam, S., Subbarayalu, P., Timilsina, S., Yadav, P., Onyeagucha, B. C., Garcia, M., Vadlamudi, R. K., Chen, Y., Brenner, A. J., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-06808-8 · Cited by 68

Recent Advances in the Use of Focused Ultrasound for Magnetic Resonance Image-Guided Therapeutic Nanoparticle Delivery to the Central Nervous System

Fisher, D. G., & Price, R. J. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.01348 · Cited by 70

Addressing BBB Heterogeneity: A New Paradigm for Drug Delivery to Brain Tumors

Griffith, J. I. G., Rathi, S., Zhang, W., Zhang, W., Drewes, L. R., Sarkaria, J. N., & Elmquist, W. F. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12121205 · Cited by 68

Magnetic Resonance-Guided Focused Ultrasound : Current Status and Future Perspectives in Thermal Ablation and Blood-Brain Barrier Opening

Lee, E., Fomenko, A., & Lozano, A. M. (2019) · Journal of Korean Neurosurgical Society · doi:10.3340/jkns.2018.0180 · Cited by 70

What scans we will read: imaging instrumentation trends in clinical oncology

Beyer, T., Bidaut, L. M., Dickson, J. C., Kachelrieß, M., Kiessling, F. M., Leitgeb, R. A., Ma, J., Sundar, L. K. S., Theek, B., & Mawlawi, O. R. (2020) · Cancer Imaging · doi:10.1186/s40644-020-00312-3 · Cited by 75

Current clinical investigations of focused ultrasound blood-brain barrier disruption: A review

Durham, P. G., Butnariu, A., Alghorazi, R., Pinton, G., Krishna, V., & Dayton, P. A. (2024) · Neurotherapeutics · doi:10.1016/j.neurot.2024.e00352 · Cited by 67

Characterizing Focused-Ultrasound Mediated Drug Delivery to the Heterogeneous Primate Brain In Vivo with Acoustic Monitoring

Wu, S.-Y., Sánchez, C. S., Samiotaki, G., Buch, A., Ferrera, V. P., & Konofagou, E. E. (2016) · Scientific Reports · doi:10.1038/srep37094 · Cited by 70

Investigation of the Safety of Focused Ultrasound-Induced Blood-Brain Barrier Opening in a Natural Canine Model of Aging

O’Reilly, M. A., Jones, R. M., Barrett, E. G., Schwab, A., Head, E., & Hynynen, K. (2017) · Theranostics · doi:10.7150/thno.20621 · Cited by 68

On glioblastoma and the search for a cure: where do we stand?

Bianco, J. I., Bastiancich, C., Jankovski, A., Rieux, A. D., Véronique Préat, A., & Danhier, F. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2483-3 · Cited by 72

Perspectives on Recent Progress in Focused Ultrasound Immunotherapy

Sheybani, N., & Price, R. J. (2019) · Theranostics · doi:10.7150/thno.37131 · Cited by 65

The effect of thermal therapy on the blood-brain barrier and blood-tumor barrier

Patel, B., Yang, P. H., & Kim, A. H. (2020) · International Journal of Hyperthermia · doi:10.1080/02656736.2020.1783461 · Cited by 63

Modulating the Blood–Brain Barrier: A Comprehensive Review

Whelan, R., Hargaden, G. C., & Knox, A. J. S. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13111980 · Cited by 65

“Focused Ultrasound-mediated Drug Delivery in Humans – a Path Towards Translation in Neurodegenerative Diseases”

Wasielewska, J. M., & White, A. R. (2022) · Pharmaceutical Research · doi:10.1007/s11095-022-03185-2 · Cited by 67

Application of Ultrasound Combined with Microbubbles for Cancer Therapy

Sharma, D., Leong, K. X., & Czarnota, G. J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23084393 · Cited by 63

Neuroinflammation associated with ultrasound-mediated permeabilization of the blood–brain barrier

Jung, O., Thomas, A., Burks, S. R., Dustin, M. L., Frank, J. A., Ferrer, M., & Stride, E. (2022) · Trends in Neurosciences · doi:10.1016/j.tins.2022.03.003 · Cited by 63

Emerging principles of brain immunology and immune checkpoint blockade in brain metastases

Fares, J., Ulasov, I. V., Timashev, P. S., & Lesniak, M. S. (2021) · Brain · doi:10.1093/brain/awab012 · Cited by 63

Probing the pressure dependence of sound speed and attenuation in bubbly media: Experimental observations, a theoretical model and numerical calculations

Sojahrood, A. J., Li, Q., Haghi, H., Karshafian, R., Porter, T. M., & Kolios, M. C. (2023) · Ultrasonics Sonochemistry · doi:10.1016/j.ultsonch.2023.106319 · Cited by 62

Ultrasound-induced blood-brain barrier disruption for the treatment of gliomas and other primary CNS tumors

Beccaria, K., Canney, M. S., Bouchoux, G., Desseaux, C., Grill, J., Heimberger, A. B., & Carpentier, A. C. (2020) · Cancer Letters · doi:10.1016/j.canlet.2020.02.013 · Cited by 62

The Monoterpenoid Perillyl Alcohol: Anticancer Agent and Medium to Overcome Biological Barriers

Chen, T. C., da Fonseca, C. O., Levin, D., & Schönthal, A. H. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13122167 · Cited by 62

Current and emerging brain applications of MR-guided focused ultrasound

Meng, Y., Suppiah, S., Mithani, K., Solomon, B., Schwartz, M. L., & Lipsman, N. (2017) · Journal of Therapeutic Ultrasound · doi:10.1186/s40349-017-0105-z · Cited by 62

Micro/nanosystems for controllable drug delivery to the brain

Tian, M., Ma, Z., & Yang, G. (2023) · The Innovation · doi:10.1016/j.xinn.2023.100548 · Cited by 64

Achieving Spatial and Molecular Specificity with Ultrasound-Targeted Biomolecular Nanotherapeutics

Szablowski, J. O., Bar‐Zion, A., & Shapiro, M. G. (2019) · Accounts of Chemical Research · doi:10.1021/acs.accounts.9b00277 · Cited by 60

Technical Principles and Clinical Workflow of Transcranial MR-Guided Focused Ultrasound

Meng, Y., Jones, R. M., Davidson, B., Huang, Y., Pople, C. B., Surendrakumar, S., Hamani, C., Hynynen, K., & Lipsman, N. (2020) · Stereotactic and Functional Neurosurgery · doi:10.1159/000512111 · Cited by 59

Ultrasound-mediated disruption of the blood tumor barrier for improved therapeutic delivery

Arsiwala, T. A., Sprowls, S. A., Blethen, K. E., Adkins, C. E., Saralkar, P. A., Fladeland, R. A., Pentz, W. H., Gabriele, A., Kielkowski, B. N., Mehta, R. I., et al. (2021) · Neoplasia · doi:10.1016/j.neo.2021.04.005 · Cited by 61

Establishing sheep as an experimental species to validate ultrasound-mediated blood-brain barrier opening for potential therapeutic interventions

Pelekanos, M., Leinenga, G., Odabaee, M., Odabaee, M., Saifzadeh, S., Steck, R., & Götz, J. (2018) · Theranostics · doi:10.7150/thno.22852 · Cited by 58

Adeno-associated virus vector delivery to the brain: Technology advancements and clinical applications

Ye, D., Chukwu, C., Yang, Y., Hu, Z., & Chen, H. (2024) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2024.115363 · Cited by 60

Translation of focused ultrasound for blood-brain barrier opening in glioma

Brighi, C., Salimova, E., de Veer, M., Puttick, S. G., & Egan, G. F. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.03.035 · Cited by 57

Applications of Focused Ultrasound in Cerebrovascular Diseases and Brain Tumors

Prada, F. U., Kalani, M. Y. S., Yağmurlu, K., Norat, P., Bene, M. D., DiMeco, F., & Kassell, N. F. (2018) · Neurotherapeutics · doi:10.1007/s13311-018-00683-3 · Cited by 57

Investigating the effects of dexamethasone on blood-brain barrier permeability and inflammatory response following focused ultrasound and microbubble exposure

McMahon, D., Oakden, W., & Hynynen, K. (2020) · Theranostics · doi:10.7150/thno.40908 · Cited by 60

Focused ultrasound for opening blood-brain barrier and drug delivery monitored with positron emission tomography

Arif, W. M., Elsinga, P. H., Gasca‐Salas, C., Versluis, M., Martínez‐Fernández, R., Dierckx, R., Borra, R., & Luurtsema, G. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.05.020 · Cited by 60

Ultrasound-mediated delivery enhances therapeutic efficacy of MMP sensitive liposomes

Olsman, M., Sereti, V., Andreassen, K. E., Snipstad, S., van Wamel, A. J. E. T., Eliasen, R., Berg, S., Urquhart, A. J., Andresen, T. L., & Davies, C. D. L. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.06.024 · Cited by 59

Overcoming the blood brain barrier in glioblastoma: Status and future perspective

Ahmed, M. H., Canney, M. S., Carpentier, A. C., & Idbaïh, A. (2023) · Revue Neurologique · doi:10.1016/j.neurol.2023.03.013 · Cited by 56

ROS regulation in gliomas: implications for treatment strategies

Yang, Y.-C., Zhu, Y., Sun, S.-J., Zhao, C.-J., Bai, Y., Wang, J., & Ma, L. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1259797 · Cited by 56

Microbubble-enhanced transcranial focused ultrasound with temozolomide for patients with high-grade glioma (BT008NA): a multicentre, open-label, phase 1/2 trial

Woodworth, G. F., Anastasiadis, P., Ozair, A., Chabros, J., Bettegowda, C., Chen, C., Gerstl, J. V. E., Douville, C. B., Mekary, R. A., Smith, T. R., et al. (2025) · The Lancet Oncology · doi:10.1016/s1470-2045(25)00492-9 · Cited by 56

Effects of contrast-enhanced ultrasound treatment on neoadjuvant chemotherapy in breast cancer

Rix, A., Piepenbrock, M., Flege, B., von Stillfried, S. F., Koczera, P., Opacic, T., Simons, N., Boor, P., Thoröe‐Boveleth, S., Deckers, R., et al. (2021) · Theranostics · doi:10.7150/thno.64767 · Cited by 55

Amyloid-β and Tau in Alzheimer’s Disease: Novel Pathomechanisms and Non-Pharmacological Treatment Strategies

Nisbet, R. M., & Götz, J. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-179907 · Cited by 57

Sonolucent Cranial Implants: Cadaveric Study and Clinical Findings Supporting Diagnostic and Therapeutic Transcranioplasty Ultrasound

Belzberg, M., Shalom, N. B., Yuhanna, E., Manbachi, A., Tekes, A., Huang, J., Brem, H., & Gordon, C. R. (2019) · Journal of Craniofacial Surgery · doi:10.1097/scs.0000000000005454 · Cited by 55

ImmunoPET-informed sequence for focused ultrasound-targeted mCD47 blockade controls glioma

Sheybani, N., Breza, V. R., Paul, S., McCauley, K. S., Berr, S. S., Miller, G. W., Neumann, K. D., & Price, R. J. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.01.023 · Cited by 56

Acoustically-Stimulated Nanobubbles: Opportunities in Medical Ultrasound Imaging and Therapy

Helfield, B. L., Zou, Y., & Matsuura, N. (2021) · Frontiers in Physics · doi:10.3389/fphy.2021.654374 · Cited by 54

Inducible endothelial leakiness in nanotherapeutic applications

Ni, N., Wang, W., Sun, Y., Sun, X. J., & Leong, D. T. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2022.121640 · Cited by 54

Optical neuromodulation at all scales: from nanomaterials to wireless optoelectronics and integrated systems

Karatum, O., Gwak, M.-J., Hyun, J., Önal, A., Koirala, G. R., Kim, T., & Nizamoğlu, S. (2023) · Chemical Society Reviews · doi:10.1039/d2cs01020h · Cited by 54

Theranostics in the vasculature: bioeffects of ultrasound and microbubbles to induce vascular shutdown

Padilla, F. R., Brenner, J., Prada, F. U., & Klibanov, A. L. (2023) · Theranostics · doi:10.7150/thno.70372 · Cited by 54

Modulating cancer mechanopathology to restore vascular function and enhance immunotherapy

Mpekris, F., Panagi, M., Charalambous, A., Voutouri, C., & Stylianopoulos, T. (2024) · Cell Reports Medicine · doi:10.1016/j.xcrm.2024.101626 · Cited by 55

Influence of Nanobubble Concentration on Blood–Brain Barrier Opening Using Focused Ultrasound Under Real-Time Acoustic Feedback Control

Cheng, B., Bing, C., Xi, Y., Shah, B., Exner, A. A., & Chopra, R. (2019) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2019.03.016 · Cited by 58

Multimodal and multiscale optical imaging of nanomedicine delivery across the blood-brain barrier upon sonopermeation

May, J., Golombek, S. K., Baues, M., Dasgupta, A., Drude, N., Rix, A., Rommel, D., von Stillfried, S. F., Appold, L. C., Pola, R., et al. (2020) · Theranostics · doi:10.7150/thno.41161 · Cited by 54

Ultrafast three-dimensional microbubble imaging in vivo predicts tissue damage volume distributions during nonthermal brain ablation

Jones, R. M., McMahon, D., & Hynynen, K. (2020) · Theranostics · doi:10.7150/thno.47281 · Cited by 54

Safety and Feasibility of Repeated and Transient Blood–Brain Barrier Disruption by Pulsed Ultrasound in Patients with Recurrent Glioblastoma

Idbaïh, A., Canney, M. S., Belin, L., Desseaux, C., Vignot, A., Bouchoux, G., Asquier, N., Law-Ye, B., Leclercq, D., Bissery, A., et al. (2019) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-18-3643 · Cited by 367

Temporary disruption of the blood-brain barrier using an implantable ultrasound system for recurrent glioblastoma patients under IV carboplatin chemotherapy: initial phase 1/2a clinical trial observations

Carpentier, A. C., Canney, M. S., Vignot, A., Horodyckid, C., Goldwirt, L., Leclercq, D., Delattre, J., Chapelon, J., & Idbaïh, A. (2015) · Journal of Therapeutic Ultrasound · doi:10.1186/2050-5736-3-s1-o14 · Cited by 11

A phase I/IIa study to evaluate the safety and efficacy of blood-brain barrier (BBB) opening with the SonoCloud-9 implantable ultrasound device in recurrent glioblastoma patients receiving IV carboplatin.

Idbaïh, A., Ducray, F., Stupp, R., Baize, N., Chinot, O. L., Groot, J. F. D., Guyotat, J., Sonabend, A. M., Meneï, P., Dufour, H., et al. (2021) · Journal of Clinical Oncology · doi:10.1200/jco.2021.39.15_suppl.2049 · Cited by 11

News in brief

(2016) · The Lancet Neurology · doi:10.1016/s1474-4422(16)30136-3

OS07.3.A Phase 1/2 clinical trial of blood-brain barrier opening with the SonoCloud-9 implantable ultrasound device in recurrent glioblastoma patients receiving IV carboplatin

Idbaïh, A., Sonabend, A. M., Stupp, R., Chinot, O. L., Dufour, H., Ducray, F., Meneï, P., de Groot, J., Desseaux, C., & Carpentier, A. C. (2022) · Neuro-Oncology · doi:10.1093/neuonc/noac174.048 · Cited by 2