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Bacteria of Dental Caries in Primary and Permanent Teeth in Children and Young Adults
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Although Streptococcus mutans has been implicated as a major etiological agent of dental caries, our cross-sectional preliminary study indicated that 10% of subjects with rampant caries in permanent teeth do not have detectable levels of S. mutans . Our aims were to use molecular methods to detect all bacterial species associated with caries in primary and permanent teeth and to determine the bacterial profiles associated with different disease states. Plaque was collected from 39 healthy controls and from intact enamel and white-spot lesions, dentin lesions, and deep-dentin lesions in each of 51 subjects with severe caries. 16S rRNA genes were PCR amplified, cloned, and sequenced to determine species identities. In a reverse-capture checkerboard assay, 243 samples were analyzed for 110 prevalent bacterial species. A sequencing analysis of 1,285 16S rRNA clones detected 197 bacterial species/phylotypes, of which 50% were not cultivable. Twenty-two new phylotypes were identified. PROC MIXED tests revealed health- and disease-associated species. In subjects with S. mutans , additional species, e.g., species of the genera Atopobium , Propionibacterium , and Lactobacillus , were present at significantly higher levels than those of S. mutans . Lactobacillus spp., Bifidobacterium dentium , and low-pH non- S. mutans streptococci were predominant in subjects with no detectable S. mutans . Actinomyces spp. and non- S. mutans streptococci were predominant in white-spot lesions, while known acid producers were found at their highest levels later in disease. Bacterial profiles change with disease states and differ between primary and secondary dentitions. Bacterial species other than S. mutans , e.g., species of the genera Veillonella , Lactobacillus , Bifidobacterium , and Propionibacterium , low-pH non- S. mutans streptococci, Actinomyces spp., and Atopobium spp., likely play important roles in caries progression.
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“Commensal microbiota comprise the majority of cells in the body and play a key role in human health1-5,10.”
From Sequencing ancient calcified dental plaque shows changes in oral microbiota with dietary shifts of the Neolithic and Industrial revolutions (2013) · cites this paper as [1]
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“However, a yet unnamed Corynebacterium phylotype has been found to be among the predominant species related to caries progression in the primary and permanent dentition [14].”
BackgroundThe metabolic profile of Bifidobacterium dentium reflects its status as a human gut commensal
Engevik, M. A., Danhof, H. A., Hall, A., Engevik, K. A., Horvath, T. D., Haidacher, S. J., Hoch, K. M., Endres, B. T., Bajaj, M., Garey, K. W., et al. (2021) · BMC Microbiology · doi:10.1186/s12866-021-02166-6 · Cited by 33
Abram, A. M., Szewczyk, M. M., Park, S. G., Sam, S., Eldana, H. B., Koria, F. J., Ferracciolo, J. M., Young, L. A., Qadir, H., Bonham, A. J., et al. (2022) · Infection and Immunity · doi:10.1128/iai.00355-22 · Cited by 30
“In agreement with other studies (12, 21, 33, 34), we also found an association between Veillonella parvula/dispar and caries.”
ResultHidas, A., Birman, N., Fux‐Noy, A., Shapira, J., Matot, I., Steinberg, D., & Moskovitz, M. (2012) · Clinical Oral Investigations · doi:10.1007/s00784-012-0876-0 · Cited by 30
“On the contrary, studies based on molecular techniques had found both mutans streptococci and lactobacilli to be dominant in advanced caries [18].”
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Kneist, S., Schmidt, F., Callaway, A., Willershausen, B., Rupf, S., Wicht, M. J., & Thiede, B. (2010) · European Archives of Paediatric Dentistry · doi:10.1007/bf03262741 · Cited by 30
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“may be present and contribute to the pH fall [Aas et al., 2008; Mantzourani et al., 2009].”
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The effects of family, dentition, and dental caries on the salivary microbiome
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Risk indicators of dental caries and gingivitis among 10−11-year-old students in Yangon, Myanmar
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“Instead, shifts in the abundance of bacteria, particularly Prevotella,[22] Lactobacillus[23] and Bifidobacterium [24] species, have been observed between health and caries.”
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Xiao, X., Liu, S., Deng, H., Song, Y., Zhang, L., & Song, Z. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1121737 · Cited by 30
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“mutans in caries-active individuals can be isolated more easily than those in caries-free individuals, which is consistent with the results of Aas [26].”
ResultFeng, J., Liu, J., Jiang, M., Chen, Q., Zhang, Y., Yang, M., & Zhai, Y. (2023) · Caries Research · doi:10.1159/000529162 · Cited by 28
Gussy, M. G., Mnatzaganian, G., Dashper, S. G., Carpenter, L. M., Calache, H., Mitchell, H. L., Reynolds, E. C., Gibbs, L. F., Hegde, S., Adams, G. G., et al. (2020) · Journal of Dentistry · doi:10.1016/j.jdent.2020.103276 · Cited by 29
Jurczak, A., Jamka-Kasprzyk, M., Bębenek, Z., Staszczyk, M., Jagielski, P., Kościelniak, D., Gregorczyk‐Maga, I., Kołodziej, I., Kępisty, M., Kukurba-Setkowicz, M., et al. (2020) · Nutrients · doi:10.3390/nu12092592 · Cited by 28
“This is evidenced by observations [37] which have shown that 10% of examined children and adolescents with caries have no S.”
Nakai, Y., & Mori, Y. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19127245 · Cited by 32
“Likewise, detection of lactobacilli and Bifidobacterium in ECC lesions [13,14] is in accordance with the extended ecological plaque hypothesis [12]: both bacterial genera are aciduric enough to colonize and proliferate in acidic carious lesions [15].”
ResultHoceini, A., Klouche-Khelil, N., Ben-Yelles, I., Mesli, A., Ziouani, S., Ghellai, L., Aissaoui, N., Nas, F., & Arab, M. (2016) · Asian Pacific Journal of Tropical Biomedicine · doi:10.1016/j.apjtb.2016.06.011 · Cited by 28
“coccus species are associated with healthy states [36], while others are associated with disease states [37].”
BackgroundEffect of Novel Antibacterial Composites on Bacterial Biofilms
Yaghmoor, R. B., Xia, W., Ashley, P. F., Allan, E., & Young, A. (2020) · Journal of Functional Biomaterials · doi:10.3390/jfb11030055 · Cited by 28
“Dentinal caries lesions contain primarily acid-producing and Gram-positive species, with Streptococcus mutans being particularly high [14,15].”
BackgroundBelstrøm, D., Constancias, F., Markvart, M., Sikora, M., Sørensen, C. E., & Givskov, M. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.752664 · Cited by 27
“parasanguinis is one of the only oral bacterial species that has been reported to associate with both caries (Aas et al., 2008), and has been given a role in periodontitis as accessory pathogen to the periodontal pathogen Aggregatibacter actinomycemcomitans (Fine et al.”
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“Clinical practice is more effective when information is shared with other professionals [48].”
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“significant portion of the children who develop caries (Aas et al., 2008), suggesting that additional species may play a significant role in dental caries development in children.”
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Oral Microbiomes in Children with Asthma and Dental Caries
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“Our data confirms a report by Aas et al. (2008), who also noted that the most prevalent species in either the occlusal or proximal caries of children with S-ECC is S. mutans [13].”
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“The selection of the bacterial profile for the qPCR analysis was based on previous studies that identified bacterial species commonly associated with dental caries or with health [Aas et al., 2008; Becker et al., 2002; Gross et al., 2012; Tanner et al., 2016].”
MethodHow Has Genomics Altered Our View of Caries Microbiology?
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“…by sequencing of rRNA have led to an expanded list of caries-associated species, including genera other than streptococci such as Actinomyces , Abiotrophia , Atopobium , Bifidobacterium, Lactobacillus and Veillonella [Munson et al., 2004; Chhour et al., 2005; Corby et al., 2005; Aas et al., 2008 ].”
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de Matos, B. M., Brighenti, F. L., Do, T., Beighton, D., & Koga‐Ito, C. Y. (2016) · Clinical Oral Investigations · doi:10.1007/s00784-016-1958-1 · Cited by 26
“[5] using molecular techniques demonstrated that 10 % of subjects with rampant caries in secondary dentition did not have detectable oral levels of Streptococcus mutans in intact enamel and white-spot lesions.”
Molecular detection of bacteria associated to caries activity in dentinal lesions
Neves, B. G., Stipp, R. N., Bezerra, D. D. S., Guedes, S. F. F., & Rodrigues, L. K. A. (2016) · Clinical Oral Investigations · doi:10.1007/s00784-016-1995-9 · Cited by 26
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Vaccine against Dental Caries- An Urgent Need
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“A wide group of microorganisms can be isolated from carious lesions of which Streptococcus mutans, Lactobacillus acidophilus, Lactobacillus fermentum, Actinomyces viscosus are the main pathogenic species involved in the initiation and development of carious lesions [9].”
BackgroundA 16S rRNA gene sequencing based study of oral microbiota in migraine patients in China
Jiang, W., Wang, T., Liu, C., Deng, M., Ren, X., Wang, F., Zhang, Y., Yu, X., Yao, L., & Wang, Y. (2021) · Bioengineered · doi:10.1080/21655979.2021.1933840 · Cited by 25
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“Mutans streptococci and red complex bacterial group, including Porphyromonas gingivalis, Tannerella forsythia, and Treponema denticola, represent species strongly correlated to a high clinical risk for tooth decay and periodontal pathologies [7,31,32].”
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“Children with high rates of tooth decay are much more heavily colonized with pathogenic bacteria than children who experience less tooth decay [27].”
BackgroundThe Role of Human Oral Microbiome in Dental Biofilm Formation
Krzyściak, W., Jurczak, A., & Piątkowski, J. (2016) · InTech eBooks · doi:10.5772/63492 · Cited by 27
“This is proved by the observations [19] that showed there was no presence of S.”
BackgroundResultSalivary Immune and Metabolic Marker Analysis (SIMMA): A Diagnostic Test to Predict Caries Risk
Mira, Á., Artacho, A., Camelo-Castillo, A. J., García‐Esteban, S., & Simón‐Soro, Á. (2017) · Diagnostics · doi:10.3390/diagnostics7030038 · Cited by 25
Combined analysis of the salivary microbiome and host defence peptides predicts dental disease
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Terminal RFLP analysis to determine the oral microbiota with hyposalivation
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Consumer Safety Considerations of Skin and Oral Microbiome Perturbation
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“As well as investigating the role of the microorganisms present in health and disease, microbiome research is increasingly being applied to investigate the fundamental biology of various skin conditions (38), oral hygiene (39), dandruff (40), dental caries (41), acne (42), and periodontitis (28, 29) (Table 1).”
BackgroundDental caries as a source of Helicobacter pylori infection in children: An RT‐PCR study
Sruthi, M. A., Mani, G., Ramakrishnan, M., & Jayaraman, S. (2022) · International Journal of Paediatric Dentistry · doi:10.1111/ipd.13017 · Cited by 24
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Korona‐Głowniak, I., Skawińska-Bednarczyk, A., Wróbel, R., Pietrak, J., Tkacz-Ciebiera, I., Maślanko, M., Krawczyk, D., Bakiera, A., Borek, A., Malm, A., et al. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph192215005 · Cited by 24
Milia, E. P., Sardellitti, L., & Eick, S. (2023) · Microorganisms · doi:10.3390/microorganisms11061378 · Cited by 26
“Due to a microbiota involving carbohydrate-fermenting Streptococcus mutans and species of the genera Actinomyces, Lactobacillus, Dialister, Eubacterium, Olsenella, Bifidobacterium, Atopobium, Propionibacterium, Scardovir, Abiotrophia, Selenomonas, Veillonella, and Candida albicans biofilms on the tooth surfaces may ca…”
BackgroundTorlakovic, L., Paster, B. J., Øgaard, B., & Olsen, I. (2013) · Acta Odontologica Scandinavica · doi:10.3109/00016357.2013.776107 · Cited by 24
“Porphyromonas gingivalis_ot619_AA93 Eubacterium[14][G-1] saburreum_ot494_W21”
BackgroundInfluentialSelf-citationHoles in teeth – Dental caries in Neolithic and Early Bronze Age populations in Central Germany
Nicklisch, N., Ganslmeier, R., Siebert, A., Friederich, S., Meller, H., & Alt, K. W. (2015) · Annals of Anatomy - Anatomischer Anzeiger · doi:10.1016/j.aanat.2015.02.001 · Cited by 23
Oral, intestinal, and skin bacteria in ventral hernia mesh implants
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“are also commonly detected in carious dentin and root canal infections (33).”
BackgroundSelf-citationBoddapati, S., Rai, R., & Gummadi, S. N. (2020) · Process Biochemistry · doi:10.1016/j.procbio.2020.07.006 · Cited by 24
Preventive effects of probiotics on dental caries in vitro and in vivo
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“…of the complex interaction between dietary carbohydrates and cario-genic microorganisms in oral bioflms, also influenced by the quality and quantity of saliva; the disease results from shifts in the balance of the resident microbiota driven by changes in the local environmental conditions [3].”
BackgroundBakale, R. P., Pathan, A. H., Naik, G. N., Machakanur, S. S., Mangannavar, C. V., Muchchandi, I. S., & Gudasi, K. B. (2014) · Applied Organometallic Chemistry · doi:10.1002/aoc.3190 · Cited by 23
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Simulating the Intraoral Aging of Dental Bonding Agents: A Narrative Review
Vilde, T., Stewart, C. A., & Finer, Y. (2022) · Dentistry Journal · doi:10.3390/dj10010013 · Cited by 23
“mutans is only one species in a highly complex microbial community, limiting such models [76], and making multispecies biofilms somewhat more representative of the oral environment, though ensuring the inclusion of appropriate species and determining the proportions of included bacteria can be a difficult process [44].”
BackgroundDaabash, R., Alqahtani, M. Q., Price, R. B., Alshabib, A., Niazy, A. A., & Alshaafi, M. M. (2023) · Journal of Dentistry · doi:10.1016/j.jdent.2023.104549 · Cited by 23
The Relationship between Sleep, Chronotype, and Dental Caries—A Narrative Review
Kurtović, A., Talapko, J., Bekić, S., & Škrlec, I. (2023) · Clocks & Sleep · doi:10.3390/clockssleep5020023 · Cited by 26
“This acidic environment can weaken the tooth’s enamel by demineralization and allow the bacteria to penetrate the tooth, leading to dental caries [28].”
BackgroundN-Acetyl- l -cysteine effects on multi-species oral biofilm formation and bacterial ecology
Rasmussen, K., Nikrad, J., Reilly, C., Li, Y., & Jones, R. S. (2015) · Letters in Applied Microbiology · doi:10.1111/lam.12513 · Cited by 23
“Furthermore, pathogenic oral species exist at detectable levels even in healthy individuals (Aas et al. 2008; Tanner et al. 2011).”
BackgroundSchweikl, H., Buchalla, W., & Krifka, S. (2017) · Dental Materials · doi:10.1016/j.dental.2017.02.006 · Cited by 23
Lamont, R. J., & Egland, P. G. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-397169-2.00052-4 · Cited by 22
Potential apply of hydrogel-carried chlorhexidine and metronidazole in root canal disinfection
Yan, Y., Zhou, P., Lu, H., Guan, Y., Ming, M. A., Wang, J., Shang, G., & Jiang, B. (2021) · Dental Materials Journal · doi:10.4012/dmj.2020-299 · Cited by 22
Size Attenuated Copper Doped Zirconia Nanoparticles Enhances In Vitro Antimicrobial Properties
Nishakavya, S., Girigoswami, A., Agraharam, G., Deepa, R., Divya, A., Ajith, S., & Girigoswami, K. (2022) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-022-03875-y · Cited by 22
“Among the widespread oral diseases, dental caries is the most common disease [24], and nowadays treatments in the dental field using biomaterials can change the mechanical, chemical, and physiological conditions inside the oral cavity.”
BackgroundDemineralization and Remineralization Dynamics and Dental Caries
Anil, A., Ibraheem, W., Meshni, A. A., Preethanath, R. S., & Anil, S. (2022) · Dentistry · doi:10.5772/intechopen.105847 · Cited by 22
Chlorhexidine Uptake and Release From Modified Titanium Surfaces and Its Antimicrobial Activity
Ryu, H.-S., Kim, Y., Lim, B., Lim, Y., & Ahn, S. (2015) · Journal of Periodontology · doi:10.1902/jop.2015.150075 · Cited by 22
Banas, J. A., Zhu, M. Y., Dawson, D. V., Blanchette, D. R., Drake, D. R., Gu, H., Frost, R., McCaulley, G., & Levy, S. M. (2016) · Journal of Oral Microbiology · doi:10.3402/jom.v8.32940 · Cited by 22
Loomba, A., Damle, S., Dhindsa, A., Loomba, A., & Beniwal, V. (2016) · Dental Research Journal · doi:10.4103/1735-3327.197035 · Cited by 22
“A selective medium, Mitis-Salivarius Sucrose Bacitracin agar (MSB), has been the outmoded method for assessing microbial or epidemiological studies related to isolation, identification, and quantification of MS bacteria.[9,15] With the advent of modern techniques in molecular biology, the use of phenotypic methods has…”
MethodVernocchi, P., CHIERICO, F. D., Quagliariello, A., Ercolini, D., Lucidi, V., & Putignani, L. (2017) · Nutrients · doi:10.3390/nu9121342 · Cited by 22
“Indeed, Bifidobacterium dentium was detected in the oral cavity in association with dental caries [38], while Eubacterium dolichum was associated with frailty in the elderly, a condition that represents the biggest problem associated with population aging [39].”
BackgroundRecent progress in experimental and human disease-associated multi-species biofilms
Bai, F., Cai, Z., & Yang, L. (2019) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2019.09.010 · Cited by 25
“predominant different sites of caries and promote the development of caries [51].”
BackgroundLiu, R. R., Liu, Y., Yi, J., Fang, Y., Guo, Q., Cheng, L., He, J., & Li, M. (2025) · BMC Microbiology · doi:10.1186/s12866-025-03762-6 · Cited by 25
Biofilm community diversity after exposure to 0·4% stannous fluoride gels
Reilly, C., Rasmussen, K., Selberg, T., Stevens, J., & Jones, R. S. (2014) · Journal of Applied Microbiology · doi:10.1111/jam.12655 · Cited by 21
“been published previously and describes the methodology and facilities (Aas et al. 2008; Colombo et al. 2009; Dewhirst et al. 2010).”
MethodDobrzański, L. A., & Dobrzański, L. B. (2020) · Materials Performance and Characterization · doi:10.1520/mpc20200020 · Cited by 22
Functionally Active Microbiome in Supragingival Biofilms in Health and Caries
Corralo, D. J., Ev, L. D., Damé‐Teixeira, N., Maltz, M., Arthur, R. A., Do, T., & Parolo, C. C. F. (2021) · Caries Research · doi:10.1159/000518963 · Cited by 21
Hops components and oral health
Abiko, Y., Paudel, D., & Uehara, O. (2022) · Journal of Functional Foods · doi:10.1016/j.jff.2022.105035 · Cited by 21
The Oral Microbiome in Health and Disease
Olsen, I. (2015) · Springer eBooks · doi:10.1007/978-3-319-25091-5_10 · Cited by 21
Self-citationComparative Antimicrobial Activity of Areca catechu Nut Extracts using Different Extracting Solvents
Rahman, M. A., Sultana, P., Islam, M. S., Mahmud, M. T., Rashid, M. M. O., & Hossen, F. (2016) · Bangladesh Journal of Microbiology · doi:10.3329/bjm.v31i1.28460 · Cited by 21
Okada, E. M. P., Ribeiro, L. N. S., Stuani, M. B. S., Borsatto, M. C., Fidalgo, T. K. D. S., Paula‐Silva, F. W. G., & Küchler, É. C. (2016) · Brazilian Oral Research · doi:10.1590/1807-3107bor-2016.vol30.0115 · Cited by 21
Quantitative analysis of biofilm bacteria according to different stages of early childhood caries
Neves, B. G., Stipp, R. N., Bezerra, D. D. S., Guedes, S. F. F., & Rodrigues, L. K. A. (2018) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2018.09.007 · Cited by 21
Wu, Y., Jansen, E. C., Peterson, K. E., Foxman, B., Goodrich, J. M., Hu, H., Solano-González, M., Cantoral, A., Téllez‐Rojo, M. M., & Martinez-Mier, E. A. (2018) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2018.11.190 · Cited by 21
“Although we did not have information on primary teeth, other studies have reported correlations between caries of primary teeth and permanent teeth [35, 36, 37]; thus for our study, permanent caries may be a reasonable proxy for primary caries.”
Philip, N. I., Leishman, S. J., Bandara, N., & Walsh, L. J. (2019) · Caries Research · doi:10.1159/000499869 · Cited by 21
“Selection of the bacteria for the qPCR assay was based on previous profile studies of bacterial species commonly associated with dental caries and health [Burne and Marquis, 2000; Becker et al., 2002; Aas et al., 2008; Gross et al., 2012; Kianoush et al., 2014; Takahashi, 2015; Tanner et al., 2016; Richards et al., 20…”
MethodEffect of silver diamine fluoride on plaque microbiome in children
Mei, M. L., Yan, Z., Duangthip, D., Niu, J. Y., Yu, O. Y., You, M., Lo, E. C. M., & Chu, C. H. (2020) · Journal of Dentistry · doi:10.1016/j.jdent.2020.103479 · Cited by 23
Immune System of Dental Pulp in Inflamed and Normal Tissue
Sarfi, S., Azaryan, E., & Naseri, M. (2024) · DNA and Cell Biology · doi:10.1089/dna.2024.0044 · Cited by 21
“The micro fl ora contains many bacterial species in moderate caries in teeth (Aas et al., 2008; Chhour et al., 2005).”
Sánchez, M. C., Velapatiño, Á., Llama‐Palacios, A., Valdés, A., Cifuentes, A., Ciudad, M. J., & Yurrita, L. C. (2022) · Molecular Oral Microbiology · doi:10.1111/omi.12363 · Cited by 30
Development of Novel Antimicrobial Dental Composite Resin with Nano Cerium Oxide Fillers
Varghese, E. J., Sihivahanan, D., & Venkatesh, K. V. (2022) · International Journal of Biomaterials · doi:10.1155/2022/3912290 · Cited by 20
“Aas and others (2008) in his research to determine the bacterial profile for dental caries have concluded that both Streptococcus and Lactobacillus species were the most commonly present bacteria in dental caries [7].”
BackgroundProbiotics: Dawn of a New Era in Dental Caries Management
Panda, A., Mishra, P., Bhuyan, L., Kumar, V., Mahapatra, N., & Adhikary, T. (2022) · Journal of Pharmacy And Bioallied Sciences · doi:10.4103/jpbs.jpbs_801_21 · Cited by 20
Oral microbial interactions from an ecological perspective: a narrative review
Fine, D. H., & Schreiner, H. C. (2023) · Frontiers in Oral Health · doi:10.3389/froh.2023.1229118 · Cited by 20
Roca, C., Alkhateeb, A. A., Deanhardt, B. K., Macdonald, J. K., Donald, L., Wang, J., & Wolfgang, M. C. (2024) · PLoS ONE · doi:10.1371/journal.pone.0301016 · Cited by 20
Is Gutta-Percha Still the “Gold Standard” among Filling Materials in Endodontic Treatment?
Dobrzańska, J., Dobrzański, L. B., Dobrzański, L. B., Gołombek, K., & Dobrzańska-Danikiewicz, A. D. (2021) · Processes · doi:10.3390/pr9081467 · Cited by 20
“The micro-organisms present in the carious dentin defect are usually strict anaerobes such as Actinomyces, Bifidobacterium, Lactobacillus, Eubacterium, Propionibacterium, and Rothia, and less-frequent Gram-negative species and streptococci [36].”
BackgroundIs Oral Health Affected in Long Period Space Missions Only by Microgravity? A Systematic Review
Lloro, V., Giovannoni, L. M., Lozano-de Luaces, V., Lloro, I., & Manzanares, M. C. (2020) · Acta Astronautica · doi:10.1016/j.actaastro.2019.11.015 · Cited by 19
Yang, Z., Du, C., Chang, Z., Yang, Y., & Hu, L. (2025) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2025.1612223 · Cited by 19
Sabbagh, H. J., AlGhamdi, K. S., Mujalled, H. T., & Bagher, S. M. (2020) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-020-2847-3 · Cited by 19
Metadata
- Authors
- Aas, J. A., Griffen, A. L., Dardis, S. R., Lee, A. M., Olsen, I., Dewhirst, F. E., Leys, E. J., & Paster, B. J.
- Affiliations
- University of Oslo (NO)
- Department of Pediatric Dentistry
- The Forsyth Institute (US)
- Harvard University (US)
- The Ohio State University (US)
- Corresponding author
- Aas, Jørn A.
- Venue
- Journal of Clinical Microbiology
- Publisher
- American Society for Microbiology
- Published
- 2008-04
- Volume
- 46
- Issue
- 4
- Pages
- 1407-1417
- ISSN
- 0095-1137 (ISSN-L)
- 1098-660X
- PMC
- PMC2292933
- OpenAlex
- W2104771379
- Cited by
- 952
- References
- 42
- Citations by year
- 2026: 22 · 2025: 36 · 2024: 61 · 2023: 62 · 2022: 87 · 2021: 80 · 2020: 84 · 2019: 64 · 2018: 63 · 2017: 46 · 2016: 50 · 2015: 42 · 2014: 53 · 2013: 43 · 2012: 46
- FWCI
- 42.44
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Clinical Microbiology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Universitetet i Oslo
- National Institutes of Health
- National Institute of Dental and Craniofacial Research (U01DE016937, DE016125, R01DE016125, DE11443, R01DE011443)
- Topics
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Health Sciences › Dentistry › General Dentistry › Dental Health and Care Utilization
- Health Sciences › Dentistry › General Dentistry › Dental materials and restorations
- Keywords
- dental caries, Streptococcus mutans, primary teeth, permanent teeth, bacterial species composition, 16S rRNA gene sequencing, white spot lesions, dentin lesions, Lactobacillus, Bifidobacterium dentium, Atopobium, Propionibacterium, Actinomyces, Veillonella, caries progression, caries etiology, children and young adults
- MeSH terms
- Adolescent, Adult, Child, Child, Preschool, Dental Caries, Gram-Positive Bacteria, Humans, Molecular Sequence Data, RNA, Ribosomal, 16S, Tooth, Tooth, Deciduous, Gram-Positive Bacterial Infections, Sequence Analysis, DNA
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