The DOI matches its Crossref record; 732 of the 732 references it cites were found in a registry or an index.
Pathogenesis of Helicobacter pylori Infection
Open accessAbstract
SUMMARY: Helicobacter pylori is the first formally recognized bacterial carcinogen and is one of the most successful human pathogens, as over half of the world's population is colonized with this gram-negative bacterium. Unless treated, colonization usually persists lifelong. H. pylori infection represents a key factor in the etiology of various gastrointestinal diseases, ranging from chronic active gastritis without clinical symptoms to peptic ulceration, gastric adenocarcinoma, and gastric mucosa-associated lymphoid tissue lymphoma. Disease outcome is the result of the complex interplay between the host and the bacterium. Host immune gene polymorphisms and gastric acid secretion largely determine the bacterium's ability to colonize a specific gastric niche. Bacterial virulence factors such as the cytotoxin-associated gene pathogenicity island-encoded protein CagA and the vacuolating cytotoxin VacA aid in this colonization of the gastric mucosa and subsequently seem to modulate the host's immune system. This review focuses on the microbiological, clinical, immunological, and biochemical aspects of the pathogenesis of H. pylori .
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“H. pylori infection can lead to antrum-predominant gastritis, in which the oxyntic mucosa is not inflamed but a gastrin-driven increase in acid output occurs, along with the possible development of duodenal ulcer[67,68].”
From Proton pump inhibitors and dysbiosis: current knowledge and aspects to be clarified (2019) · cites this paper as [67]
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Cites
5 retracted
Eradication of Helicobacter pylori for non-ulcer dyspepsia
Moayyedi, P., Soo, S., Deeks, J. J., Delaney, B. C., Harris, A. W., Innes, M. A., Oakes, R., Wilson, S., Roalfe, A. K., Bennett, C., et al. (2003) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002096 · Cited by 371
RetractedInitial management strategies for dyspepsia
Delaney, B. C., Moayyedi, P., & Forman, D. (2003) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd001961 · Cited by 181
RetractedInitial management strategies for dyspepsia
Delaney, B. C., Ford, A. C., Forman, D., Moayyedi, P., & Qume, M. (2005) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd001961.pub2 · Cited by 88
RetractedEradication of Helicobacter pylori for non-ulcer dyspepsia
Moayyedi, P., Soo, S., Deeks, J. J., Delaney, B. C., Harris, A. W., Innes, M. A., Oakes, R., Wilson, S., Roalfe, A. K., Bennett, C., et al. (2005) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002096.pub2 · Cited by 60
RetractedHelicobacter pylori Induces RANTES through Activation of NF-κB
Mori, N., Krensky, A. M., Geleziunas, R., Wada, A., Hirayama, T., Sasakawa, C., & Yamamoto, N. (2003) · Infection and Immunity · doi:10.1128/iai.71.7.3748-3756.2003 · Cited by 24
RetractedInternational Agency for Research on Cancer
National Cancer Institute (2020) · Definitions · doi:10.32388/pfg7jq · Cited by 9,394
Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration
Marshall, B., & Warren, J. R. (1984) · The Lancet · doi:10.1016/s0140-6736(84)91816-6 · Cited by 5,509
UNIDENTIFIED CURVED BACILLI ON GASTRIC EPITHELIUM IN ACTIVE CHRONIC GASTRITIS
ROBINWARREN, J. (1983) · The Lancet · doi:10.1016/s0140-6736(83)92719-8 · Cited by 3,597
The complete genome sequence of the gastric pathogen Helicobacter pylori
Tomb, J.-F., White, O., Kerlavage, A. R., Clayton, R. A., Sutton, G. G., Fleischmann, R. D., Ketchum, K. A., Klenk, H. P., Gill, S., Dougherty, B. A., et al. (1997) · Nature · doi:10.1038/41483 · Cited by 3,529
DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells
Geijtenbeek, T. B. H., Kwon, D. S., Torensma, R., van Vliet, S. J., van Duijnhoven, G. C. F., Middel, J., Cornelissen, I. L. M. H. A., Nottet, H. S. L. M., KewalRamani, V. N., Littman, D. R., et al. (2000) · Cell · doi:10.1016/s0092-8674(00)80694-7 · Cited by 2,447
Research works printed but not linked: 8
- 10.1016/S0002-9270(01)02335-8 · DOI
- Fox, J. G. 1998. Anatomy of the ferret, p. 19-69. In J. G. Fox (ed.), Biology and diseases of the ferret. The Williams & Wilkins Co., Baltimore, Md.
- Fox, J. G. 1995. Nonhuman reservoirs of Helicobacter pylori. Aliment. Pharmacol. Ther.9(Suppl. 2):93-103.
- Krienitz, W. 1906. Ueber das auftreten von mageninhalt bei carcinoma ventriculi. Dtsch. Med. Wochenschr.22:872.
- Luger, A. 1917. Ueber spirochaeten und fusiforme bazillen im darm, mit einer beitrag zur frage der lamblien-enteritis. Wiein. Klin. Wochenschr.52:1643-1647.
- Mellgard, B., S. Arvidsson, A. Lee, G. Sundell, and H. Larsson. 1994. Helicobacter felis infected rat as a model for Helicobacter pylori infection, colonisation pattern and inflammatory response. Am. J. Gastroenterol.89:1320.
- Sakamoto, S., T. Watanabe, T. Tokumaru, H. Takagi, H. Nakazato, and K. O. Lloyd. 1989. Expression of Lewis a, Lewis b, Lewis x, Lewis y, sialyl-Lewis a, and sialyl-Lewis x blood group antigens in human gastric carcinoma and in normal gastric tissue. Cancer Res.49:745-752.
- Stolte, M., G. Kroher, A. Meining, A. Morgner, E. Bayerdörffer, and B. Bethke. 1997. A comparison of Helicobacter pylori and H. heilmannii gastritis. A matched control study involving 404 patients. Scand. J. Gastroenterol.32:28-33.
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Proton pump inhibitors and dysbiosis: current knowledge and aspects to be clarified
Bruno, G., Zaccari, P., Rocco, G., Scalese, G., Panetta, C., Porowska, B., Pontone, S., & Severi, C. (2019) · World Journal of Gastroenterology · doi:10.3748/wjg.v25.i22.2706 · Cited by 258
Hayashi, C., Gudino, C. V., Gibson III, F. C., & Genco, C. A. (2010) · Molecular Oral Microbiology · doi:10.1111/j.2041-1014.2010.00582.x · Cited by 244
The influence of the gut microbiome on obesity, metabolic syndrome and gastrointestinal disease
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Cindoruk, M., Erkan, G., Karakan, T., Dursun, A., & Unal, S. (2007) · Helicobacter · doi:10.1111/j.1523-5378.2007.00516.x · Cited by 135
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Gorlé, N., Blaecher, C., Bauwens, E., Vandendriessche, C., Balusu, S., Vandewalle, J., Van Cauwenberghe, C., Van Wonterghem, E., Van Imschoot, G., Liu, C., et al. (2018) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2017.12.010 · Cited by 49
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Metadata
- Authors
- Kusters, J. G., van Vliet, A. H. M., & Kuipers, E. J.
- Affiliations
- Erasmus MC (NL)
- Department of Gastroenterology and Hepatology, Erasmus MC—University Medical Center, Rotterdam, The Netherlands
- Venue
- Clinical Microbiology Reviews
- Publisher
- American Society for Microbiology
- Published
- 2006-07
- Volume
- 19
- Issue
- 3
- Pages
- 449-490
- ISSN
- 0893-8512 (ISSN-L)
- 1098-6618
- PMC
- PMC1539101
- OpenAlex
- W2153354382
- Cited by
- 2,526
- References
- 732
- Citations by year
- 2026: 93 · 2025: 127 · 2024: 117 · 2023: 119 · 2022: 133 · 2021: 180 · 2020: 174 · 2019: 153 · 2018: 129 · 2017: 144 · 2016: 137 · 2015: 140 · 2014: 172 · 2013: 140 · 2012: 97
- FWCI
- 15.43
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Clinical Microbiology Reviews (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- RePub (Erasmus University Rotterdam) (submittedVersion, other-oa)
- Surrey Research Insight Open Access (The University of Surrey) (submittedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Helicobacter pylori-related gastroenterology studies
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Agricultural and Biological Sciences › Food Science › Salmonella and Campylobacter epidemiology
- Keywords
- Helicobacter pylori, pathogenesis, bacterial colonization, chronic active gastritis, peptic ulcer, gastric adenocarcinoma, gastric MALT lymphoma, host-pathogen interaction, gastric acid secretion, CagA, VacA, virulence factors
- MeSH terms
- Animals, Gastritis, Guinea Pigs, Humans, Peptic Ulcer, Stomach Neoplasms, Helicobacter pylori, Helicobacter Infections, Virulence Factors, Mice
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