Silver nanoantibiotics display strong antifungal activity against the emergent multidrug-resistant yeast Candida auris under both planktonic and biofilm growing conditions

Vazquez-Munoz, Roberto; Lopez, Fernando D.; Lopez-Ribot, Jose L.

doi:10.3389/fmicb.2020.01673

Cited by 59Antifungal resistance and susceptibilityNanoparticles: synthesis and applicationsEssential Oils and Antimicrobial Activity

Silver nanoantibiotics display strong antifungal activity against the emergent multidrug-resistant yeast Candida auris under both planktonic and biofilm growing conditions

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Vazquez-Munoz, Roberto, Lopez, Fernando D., Lopez-Ribot, Jose L.·2020·Frontiers in Microbiology

DOI 10.3389/fmicb.2020.01673PMC PMC7399222

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Abstract

Candida auris is an emergent multidrug-resistant pathogenic yeast with an unprecedented ability for a fungal organism to easily spread between patients in clinical settings, leading to major outbreaks in healthcare facilities. The formation of biofilms by C. auris contributes to infection and its environmental persistence. Most antifungals and sanitizing procedures are not effective against C. auris, but antimicrobial nanomaterials could represent a viable alternative to combat the infections caused by this emerging pathogen. We have previously described an easy and inexpensive method to synthesize silver nanoparticles (AgNPs) in non-specialized laboratories. Here we have assessed the antimicrobial activity of the resulting AgNPs on C. auris planktonic and biofilm growth phases. AgNPs displayed a strong antimicrobial activity against all the stages of all C. auris strains tested, representative of four different clades. Under planktonic conditions, MIC values of AgNPs against the different strains were <0.5 µg mL -1 ; whereas calculated IC50 values for inhibition of biofilms formation were < 2 µg mL -1 for all but one of the C. auris strains tested. AgNPs were also active against preformed biofilms formed by all different C. auris strains, with IC50 values ranging from 1.2 to 6.2 µg mL -1 . Overall, our results indicate potent activity of AgNPs against strains of C. auris, both under planktonic and biofilm growing conditions and indicate that AgNPs may contribute to the control of infections caused by this emerging nosocomial threat.

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Initial experiments demonstrated increased activity of AgNPs against C. albicans, including preformed biofilms, and most recently this research has expanded to other Candida spp., particularly C. auris.
“While initial experiments demonstrated the increased activity of AgNPs against C. albicans, including preformed biofilms [76,77], most recently this research has also expanded to other Candida spp., and in particular C. auris [78,79].”
From Antifungal therapy of Candida biofilms: Past, present and future (2023) · cites this paper as [79]

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Authors: Vazquez-Munoz, R., Lopez, F. D., & Lopez-Ribot, J. L.
Affiliations: The University of Texas at Austin (US)
The University of Texas at San Antonio (US)
Corresponding author: Lopez-Ribot, Jose L.
ORCID: Lopez-Ribot, Jose L.
Venue: Frontiers in Microbiology
Publisher: Frontiers Media SA
Published: 2020-07-28
Volume: 11
Pages: 1673-1673
ISSN: 1664-302X (ISSN-L)
DOI: 10.3389/fmicb.2020.01673
PMC: PMC7399222
OpenAlex: W3045961393
Cited by: 59
References: 51
Citations by year: 2026: 7 · 2025: 14 · 2024: 11 · 2023: 6 · 2022: 10 · 2021: 9 · 2020: 2
FWCI: 0.86
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Frontiers in Microbiology (publishedVersion, cc-by)
bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc-nd)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: Consejo Nacional de Ciencia y Tecnología
Topics: Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Physical Sciences › Materials Science › Materials Chemistry › Nanoparticles: synthesis and applications
Life Sciences › Agricultural and Biological Sciences › Food Science › Essential Oils and Antimicrobial Activity
Keywords: Candida auris, silver nanoparticles, antifungal activity, biofilm inhibition, planktonic growth, multidrug resistance, nosocomial infections, antimicrobial nanomaterials, minimum inhibitory concentration

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Silver nanoantibiotics display strong antifungal activity against the emergent multidrug-resistant yeast Candida auris under both planktonic and biofilm growing conditions

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