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Cited by 101Viral Infections and Immunology ResearchEvolution and Genetic DynamicsGenomics and Phylogenetic Studies

Microarray analysis of evolution of RNA viruses: Evidence of circulation of virulent highly divergent vaccine-derived polioviruses

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Cherkasova, Elena, Laassri, Majid, Chizhikov, Vladimir, Korotkova, Ekaterina, Dragunsky, Eugenia, Agol, Vadim I., Chumakov, Konstantin·2003·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.1633511100PMC PMC170930
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Abstract

Two approaches based on hybridization of viral probes with oligonucleotide microarrays were developed for rapid analysis of genetic variations during microevolution of RNA viruses. Microarray analysis of viral recombination and microarray for resequencing and heterogeneity analysis were able to generate instant genetic maps of vaccine-derived polioviruses (VDPVs) and reveal the degree of their evolutionary divergence. Unlike conventional methods based on cDNA sequencing and restriction fragment length polymorphism, the microarray approaches are better suited for analysis of heterogeneous populations and mixtures of different strains. The microarray hybridization profile is very sensitive to the cumulative presence of small quantities of different mutations, including those that cannot be revealed by sequencing, making this approach useful for characterization of profiles of nucleotide sequence diversity in viral populations. By using these methods, we identified a type-3 VDPV isolated from a healthy person and missed by conventional methods of screening. The mutational profile of the polio strain was consistent with >1 yr of circulation in human population and was highly virulent in transgenic mice, confirming the ability of VDPV to persist in communities despite high levels of immunity. The proposed methods for fine genotyping of heterogeneous viral populations can also have utility for a variety of other applications in studies of genetic changes in viruses, bacteria, and genes of higher organisms.

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  • The first new molecular approach, based upon microarrays sampling comprehensively across the genome, can detect genetic divergence or recombination in vaccine-related isolates by oligonucleotide duplex stability.

    “The first approach, based upon microarrays sampling comprehensively across the genome, can detect genetic divergence or recombination in vaccine-related isolates by oligonucleotide duplex stability”

    From VACCINE-DERIVED POLIOVIRUSES AND THE ENDGAME STRATEGY FOR GLOBAL POLIO ERADICATION (2005) · cites this paper as [25]

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Authors
Cherkasova, E., Laassri, M., Chizhikov, V., Korotkova, E., Dragunsky, E., Agol, V. I., & Chumakov, K.
Affiliations
Lomonosov Moscow State University (RU)
ORCID
Venue
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences
Published
2003-07-23
Volume
100
Issue
16
Pages
9398-9403
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.1633511100
PMC
PMC170930
OpenAlex
W2169734644
Cited by
101
References
46
Citations by year
2025: 1 · 2023: 1 · 2020: 1 · 2019: 2 · 2018: 1 · 2016: 2 · 2015: 4 · 2014: 2 · 2012: 6
FWCI
9.44
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Viral Infections and Immunology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
Keywords
vaccine-derived poliovirus, poliovirus evolution, viral recombination, viral heterogeneity, gene mapping, type 3 poliovirus, viral genotyping, nucleotide diversity
MeSH terms
Animals, Genotype, Humans, Mice, Transgenic, Mutation, Nucleic Acid Hybridization, RNA Viruses, Vaccines, Genome, Viral, Point Mutation, Poliovirus, DNA, Complementary, Oligonucleotide Array Sequence Analysis, Mice

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