Clinical trial of blood-brain barrier disruption by pulsed ultrasound

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Accelerated Titration Designs for Phase I Clinical Trials in Oncology

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Temporary Disruption of the Blood–Brain Barrier by Use of Ultrasound and Microbubbles: Safety and Efficacy Evaluation in Rhesus Macaques

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Scanning ultrasound removes amyloid-β and restores memory in an Alzheimer’s disease mouse model

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Blood-brain barrier disruption with focused ultrasound enhances delivery of chemotherapeutic drugs for glioblastoma treatment.

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Amyloid-β plaque reduction, endogenous antibody delivery and glial activation by brain-targeted, transcranial focused ultrasound

Jordão, J. F., Thévenot, E., Markham-Coultes, K., Scarcelli, T., Weng, Y.-Q., Xhima, K., O'Reilly, M., Huang, Y., McLaurin, J., Hynynen, K., et al. (2013) · Experimental Neurology · doi:10.1016/j.expneurol.2013.05.008 · Cited by 326

Improved Anti-Tumor Effect of Liposomal Doxorubicin After Targeted Blood-Brain Barrier Disruption by MRI-Guided Focused Ultrasound in Rat Glioma

Treat, L. H., McDannold, N. J., Zhang, Y., Vykhodtseva, N. I., & Hynynen, K. (2012) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2012.04.015 · Cited by 296

Theranostic Trigger‐Responsive Carbon Monoxide‐Generating Microbubbles

Pathak, V., Roemhild, K., Schipper, S., Groß‐Weege, N., Nolte, T., Ruetten, S., Buhl, E. M., Elshafei, A. S., Weiler, M., Märtin, L., et al. (2022) · Small · doi:10.1002/smll.202200924 · Cited by 30

Cardiac-targeted delivery of nuclear receptor RORα via ultrasound targeted microbubble destruction optimizes the benefits of regular dose of melatonin on sepsis-induced cardiomyopathy

Wang, S., Chen, K., Wang, Y., Wang, Z., Li, Z., Guo, J., Chen, J., Liu, W., Guo, X., Yan, G., et al. (2023) · Biomaterials Research · doi:10.1186/s40824-023-00377-8 · Cited by 30

Brain Metastasis Treatment: The Place of Tyrosine Kinase Inhibitors and How to Facilitate Their Diffusion across the Blood–Brain Barrier

Angeli, E., & Bousquet, G. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13091446 · Cited by 30

Magnetic mediators for ultrasound theranostics

Józefczak, A., Kaczmarek, K., & Bielas, R. (2021) · Theranostics · doi:10.7150/thno.62218 · Cited by 29

Perfluorocarbon Nanodroplets as Potential Nanocarriers for Brain Delivery Assisted by Focused Ultrasound-Mediated Blood–Brain Barrier Disruption

Bérard, C., Desgranges, S., Dumas, N., Novell, A., Larrat, B., Hamimed, M., Taulier, N., Estève, M., Corréard, F., & Contino-Pepin, C. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14071498 · Cited by 30

Ultrasound-excited temozolomide sonosensitization induces necroptosis in glioblastoma

Wang, F., Xu, L., Wen, B., Song, S., Zhou, Y., Wu, H., Wu, Q., Wang, Y., Tong, X., & Yan, H. (2022) · Cancer Letters · doi:10.1016/j.canlet.2022.216033 · Cited by 29

Nanotechnology in Stroke: New Trails with Smaller Scales

Toljan, K., Ashok, A., Labhasetwar, V. D., & Hussain, M. S. (2023) · Biomedicines · doi:10.3390/biomedicines11030780 · Cited by 29

Minireview: Biophysical Mechanisms of Cell Membrane Sonopermeabilization. Knowns and Unknowns

Escoffre, J., & Bouakaz, A. (2018) · Langmuir · doi:10.1021/acs.langmuir.8b03538 · Cited by 29

Ultrasound-Induced Blood–Spinal Cord Barrier Opening in Rabbits

Montero, A.-S., Bielle, F., Goldwirt, L., Lalot, A., Bouchoux, G., Canney, M. S., Belin, F., Beccaria, K., Pradat, P., Salachas, F., et al. (2019) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2019.05.022 · Cited by 29

Low-frequency ultrasound-mediated blood-brain barrier opening enables non-invasive lipid nanoparticle RNA delivery to glioblastoma

Elbaz, M., Ad-El, N., Chulanova, Y., Brier, D., Goldsmith, M., Bismuth, M., Brosque, A., Sher, D., Gutkin, A., Bar-On, D., et al. (2025) · doi:10.1101/2025.01.23.634427 · Cited by 28

A Role for the Drosophila Blood-Brain Barrier in the Regulation of Sleep

Axelrod, S., Li, X., Sun, Y., Lincoln, S., Terceros, A. A., O'Neil, J. L., Wang, Z., Nguyen, A. D., Vora, A., Spicer, C., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2309331120 · Cited by 29

Laser-activated perfluorocarbon nanodroplets: a new tool for blood brain barrier opening

Hallam, K. A., Donnelly, E. M., Karpiouk, A. B., Hartman, R. K., & Emelianov, S. (2018) · Biomedical Optics Express · doi:10.1364/boe.9.004527 · Cited by 28

Magnetic Resonance Imaging-Guided Focused Ultrasound-Based Delivery of Radiolabeled Copper Nanoclusters to Diffuse Intrinsic Pontine Glioma

Zhang, X., Ye, D., Yang, L., Yue, Y., Sultan, D. H., Pacia, C. P., Pang, H., Detering, L., Heo, G. S., Luehmann, H. P., et al. (2020) · ACS Applied Nano Materials · doi:10.1021/acsanm.0c02297 · Cited by 28

Novel Cranial Implants of Yttria‐Stabilized Zirconia as Acoustic Windows for Ultrasonic Brain Therapy

Gutiérrez, M. I., Penilla, E. H., Leija, L., Vera, A., Garay, J. E., & Aguilar, G. (2017) · Advanced Healthcare Materials · doi:10.1002/adhm.201700214 · Cited by 28

Dynamic nanoassemblies for imaging and therapy of neurological disorders

Zhang, L., Sun, H., Zhao, J., Lee, J., Low, L. E., Gong, L., Chen, Y., Wang, N., Zhu, C., Lin, P., et al. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.113832 · Cited by 27

Static Magnetic Fields Dampen Focused Ultrasound–mediated Blood-Brain Barrier Opening

Yang, Y., Pacia, C. P., Ye, D., Yue, Y., Chien, C.-Y., & Chen, H. (2021) · Radiology · doi:10.1148/radiol.2021204441 · Cited by 27

An Affordable and Easy-to-Use Focused Ultrasound Device for Noninvasive and High Precision Drug Delivery to the Mouse Brain

Hu, Z., Chen, S., Yang, Y., Gong, Y., & Chen, H. (2022) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2022.3150781 · Cited by 27

Emerging strategies for delivering antiangiogenic therapies to primary and metastatic brain tumors

Askoxylakis, V., Arvanitis, C., Wong, C. S. F., Ferraro, G. B., & Jain, R. K. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2017.06.011 · Cited by 27

The potential for remodelling the tumour vasculature in glioblastoma

Brighi, C., Puttick, S. G., Rose, S., & Whittaker, A. K. (2018) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.10.001 · Cited by 28

Investigating the Accumulation of Submicron Phase-Change Droplets in Tumors

Helfield, B. L., Yoo, K., Liu, J., Williams, R., Sheeran, P. S., Goertz, D. E., & Burns, P. N. (2020) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2020.06.021 · Cited by 27

Targeted suppression of glioma by ultralow-dose x-ray–induced photodynamic therapy and gold-based nanoclusters in preclinical models

Li, S., Chen, S., Li, Y., Sun, W., Li, J., Deng, H., Ding, H., Wang, Z., Zhu, L., Liu, J., et al. (2025) · Science Translational Medicine · doi:10.1126/scitranslmed.adq5331 · Cited by 27

Invasive and non-invasive therapies for Alzheimer’s disease and other amyloidosis

Pandey, G., & Ramakrishnan, V. (2020) · Biophysical Reviews · doi:10.1007/s12551-020-00752-y · Cited by 26

Quantitative analysis of in-vivo microbubble distribution in the human brain

Prada, F. U., Gennari, A. G., Linville, I., Mutersbaugh, M., Chen, Z., Sheybani, N., DiMeco, F., Padilla, F. R., & Hossack, J. A. (2021) · Scientific Reports · doi:10.1038/s41598-021-91252-w · Cited by 26

Discovery of a Highly Conserved Peptide in the Iron Transporter Melanotransferrin that Traverses an Intact Blood Brain Barrier and Localizes in Neural Cells

Singh, C. S. B., Eyford, B. A., Abraham, T., Munro, L., Choi, K. B., Okon, M., Vitalis, T. Z., Gabathuler, R., Lu, C., Pfeifer, C. G., et al. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.596976 · Cited by 27

Overcoming Vascular Barriers to Improve the Theranostic Outcomes of Nanomedicines

Tang, Y., Yu, Z., Lü, X., Fan, Q., & Huang, W. (2022) · Advanced Science · doi:10.1002/advs.202103148 · Cited by 26

Involvement of Ceramide Signalling in Radiation-Induced Tumour Vascular Effects and Vascular-Targeted Therapy

Sharma, D., & Czarnota, G. J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23126671 · Cited by 28

A preliminary study of Parkinson’s gene therapy via sono-magnetic sensing gene vector for conquering extra/intracellular barriers in mice

Wu, C.-Y., Huang, R.-Y., Liao, E., Lin, Y., Ho, Y.-J., Chang, C., Chan, H., Huang, Y., Hsieh, T.-H., Fan, C., et al. (2020) · Brain stimulation · doi:10.1016/j.brs.2020.02.024 · Cited by 26

A narrative review of research progress on drug therapies for glioblastoma multiforme

Zheng, X., Tang, Q., Ren, L., Liu, J., Wan, L., Fu, W., Wang, J., & Du, G. (2021) · Annals of Translational Medicine · doi:10.21037/atm-20-8017 · Cited by 26

Nanotechnology in glioblastoma therapy: Advances in drug delivery systems and diagnostic approaches

Qindeel, M., Irfan, M., Ullah, S., Fathi‐karkan, S., Kharaba, Z. J., Rahdar, A., Aliahmad, M., & Aboudzadeh, M. A. (2024) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2024.106322 · Cited by 26

Efficient and precise delivery of microRNA by photoacoustic force generated from semiconducting polymer-based nanocarriers

Kang, T., Ni, J., Li, T., Wang, J., Li, Z., Li, Y., Zha, M., Zhang, C., Wu, X., Guo, H., et al. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.120907 · Cited by 25

The Associative Thalamus: A Switchboard for Cortical Operations and a Promising Target for Schizophrenia

Mukherjee, A., & Halassa, M. M. (2022) · The Neuroscientist · doi:10.1177/10738584221112861 · Cited by 25

MR-guided focused ultrasound–induced blood-brain barrier opening for brain metastasis: a review

Grasso, G., Torregrossa, F., Noto, M., Bruno, E., Feraco, P., Buscemi, F., Bartolotta, T. V., & Gagliardo, C. (2023) · Neurosurgical FOCUS · doi:10.3171/2023.5.focus23227 · Cited by 25

Simulating transvertebral ultrasound propagation with a multi-layered ray acoustics model

Xu, R., & O’Reilly, M. A. (2018) · Physics in Medicine and Biology · doi:10.1088/1361-6560/aacf75 · Cited by 25

Overcoming the Blood–Brain Barrier with an Implantable Ultrasound Device

Sonabend, A. M., & Stupp, R. (2019) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-19-0932 · Cited by 25

Biological Role of MYCN in Medulloblastoma: Novel Therapeutic Opportunities and Challenges Ahead

Shrestha, S., Morcavallo, A., Gorrini, C., & Chesler, L. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.694320 · Cited by 24

Sonopermeation with Nanoparticle‐Stabilized Microbubbles Reduces Solid Stress and Improves Nanomedicine Delivery to Tumors

Sulheim, E., Hanson, I., Snipstad, S., Vikedal, K., Mørch, Y. A., Boucher, Y., & Davies, C. D. L. (2021) · Advanced Therapeutics · doi:10.1002/adtp.202100147 · Cited by 25

Modifying the blood–brain barrier by targeting claudin‐5: Safety and risks

Wakayama, E., Kuzu, T., Tachibana, K., Hirayama, R., Okada, Y., & Kondoh, M. (2022) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14787 · Cited by 24

Delivery of hydroxycamptothecin via sonoporation: An effective therapy for liver fibrosis

Chen, Q., Huang, J., Ye, Y., Hu, A., Xu, B., Hu, D., Wang, L., Xing, L., Chen, S., Gui, X., et al. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.05.002 · Cited by 24

Ultrasound technology assisted colloidal nanocrystal synthesis and biomedical applications

Jiao, H., Mao, Q., Razzaq, N., Ankri, R., & Cui, J. (2024) · Ultrasonics Sonochemistry · doi:10.1016/j.ultsonch.2024.106798 · Cited by 25

Strategies for enhanced gene delivery to the central nervous system

Gao, Z. (2024) · Nanoscale Advances · doi:10.1039/d3na01125a · Cited by 26

Tumor ablation using low-intensity ultrasound and sound excitable drug

Tung, C., Han, M. S., Kim, Y., Qi, J., & O’Neill, B. E. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.05.009 · Cited by 24

An advanced focused ultrasound protocol improves the blood-brain barrier permeability and doxorubicin delivery into the rat brain

Jung, B., Huh, H., Lee, E., Han, M., & Park, J. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2019.10.044 · Cited by 24

In vitro potentiation of doxorubicin by unseeded controlled non-inertial ultrasound cavitation

Fant, C., Lafond, M., Rogez, B., Castellanos, I. M. S., Ngo, J., Mestas, J., Padilla, F. R., & Lafon, C. (2019) · Scientific Reports · doi:10.1038/s41598-019-51785-7 · Cited by 24

In vitro and in vivo characterization of a cranial window prosthesis for diagnostic and therapeutic cerebral ultrasound

Prada, F. U., Franzini, A., Moosa, S., Padilla, F. R., Moore, D., Solbiati, L., DiMeco, F., & Legon, W. (2020) · Journal of neurosurgery · doi:10.3171/2019.10.jns191674 · Cited by 24

Focused Ultrasound

MOONEN, C. T. W., Kilroy, J. P., & Klibanov, A. L. (2024) · Investigative Radiology · doi:10.1097/rli.0000000000001116 · Cited by 24

Clinical translation and landscape of stimuli-responsive nanomedicines and microscale therapeutics

Kobzev, D., Kulyk, O., Barmin, R. A., Tatarets, A. L., Pallares, R. M., Kiessling, F. M., Lammers, T., & Peña, Q. (2026) · Chemical Society Reviews · doi:10.1039/d6cs00165c · Cited by 25

Enhanced Vascular Permeability by Microbubbles and Ultrasound in Drug Delivery

Omata, D., Munakata, L., Maruyama, K., & Suzuki, R. (2021) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b21-00453 · Cited by 23

From Focused Ultrasound Tumor Ablation to Brain Blood Barrier Opening for High Grade Glioma: A Systematic Review

Paun, L., Moiraghi, A., Jannelli, G., Nouri, A., DiMeco, F., Pallud, J., Meling, T. R., Momjian, S., Schaller, K., Prada, F. U., et al. (2021) · Cancers · doi:10.3390/cancers13225614 · Cited by 23

Image-Guided Focused-Ultrasound CNS Molecular Delivery: An Implementation via Dynamic Contrast-Enhanced Magnetic-Resonance Imaging

Chai, W., Chu, P., Tsai, C.-H., Lin, C., Yang, H., Lai, H., & Liu, H.-L. (2018) · Scientific Reports · doi:10.1038/s41598-018-22571-8 · Cited by 23

Applications of Ultrasound to Stimulate Therapeutic Revascularization

Gorick, C. M., Chappell, J. C., & Price, R. J. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20123081 · Cited by 23

The effect of transcranial focused ultrasound target location on the acoustic feedback control performance during blood-brain barrier opening with nanobubbles

Cheng, B., Bing, C., & Chopra, R. (2019) · Scientific Reports · doi:10.1038/s41598-019-55629-2 · Cited by 23

Potential drug delivery nanosystems for improving tumor penetration

Peng, F., Li, R., Zhang, F., Qin, L., Ling, G., & Zhang, P. (2020) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2020.04.009 · Cited by 23

Targeting Therapeutic Antibodies to the CNS: a Comparative Study of Intrathecal, Intravenous, and Subcutaneous Anti-Nogo A Antibody Treatment after Stroke in Rats

Wahl, A.-S., Correa, D., Imobersteg, S., Maurer, M., Kaiser, J., Augath, M. A., & Schwab, M. E. (2020) · Neurotherapeutics · doi:10.1007/s13311-020-00864-z · Cited by 23

Ultrasound-Targeted Delivery Technology: A Novel Strategy for Tumor- Targeted Therapy

Du, M., Chen, Z., Chen, Y., & Li, Y. (2018) · Current Drug Targets · doi:10.2174/1389450119666180731095441 · Cited by 22

Ultrasounds induce blood–brain barrier opening across a sonolucent polyolefin plate in an in vitro isolated brain preparation

Librizzi, L., Uva, L., Raspagliesi, L., Gionso, M., Regondi, M. C., Durando, G., DiMeco, F., de Curtis, M., & Prada, F. U. (2022) · Scientific Reports · doi:10.1038/s41598-022-06791-7 · Cited by 22

Paclitaxel and Carboplatin in Combination with Low-intensity Pulsed Ultrasound for Glioblastoma

Habashy, K. J., Dmello, C., Chen, L., Arrieta, V. A., Kim, K., Gould, A., Youngblood, M. W., Bouchoux, G., Burdett, K. B., Zhang, H., et al. (2024) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-23-2367 · Cited by 22

Current Progress in Magnetic Resonance-Guided Focused Ultrasound to Facilitate Drug Delivery across the Blood-Brain Barrier

Meng, Y., Kalia, L. V., Kalia, S. K., Hamani, C., Huang, Y., Hynynen, K., Lipsman, N., & Davidson, B. (2024) · Pharmaceutics · doi:10.3390/pharmaceutics16060719 · Cited by 24

Modulators of IgG penetration through the blood-brain barrier: Implications for Alzheimer's disease immunotherapy

Finke, J. M., & Banks, W. A. (2016) · Human Antibodies · doi:10.3233/hab-160306 · Cited by 23

Preventing microbial biofilms on catheter tubes using ultrasonic guided waves

Wang, H., Teng, F., Yang, X., Guo, X., Tu, J., Zhang, C., & Zhang, D. (2017) · Scientific Reports · doi:10.1038/s41598-017-00705-8 · Cited by 22

Targeted manipulation of pain neural networks: The potential of focused ultrasound for treatment of chronic pain

Todd, N., McDannold, N. J., & Borsook, D. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.06.007 · Cited by 22

Magnetic Resonance Methods for Focused Ultrasound-Induced Blood-Brain Barrier Opening

Conti, A., Kamimura, H. A. S., Novell, A., Duggento, A., & Toschi, N. (2020) · Frontiers in Physics · doi:10.3389/fphy.2020.547674 · Cited by 22

Spatio-temporal characterization of causal electrophysiological activity stimulated by single pulse focused ultrasound: an ex vivo study on hippocampal brain slices

Castellanos, I. M. S., Dossi, E., Vion‐Bailly, J., Salette, L., Chapelon, J., Carpentier, A. C., Huberfeld, G., & N’Djin, W. A. (2021) · Journal of Neural Engineering · doi:10.1088/1741-2552/abdfb1 · Cited by 22

Transcranial focused ultrasound in the human brain

Lipsman, N., Hynynen, K., Chen, R., & Lozano, A. M. (2026) · Neuron · doi:10.1016/j.neuron.2025.11.015 · Cited by 24

Rapid identification and validation of novel targeted approaches for Glioblastoma: A combined ex vivo-in vivo pharmaco-omic model

Daher, A., & de Groot, J. (2017) · Experimental Neurology · doi:10.1016/j.expneurol.2017.09.006 · Cited by 21

Next Steps for Immunotherapy in Glioblastoma

Cao, T., Wainwright, D. A., Lee-Chang, C., Miska, J. M., Sonabend, A. M., Heimberger, A. B., & Lukas, R. V. (2022) · Cancers · doi:10.3390/cancers14164023 · Cited by 21

Translational strategies and systems biology insights for blood-brain barrier opening and delivery in brain tumors and Alzheimer’s disease

Song, G., Plumlee, P., Ahn, J. Y., Wong, S. T. C., & Zhao, H. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115450 · Cited by 22

Destabilization of amyloid fibrils on interaction with MoS 2 -based nanomaterials

Mudedla, S. K., Murugan, N. A., Subramanian, V., & Ågren, H. (2019) · RSC Advances · doi:10.1039/c8ra10184a · Cited by 21

Reversible opening of the blood-labyrinth barrier by low-pressure pulsed ultrasound and microbubbles for the treatment of inner ear diseases

He, Y., Chen, Z., Liu, Q., Li, Z., Wen, D., Zhang, H., Zhang, M., Jiang, D. M., Li, H., Wen, L., et al. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2024.06.043 · Cited by 20

Characterization of ultrasound-mediated delivery of trastuzumab to normal and pathologic spinal cord tissue

Smith, P. N., Ogrodnik, N., Satkunarajah, J., & O’Reilly, M. A. (2021) · Scientific Reports · doi:10.1038/s41598-021-83874-x · Cited by 20

Ultrasound‐targeted microbubbles destruction assists dual delivery of beta‐amyloid antibody and neural stem cells to restore neural function in transgenic mice of Alzheimer's disease

Zhu, Q., Xu, X., Chen, B., Liao, Y., Guan, X., He, Y., Cui, H., Rong, Y., Liu, Z., & Xu, Y. (2022) · Medical Physics · doi:10.1002/mp.15500 · Cited by 21

Nanotherapeutics and the Brain

Joseph, A., & Nance, E. A. (2022) · Annual Review of Chemical and Biomolecular Engineering · doi:10.1146/annurev-chembioeng-092220-030853 · Cited by 20

Use of metal-based contrast agents for in vivo MR and CT imaging of phagocytic cells in neurological pathologies

Wiart, M., Tavakoli, C., Hubert, V., Hristovska, I., Dumot, C., Parola, S., Lerouge, F., Chauveau, F., Canet‐Soulas, E., Pascual, O., et al. (2022) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2022.109729 · Cited by 20

Rapid short-pulses of focused ultrasound and microbubbles deliver a range of agent sizes to the brain

Chang, W. L. K., Chan, T. G., Raguseo, F., Mishra, A., Chattenton, D., de Rosales, R. T. M., Long, N. J., & Morse, S. V. (2023) · Scientific Reports · doi:10.1038/s41598-023-33671-5 · Cited by 20

Rotor-based image-guided therapy of glioblastoma

Pan, Z., Zeng, Y., Ye, Z., Li, Y., Wang, Y., Feng, Z., Bao, Y., Yuan, J., Cao, G., Dong, J., et al. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2024.03.020 · Cited by 20

Drug development for glioma: are we repeating the same mistakes?

Stupp, R. (2018) · The Lancet Oncology · doi:10.1016/s1470-2045(18)30827-1 · Cited by 20

Toward optimization of blood brain barrier opening induced by laser-activated perfluorocarbon nanodroplets

Hallam, K. A., & Emelianov, S. (2019) · Biomedical Optics Express · doi:10.1364/boe.10.003139 · Cited by 20

Characterization of Brain-Targeted Drug Delivery Enhanced by a Combination of Lipid-Based Microbubbles and Non-Focused Ultrasound

Omata, D., 芙美子, 萩., Munakata, L., Shima, T., Kageyama, S., Suzuki, Y., Azuma, T., Takagi, S., Seki, K., Maruyama, K., et al. (2020) · Journal of Pharmaceutical Sciences · doi:10.1016/j.xphs.2020.06.008 · Cited by 20

Immunology Meets Bioengineering: Improving the Effectiveness of Glioblastoma Immunotherapy

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A phase I/IIa study to evaluate the safety and efficacy of blood-brain barrier (BBB) opening with the SonoCloud-9 implantable ultrasound device in recurrent glioblastoma patients receiving IV carboplatin.

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News in brief

(2016) · The Lancet Neurology · doi:10.1016/s1474-4422(16)30136-3

OS07.3.A Phase 1/2 clinical trial of blood-brain barrier opening with the SonoCloud-9 implantable ultrasound device in recurrent glioblastoma patients receiving IV carboplatin

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