Clinical trial of blood-brain barrier disruption by pulsed ultrasound

Updated Response Assessment Criteria for High-Grade Gliomas: Response Assessment in Neuro-Oncology Working Group

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Accelerated Titration Designs for Phase I Clinical Trials in Oncology

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Temporary Disruption of the Blood–Brain Barrier by Use of Ultrasound and Microbubbles: Safety and Efficacy Evaluation in Rhesus Macaques

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Scanning ultrasound removes amyloid-β and restores memory in an Alzheimer’s disease mouse model

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Blood-brain barrier disruption with focused ultrasound enhances delivery of chemotherapeutic drugs for glioblastoma treatment.

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Amyloid-β plaque reduction, endogenous antibody delivery and glial activation by brain-targeted, transcranial focused ultrasound

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Improved Anti-Tumor Effect of Liposomal Doxorubicin After Targeted Blood-Brain Barrier Disruption by MRI-Guided Focused Ultrasound in Rat Glioma

Treat, L. H., McDannold, N. J., Zhang, Y., Vykhodtseva, N. I., & Hynynen, K. (2012) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2012.04.015 · Cited by 296

Ultrasound‑targeted microbubble destruction technology delivering β‑klotho to the heart enhances FGF21 sensitivity and attenuates heart remodeling post‑myocardial infarction

Yue, C., Li, R., Li, C., Yang, T., Huang, X., Lei, R., Yan, Y., Liu, Y., Li, Q., Yan, Q., et al. (2024) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2024.5378 · Cited by 18

Effect of Microbubble Size, Composition, and Multiple Sonication Points on Sterile Inflammatory Response in Focused Ultrasound-Mediated Blood–Brain Barrier Opening

Martinez, P. J., Song, J. J., Castillo, J. I., DeSisto, J. A., Song, K.-H., Green, A. L., & Borden, M. A. (2024) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.4c00777 · Cited by 18

Microbubble dynamics in brain microvessels

Bezer, J. H., Prentice, P., Chang, W. L. K., Morse, S. V., Christensen-Jeffries, K. M., Rowlands, C. J., Kozlov, A. S., & Choi, J. J. (2025) · PLoS ONE · doi:10.1371/journal.pone.0310425 · Cited by 18

CNS cancer immunity cycle and strategies to target this for glioblastoma

Ameratunga, M., Coleman, N., Welsh, L. C., Saran, F. H., & Lopez, J. S. (2018) · Oncotarget · doi:10.18632/oncotarget.24896 · Cited by 18

Therapeutic Ultrasound-Enhanced Immune Checkpoint Inhibitor Therapy

Yuan, J., Ye, D., Chen, S., & Chen, H. (2021) · Frontiers in Physics · doi:10.3389/fphy.2021.636985 · Cited by 18

Drug penetration in pediatric brain tumors: Challenges and opportunities

Patel, J. P., Spiller, S. E., & Barker, E. D. (2021) · Pediatric Blood & Cancer · doi:10.1002/pbc.28983 · Cited by 19

Brain-targeted drug delivery assisted by physical techniques and its potential applications in traditional Chinese medicine

Sun, Y., Du, L., Yang, M., Li, Q., Jia, X., Li, Q., Zhu, L., Zhang, Y., Liu, Y., & Liu, S. (2021) · Journal of Traditional Chinese Medical Sciences · doi:10.1016/j.jtcms.2021.07.003 · Cited by 18

Time-sequenced drug delivery approaches towards effective chemotherapeutic treatment of glioma

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Towards tailored management of malignant brain tumors with nanotheranostics

Aparicio-Blanco, J., & Torres‐Suárez, A. I. (2018) · Acta Biomaterialia · doi:10.1016/j.actbio.2018.04.029 · Cited by 18

Assessing central nervous system drug delivery

Hammarlund‐Udenaes, M., & Loryan, I. (2025) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2025.2462767 · Cited by 17

The promise of mitochondria in the treatment of glioblastoma: a brief review

Liang, Z., Zhao, S., Liu, Y., & Cheng, C. (2025) · Discover Oncology · doi:10.1007/s12672-025-01891-y · Cited by 17

Advancement in nanobubble technology: enhancing drug and nutraceutical delivery with focus on bioavailability, targeted therapy, safety, and sustainability

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Smart micro/nanorobots for drug delivery in the brain

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Advances in Blood-Brain Barrier Disruption to Facilitate Drug Delivery for Infiltrative Gliomas

Gould, A., Arrieta, V. A., Dmello, C., Saganty, R., Lukas, R. V., Zhang, D. Y., Heimberger, A. B., Canney, M. S., Carpentier, A. C., Desseaux, C., et al. (2023) · Advances in Oncology · doi:10.1016/j.yao.2023.01.017 · Cited by 17

Therapeutic ultrasound transducer technology and monitoring techniques: a review with clinical examples

Lafond, M., Payne, A., & Lafon, C. (2024) · International Journal of Hyperthermia · doi:10.1080/02656736.2024.2389288 · Cited by 17

Comprehensive Review on Bubbles: Synthesis, Modification, Characterization and Biomedical Applications

Fernandes, D. A. (2024) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.4c00137 · Cited by 17

Hierarchically Engineered Self-Adaptive Nanoplatform Guided Intuitive and Precision Interventions for Deep-Seated Glioblastoma

Cheng, W., Qu, H., Yang, J., Chen, H., Pan, Y., Duan, Z., & Xue, X. (2025) · ACS Nano · doi:10.1021/acsnano.4c11006 · Cited by 17

Intracerebroventricular Infusion of Gangliosides Augments the Adult Neural Stem Cell Pool in Mouse Brain

Itokazu, Y., Li, D.-P., & Yu, R. K. (2019) · ASN Neuro · doi:10.1177/1759091419884859 · Cited by 12

Immune Microenvironment Landscape in CNS Tumors and Role in Responses to Immunotherapy

Najem, H., Khasraw, M., & Heimberger, A. B. (2021) · Cells · doi:10.3390/cells10082032 · Cited by 17

Ultrasound-Enabled Therapeutic Delivery and Regenerative Medicine: Physical and Biological Perspectives

Bansal, K., Jha, C. K., Bhatia, D. D., & Shekhar, H. (2021) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.1c00276 · Cited by 17

Ultrasound and microbubble-mediated drug delivery and immunotherapy

Omata, D., Munakata, L., Maruyama, K., & Suzuki, R. (2022) · Journal of Medical Ultrasonics · doi:10.1007/s10396-022-01201-x · Cited by 17

Ultrasound-responsive micro/nanobubbles based intelligent theranostic systems for precision tumor therapy

Liu, D., Ling, Y., Liu, W., Deng, J., & Guo, Y. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03959-x · Cited by 16

A causal study of the phenomenon of ultrasound neurostimulation applied to an in vivo invertebrate nervous model

Vion‐Bailly, J., N’Djin, W. A., Castellanos, I. M. S., Mestas, J., Carpentier, A. C., & Chapelon, J. (2019) · Scientific Reports · doi:10.1038/s41598-019-50147-7 · Cited by 16

Towards standardization of the parameters for opening the blood–brain barrier with focused ultrasound to treat glioblastoma multiforme: A systematic review of the devices, animal models, and therapeutic compounds used in rodent tumor models

Thombre, R., Mess, G., Leadingham, K. M. K., Kapoor, S., Hersh, A. M., Acord, M., Kaovasia, T. P., Theodore, N., Tyler, B., & Manbachi, A. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2022.1072780 · Cited by 16

Current and Emerging Systems for Focused Ultrasound-Mediated Blood–Brain Barrier Opening

Hughes, A., Khan, D. S., & Alkins, R. D. (2023) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2023.02.017 · Cited by 16

Shell viscosity estimation of lipid-coated microbubbles

Cattaneo, M., & Supponen, O. (2023) · Soft Matter · doi:10.1039/d3sm00871a · Cited by 16

Nanosponge-mediated oligonucleotide delivery: A cutting-edge technology towards cancer management

Khairnar, P., Kolipaka, T., Pandey, G., Phatale, V., Shah, S., Srinivasarao, D. A., Saraf, S., & Srivastava, S. (2023) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2023.105226 · Cited by 16

Quality assurance for focused ultrasound-induced blood-brain barrier opening procedure using passive acoustic detection

Chien, C.-Y., Xu, L., Yuan, J., Fadera, S., Stark, A. H., Athiraman, U., Leuthardt, E. C., & Chen, H. (2024) · EBioMedicine · doi:10.1016/j.ebiom.2024.105066 · Cited by 17

Parkinson's disease gene therapy: Will focused ultrasound and nanovectors be the next frontier?

Price, R. J., Fisher, D. G., Suk, J. S., Hanes, J. S., Ko, H. S., & Kordower, J. H. (2019) · Movement Disorders · doi:10.1002/mds.27675 · Cited by 16

Prospects of biological and synthetic pharmacotherapies for glioblastoma

Altshuler, D. B., Kadiyala, P., Núñez, F. J., Núñez, F. M., Carney, S. V., Alghamri, M. S., Garcia-Fabiani, M. B., Asad, A. S., Candia, A. J. N., Candolfi, M., et al. (2020) · Expert Opinion on Biological Therapy · doi:10.1080/14712598.2020.1713085 · Cited by 16

A Comparison of Focused and Unfocused Ultrasound for Microbubble-Mediated Gene Delivery

Anderson, C. D., Walton, C. B., & Shohet, R. V. (2021) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2021.02.016 · Cited by 16

An Ultrasound-Guided Hemispherical Phased Array for Microbubble-Mediated Ultrasound Therapy

Deng, L., Yang, S. D., O'Reilly, M. A., Jones, R. M., & Hynynen, K. (2021) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2021.3132014 · Cited by 16

Combined Therapy Planning, Real-Time Monitoring, and Low Intensity Focused Ultrasound Treatment Using a Diagnostic Imaging Array

Thies, M., & Oelze, M. L. (2022) · IEEE Transactions on Medical Imaging · doi:10.1109/tmi.2021.3140176 · Cited by 16

Therapeutic ultrasound: The future of epilepsy surgery?

Bex, A., Bex, V., Carpentier, A. C., & Mathon, B. (2022) · Revue Neurologique · doi:10.1016/j.neurol.2022.03.015 · Cited by 16

Surgery procedures in temporal lobe epilepsies

Mathon, B., & Clémenceau, S. (2022) · Handbook of clinical neurology · doi:10.1016/b978-0-12-823493-8.00007-9 · Cited by 16

Small volume blood-brain barrier opening in macaques with a 1 MHz ultrasound phased array

Manuel, T. J., Sigona, M. K., Phipps, M. A., Kusunose, J., Luo, H., Yang, P., Newton, A. T., Gore, J. C., Grissom, W. A., Chen, L. M., et al. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.10.015 · Cited by 16

A roadmap for focused ultrasound applications in psychiatry: Proceedings of the 2024 symposium on focused ultrasound in psychiatry (FUS-PULSE)

Davidson, B., Xhima, K., Cosgrove, R. G., Hamani, C., Eitan, R., Rezai, A. R., LeBlang, S., Philip, N. S., & Lipsman, N. (2025) · Brain stimulation · doi:10.1016/j.brs.2025.08.012 · Cited by 15

An Oral Nanovaccine Secreted by Genetically Engineered and Ultrasound‐Responsive Bacteria for Colon Cancer Immunotherapy

Li, J., Yang, R., Yuan, Y., Ren, H., Fang, C., Lovell, J. F., & Zhang, Y. (2024) · Advanced Functional Materials · doi:10.1002/adfm.202414994 · Cited by 15

Sonopermeation combined with stroma normalization enables complete cure using nano-immunotherapy in murine breast tumors

Neophytou, C., Charalambous, A., Voutouri, C., Angeli, S., Panagi, M., Stylianopoulos, T., & Mpekris, F. (2025) · Journal of Controlled Release · doi:10.1016/j.jconrel.2025.113722 · Cited by 15

Enhanced Amikacin Diffusion With Ultrasound and Microbubbles in a Mechanically Ventilated Condensed Lung Rabbit Model

Espitalier, F., Darrouzain, F., Escoffre, J., Ternant, D., Piver, É., Bouakaz, A., & Remérand, F. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.01562 · Cited by 15

Effects of Focused-Ultrasound-and-Microbubble-Induced Blood-Brain Barrier Disruption on Drug Transport under Liposome-Mediated Delivery in Brain Tumour: A Pilot Numerical Simulation Study

Zhan, W. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12010069 · Cited by 15

Microbubbles Containing Lysolipid Enhance Ultrasound‐Mediated Blood–Brain Barrier Breakdown In Vivo

Vince, O., Peeters, S. G. J. A., Johanssen, V. A., Gray, M. D., Smart, S., Sibson, N. R., & Stride, E. (2020) · Advanced Healthcare Materials · doi:10.1002/adhm.202001343 · Cited by 15

Focused ultrasound: growth potential and future directions in neurosurgery

Zhang, M., Rodrigues, A. J., Zhou, Q., & Li, G. (2021) · Journal of Neuro-Oncology · doi:10.1007/s11060-021-03820-9 · Cited by 15

Focused ultrasound for brain metastases: an update on global clinical trials

Chen, Y.-H., Moore, D., Lee, C., & Su, Y.-H. (2023) · Journal of Neuro-Oncology · doi:10.1007/s11060-023-04492-3 · Cited by 15

Therapeutic Dose Response of Acoustic Cluster Therapy in Combination With Irinotecan for the Treatment of Human Colon Cancer in Mice

Bush, N., Healey, A., Shah, A., Box, G., Kirkin, V., Kotopoulis, S., Kvåle, S., Sontum, P. C., & Bamber, J. C. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.01299 · Cited by 15

Involvement of Heparan Sulfate and Heparanase in Neural Development and Pathogenesis of Brain Tumors

Xiong, A., Spyrou, A., & Forsberg‐Nilsson, K. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-34521-1_14 · Cited by 15

Targeting Early Dementia: Using Lipid Cubic Phase Nanocarriers to Cross the Blood–Brain Barrier

D'Arrigo, J. S. (2018) · Biomimetics · doi:10.3390/biomimetics3010004 · Cited by 15

Delivering albumin-bound paclitaxel across the blood-brain barrier for gliomas

Gould, A., Zhang, D. Y., Arrieta, V. A., Stupp, R., & Sonabend, A. M. (2021) · Oncotarget · doi:10.18632/oncotarget.28018 · Cited by 15

Sonosensitive Cavitation Nuclei—A Customisable Platform Technology for Enhanced Therapeutic Delivery

Lyons, B., Balkaran, J. P. R., Dunn-Lawless, D. M., Lucian, V. M., Keller, S. B., O’Reilly, C. S., Hu, L., Rubasingham, J., Nair, M., Carlisle, R. C., et al. (2023) · Molecules · doi:10.3390/molecules28237733 · Cited by 15

The nanocarrier strategy for crossing the blood-brain barrier in glioma therapy

Wu, H., Wang, Y., Ren, Z., Cong, H., Shen, Y., & Yu, B. (2024) · Chinese Chemical Letters · doi:10.1016/j.cclet.2024.109996 · Cited by 14

Characterization of Microbubble Cavitation in Theranostic Ultrasound-mediated Blood-Brain Barrier Opening and Gene Delivery

Tsitsos, F. N., Batts, A. J., Jimenez, D. A., Macsemchuk, C. A., Li, C., Ji, R., Bae, S., Ciaccio, G. L., Theodorou, A., Ramirez, R. K., et al. (2025) · Journal of Controlled Release · doi:10.1016/j.jconrel.2025.113986 · Cited by 14

Smart responsive biomaterials for spatiotemporal modulation of functional tissue repair

He, X., Han, Z., Ruan, Y., Wang, Z., Liao, B., Li, X., Tan, J., Han, X., Shen, J., & Bai, D. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.102063 · Cited by 14

Therapeutic Ultrasound as a Treatment Modality for Physiological and Pathological Ageing Including Alzheimer’s Disease

Götz, J., Richter-Stretton, G. L., & Cruz, E. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13071002 · Cited by 15

Imaged-guided focused ultrasound in combination with various formulations of doxorubicin for the treatment of diffuse intrinsic pontine glioma

Haumann, R., Bianco, J. I., Waranecki, P., Gaillard, P. J., Storm, G., Ries, M. G., van Vuurden, D. G., Kaspers, G. J. L., & Hulleman, E. (2022) · Translational Medicine Communications · doi:10.1186/s41231-022-00115-7 · Cited by 14

Improving the Function and Engraftment of Transplanted Pancreatic Islets Using Pulsed Focused Ultrasound Therapy

Razavi, M., Zheng, F., Telichko, A. V., Wang, J., Ren, G., Dahl, J., & Thakor, A. S. (2019) · Scientific Reports · doi:10.1038/s41598-019-49933-0 · Cited by 14

Characterization of focused ultrasound-mediated brainstem delivery of intranasally administered agents

Ye, D., Luan, J., Pang, H., Yang, Y., Nazeri, A., Rubin, J. B., & Chen, H. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.08.053 · Cited by 15

Emerging two-dimensional materials-enabled diagnosis and treatments of Alzheimer's disease: Status and future challenges

Song, S., Wu, J., Cheng, Y., Ma, L., Liu, T., Liu, J., Liu, J., Sotor, J. Z., & Luan, P. (2021) · Applied Materials Today · doi:10.1016/j.apmt.2021.101028 · Cited by 14

Cascade Drug Delivery through Tumor Barriers of Pancreatic Cancer via Ultrasound in Combination with Functional Microbubbles

Zhang, L., Sun, L., Tang, Q., Sun, S., Zeng, L., Ma, J., Li, X., Ge, H., & Liang, X. (2022) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.2c00069 · Cited by 14

Endothelial response to blood-brain barrier disruption in the human brain

Gould, A., Luan, Y., Hou, Y., Korobova, F. V., Chen, L., Arrieta, V. A., Amidei, C., Ward, R., Gomez, C., Castro, B. A., et al. (2024) · JCI Insight · doi:10.1172/jci.insight.187328 · Cited by 14

Real-Time Visualization of a Focused Ultrasound Beam Using Ultrasonic Backscatter

Thies, M., & Oelze, M. L. (2020) · IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control · doi:10.1109/tuffc.2020.3035784 · Cited by 13

Technical Note: Quantification of blood‐spinal cord barrier permeability after application of magnetic resonance‐guided focused ultrasound in spinal cord injury

Cross, C. G., Payne, A., Hawryluk, G. W. J., Haag‐Roeger, R., Cheeniyil, R., Brady, D., Odéen, H., Minoshima, S., Cross, D. J., & Anzai, Y. (2021) · Medical Physics · doi:10.1002/mp.14947 · Cited by 15

Gene and oligonucleotide delivery via micro- and nanobubbles by ultrasound exposure

Endo‐Takahashi, Y., & Negishi, Y. (2022) · Drug Metabolism and Pharmacokinetics · doi:10.1016/j.dmpk.2022.100445 · Cited by 13

Ultrasound Molecular Imaging and Drug Delivery

Caskey, C. F. (2017) · Molecular Imaging and Biology · doi:10.1007/s11307-017-1058-x · Cited by 13

Ultrasonic cavitation induces necrosis and impairs growth in three-dimensional models of pancreatic ductal adenocarcinoma

Ali, E. A., Bordaçahar, B., Mestas, J., Batteux, F., Lafon, C., Camus, M., & Prat, F. (2018) · PLoS ONE · doi:10.1371/journal.pone.0209094 · Cited by 13

Cell and Gene Therapies for Mucopolysaccharidoses: Base Editing and Therapeutic Delivery to the CNS

Christensen, C. L., Ashmead, R. E., & Choy, F. Y. M. (2019) · Diseases · doi:10.3390/diseases7030047 · Cited by 13

Focused Ultrasonography-Mediated Blood-Brain Barrier Disruption in the Enhancement of Delivery of Brain Tumor Therapies

Ghali, M. G. Z., Srinivasan, V. M., & Kan, P. T. M. (2019) · World Neurosurgery · doi:10.1016/j.wneu.2019.07.096 · Cited by 13

Focused ultrasound induced-blood–brain barrier opening in mouse brain receiving radiosurgery dose of radiation enhances local delivery of systemic therapy

Wang, S., Wu, C., Zhang, H., Karakatsani, M. E., Wang, Y., Han, Y., Chaudhary, K. R., Wuu, C., Konofagou, E. E., & Cheng, S. K. (2020) · British Journal of Radiology · doi:10.1259/bjr.20190214 · Cited by 13

Nanomedicine Disrupts Stromal Barriers to Augment Drug Penetration for Improved Cancer Therapy†

Luo, G., Chen, W., & Zhang, X. (2023) · Chinese Journal of Chemistry · doi:10.1002/cjoc.202300642 · Cited by 12

Focused ultrasound blood-brain barrier disruption in high-grade gliomas: Scoping review of clinical studies

Maroufi, S. F., Fallahi, M. S., Maroufi, S. P., & Sheehan, J. P. (2024) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2024.110786 · Cited by 12

Identifying new therapeutics for focused ultrasound-enhanced drug delivery in the management of glioblastoma

Holman, R., & McDannold, N. J. (2025) · Frontiers in Oncology · doi:10.3389/fonc.2025.1507940 · Cited by 12

Micro-Particle Image Velocimetry Investigation of Flow Fields of SonoVue Microbubbles Mediated by Ultrasound and Their Relationship With Delivery

Zou, P., Li, M., Wang, Z., Zhang, G., Jin, L., Pang, Y., Du, L., Duan, Y., Liu, Z., & Shi, Q. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.01651 · Cited by 12

Ultrasound lighting up AIEgens for potential surgical navigation

Chen, L., Xia, B., Yan, B. C., Liu, J., Miao, Z., Ma, Y., Wang, J., Peng, H., He, T., & Zha, Z. (2021) · Journal of Materials Chemistry B · doi:10.1039/d0tb02832k · Cited by 12

Effect of acoustic cluster therapy (ACT®) combined with chemotherapy in a patient-derived xenograft mouse model of pancreatic cancer

Ng, S., Healey, A. J., Sontum, P. C., Kvåle, S., TORP, S. H., Sulheim, E., Hoff, D. D. V., & Han, H. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.11.016 · Cited by 12

Focused Delivery of Chemotherapy to Augment Surgical Management of Brain Tumors

Mehkri, Y., Woodford, S. J., Pierre, K., Dagra, A., Hernandez, J. S., Siyanaki, M. R. H., Azab, M. A., & Lucke-Wold, B. P. (2022) · Current Oncology · doi:10.3390/curroncol29110696 · Cited by 12

Modeling ultrasound propagation through material of increasing geometrical complexity

Odabaee, M., Odabaee, M., Pelekanos, M., Leinenga, G., & Götz, J. (2018) · Ultrasonics · doi:10.1016/j.ultras.2018.05.014 · Cited by 12

Genome Medicine for Brain Tumors: Current Status and Future Perspectives

Mukasa, A. (2020) · Neurologia medico-chirurgica · doi:10.2176/nmc.ra.2020-0175 · Cited by 12

Sonoporation-Mediated Gene Transfection: A Novel Direction for Cell Reprogramming In Vivo

Du, M., Li, Y., & Chen, Z. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.803055 · Cited by 12

Focused Ultrasound-Mediated Delivery of Anti-Programmed Cell Death-Ligand 1 Antibody to the Brain of a Porcine Model

Fadera, S., Chukwu, C., Stark, A. H., Yue, Y., Xu, L., Chien, C.-Y., Yuan, J., & Chen, H. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15102479 · Cited by 11

Effect of ultrasound-mediated blood-spinal cord barrier opening on survival and motor function in females in an amyotrophic lateral sclerosis mouse model

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Ultrasound-stimulated microbubbles enhanced vascular disruption in fractionated radiotherapy-treated tumours via ASMase activation

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Efficacy of chronic ultrasound neurostimulation on behaviors and distributed brain metabolism in depressive-like micePreprint

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Local therapy in glioma: An evolving paradigm from history to horizons (Review)

Ius, T., Somma, T., Pasqualetti, F., Berardinelli, J., Vitulli, F., Caccese, M., Cella, E., Cenciarelli, C., Pozzoli, G., Sconocchia, G., et al. (2024) · Oncology Letters · doi:10.3892/ol.2024.14573 · Cited by 10

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Ex vivo validation of non-invasive phase correction for transspine focused ultrasound: model performance and target feasibility

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Focused ultrasound therapy as a strategy for improving glioma treatment

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Bacterial community assembly of specific pathogen-free neonatal mice

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Imaging strategies to assess efficacy and safety of ultrasound-induced blood-brain barrier opening

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Efficacy and safety of low- and high-intensity focused ultrasound in glioblastoma: a systematic review of preclinical and clinical studies

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Cavitation-induced release of liposomal chemotherapy in orthotopic murine pancreatic cancer models: A feasibility study

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3D optical/CT as a preclinical companion imaging platform for glioblastoma drug development

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Is there a role for MR‐guided focused ultrasound in Parkinson's disease?

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Numerical Investigation of Layered Homogeneous Skull Model for Simulations of Transcranial Focused Ultrasound

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Safety and Feasibility of Repeated and Transient Blood–Brain Barrier Disruption by Pulsed Ultrasound in Patients with Recurrent Glioblastoma

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Temporary disruption of the blood-brain barrier using an implantable ultrasound system for recurrent glioblastoma patients under IV carboplatin chemotherapy: initial phase 1/2a clinical trial observations

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A phase I/IIa study to evaluate the safety and efficacy of blood-brain barrier (BBB) opening with the SonoCloud-9 implantable ultrasound device in recurrent glioblastoma patients receiving IV carboplatin.

Idbaïh, A., Ducray, F., Stupp, R., Baize, N., Chinot, O. L., Groot, J. F. D., Guyotat, J., Sonabend, A. M., Meneï, P., Dufour, H., et al. (2021) · Journal of Clinical Oncology · doi:10.1200/jco.2021.39.15_suppl.2049 · Cited by 11

News in brief

(2016) · The Lancet Neurology · doi:10.1016/s1474-4422(16)30136-3

OS07.3.A Phase 1/2 clinical trial of blood-brain barrier opening with the SonoCloud-9 implantable ultrasound device in recurrent glioblastoma patients receiving IV carboplatin

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