The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
Hypoxia-Inducible Factor 1α Induces Fibrosis and Insulin Resistance in White Adipose Tissue
Open accessAbstract
Adipose tissue can undergo rapid expansion during times of excess caloric intake. Like a rapidly expanding tumor mass, obese adipose tissue becomes hypoxic due to the inability of the vasculature to keep pace with tissue growth. Consequently, during the early stages of obesity, hypoxic conditions cause an increase in the level of hypoxia-inducible factor 1alpha (HIF1alpha) expression. Using a transgenic model of overexpression of a constitutively active form of HIF1alpha, we determined that HIF1alpha fails to induce the expected proangiogenic response. In contrast, we observed that HIF1alpha initiates adipose tissue fibrosis, with an associated increase in local inflammation. "Trichrome- and picrosirius red-positive streaks," enriched in fibrillar collagens, are a hallmark of adipose tissue suffering from the early stages of hypoxia-induced fibrosis. Lysyl oxidase (LOX) is a transcriptional target of HIF1alpha and acts by cross-linking collagen I and III to form the fibrillar collagen fibers. Inhibition of LOX activity by beta-aminoproprionitrile treatment results in a significant improvement in several metabolic parameters and further reduces local adipose tissue inflammation. Collectively, our observations are consistent with a model in which adipose tissue hypoxia serves as an early upstream initiator for adipose tissue dysfunction by inducing a local state of fibrosis.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Under conditions of over‐nutrition, chronic stress, and/or long periods of physical inactivity, maladaptive adipose tissue expansion causes an increase in hypoxia in these cells, because of their expanded size.[ 24 ]”
From Pathogenesis of sarcopenia and the relationship with fat mass: descriptive review (2022) · cites this paper as [24]
In the citing paper
“HIF-1α activation is classically described as pro-angiogenic, but recent studies have shown it to also be pro-fibrotic and proinflammatory (4).”
From The ominous triad of adipose tissue dysfunction: inflammation, fibrosis, and impaired angiogenesis. (2017) · cites this paper as [4]
In the citing paper
“Interestingly, unlike acute AT expansion, the hypoxia response of obese ob/ob mice fails to induce VEGF expression, and instead a decrease in vascular density is observed (4).”
From The ominous triad of adipose tissue dysfunction: inflammation, fibrosis, and impaired angiogenesis. (2017) · cites this paper as [4]
In the citing paper
“Genetic introduction of dominant-active HIF-1α in mice was unable to induce an angiogenic response but instead increased the expression of several fibrotic genes (4).”
From The ominous triad of adipose tissue dysfunction: inflammation, fibrosis, and impaired angiogenesis. (2017) · cites this paper as [4]
In the citing paper
“merely 24 to 48 hours of exposure to a high-fat diet (HFD) can cause a prompt increase in adipocyte size (4).”
From Adipose tissue remodeling and obesity (2011) · cites this paper as [4]
In the citing paper
“Many physiologically relevant processes important for human AT remodeling can be studied in rodent models, with the added advantage that processes related to AT expansion and reduction can occur at an extremely rapid rate.”
From Adipose tissue remodeling and obesity (2011) · cites this paper as [4]
In the citing paper
“A 24-hour fast in a mouse is associated with a dramatic loss of AT mass and an acute remodeling process that involves rapid infiltration of macrophages;”
From Adipose tissue remodeling and obesity (2011) · cites this paper as [4]
In the citing paper
“Moreover, we did not detect any increases in key components of the angiogenic or anaerobic glycolytic programs (4).”
From Adipose tissue remodeling and obesity (2011) · cites this paper as [4]
In the citing paper
“Collectively, our results suggest that hypoxia-induced fibrosis in AT may be a key factor that ultimately stimulates the local inflammatory responses.”
From Adipose tissue remodeling and obesity (2011) · cites this paper as [4]
In the citing paper
“As the result of this aberrant HIF-mediated transcriptional program, we proposed that the ECM in white AT accumulates fibrillar collagens; the upregulation of ECM thus causes local fibrosis.”
From Adipose tissue remodeling and obesity (2011) · cites this paper as [4]
In the citing paper
“To investigate the effects of HIF-1α in white AT, we analyzed a transgenic mouse model in which we overexpressed a dominant active (degradation-resistant) deletion mutant of HIF-1α (HIF-1α-ΔODD) specifically in adipocytes (4).Unexpectedly, our model failed to induce any classical HIF-1α targets, such as VEGF-A.”
From Adipose tissue remodeling and obesity (2011) · cites this paper as [4]
In the citing paper
“The most striking alteration we observed in this model was an enhanced fibrotic response, which included an upregulation lysyl oxidase (LOX), elastin, collagens I and III, tissue inhibitor of metalloproteinase I, and connective tissue growth factor.”
From Adipose tissue remodeling and obesity (2011) · cites this paper as [4]
In the citing paper
“Compared to brown AT, white AT is not particularly well vascularized (4,20)”
From Adipose tissue remodeling and obesity (2011) · cites this paper as [4]
In the citing paper
“this consequently leads to an acute hypoxic response within the adipocytes themselves (4)”
From Adipose tissue remodeling and obesity (2011) · cites this paper as [4]
In the citing paper
“We have also shown that exposure to a HFD for merely a few days results in a significant increase in adipocyte cell size”
From Adipose tissue remodeling and obesity (2011) · cites this paper as [4]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
1 retracted
Lysyl oxidase is essential for hypoxia-induced metastasis
Erler, J. T., Bennewith, K. L., Nicolau, M., Dornhöfer, N., Kong, C., Le, Q.-T., Chi, J.-T. A., Jeffrey, S. S., & Giaccia, A. J. (2006) · Nature · doi:10.1038/nature04695 · Cited by 1,309
RetractedAnalysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
Livak, K. J., & Schmittgen, T. D. (2001) · Methods · doi:10.1006/meth.2001.1262 · Cited by 180,860
Obesity is associated with macrophage accumulation in adipose tissue
Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041
Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance
Hotamisligil, G. S., Shargill, N. S., & Spiegelman, B. M. (1993) · Science · doi:10.1126/science.7678183 · Cited by 7,518
Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760
Targeting HIF-1 for cancer therapy
Semenza, G. L. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1187 · Cited by 6,717
Woessner, J. F. (1961) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(61)90291-0 · Cited by 3,849
A central role for JNK in obesity and insulin resistance
Hirosumi, J., Tuncman, G., Chang, L., Görgün, C. Z., Uysal, K. T., Maeda, K., Karin, M., & Hotamisligil, G. S. (2002) · Nature · doi:10.1038/nature01137 · Cited by 3,359
Adipokines: inflammation and the pleiotropic role of white adipose tissue
Trayhurn, P., & Wood, I. S. (2004) · British Journal of Nutrition · doi:10.1079/bjn20041213 · Cited by 2,210
Huang, L. E., Gu, J., Schau, M., & Bunn, H. F. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.14.7987 · Cited by 2,113
Cited by
Sorted by citations
Items 101–200 of 891
Metabolic Pitfalls of CNS Cre-Based Technology
Harno, E., Cottrell, E. C., & White, A. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.05.019 · Cited by 200
Hypoxia and Adipocyte Physiology: Implications for Adipose Tissue Dysfunction in Obesity
Trayhurn, P. (2014) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071812-161156 · Cited by 194
SPARC: a key player in the pathologies associated with obesity and diabetes
Kos, K., & Wilding, J. P. H. (2010) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2010.18 · Cited by 197
Metabolic inflammation: Connecting obesity and insulin resistance
Dali‐Youcef, N., Mecili, M., Ricci, R., & Andrès, E. (2012) · Annals of Medicine · doi:10.3109/07853890.2012.705015 · Cited by 201
Buso, G., Depairon, M., Tomson, D., Raffoul, W., Vettor, R., & Mazzolai, L. (2019) · Obesity · doi:10.1002/oby.22597 · Cited by 208
Contribution of adipose tissue to development of cancer
Cozzo, A. J., Fuller, A. M., & Makowski, L. (2017) · Comprehensive Physiology · doi:10.1002/cphy.c170008 · Cited by 188
Adipose Tissue Fibrosis in Obesity: Etiology and Challenges
Marcelin, G., Gautier, E. L., & Clément, K. (2021) · Annual Review of Physiology · doi:10.1146/annurev-physiol-060721-092930 · Cited by 201
IRF3 promotes adipose inflammation and insulin resistance and represses browning
Kumari, M., Wang, X., Lantier, L., Lyubetskaya, A., Eguchi, J., Kang, S., Tenen, D. E., Roh, H. C., Kong, X., Kazak, L., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci86080 · Cited by 181
Chan, S. M. H., Selemidis, S., Bozinovski, S., & Vlahos, R. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.02.013 · Cited by 186
Hasegawa, Y., Ikeda, K., Chen, Y., Alba, D., Stifler, D. R., Shinoda, K., Hosono, T., Maretich, P., Yang, Y., Ishigaki, Y., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2017.12.005 · Cited by 182
Medříková, D., Jílková, Z. M., Bardová, K., Janovská, P., Rossmeisl, M., & Kopecký, J. (2011) · International Journal of Obesity · doi:10.1038/ijo.2011.87 · Cited by 177
Chronic intermittent hypoxia induces atherosclerosis via activation of adipose angiopoietin-like 4
Drager, L. F., Yao, Q., Hernandez, K. L., Shin, M.-K., Bevans-Fonti, S., Gay, J., Sussan, T. E., Jun, J. C., Myers, A. C., Olivecrona, G., et al. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201209-1688oc · Cited by 175
Self-citationEffects of different acute hypoxic regimens on tissue oxygen profiles and metabolic outcomes
Reinke, C., Bevans‐Fonti, S., Drager, L. F., Shin, M., & Polotsky, V. Y. (2011) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00492.2011 · Cited by 179
Pathophysiological dilemmas of lipedema
Szél, E., Kemény, L. V., Groma, G., & Szolnoky, G. (2014) · Medical Hypotheses · doi:10.1016/j.mehy.2014.08.011 · Cited by 174
Inflammation during obesity is not all bad: evidence from animal and human studies
Ye, J., & McGuinness, O. P. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00266.2012 · Cited by 178
Regulation of energy balance by inflammation: Common theme in physiology and pathology
Wang, H., & Ye, J. (2014) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-014-9306-8 · Cited by 179
Luo, T., Nocon, A., Fry, J., Sherban, A., Rui, X., Jiang, B., Xu, X. J., Han, J., Yan, Y., Yang, Q., et al. (2016) · Diabetes · doi:10.2337/db15-1122 · Cited by 172
Ye, J., & Keller, J. N. (2010) · Aging · doi:10.18632/aging.100155 · Cited by 175
Metabolically healthy and unhealthy obese – the 2013 S tock C onference report
Samocha‐Bonet, D., Dixit, V. D., Kahn, C. R., Leibel, R. L., Lin, X., Nieuwdorp, M., Pietiläinen, K. H., RABASA-LHORET, R. P. R., Roden, M., Scherer, P. E., et al. (2014) · Obesity Reviews · doi:10.1111/obr.12199 · Cited by 176
Self-citationPhytochemicals and their impact on adipose tissue inflammation and diabetes
Leiherer, A., Muendlein, A., & Drexel, H. (2012) · Vascular Pharmacology · doi:10.1016/j.vph.2012.09.002 · Cited by 172
‘Metabolically healthy obesity’: Origins and implications
Denis, G. V., & Obin, M. S. (2012) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2012.10.004 · Cited by 176
Effects of Bariatric Surgery on Human Small Artery Function
Aghamohammadzadeh, R., Greenstein, A. S., Yadav, R., Jeziorska, M., Hama, S., Soltani, F., Pemberton, P., Ammori, B. J., Malik, R. A., Soran, H., et al. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.04.027 · Cited by 170
Goodwin, J., Choi, H., Hsieh, M.-H., Neugent, M. L., Ahn, J., Hayenga, H. N., Singh, P. K., Shackelford, D. B., Lee, I., Shulaev, V., et al. (2017) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2016-0186oc · Cited by 174
The immune system's involvement in obesity-driven type 2 diabetes
Shu, C. J., Benoist, C. O., & Mathis, D. J. (2012) · Seminars in Immunology · doi:10.1016/j.smim.2012.12.001 · Cited by 170
Adipokines: inflammation and the pleiotropic role of white adipose tissue
Trayhurn, P. (2022) · British Journal Of Nutrition · doi:10.1017/s0007114521003962 · Cited by 164
Hypoxia-inducible factors and diabetes
Gunton, J. E. (2020) · Journal of Clinical Investigation · doi:10.1172/jci137556 · Cited by 159
Wang, Z. V., Deng, Y., Wang, Q. A., Sun, K., & Scherer, P. E. (2010) · Endocrinology · doi:10.1210/en.2010-0136 · Cited by 160
Self-citationAdipose Tissue Inflammation in the Pathogenesis of Type 2 Diabetes
Kohlgruber, A. C., & Lynch, L. (2015) · Current Diabetes Reports · doi:10.1007/s11892-015-0670-x · Cited by 163
Adipose tissue macrophages as potential targets for obesity and metabolic diseases
Li, X., Ren, Y., Chang, K.-W., Wu, W., Griffiths, H. R., Lu, S., & Gao, D. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1153915 · Cited by 181
Brown adipose tissue derived VEGF-A modulates cold tolerance and energy expenditure
Sun, K., Kusminski, C. M., Luby‐Phelps, K., Spurgin, S. B., An, Y., Wang, Q. A., Holland, W. L., & Scherer, P. E. (2014) · Molecular Metabolism · doi:10.1016/j.molmet.2014.03.010 · Cited by 152
Self-citationZhang, X., Zhang, Y., Wang, P., Zhang, S., Dong, Y., Zeng, G., Yan, Y., Sun, L., Wu, Q., Liu, H., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.09.016 · Cited by 154
Human adipocyte function is impacted by mechanical cues
Pellegrinelli, V., Heuvingh, J., du Roure, O., Rouault, C., Devulder, A., Klein, C., Lacasa, M., Clément, É., Lacasa, D., & Clément, K. (2014) · The Journal of Pathology · doi:10.1002/path.4347 · Cited by 170
The many secret lives of adipocytes: implications for diabetes
Scherer, P. E. (2018) · Diabetologia · doi:10.1007/s00125-018-4777-x · Cited by 164
Self-citationThe Epithelial-to-Mesenchymal Transition as a Possible Therapeutic Target in Fibrotic Disorders
Gregorio, J. D., Robuffo, I., Spalletta, S., Giambuzzi, G., Iuliis, V. D., Toniato, E., Martinotti, S., Conti, P., & Flati, V. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.607483 · Cited by 155
Yahyapour, R., Motevaseli, E., Rezaeyan, A., Abdollahi, H., Farhood, B., Cheki, M., Rezapoor, S., Shabeeb, D., Musa, A. E., Najafi, M., et al. (2018) · Clinical & Translational Oncology · doi:10.1007/s12094-017-1828-6 · Cited by 145
Obesity and COVID-19: Molecular Mechanisms Linking Both Pandemics
Ritter, A., Kreis, N., Louwen, F., & Yuan, J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21165793 · Cited by 145
Innate Immune Cells in the Adipose Tissue in Health and Metabolic Disease
Michailidou, Z., Gomez-Salazar, M. A., & Alexaki, V. I. (2021) · Journal of Innate Immunity · doi:10.1159/000515117 · Cited by 143
Adipose tissue macrophage in obesity-associated metabolic diseases
Yao, J., Wu, D., & Qiu, Y. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.977485 · Cited by 151
Winer, S., & Winer, D. A. (2012) · Immunology and Cell Biology · doi:10.1038/icb.2011.110 · Cited by 141
Chronic obstructive pulmonary disease and glucose metabolism: a bitter sweet symphony
Mirrakhimov, A. E. (2012) · Cardiovascular Diabetology · doi:10.1186/1475-2840-11-132 · Cited by 135
Decreased Adipose Tissue Oxygenation Associates with Insulin Resistance in Individuals with Obesity
Cifarelli, V., Beeman, S. C., Smith, G. I., Yoshino, J., Morozov, D., Beals, J. W., Kayser, B. D., Watrous, J. D., Jain, M., Patterson, B. W., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci141828 · Cited by 132
Obesity, estrogens and adipose tissue dysfunction - implications for pulmonary arterial hypertension
Mair, K. M., Gaw, R., & MacLean, M. R. (2020) · Pulmonary Circulation · doi:10.1177/2045894020952023 · Cited by 129
Vascular biology of metabolic syndrome
Vykoukal, D. M., & Davies, M. G. (2011) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2011.01.003 · Cited by 135
Csák, T., Bala, S., Lippai, D., Satishchandran, A., Catalano, D., Kodys, K., & Szabó, G. (2014) · Liver International · doi:10.1111/liv.12633 · Cited by 130
Adipocytes: Impact on tumor growth and potential sites for therapeutic intervention
Hefetz-Sela, S., & Scherer, P. E. (2013) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.01.008 · Cited by 136
Self-citationHypoxic tumor microenvironment: Implications for cancer therapy
Roy, S., Kumaravel, S., Sharma, A., Duran, C. L., Bayless, K. J., & Chakraborty, S. (2020) · Experimental Biology and Medicine · doi:10.1177/1535370220934038 · Cited by 134
Iftikhar, I. H., Hoyos, C. M., Phillips, C. L., & Magalang, U. J. (2015) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.4610 · Cited by 126
Self-citationCipolletta, D., Kolodin, D., Benoist, C. O., & Mathis, D. J. (2011) · Seminars in Immunology · doi:10.1016/j.smim.2011.06.002 · Cited by 127
Liu, Y., Aron‐Wisnewsky, J., Marcelin, G., Genser, L., Naour, G. L., Torcivia, A., Bauvois, B., Bouchet, S., Pelloux, V., Sasso, M., et al. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-3348 · Cited by 132
The Immune Landscape of Visceral Adipose Tissue During Obesity and Aging
Khan, S. M., Chan, Y. T., Revelo, X. S., & Winer, D. A. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00267 · Cited by 140
Alcalá, M., Sánchez‐Vera, I., Sevillano, J., Herrero, L., Serra, D., Ramos, P., & Viana, M. (2015) · Obesity · doi:10.1002/oby.21135 · Cited by 129
Engin, A. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-48382-5_13 · Cited by 129
Dietary Regulation of Immunity
Lee, A. H., & Dixit, V. D. (2020) · Immunity · doi:10.1016/j.immuni.2020.08.013 · Cited by 127
Adipose Tissue Remodeling in Pathophysiology
Auger, C., & Kajimura, S. (2022) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-042220-023633 · Cited by 135
Omental adipose tissue fibrosis and insulin resistance in severe obesity
Guglielmi, V., Cardellini, M., Cinti, F., Corgosinho, F. C., Cardolini, I., D’Adamo, M., Zingaretti, M. C., Bellia, A., Lauro, D., Gentileschi, P., et al. (2015) · Nutrition and Diabetes · doi:10.1038/nutd.2015.22 · Cited by 123
The Interplay between Obesity and Inflammation
Săvulescu-Fiedler, I., Mihalcea, R., Dragosloveanu, Ş., Scheau, C., Baz, R. O., Căruntu, A., Scheau, A.-E., Căruntu, C., & Benea, S. N. (2024) · Life · doi:10.3390/life14070856 · Cited by 138
Cipolletta, D. (2014) · Immunology · doi:10.1111/imm.12262 · Cited by 125
Chapman, K. E., Coutinho, A. E., Zhang, Z., Kipari, T. M. J., Savill, J., & Seckl, J. R. (2013) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2013.02.002 · Cited by 125
The hypoxia response pathway and β ‐cell function
Cantley, J., Grey, S. T., Maxwell, P. H., & Withers, D. J. (2010) · Diabetes, Obesity and Metabolism · doi:10.1111/j.1463-1326.2010.01276.x · Cited by 119
Datta, R., Podolsky, M. J., & Atabai, K. (2018) · JCI Insight · doi:10.1172/jci.insight.122289 · Cited by 131
From obesity to cancer: a review on proposed mechanisms
Tahergorabi, Z., Khazaei, M., Moodi, M., & Chamani, E. (2016) · Cell Biochemistry and Function · doi:10.1002/cbf.3229 · Cited by 118
Oxygen sensing and metabolic homeostasis
Palmer, B. F., & Clegg, D. J. (2014) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2014.08.001 · Cited by 120
Dankel, S. N., Fadnes, D. J., Stavrum, A.-K., Stansberg, C. T., Holdhus, R., Hoang, T., Veum, V. L., Christensen, B. J., Våge, V., Sagen, J. V., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011033 · Cited by 120
HIF-1α in Myeloid Cells Promotes Adipose Tissue Remodeling Toward Insulin Resistance
Takikawa, A., Mahmood, A., Nawaz, A., Kado, T., Okabe, K., Yamamoto, S., Aminuddin, A., Senda, S., Tsuneyama, K., Ikutani, M., et al. (2016) · Diabetes · doi:10.2337/db16-0012 · Cited by 117
Knockdown of ANT2 reduces adipocyte hypoxia and improves insulin resistance in obesity
Seo, J. B., Riopel, M., Cabrales, P., Huh, J. Y., Bandyopadhyay, G. K., Andreyev, A. Y., Murphy, A. N., Beeman, S. C., Smith, G. I., Klein, S., et al. (2018) · Nature Metabolism · doi:10.1038/s42255-018-0003-x · Cited by 111
Zhang, X., Lam, K. S. L., Ye, H., Chung, S. K., Zhou, M., Wang, Y., & Xu, A. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.135509 · Cited by 112
Adipose Tissue in Metabolic Syndrome: Onset and Progression of Atherosclerosis
Luna‐Luna, M., Medina-Urrutia, A. X., Vargas‐Alarcón, G., Coss-Rovirosa, F., Vargas‐Barrón, J., & Pérez-Méndez, O. A. (2015) · Archives of Medical Research · doi:10.1016/j.arcmed.2015.05.007 · Cited by 111
Macrophages and the Regulation of Adipose Tissue Remodeling
Martinez-Santibañez, G., & Nien-Kai Lumeng, C. (2014) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071812-161113 · Cited by 111
Kim, B., Farruggia, C., Ku, C. S., Pham, T. X., Yang, Y. J., Bae, M., Wegner, C., Farrell, N., Harness, E., Park, Y., et al. (2016) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2016.01.006 · Cited by 112
Adipose tissue changes in obesity and the impact on metabolic function
Sam, S., & Mazzone, T. (2014) · Translational research · doi:10.1016/j.trsl.2014.05.008 · Cited by 113
Adipose Tissue Vascularization: Its Role in Chronic Inflammation
Ye, J. (2011) · Current Diabetes Reports · doi:10.1007/s11892-011-0183-1 · Cited by 113
The Hippo pathway links adipocyte plasticity to adipose tissue fibrosis
Shen, H., Huang, X., Zhao, Y., Wu, D., Xue, K., Yao, J., Wang, Y., Tang, N., & Qiu, Y. (2022) · Nature Communications · doi:10.1038/s41467-022-33800-0 · Cited by 118
Trimmer, C., Sotgia, F., Whitaker‐Menezes, D., Balliet, R. M., Eaton, G. J., Martinez‐Outschoorn, U., Pavlides, S., Howell, A., Iozzo, R. V., Pestell, R. G., et al. (2011) · Cancer Biology & Therapy · doi:10.4161/cbt.11.4.14101 · Cited by 107
Self-citationKwon, E., Shin, S., Cho, Y.-Y., Jung, U. J., Kim, E., Park, T., Park, J. H. Y., Yun, J. W., McGregor, R. A., Park, Y. B., et al. (2012) · BMC Genomics · doi:10.1186/1471-2164-13-450 · Cited by 111
Therapy Resistance, Cancer Stem Cells and ECM in Cancer: The Matrix Reloaded
Kesh, K., Gupta, V. K., Durden, B. C., Garrido, V. T., Mateo-Victoriano, B., Lavania, S., & Banerjee, S. (2020) · Cancers · doi:10.3390/cancers12103067 · Cited by 112
Lipoedema: a paradigm shift and consensus
Bertsch, T., Erbacher, G., Elwell, R., & Partsch, H. (2020) · Journal of Wound Care · doi:10.12968/jowc.2020.29.sup11b.1 · Cited by 111
Allicin Improves Metabolism in High-Fat Diet-Induced Obese Mice by Modulating the Gut Microbiota
Shi, X., Zhou, X., Chu, X., Wang, J., Xie, B., Ge, J., Guo, Y., Li, X., & Yang, G. (2019) · Nutrients · doi:10.3390/nu11122909 · Cited by 106
Body composition and breast cancer risk and treatment: mechanisms and impact
Iwase, T., Wang, X., Shrimanker, T. V., Kolonin, M. G., & Ueno, N. T. (2021) · Breast Cancer Research and Treatment · doi:10.1007/s10549-020-06092-5 · Cited by 111
Extracellular matrix remodeling in human disease
Sonbol, H. S. (2018) · Journal of Microscopy and Ultrastructure · doi:10.4103/jmau.jmau_4_18 · Cited by 103
Vascular endothelial growth factor is important for brown adipose tissue development and maintenance
Bagchi, M., Kim, L. A., Boucher, J., Walshe, T. E., Kahn, C. R., & D'Amore, P. A. (2013) · The FASEB Journal · doi:10.1096/fj.12-221812 · Cited by 101
Etoh, K., & Nakao, M. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.104810 · Cited by 101
Macrophage HIF-2α Ameliorates Adipose Tissue Inflammation and Insulin Resistance in Obesity
Choe, S. S., Shin, K. C., Ka, S., Lee, Y. K., Chun, J., & Kim, J. B. (2014) · Diabetes · doi:10.2337/db13-1965 · Cited by 102
Targeting Hypoxia Inducible Factors-1α As a Novel Therapy in Fibrosis
Xiong, A., & Liu, Y. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00326 · Cited by 107
Warbrick, I., & Rabkin, S. W. (2019) · Obesity Reviews · doi:10.1111/obr.12828 · Cited by 100
Critical Role of Matrix Metalloproteinase 14 in Adipose Tissue Remodeling during Obesity
Li, X., Zhao, Y., Chen, C., Yang, L., Lee, H.-H., Wang, Z., Zhang, N., Kolonin, M. G., An, Z., Ge, X., et al. (2020) · Molecular and Cellular Biology · doi:10.1128/mcb.00564-19 · Cited by 110
Self-citationAging adipose: Depot location dictates age-associated expansion and dysfunction
Bank, H. C. V., Kirsh, C., & Simcox, J. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101259 · Cited by 109
Suppressing adipocyte inflammation promotes insulin resistance in mice
Zhu, Q., An, Y., Kim, M., Zhang, Z., Zhao, S., Zhu, Y., Asterholm, I. W., Kusminski, C. M., & Scherer, P. E. (2020) · Molecular Metabolism · doi:10.1016/j.molmet.2020.101010 · Cited by 104
Self-citationCytokines and inflammation in adipogenesis: an updated review
Jiang, N., Yao, L., Shu, T., & Wang, J. (2018) · Frontiers of Medicine · doi:10.1007/s11684-018-0625-0 · Cited by 104
Genetic Link Between Obesity and MMP14-Dependent Adipogenic Collagen Turnover
Chun, T.-H., Inoue, M., Morisaki, H., Yamanaka, I., Miyamoto, Y., Okamura, T., Sato-Kusubata, K., & Weiss, S. J. (2010) · Diabetes · doi:10.2337/db10-0073 · Cited by 97
Sex Differences in Brown Adipose Tissue Function: Sex Hormones, Glucocorticoids, and Their Crosstalk
Kaikaew, K., Grefhorst, A., & Visser, J. A. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.652444 · Cited by 103
An update on immune dysregulation in obesity‐related insulin resistance
Daryabor, G., Kabelitz, D., & Kalantar, K. (2018) · Scandinavian Journal of Immunology · doi:10.1111/sji.12747 · Cited by 99
Gaspar, J. M., & Velloso, L. A. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00813 · Cited by 97
Adipose tissue angiogenesis in obesity
Lemoine, A. Y., Ledoux, S., & Larger, É. (2013) · Thrombosis and Haemostasis · doi:10.1160/th13-01-0073 · Cited by 98
Obesity-related kidney disease: Beyond hypertension and insulin-resistance
Arabi, T. Z., Shafqat, A., Sabbah, B. N., Ashraf, N., Shah, H., Abdulkader, H. S., Razak, A., Sabbah, A. N., & Arabi, Z. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1095211 · Cited by 102
Miao, H., Chen, L., Hao, L., Zhang, X., Chen, Y., Ruan, Z., & Liang, H. (2015) · Scientific Reports · doi:10.1038/srep13092 · Cited by 97
Michailidou, Z., Turban, S., Miller, E., Zou, X., Schrader, J., Ratcliffe, P. J., Hadoke, P. W. F., Walker, B. R., Iredale, J. P., Morton, N. M., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.259325 · Cited by 98
New insights into adipose tissue VEGF-A actions in the control of obesity and insulin resistance
Elias, I., Franckhauser, S., & Bosch, F. (2013) · Adipocyte · doi:10.4161/adip.22880 · Cited by 92
Trayhurn, P., & Alomar, S. Y. (2015) · Frontiers in Endocrinology · doi:10.3389/fendo.2015.00019 · Cited by 99
Declèves, A., & Sharma, K. (2014) · Current Opinion in Nephrology & Hypertension · doi:10.1097/mnh.0000000000000087 · Cited by 96
Lee, K. Y., Gesta, S., Boucher, J., Wang, X. L., & Kahn, C. R. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.08.006 · Cited by 97
Metadata
- Authors
- Halberg, N., Khan, T., Trujillo, M. E., Wernstedt-Asterholm, I., Attie, A. D., Sherwani, S., Wang, Z. V., Landskroner-Eiger, S., Dineen, S., Magalang, U. J., Brekken, R. A., & Scherer, P. E.
- Affiliations
- University of Copenhagen (DK)
- Albert Einstein College of Medicine (US)
- Merck & Co., Inc., Rahway, NJ, USA (United States) (US)
- Touchstone Diabetes Center, Department of Internal Medicine
- University of Wisconsin–Madison (US)
- The Ohio State University (US)
- Hamon Center for Therapeutic Oncology and Division of Surgical Oncology
- The University of Texas Southwestern Medical Center (US)
- Corresponding author
- Scherer, Philipp E.
- ORCID
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 2009-08
- Volume
- 29
- Issue
- 16
- Pages
- 4467-4483
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- PMC
- PMC2725728
- OpenAlex
- W2145323170
- Semantic Scholar
- 3bb117eb23d88a302c07f3497fedf4404f35dc4a
- Cited by
- 896
- References
- 56
- Citations by year
- 2026: 42 · 2025: 41 · 2024: 50 · 2023: 43 · 2022: 81 · 2021: 62 · 2020: 71 · 2019: 47 · 2018: 62 · 2017: 53 · 2016: 59 · 2015: 54 · 2014: 55 · 2013: 61 · 2012: 51
- FWCI
- 25.59
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Molecular and Cellular Biology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Cancer Institute (R01CA112023)
- National Institute of Diabetes and Digestive and Kidney Diseases (PL1DK081182, R01DK055758)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- hypoxia-inducible factor-1α, adipose tissue fibrosis, insulin resistance, adipose tissue hypoxia, obesity, lysyl oxidase, collagen cross-linking, adipose tissue inflammation, transgenic overexpression, adipose tissue dysfunction
- MeSH terms
- Animals, Hypoxia, Blood Glucose, Enzyme Inhibitors, Fibrosis, Gene Expression Regulation, Multigene Family, Glucose Tolerance Test, Humans, Insulin Resistance, Lipoxygenase, Mice, Obese, Mice, Transgenic, Molecular Sequence Data, Obesity, Transcription, Genetic, Neovascularization, Physiologic, Oligonucleotide Array Sequence Analysis, Gene Expression Profiling, Mice, Hypoxia-Inducible Factor 1, alpha Subunit, Adipose Tissue, White
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
