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Endosomal Trafficking in Alzheimer's Disease, Parkinson's Disease, and Neuronal Ceroid Lipofuscinosis

Qureshi, Yasir H., Baez, Penelope, Reitz, Christiane·2020·Molecular and Cellular Biology
DOI 10.1128/mcb.00262-20
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  • The retromer's actions in the recycling pathway towards the cell membrane can facilitate synaptic plasticity by transporting glutamate receptors to the synapse.

    “Furthermore, the retromer’s actions in the recycling pathway towards the cell membrane can facilitate synaptic plasticity by transporting glutamate receptors to the synapse [4, 14, 15].”

    From Retromer Stabilization Improves Cognitive Function and Synaptic Plasticity in a Mouse Model of Down Syndrome (2023) · cites this paper as [14]

  • Perturbed endosomal transport is a contributing factor and, in some cases, a causative factor in human diseases, including neurodegenerative and neurological, and metabolic syndromes and cardiovascular disease.

    “An increasing body of evidence points to perturbed endosomal transport being a contributing factor and, in some cases, a causative factor in human diseases, including neurodegenerative and neurological2–4, and metabolic syndromes and cardiovascular disease5.”

    From Mapping of endosomal proximity proteomes reveals Retromer as a hub for RAB GTPase regulation (2025) · cites this paper as [4]

  • Functional retrieval sub-domains are essential for development and homeostasis, and disease-associated sub-domain dysregulation is associated with human disease.

    “Analysis in cells and organisms have established the essential importance of functional retrieval sub-domains for development and homeostasis, and disease-associated sub-domain dysregulation is associated with human disease2–5.”

    From Mapping of endosomal proximity proteomes reveals Retromer as a hub for RAB GTPase regulation (2025) · cites this paper as [4]

  • Sub-domain dysfunction is associated with human disease.

    “Sub-domain dysfunction is associated with human disease, but our mechanistic understanding of its function remains poorly described.”

    From Mapping of endosomal proximity proteomes reveals Retromer as a hub for RAB GTPase regulation (2025) · cites this paper as [4]

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Metadata

Authors
Qureshi, Y. H., Baez, P., & Reitz, C.
Affiliations
The Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Columbia University, New York
ORCID
Reitz, Christiane
Venue
Molecular and Cellular Biology
Publisher
Informa UK Limited
Published
2020-09-14
Volume
40
Issue
19
ISSN
1098-5549
DOI
10.1128/mcb.00262-20
Cited by
25
References
18
Language
en
Licence
doi.org/10.1080/policies-text-data-mining (tdm)
Funders
HHS | National Institutes of Health (RF1AG054080, R01AG064614, U01AG052410, P50AG008702)

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