Cited by 953Oral microbiology and periodontitis researchDental Health and Care UtilizationDental materials and restorations

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Bacteria of Dental Caries in Primary and Permanent Teeth in Children and Young Adults

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Aas, Jørn A., Griffen, Ann L., Dardis, Sara R., Lee, Alice M., Olsen, Ingar, Dewhirst, Floyd E., Leys, Eugene J., Paster, Bruce J.·2008·Journal of Clinical Microbiology

DOI 10.1128/jcm.01410-07PMC PMC2292933

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Abstract

Although Streptococcus mutans has been implicated as a major etiological agent of dental caries, our cross-sectional preliminary study indicated that 10% of subjects with rampant caries in permanent teeth do not have detectable levels of S. mutans . Our aims were to use molecular methods to detect all bacterial species associated with caries in primary and permanent teeth and to determine the bacterial profiles associated with different disease states. Plaque was collected from 39 healthy controls and from intact enamel and white-spot lesions, dentin lesions, and deep-dentin lesions in each of 51 subjects with severe caries. 16S rRNA genes were PCR amplified, cloned, and sequenced to determine species identities. In a reverse-capture checkerboard assay, 243 samples were analyzed for 110 prevalent bacterial species. A sequencing analysis of 1,285 16S rRNA clones detected 197 bacterial species/phylotypes, of which 50% were not cultivable. Twenty-two new phylotypes were identified. PROC MIXED tests revealed health- and disease-associated species. In subjects with S. mutans , additional species, e.g., species of the genera Atopobium , Propionibacterium , and Lactobacillus , were present at significantly higher levels than those of S. mutans . Lactobacillus spp., Bifidobacterium dentium , and low-pH non- S. mutans streptococci were predominant in subjects with no detectable S. mutans . Actinomyces spp. and non- S. mutans streptococci were predominant in white-spot lesions, while known acid producers were found at their highest levels later in disease. Bacterial profiles change with disease states and differ between primary and secondary dentitions. Bacterial species other than S. mutans , e.g., species of the genera Veillonella , Lactobacillus , Bifidobacterium , and Propionibacterium , low-pH non- S. mutans streptococci, Actinomyces spp., and Atopobium spp., likely play important roles in caries progression.

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The neighbor-joining method: a new method for reconstructing phylogenetic trees.
Saitou, N., & Nei, M. (1987) · Molecular Biology and Evolution · doi:10.1093/oxfordjournals.molbev.a040454 · Cited by 59,959
Evolution of Protein Molecules
JUKES, T. H., & CANTOR, C. R. (1969) · Mammalian Protein Metabolism · doi:10.1016/b978-1-4832-3211-9.50009-7 · Cited by 11,032
Defining the normal bacterial flora of the oral cavity
Aas, J. A., Paster, B. J., Stokes, L. N., Olsen, I., & Dewhirst, F. E. (2005) · Journal of Clinical Microbiology · doi:10.1128/jcm.43.11.5721-5732.2005 · Cited by 3,092
Self-citation
TREECON for Windows: a software package for the construction and drawing of evolutionary trees for the Microsoft Windows environment
de Peer, Y. V., & Wächter, R. D. (1994) · Computer applications in the biosciences · doi:10.1093/bioinformatics/10.5.569 · Cited by 2,247
Occlusal Caries: Biological Approach for Its Diagnosis and Management
Carvalho, J. C., Dige, I., Mačhiulskienė, V., Qvist, V., Bakhshandeh, A., Parolo, C. C. F., & Maltz, M. (2016) · Caries Research · doi:10.1159/000448662 · Cited by 2,159
Bacterial Diversity in Human Subgingival Plaque
Paster, B. J., Boches, S. K., Galvin, J. L., Ericson, R. E., Lau, C. N., Levanos, V. A., Sahasrabudhe, A., & Dewhirst, F. E. (2001) · Journal of Bacteriology · doi:10.1128/jb.183.12.3770-3783.2001 · Cited by 2,008
Self-citation
Microbial ecology of dental plaque and its significance in health and disease
Marsh, P. D. (1994) · Advances in Dental Research · doi:10.1177/08959374940080022001 · Cited by 1,278
Oral Microbial Communities: Biofilms, Interactions, and Genetic Systems
Kolenbrander, P. E. (2000) · Annual Review of Microbiology · doi:10.1146/annurev.micro.54.1.413 · Cited by 894
Ecological Hypothesis of Dentin and Root Caries
Takahashi, N., & Nyvad, B. (2016) · Caries Research · doi:10.1159/000447309 · Cited by 737
The lactic acid bacteria
Orla-Jensen, S. (1919) · Cited by 698

Show all 42 references

Research works printed but not linked: 1

Anusavice, K. J. 2002. Dental caries: risk assessment and treatment solutions for an elderly population. Compend. Contin. Educ. Dent.23:12-20.

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[Recent achievements in the microbiological etiology of dental caries].
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BackgroundMethod
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“mutans [14].”
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Background
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“[23], demonstrated that caries can occur in the absence of S.”
Background
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“Aas et al.‘s research assessed alterations in the oral microbiota across primary and permanent dentition at different phases of dental caries progression, highlighting modifications particularly evident upon the onset of dentin cavities, where acid-producing bacteria play a pivotal role [23].”
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Background
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“mutans streptococci and Actinomyces spp were involved in initiating dental caries [8].”
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Background
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Lactic Acid Bacteria in Oral Health
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Microbiology Br., B. D., & Sabra, S. M. M. (2014) · IOSR Journal of Dental and Medical Sciences · doi:10.9790/0853-133295100 · Cited by 3
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Ezzeldin, N., Elshishtawy, H. M., & Mohamed, M. (2021) · Egyptian Dental Journal /Egyptian Dental Journal · doi:10.21608/edj.2020.44382.1281 · Cited by 3
Role of Silver Diamine Fluoride in Dentistry
Khurshid, Z., Shabbir, J., Al-Otaibi, A. K., Alsalem, A. M., Alhamdan, A. A., Jouhar, R., & Ahmed, M. A. (2020) · European Dental Research and Biomaterials Journal · doi:10.1055/s-0040-1710140 · Cited by 3
Virulence traits-based behavior of Streptococcus mutans bacteria from dental plaque and dental caries conditions
Bakr, R. A., Tawfick, M. M., Mostafa, Z., & Abdulall, A. K. (2021) · Microbial Biosystems · doi:10.21608/mb.2021.100068.1044 · Cited by 4
“The samples comprised 70 plaque samples collected by swabbing the surface of the intact enamel of the teeth from caries-free (n = 35) and caries active (n = 35) cases, and 70 soft caries lesion samples from soft caries lesions obtained from the outermost layer of carious dentin and removed with a sharp, sterile excava…”
Background
Correlation analysis of the oral mucosal microbiome and diabetes mellitus using microbial DNA in elderly male subjects
Lee, J.-H., Lee, Y., Choi, S., Bae, E., & Lee, D. (2022) · Oral Biology Research · doi:10.21851/obr.46.01.202203.10 · Cited by 3
Clinical characteristics of children and guardians possessing CBP-positive Streptococcus mutans strains: a cross-sectional study
Otsugu, M., Mikasa, Y., Kitamura, T., Suehiro, Y., Matayoshi, S., Nomura, R., & Nakano, K. (2022) · Scientific Reports · doi:10.1038/s41598-022-22378-8 · Cited by 3
An Observation Study of Caries Experience and Potential Risk Assessments among Disabled Individuals Living in an Institutional Rehabilitation Centre
Alzahrani, A. A. H., & Bhat, N. (2024) · Life · doi:10.3390/life14050605 · Cited by 3
“It is considered a potential risk factor when the unstimulated salivary flow rate is lower than 0.30 mL/min, and the stimulated salivary flow rate is lower than 0.7 mL/min [33,34].”
BackgroundInfluential
Quantitative analysis of Streptococcus mutans, Bifidobacterium, and Scardovia Wiggsiae in occlusal biofilm and their association with Visible Occlusal Plaque Index (VOPI) and International Caries Detection and Assessment System (ICDAS)
Thitisakyothin, P., Chanrat, S., Srisatjaluk, R. L., & Mitrakul, K. (2024) · European Archives of Paediatric Dentistry · doi:10.1007/s40368-024-00962-y · Cited by 3
“Results from previous studies also found an evident increase in aciduric bacteria associated with dental caries with cavitation, including S. mutans and Bifidobacterium (Aas et al. 2008; Munson et al. 2004; Celik et al. 2021)].”
Streptococcus Mutans Serotype Analysis from Dental Plaque of Caries Patients in Banda Aceh Based on the GTF Gene
Chismirina, S., Sungkar, S., Adlim, M., & Darmawi, D. (2023) · Reports of Biochemistry and Molecular Biology · doi:10.61186/rbmb.12.1.205 · Cited by 3
Biology of the oral environment and its impact on the stability of dental and craniofacial reconstructions
Tanaka, M. H., Lima, G. M. G., & Ito, C. Y. K. (2016) · Elsevier eBooks · doi:10.1016/b978-0-08-100330-5.00007-8 · Cited by 3
Dysbiosis of the Oral Microbiome
Ribeiro, A. A., & Arnold, R. R. (2019) · Springer eBooks · doi:10.1007/978-3-030-28737-5_8 · Cited by 3
Modulation of Systemic Immune Responses Through Genital, Skin, and oral Microbiota: Unveiling the Fundamentals of Human Microbiomes
Sanapala, P., & Pola, S. (2021) · Springer eBooks · doi:10.1007/978-981-16-3156-6_2 · Cited by 3
Development Strategy of Endodontic Filling Materials Based on Engineering and Medical Approaches
Dobrzański, L. A., Dobrzańska, J., Dobrzański, L. B., Dobrzańska-Danikiewicz, A. D., & Gołombek, K. (2021) · Processes · doi:10.3390/pr9112014 · Cited by 4
“However, biofilm may play a different role [43,45] because bacteria can produce alkalis, especially in the presence of nitrogen [46], and some bacteria even use lactic acid as an energy source [47].”
Background
Prevalence of Salivary Streptococcus mutans Serotype k in Children Undergoing Congenital Heart Surgery
Topçuoğlu, N., Bozdoğan, E., Özsoy, S. D., Haberal, İ., Çetin, G., Aktören, O., & Külekçi, G. (2013) · Journal of Clinical Pediatric Dentistry · doi:10.17796/jcpd.38.2.f0312413110kq00w · Cited by 3
Factores de riesgo en lesiones incipientes de caries dental en niños
Hidalgo, N. N., Abreu, E. D. L. Á. G., Martínez, A. R., Mon, M. A., & Triguero, R. J. P. (2013) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 3
Lactobacillus characterization and effects on oral biofilm composition
Vestman, N. R. (2013) · Cited by 3
Avances en el Estudio de la Diversidad Bacteriana Oral Asociada a Caries Dental Mediante el Estudio Genómico
Astorga, B., Barraza, C., Casals, J. M., Cisterna, M. J., Mena, D., Morales, F., González, S., de Oliveira, O. B., & Moncada, G. A. (2015) · International journal of odontostomatology · doi:10.4067/s0718-381x2015000300002 · Cited by 3
Study of microbial diversity in saliva and plaque samples from caries-free and caries-affected children using denaturing gradient gel electrophoresis
Raviraj, G. A., Bhat, K. G., Kugaji, M. S., Kumbar, V. M., & Hooli, A. (2018) · Journal of Indian Society of Pedodontics and Preventive Dentistry · doi:10.4103/jisppd.jisppd_206_18 · Cited by 3
‘One tooth one child’: evaluating the effects of diet and fertility on the oral health of women from archaeological sites in South America
Carvalho, M. R. G., Pezo‐Lanfranco, L., & Eggers, S. (2018) · European Journal Of Oral Sciences · doi:10.1111/eos.12586 · Cited by 3
Influence of black tea on Streptococcus mutans and Lactobacillus levels in saliva in a Saudi cohort
Ramadan, A. M., Bakeer, H. A., Mahrous, M. S., & Hifnawy, T. M. S. (2019) · Journal of Taibah University Medical Sciences · doi:10.1016/j.jtumed.2019.02.008 · Cited by 3
“producing dental caries agents are restricted to several known strains of bacteria present in the dental biofilm (plaque) on tooth surfaces.(16,18,20,24,25) Numerous microorganisms have been isolated from carious lesions.”
Background
Antibacterial effect of a brominated self-etch adhesive on carious dentin - An in vivo study
Schmidt, J., Krohn, S., Kallies, R., Schneider, H., Zeller, K., Ziebolz, D., Berg, T., & Haak, R. (2020) · Journal of Dentistry · doi:10.1016/j.jdent.2020.103555 · Cited by 3
Anaerobic Bacteria in Oral Cavities and Dental Health
Chakrabarty, R. P., & Karim, M. M. (2018) · Annals of Dentistry · Cited by 3
Genotypic and Phenotypic Characterization of Streptococcus Mutans Isolated From Dental CariesPreprint
Hossain, M. R., Alam, S. M. S., Nibir, Y. M., Tusty, T. A., Bulbul, S. M., Islam, M., & Hossain, M. S. (2020) · Research Square · doi:10.21203/rs.3.rs-132779/v1 · Cited by 3
Knowledge, attitudes, and behaviors (KAB) related to brushing teeth with powered toothbrush among doctors: a cross-sectional studyPreprint
Wang, Y., & Jiang, L. (2020) · doi:10.21203/rs.2.21547/v1 · Cited by 3
Ethnicity-specific microbiome in early childhood caries: from the functional perspectives of oral biofilmPreprint
Hsu, K.-L. C., Shaffer, I. N., Furstenau, T., Ernst, R. K., & Fofanov, V. Y. (2024) · Research Square · doi:10.21203/rs.3.rs-5153245/v1 · Cited by 3
Bacteriological investigations of the human oral microbiota in health and disease
Kampoo, K. (2011) · Research Explorer (The University of Manchester) · Cited by 3
Evaluation of the Impact of some Plant Extracts against Streptococcus Spp. Isolated from Dental Decay Infection
Hamad, A. A., Alhumaidi, M. S., & Manayi, A. (2023) · The Open Microbiology Journal · doi:10.2174/18742858-v17-e230405-2022-25 · Cited by 2
The importance of Veillonella in the oral microbiome and its impact on dental and periodontal pathology: a literature review
Saganova, T. R., Tsarev, V. N., Giannì, A. B., Signorini, L., & Cavallè, E. (2023) · Parodontologiya · doi:10.33925/1683-3759-2023-792 · Cited by 5
Streptococci Biotypes in Primary and Permanent Caries: A Case–Control Study
Bhardwaj, S. B., Sharma, U., Mehta, M., & Sharma, J. (2024) · International Journal of Clinical Pediatric Dentistry · doi:10.5005/jp-journals-10005-2925 · Cited by 2
“11 A recent study indicates that the maximum caries is recorded in the first teeth to emerge, particularly the primary molars (D’s), which are later replaced by permanent molars (6’s).”
Chemical composition, antibacterial, and antifungal effects of Citrus medica (citron), Pimpinella anisum (anise), and Artemisia dracunculus (tarragon) on oral pathogens: An in vitro study
Mohammadzadeh, S., Rezazadeh, Z., Jafari, P., Tomatari, F. H., Jafari, S., & Mohebian, M. (2025) · Dental Research Journal · doi:10.4103/drj.drj_390_24 · Cited by 2
“[3] Oral candidiasis, an opportunistic infection of the mouth by Candida yeast, is another oral condition that significantly affects the quality of life.”
Antibacterial Efficacy of Syzygium cumini-Based Mouthwash against Streptococcus mutans: A Laboratory and Clinical Study
Chismirina, S., Andayani, R., Afrina, A., Nafisah, Q., Sungkar, S., & Rezeki, S. (2025) · Journal of international oral health · doi:10.4103/jioh.jioh_81_24 · Cited by 2
Modular Deep-Learning Pipelines for Dental Caries Data Streams: A Twin-Cohort Proof-of-Concept
Burlea, Ș. L., Buzea, C. G., Nedeff, F., Mirilă, D., Nedeff, V., Agop, M., Rusu, D. I., & Checheriță, L. E. (2025) · Dentistry Journal · doi:10.3390/dj13090402 · Cited by 2
The genomic history of Streptococcus mutans from the Mesolithic until modern times
Thygesen, V. F. D. F., Farahani, M. F., Nielsen, S. H., Constancias, F., Givskov, M., Abranches, J., Scorrano, G., Jørkov, M. L. S., Ebrahimi, G., Bendezú-Sarmiento, J., et al. (2026) · Genome biology · doi:10.1186/s13059-026-04018-w · Cited by 1
Isolation and genetic characterization of mutans streptococci associated with dental caries in rural field practice of a dental institution: In vivo study
Narayana, H., Kumar, B., Murthy, B. S., Mathew, S., Damodhar, P., & Kumar, S. S. (2019) · Indian Journal of Dental Research · doi:10.4103/ijdr.ijdr_269_17 · Cited by 2
“com Streptococcus sobrinus, are dynamically involved in the carious process.[3] The acid and extracellular polymers produced from carbohydrate metabolism by these bacteria and the consequent decrease in environmental pH is responsible for the demineralization of tooth surfaces.”
Background

Authors: Aas, J. A., Griffen, A. L., Dardis, S. R., Lee, A. M., Olsen, I., Dewhirst, F. E., Leys, E. J., & Paster, B. J.
Affiliations: University of Oslo (NO)
Department of Pediatric Dentistry
The Forsyth Institute (US)
Harvard University (US)
The Ohio State University (US)
Corresponding author: Aas, Jørn A.
ORCID: Griffen, Ann L.
Lee, Alice M.
Olsen, Ingar
Dewhirst, Floyd E.
Leys, Eugene J.
Paster, Bruce J.
Venue: Journal of Clinical Microbiology
Publisher: American Society for Microbiology
Published: 2008-04
Volume: 46
Issue: 4
Pages: 1407-1417
ISSN: 0095-1137 (ISSN-L)
1098-660X
DOI: 10.1128/jcm.01410-07
PMC: PMC2292933
OpenAlex: W2104771379
Cited by: 952
References: 42
Citations by year: 2026: 22 · 2025: 36 · 2024: 61 · 2023: 62 · 2022: 87 · 2021: 80 · 2020: 84 · 2019: 64 · 2018: 63 · 2017: 46 · 2016: 50 · 2015: 42 · 2014: 53 · 2013: 43 · 2012: 46
FWCI: 42.44
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Journal of Clinical Microbiology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Universitetet i Oslo
National Institutes of Health
National Institute of Dental and Craniofacial Research (U01DE016937, DE016125, R01DE016125, DE11443, R01DE011443)
Topics: Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
Health Sciences › Dentistry › General Dentistry › Dental Health and Care Utilization
Health Sciences › Dentistry › General Dentistry › Dental materials and restorations
Keywords: dental caries, Streptococcus mutans, primary teeth, permanent teeth, bacterial species composition, 16S rRNA gene sequencing, white spot lesions, dentin lesions, Lactobacillus, Bifidobacterium dentium, Atopobium, Propionibacterium, Actinomyces, Veillonella, caries progression, caries etiology, children and young adults
MeSH terms: Adolescent, Adult, Child, Child, Preschool, Dental Caries, Gram-Positive Bacteria, Humans, Molecular Sequence Data, RNA, Ribosomal, 16S, Tooth, Tooth, Deciduous, Gram-Positive Bacterial Infections, Sequence Analysis, DNA

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Bacteria of Dental Caries in Primary and Permanent Teeth in Children and Young Adults

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