Candida auris Isolates of the Southern Asian and South African Lineages Exhibit Different Phenotypic and Antifungal Susceptibility Profiles In Vitro
Open accessAbstract
Candida auris is a serious nosocomial health risk, with widespread outbreaks occurring in hospitals worldwide. Sequence analyses of outbreak isolates revealed that C. auris has simultaneously emerged as four distinct continentally restricted clonal lineages.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Exposure to triazoles and echinocandins induced cell aggregation in C. auris clinical isolates of the South Asian clade, which are non-aggregative.
“On the other hand, the exposure to triazoles and echinocandins also induced cell aggregation in C. auris clinical isolates of the South Asian clade, which are non-aggregative (16).”
From Cell aggregation mediated by <i>ACE2</i> deletion in <i>Candida auris</i> modulates fungal colonization and host immune responses in the skin (2024) · cites this paper as [16]
Aggregation is mainly observed among clade III isolates but has also been reported in other clades.
“Aggregation has been mainly observed among clade III isolates but has also been reported in other clades and can be induced under some in vitro or in vivo conditions (18, 49–51).”
From Ume6-dependent pathways of morphogenesis and biofilm formation in <i>Candida auris</i> (2024) · cites this paper as [18]
Cites
Chowdhary, A., Sharma, C., & Meis, J. F. (2017) · PLOS Pathogens · doi:10.1371/journal.ppat.1006290 · Cited by 750 · see citing works
Multidrug-resistant endemic clonal strain of Candida auris in India
Chowdhary, A., Anil Kumar, V., Sharma, C., Prakash, A., Agarwal, K., Babu, R., Dinesh, K. R., Karim, S., Singh, S. K., Hagen, F., et al. (2014) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-013-2027-1 · Cited by 373 · see citing works
Chow, N. A., Gade, L., Tsay, S. V., Forsberg, K., Greenko, J. A., Southwick, K. L., Barrett, P. M., Kerins, J. L., Lockhart, S. R., Chiller, T. M., et al. (2018) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(18)30597-8 · Cited by 289 · see citing works
Current Perspectives on Echinocandin Class Drugs
Perlin, D. S. (2011) · Future Microbiology · doi:10.2217/fmb.11.19 · Cited by 274 · see citing works
Kean, R., Delaney, C., Sherry, L., Borman, A., Johnson, E. M., Richardson, M. D., Rautemaa-Richardson, R., Williams, C., & Ramage, G. (2018) · mSphere · doi:10.1128/msphere.00334-18 · Cited by 220 · see citing works
Self-citationEpidemiology of Candida albicans Infections and Role of Non-Candidaalbicans Yeasts
Ruhnke, M. (2006) · Current Drug Targets · doi:10.2174/138945006776359421 · Cited by 210 · see citing works
Shifting patterns in the epidemiology of nosocomial Candida infections
Snydman, D. R. (2003) · Chest · doi:10.1378/chest.123.5_suppl.500s · Cited by 142 · see citing works
First report of sporadic cases of Candida auris in Colombia
Parra-Giraldo, C. M., Valderrama, S. L., Cortes-Fraile, G., Garzón, J. R., Ariza, B. E., Morio, F., Linares-Linares, M. Y., Ceballos-Garzón, A., de la Hoz, A., Hernandez, C., et al. (2018) · International Journal of Infectious Diseases · doi:10.1016/j.ijid.2018.01.034 · Cited by 74 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Ahmad, S., & Alfouzan, W. (2021) · Microorganisms · doi:10.3390/microorganisms9040807 · Cited by 269 · see citing works
Bruno, M., Kersten, S., Bain, J. M., Jaeger, M., Rosati, D., Kruppa, M. D., Lowman, D. W., Rice, P. J., Graves, B., Ma, Z., et al. (2020) · Nature Microbiology · doi:10.1038/s41564-020-0780-3 · Cited by 145 · see citing works
Santana, D. J., & O’Meara, T. R. (2021) · Nature Communications · doi:10.1038/s41467-021-27545-5 · Cited by 91 · see citing works
Rapid evolution of an adaptive multicellular morphology of Candida auris during systemic infection
Bing, J., Guan, Z., Zheng, T., Ennis, C. L., Nobile, C. J., Chen, C., Chu, H., & Huang, G. (2024) · Nature Communications · doi:10.1038/s41467-024-46786-8 · Cited by 74 · see citing works
Vazquez-Munoz, R., Lopez, F. D., & Lopez-Ribot, J. L. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.01673 · Cited by 59 · see citing works
Vila, T., Montelongo-Jauregui, D., Ahmed, H., Puthran, T., Sultan, A. S., & Jabra-Rizk, M. A. (2020) · mSphere · doi:10.1128/msphere.00760-20 · Cited by 58 · see citing works
Eldesouky, H. E., Salama, E. A., Lanman, N. A., Hazbun, T. R., & Seleem, M. N. (2020) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00684-20 · Cited by 56 · see citing works
Upc2-mediated mechanisms of azole resistance in <i>Candida auris</i>
Li, J., Aubry, L., Brandalise, D., Coste, A. T., Sanglard, D., & Lamoth, F. (2024) · Microbiology Spectrum · doi:10.1128/spectrum.03526-23 · Cited by 33 · see citing works
Jenull, S., Shivarathri, R., Tsymala, I., Penninger, P., Trinh, P.-C., Nogueira, F., Chauhan, M., Singh, A., Petryshyn, A., Stoiber, A., et al. (2022) · mBio · doi:10.1128/mbio.00799-22 · Cited by 32 · see citing works
“Additionally, despite rather low genetic diversities within a clade (14), phenotypic intraclade variations, such as in antifungal susceptibility profiles (13, 33), cell wall structures (28), or aggregate formation (63), are known.”
BackgroundTranscriptome Signatures Predict Phenotypic Variations of Candida auris
Jenull, S., Tscherner, M., Kashko, N., Shivarathri, R., Stoiber, A., Chauhan, M., Petryshyn, A., Chauhan, N., & Kuchler, K. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.662563 · Cited by 32 · see citing works
Native human and mouse skin infection models to study Candida auris-host interactions
Seiser, S., Arzani, H., Ayub, T., Phan-Canh, T., Staud, C., Worda, C., Kuchler, K., & Elbe-Bürger, A. (2024) · Microbes and Infection · doi:10.1016/j.micinf.2023.105234 · Cited by 29 · see citing works
Ume6-dependent pathways of morphogenesis and biofilm formation in <i>Candida auris</i>
Louvet, M., Li, J., Brandalise, D., Bachmann, D., Sala de Oyanguren, F., Labes, D., Jacquier, N., Genoud, C., Mucciolo, A., Coste, A. T., et al. (2024) · Microbiology Spectrum · doi:10.1128/spectrum.01531-24 · Cited by 20 · see citing works
Balakumar, A., Cox, A., & Thangamani, S. (2024) · mSphere · doi:10.1128/msphere.00734-24 · Cited by 12 · see citing works
- Authors
- Szekely, A., Borman, A. M., & Johnson, E. M.
- Affiliations
- UK National Mycology Reference Laboratory (MRL), Public Health England South-West, Bristol, United Kingdom
- Public Health England (GB)
- Venue
- Journal of Clinical Microbiology
- Publisher
- American Society for Microbiology
- Published
- 2019-05
- Volume
- 57
- Issue
- 5
- ISSN
- 0095-1137 (ISSN-L)
- 1098-660X
- PMC
- PMC6498034
- OpenAlex
- W2922422721
- Cited by
- 125
- References
- 8
- Citations by year
- 2026: 11 · 2025: 14 · 2024: 23 · 2023: 16 · 2022: 15 · 2021: 21 · 2020: 18 · 2019: 7
- FWCI
- 11.69
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Microbiology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Yeasts and Rust Fungi Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Keywords
- Candida auris, antifungal susceptibility, triazole resistance, echinocandin resistance, amphotericin B, 5-fluorocytosine, Galleria mellonella, phenotypic profiles
- MeSH terms
- Animals, Antifungal Agents, Asia, Candida, Cycloheximide, United Kingdom, Humans, Larva, Microbial Sensitivity Tests, Moths, Phenotype, South Africa, Virulence, Communicable Diseases, Emerging
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
