Clinical trial of blood-brain barrier disruption by pulsed ultrasound

Updated Response Assessment Criteria for High-Grade Gliomas: Response Assessment in Neuro-Oncology Working Group

Wen, P. Y., Macdonald, D. R., Reardon, D. A., Cloughesy, T. F., Sorensen, A. G., Galanis, E., DeGroot, J. F., Wick, W., Gilbert, M. R., Lassman, A. B., et al. (2010) · Journal of Clinical Oncology · doi:10.1200/jco.2009.26.3541 · Cited by 3,890

Carboplatin dosage: prospective evaluation of a simple formula based on renal function.

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Noninvasive MR Imaging–guided Focal Opening of the Blood-Brain Barrier in Rabbits

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Direct brain infusion of glial cell line–derived neurotrophic factor in Parkinson disease

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Accelerated Titration Designs for Phase I Clinical Trials in Oncology

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Temporary Disruption of the Blood–Brain Barrier by Use of Ultrasound and Microbubbles: Safety and Efficacy Evaluation in Rhesus Macaques

McDannold, N. J., Arvanitis, C., Vykhodtseva, N. I., & Livingstone, M. S. (2012) · Cancer Research · doi:10.1158/0008-5472.can-12-0128 · Cited by 600

Scanning ultrasound removes amyloid-β and restores memory in an Alzheimer’s disease mouse model

Leinenga, G., & Götz, J. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aaa2512 · Cited by 498

Blood-brain barrier disruption with focused ultrasound enhances delivery of chemotherapeutic drugs for glioblastoma treatment.

Liu, H.-L., Hua, M., Chen, P.-Y., Chu, P.-C., Pan, C.-H., Yang, H.-W., Huang, C.-Y., Wang, J.-J., Yen, T., & Wei, K.-C. (2010) · Radiology · doi:10.1148/radiol.10090699 · Cited by 387

Amyloid-β plaque reduction, endogenous antibody delivery and glial activation by brain-targeted, transcranial focused ultrasound

Jordão, J. F., Thévenot, E., Markham-Coultes, K., Scarcelli, T., Weng, Y.-Q., Xhima, K., O'Reilly, M., Huang, Y., McLaurin, J., Hynynen, K., et al. (2013) · Experimental Neurology · doi:10.1016/j.expneurol.2013.05.008 · Cited by 326

Improved Anti-Tumor Effect of Liposomal Doxorubicin After Targeted Blood-Brain Barrier Disruption by MRI-Guided Focused Ultrasound in Rat Glioma

Treat, L. H., McDannold, N. J., Zhang, Y., Vykhodtseva, N. I., & Hynynen, K. (2012) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2012.04.015 · Cited by 296

Blood-brain-barrier opening in small animals using focused ultrasound

Limens-Pinaque, J., Rodríguez-Sendra, J., Rodríguez-García, J. J., Arándiga, A., Alonso-Ramos, J. L., Soler, D. P., Jiménez, N., Rico, P., Canals, S., & Camarena, F. (2025) · Convention of the European Acoustics Association Forum Acusticum · doi:10.61782/fa.2025.0179

Novel Drug Delivery and Dosage Forms for Glioblastoma

Kiran, P. S. S. S., Dasari, N., Kumar, A. S., & Amala, S. (2025) · IGI Global eBooks · doi:10.4018/979-8-3373-2695-5.ch009

Drug Regimens Used for Glioblastoma

Sajini, D. V., Chakkittukandiyil, A., Swaroop, A. K., Sujith Varma, K., & Venugopal, V. (2025) · IGI Global eBooks · doi:10.4018/979-8-3373-2695-5.ch004

Ultrasound-Enhanced Retinal Delivery of Engineered Viral Vectors

Link, S. S., Fan, K., Adame, J., Keehn, C. C., Shen, G., Frankfort, B. J., & Szablowski, J. (2026) · Investigative Ophthalmology & Visual Science · doi:10.64898/2026.01.04.697446

Qualitative review of reported parameter ranges in focused ultrasound neuromodulation

Burianek, A., Cruz, S. D. L., Obaid, A., & Hickey, B. (2026) · WFUMB Ultrasound Open · doi:10.1016/j.wfumbo.2026.100106

An In Silico Exploration of Aberration-Corrected Transspinal Focused Ultrasound Using Zero Echo Time MRI

Martin, D., & O’Reilly, M. A. (2026) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2026.01.018

Ultrasound-Based Therapies in Primary Central Nervous System Tumors

Dima, G., Olivari, A., Nunno, V. D., Aprile, M., Tosoni, A., Gatto, L., Argento, C. M., Margotti, M., Bartolini, S., Conti, A., et al. (2026) · Cancers · doi:10.3390/cancers18061010

Focused ultrasound for brain metastases

Ozair, A., Moiz, B., Anastasiadis, P., Gandhi, D., Amatya, B., McDermott, M. W., Woodworth, G. F., & Ahluwalia, M. S. (2025) · Neuro-Oncology Advances · doi:10.1093/noajnl/vdaf131

Development of skull-implanted ultrasound for blood-brain barrier opening and drug delivery in neuro-oncology

Habashy, K. J., Arrieta, V. A., Haupt, B. E., Gomez, M., Hajj, V. G. E., Kim, K.-S., Dmello, C., Chen, L., Carpentier, A. C., Canney, M. S., et al. (2025) · Neuro-Oncology Advances · doi:10.1093/noajnl/vdaf044

Isocitrate Dehydrogenase‐Mutant Astrocytomas: Risk Stratification and Therapeutic Advance

Wei, S., Xu, X., Bao, J., & Pan, Z. (2026) · MedComm · doi:10.1002/mco2.70686

Crossing the barrier, crossing the line: neurotoxicity of nanomedicines in brain cancer therapy

Rochfort, K. D. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-44579-8.00001-1

Chimiosensibilisation de l’adénocarcinome canalaire du pancréas par la perturbation du microenvironnement tumoral et l’augmentation de la biodisponibilité dans la cellule tumorale : effets de la cavitation ultrasonore et de l’inhibition de nrf2

Camus, M. (2017) · theses.fr (ABES) · doi:10.70675/4def68c4zdc9ez422eza783z692c3f1ea21e

Détection de cibles pour la neuromodulation dans les maladies neurodégénératives : nouveaux apports de l'IRM de diffusion

Sébille, S. B. (2017) · theses.fr (ABES) · doi:10.70675/4e37297dz2184z4922z8e00zcd878532e429

Potentialisation des chimiothérapies dans le traitement du glioblastome : étude des transporteurs ABC et ouverture de la barrière hémato-encéphalique par ultrasons

Dréan, A. (2018) · theses.fr (ABES) · doi:10.70675/4f15a9f7z92e6z4973z9e0bz065b3edec352

Targeting IRE1 activity in Glioblastoma Multiforme

Doultsinos, D. (2019) · theses.fr (ABES) · doi:10.70675/144ae2a8z9211z4b25za8aeza4d20ed0eafd

Exploring the Role of Intercellular and Intracellular Signaling in the Sustenance of Glioblastoma Stem-like Cells

Jacobs, K. (2020) · theses.fr (ABES) · doi:10.70675/7d25afb8z3349z41abz9a2fz667e402f1463

Préparation et caractérisation de microbulles et microgouttelettes par procédés membranaires pour des applications biomédicales ultrasonores

Melich, R. (2018) · theses.fr (ABES) · doi:10.70675/439c0475z187dz4541zbfb4z207b8b251cb5

Mécanismes et implications thérapeutiques de l'hypermutation dans les gliomes

Touat, M. (2020) · theses.fr (ABES) · doi:10.70675/3cf296c0z53a7z446dz8927zbeeea7661f6a

Characterization of focalized hypothermia effects on the central nervous system for brain pathologies treatment

Fulbert, C. (2021) · theses.fr (ABES) · doi:10.70675/8d05f8f9z73edz448fz8deaz7335900a1106

Description, évaluation et perfectionnement d’une nouvelle technique de prise en charge de l'endométriose profonde postérieure recto-sigmoïdienne par ultrasons focalisés de haute intensité (HIFU) échoguidés par voie transrectale

Philip, C. (2020) · theses.fr (ABES) · doi:10.70675/17902a36zc903z4351zaebez36f9f6cfcbf8

Use of nanoliposomes rich in omega-3 for the prevention of neurodegenerative diseases : bioavailability in vivo and in cortical neurons

Passeri, E. (2021) · theses.fr (ABES) · doi:10.70675/166b0026zefe8z41f8z88e1zc5f79765fd6a

Implication du récepteur sérotoninergique 5-HT4 dans la modulation de la perméabilité de la barrière hémato-encéphalique

Becker, G. (2021) · theses.fr (ABES) · doi:10.70675/4e9b29c7z0775z47f0zb6f3z07cef62d92ef

Ouverture de la barrière hémato-encéphalique par ultrasons pulsés de basse intensité chez un modèle animal d'épilepsie mésiotemporale associée à une sclérose hippocampique

Mathon, B. (2022) · theses.fr (ABES) · doi:10.70675/8a263130zfd61z47cbzb4d7zf45a1c68c5a8

Étude pharmacologique in vitro et in vivo de nanogouttes de perfluorocarbure pour la délivrance cérébrale de principes actifs hydrophobes dans le glioblastome

Bérard, C. (2021) · theses.fr (ABES) · doi:10.70675/2dab9013z492dz454fzbfb9zfc8d611be43b

Conception de la partie acoustique d'un dispositif médical pour l'ouverture transitoire de la barrière hémato-encéphalique par ultrasons focalisés transcraniens et sa validation préclinique

Agou, P. (2022) · theses.fr (ABES) · doi:10.70675/815e118fzc6cez41daza4f5zb07d8781c5fb

From barrier invasion to niche formation: mechanisms and therapies in breast cancer brain metastases

Yang, H., Li, X., Xu, S., Zhao, Y., Cai, S. J., Feng, D., & Yao, Y. (2026) · Journal of Advanced Research · doi:10.1016/j.jare.2026.05.017

A numerical analysis of anti-focus driving to improve focal quality in transvertebral focused ultrasound

Martin, D., Jones, R. M., & O’Reilly, M. A. (2026) · The Journal of the Acoustical Society of America · doi:10.1121/10.0041763

IgA Targeting in the Infant Gut Is Modulated by Diet and Increasingly Directed Towards Persistent SpeciesPreprint

Liu, C., Ghadermazi, P., Maret, S., Kemp, J. F., Frank, D., Melanson, E., Hendricks, A. E., Krebs, N. F., Tang, M., & Olm, M. R. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.05.19.726352

Translational Strategies for Blood-Brain Barrier Penetration and Targeted Central Nervous System Drug Delivery

Ghosh, A., & Dutta, S. (2026) · Biochemistry and Molecular Biology · doi:10.11648/j.bmb.20261102.11

Evaluation of the pharmacokinetics of emerging therapeutics for high grade glioma

Ruggiero, A. (2026) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1080/17425255.2026.2683584

Bridging the barrier: Micro- and nanorobotics for active brain delivery

Yoo, J., Joo, J., & Gao, W. (2026) · Matter · doi:10.1016/j.matt.2026.102858

A dual-mode ultrasound transducer array with dual anti-matching layers for imaging-guided tumor perfusion enhancement

Zhang, T., Zhang, X., Dong, X., Luo, T., Lian, L., Liu, Z. H., Li, N., & Ma, J. (2026) · Sensors and Actuators A Physical · doi:10.1016/j.sna.2026.118143

Sonopermeation to Overcome Barriers for Delivery of Drugs to Tumors and Brain Tissue

Davies, C. D. L., & Snipstad, S. (2026) · Cellular and Molecular Bioengineering · doi:10.1007/s12195-026-00928-8

Cross-scale mechanistic insights into ultrasound pulse-length dependent BBB opening

Shen, Y., Qiao, C., Cai, Y., Liu, Z., Xu, Y., Hu, M., Zhang, J., Ma, L., & Li, F. (2026) · Journal of Controlled Release · doi:10.1016/j.jconrel.2026.115165

WITHDRAWN: MR-Guided Focused Ultrasound-Enhanced Liquid Biopsy (Sonobiopsy) for the Definitive Differentiation of True Progression from Pseudoprogression in Glioblastoma: A Prospective Phase II Clinical TrialPreprint

Arabestanino, A. R., Irvani, S. N., Vahidimoghaddam, R., Ardestani, M. S., & Daneshpajooh, A. (2026) · Research Square · doi:10.21203/rs.3.rs-10264269/v1

How can we best utilize magnetic resonance for microbubble-mediated drug delivery to the brain

Huang, Y., & Hynynen, K. (2026) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2026.2711975

Smart and Sustainable Nanomaterials for Digital Healthcare: Application in Drug Delivery

Pal, R., Kumar, R., Kumar, T., Singh, D., & Kumar, K. (2026) · Springer eBooks · doi:10.1007/978-981-95-9386-6_5

Optimization of Focused Ultrasound-Mediated Blood–Brain Barrier Opening for CNS Therapeutic Delivery: Mechanistic Insights, Technical Parameters, and Clinical Translation

Rashad, M. S., Mittal, A., Chirasani, S., Kim, J., Rawson, C. D., Lucke-Wold, B. P., Karsy, M. J., & Pahlevani, M. (2026) · Journal of Molecular Pathology · doi:10.3390/jmp7030029

Exploring the landscape of targetable alterations in patients with glioblastoma

Aquilanti, E., Touat, M., French, P. J., Iavarone, A., Capper, D., Geurts, M., Rahman, R. M., Verhaak, R. G. W., Preusser, M., van den Bent, M. J., et al. (2026) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-026-01190-7

CAR-T Cell Therapy for Glioblastoma: Obstacles and Advances

Chen, L., & Zou, Z. (2026) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2026.105556

Ultrasound-responsive nanotheranostic systems for glioblastoma: Materials evolution, design strategies and clinical translation perspectives

Kapare, H. S., Patil, S., Karwa, P. N., Jha, A., Bhole, R. P., Labhade, S., & Kumawat, M. (2026) · Next Nanotechnology · doi:10.1016/j.nxnano.2026.100724

Spatiotemporal control of protein degradation: Advances in stimuli-responsive nano-PROTACs for precision cancer therapy

Wang, A., Sang, Y., Zheng, M., Zhang, D., & Ismail, M. (2026) · Asian Journal of Pharmaceutical Sciences · doi:10.1016/j.ajps.2026.101199

WITHDRAWN: MR-Guided Focused Ultrasound-Enhanced Liquid Biopsy (Sonobiopsy) for the Definitive Differentiation of True Progression from Pseudoprogression in Glioblastoma: A Prospective Phase II Clinical TrialPreprint

Arabestanino, A. R., Irvani, S. N., Vahidimoghaddam, R., Ardestani, M. S., & Daneshpajooh, A. (2026) · Research Square · doi:10.21203/rs.3.rs-10264269/v2

Safety and efficacy of sonodynamic therapy combined with Stupp regimen in controlling postoperative residual lesions of glioblastoma: A prospective pilot phase I study

Wang, L., Ding, J., Liu, X., Li, T., Liu, Y., You, Y., Yu, Y., & Zheng, Y. (2026) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2026.105655

Focused ultrasound blood-brain barrier opening: a review of post-procedure MRI outcomes

LeBlang, S., Mehta, R. I., D’haese, P.-F., Grinspan, A., Sokolov, A., & Frazzetta, G. (2026) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2026.2737272

High- and Low-Intensity Focused Ultrasound in the Treatment of Glioblastoma: a Systematic Review

Dolgushin, M. B., Prishchepina, C. A., Senko, I. V., Tairova, R. T., Москвина, Е. А., Grigoriev, I. V., & Dvoryanchikov, A. V. (2026) · Journal of oncology diagnostic radiology and radiotherapy · doi:10.37174/2587-7593-2026-9-3-74-84

Focused ultrasound for reshaping the immune microenvironment in glioblastoma

Gattegno, R., Bismuth, M., Sher, D., Friedmann‐Morvinski, D., & Ilovitsh, T. (2026) · Journal of Controlled Release · doi:10.1016/j.jconrel.2026.115443

Beyond target presence: A cross-cancer contextual framework for siRNA therapeutics in solid tumors

Zhao, N., Zhang, Y., Qian, C., 张华巍, & Wang, L. (2026) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2026.189732

Next-Generation Intelligent Adaptive Micro/Nanorobots for Precise Intervention of Central Nervous System Injuries: Advances, Clinical Hurdles, and Future Directions

Liu, S., Huang, Y., & He, Q. Z. (2026) · ACS Nano Medicine · doi:10.1021/acsnanomed.6c00229

Overcoming drug delivery barriers to Unlock the therapeutic potential of conventional chemotherapy in glioblastoma

Qian, K., Cen, X., Zhao, Y., Xuan, Z., Jia, Z., Jiang, T., Ma, C., Di, Z., Zhang, W., & Lin, X. (2026) · Biochemical Pharmacology · doi:10.1016/j.bcp.2026.118552

Intranasal nano-immunotherapy for glioma: bypassing the blood–brain barrier, reprogramming the immune microenvironment, and bridging preclinical validation

Li, L., Wu, M., & Li, L. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1950362

Ultrasound-Guided Mobilization of Dual Autophagic Cleaning Crew by Exosomal Rapamycin Ameliorates the Progression of Parkinsonism

Liu, Y., Guo, K., Li, X., Li, Y., Zheng, X., & Wang, P. (2026) · International Journal of Nanomedicine · doi:10.2147/ijn.s625730

BindingDB Entry 50016954: Glioblastoma: Current Status, Emerging Targets, and Recent Advances.

BindingDB (2023) · UC San Diego · doi:10.7270/q2d79gfs

Glioblastoma as a dynamic tumor ecosystem: from molecular alterations to therapeutic translation

Górecki, L. (2026) · Experimental Hematology and Oncology · doi:10.1186/s40164-026-00854-5

Scutellarin as a multi-target neuroprotective agent: Analytical evidence, pharmacokinetic insights and translational strategies across neurodegenerative disorders

Xiao, Y., Li, X.-Y., Ding, H., Wen, J.-X., Dai, Y.-X., Zhang, Y.-J., Li, S.-P., Wang, Y., Zhou, H.-J., Zhang, B.-M., et al. (2026) · Pharmacological Research · doi:10.1016/j.phrs.2026.109714

Ultrasound-Stimulated Microbubbles in Cancer Therapy: A Review of Clinical and Translational Evidence

Khatami, S. M., Rahmani, A., Liu, J.-B., & Eisenbrey, J. R. (2026) · Advanced ultrasound in diagnosis and therapy · doi:10.26599/audt.2026.260027

Neuron–tumor communication as a target for neuromodulatory drug delivery in cancer

Esa, M., Ahmad, T., Khan, M., & Rahman, A. U. (2026) · Frontiers in Oncology · doi:10.3389/fonc.2026.1929593

Multidimensional Characteristics of the Tumor Microenvironment and Advances in Targeted Drug Research

田, 萌. (2026) · Hans Journal of Biomedicine · doi:10.12677/hjbm.2026.166100

The blood–brain barrier and strategies for drug delivery to brain tumors

Nakhate, V., & Wen, P. Y. (2026) · Current Opinion in Neurology · doi:10.1097/wco.0000000000001521

Safety and Feasibility of Repeated and Transient Blood–Brain Barrier Disruption by Pulsed Ultrasound in Patients with Recurrent Glioblastoma

Idbaïh, A., Canney, M. S., Belin, L., Desseaux, C., Vignot, A., Bouchoux, G., Asquier, N., Law-Ye, B., Leclercq, D., Bissery, A., et al. (2019) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-18-3643 · Cited by 367

Temporary disruption of the blood-brain barrier using an implantable ultrasound system for recurrent glioblastoma patients under IV carboplatin chemotherapy: initial phase 1/2a clinical trial observations

Carpentier, A. C., Canney, M. S., Vignot, A., Horodyckid, C., Goldwirt, L., Leclercq, D., Delattre, J., Chapelon, J., & Idbaïh, A. (2015) · Journal of Therapeutic Ultrasound · doi:10.1186/2050-5736-3-s1-o14 · Cited by 11

A phase I/IIa study to evaluate the safety and efficacy of blood-brain barrier (BBB) opening with the SonoCloud-9 implantable ultrasound device in recurrent glioblastoma patients receiving IV carboplatin.

Idbaïh, A., Ducray, F., Stupp, R., Baize, N., Chinot, O. L., Groot, J. F. D., Guyotat, J., Sonabend, A. M., Meneï, P., Dufour, H., et al. (2021) · Journal of Clinical Oncology · doi:10.1200/jco.2021.39.15_suppl.2049 · Cited by 11

News in brief

(2016) · The Lancet Neurology · doi:10.1016/s1474-4422(16)30136-3

OS07.3.A Phase 1/2 clinical trial of blood-brain barrier opening with the SonoCloud-9 implantable ultrasound device in recurrent glioblastoma patients receiving IV carboplatin

Idbaïh, A., Sonabend, A. M., Stupp, R., Chinot, O. L., Dufour, H., Ducray, F., Meneï, P., de Groot, J., Desseaux, C., & Carpentier, A. C. (2022) · Neuro-Oncology · doi:10.1093/neuonc/noac174.048 · Cited by 2