Spread of Vaccine-Derived Poliovirus from a Paralytic Case in an Immunodeficient Child: an Insight into the Natural Evolution of Oral Polio Vaccine
Open accessAbstract
Sabin strains used in the manufacture of oral polio vaccine (OPV) replicate in the human organism and can give rise to vaccine-derived polioviruses. The increased neurovirulence of vaccine derivatives has been known since the beginning of OPV use, but their ability to establish circulation in communities has been recognized only recently during the latest stages of the polio eradication campaign. This important observation called for studies of their emergence and evolution as well as extensive surveillance to determine the scope of this phenomenon. Here, we present the results of a study of vaccine-derived isolates from an immunocompromised poliomyelitis patient, the contacts, and the local sewage. All isolates were identified as closely related and slightly evolved vaccine derivatives with a recombinant type 2/type 1 genome. The strains also shared several amino acid substitutions including a mutation in the VP1 protein that was previously shown to be associated with the loss of attenuation. Another mutation in the VP3 protein resulted in altered immunological properties of the isolates, possibly facilitating virus spread in immunized populations. The patterns and rates of the accumulation of synonymous mutations in isolates collected from the patient over the extended period of excretion suggest either a substantially nonuniform rate of mutagenesis throughout the genome, or, more likely, the strains may have been intratypic recombinants between coevolving derivatives with different degrees of divergence from the vaccine parent. This study provides insight into the early stages of the establishment of circulation by runaway vaccine strains.
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The nature and location of recombination junctions provide additional markers for the resolution of poliovirus lineages, especially for closely related isolates.
“The nature and location of recombination junctions provide additional markers for the resolution of poliovirus lineages (84, 107), especially for closely related isolates (27).”
From VACCINE-DERIVED POLIOVIRUSES AND THE ENDGAME STRATEGY FOR GLOBAL POLIO ERADICATION (2005) · cites this paper as [27]
The properties of some aVDPV isolates, and even some OPV-like isolates in certain settings, may yield insights into the early dynamics of cVDPV emergence which in other settings could result in an outbreak.
“The properties of some aVDPVisolates, and even some OPV-like isolates in certain settings (27, 100), may yield insights into the early dynamics of cVDPV emergence which in other settings could result in an outbreak.”
From VACCINE-DERIVED POLIOVIRUSES AND THE ENDGAME STRATEGY FOR GLOBAL POLIO ERADICATION (2005) · cites this paper as [27]
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- Authors
- Cherkasova, E. A., Yakovenko, M. L., Rezapkin, G. V., Korotkova, E. A., Ivanova, O. E., Eremeeva, T. P., Krasnoproshina, L. I., Romanenkova, N. I., Rozaeva, N. R., Sirota, L., Agol, V. I., & Chumakov, K. M.
- Affiliations
- Center for Biologics Evaluation and Research (US)
- Lomonosov Moscow State University (RU)
- Chumakov Institute of Poliomyelitis and Viral Encephalitides (RU)
- I. I. Mechnikov Institute of Vaccines and Sera, Moscow
- Saint Petersburg Pasteur Institute (RU)
- Corresponding author
- Chumakov, K. M.
- ORCID
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 2005-01-15
- Volume
- 79
- Issue
- 2
- Pages
- 1062-1070
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- PMC
- PMC538583
- OpenAlex
- W2134693843
- Cited by
- 55
- References
- 43
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 2 · 2020: 1 · 2019: 2 · 2018: 2 · 2017: 2 · 2016: 4 · 2015: 1 · 2014: 1 · 2013: 1 · 2012: 1
- FWCI
- 3.26
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Virology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Defense Advanced Research Projects Agency
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Viral Infections and Immunology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
- Keywords
- vaccine-derived poliovirus, oral polio vaccine, Sabin strains, paralytic poliomyelitis, neurovirulence, VP1 mutations, synonymous mutations, wastewater surveillance, viral evolution, polio eradication
- MeSH terms
- Humans, Infant, Mutation, Poliomyelitis, Poliovirus Vaccine, Oral, Recombination, Genetic, Genome, Viral, Poliovirus, Evolution, Molecular
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