Cited by 107Telomeres, Telomerase, and SenescenceGenomics and Chromatin DynamicsGenetics, Aging, and Longevity in Model Organisms

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Function of AP-1 in Transcription of the Telomerase Reverse Transcriptase Gene (TERT) in Human and Mouse Cells

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Takakura, Masahiro, Kyo, Satoru, Inoue, Masaki, Wright, Woodring E., Shay, Jerry W.·2005·Molecular and Cellular Biology

DOI 10.1128/mcb.25.18.8037-8043.2005PMC PMC1234330

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Abstract

The transcriptional regulation of the human telomerase catalytic subunit (hTERT) plays a critical role in telomerase activity. Approximately 200 bp of the proximal core promoter is responsible for basic hTERT expression; however, the function of the distal regulatory elements remains unclear. The transcription factor activator protein 1 (AP-1) is involved in cellular proliferation, differentiation, carcinogenesis, and apoptosis and is expressed broadly in both cancer and normal cells. There are several putative AP-1 sites in the hTERT promoter, but their functions are unknown. The present study examined the regulatory role of AP-1 in hTERT gene transcription. Overexpression of AP-1 leads to transcriptional suppression of hTERT in cancer cells. The combination of c-Fos and c-Jun or c-Fos and JunD strongly suppresses hTERT promoter activity in transient-expression analyses. The hTERT promoter region between -2000 and -378 is responsible for this function. Gel shift and supershift analyses, as well as ChIP, show binding of JunD and c-Jun on two putative AP-1 sites within this region. Mutations in the AP-1 binding sites rescued suppressions caused by AP-1, suggesting this is a direct regulation of the hTERT promoter. In contrast, there was no effect on mTERT expression or mTERT promoter activity by AP-1 overexpression in mouse fibroblasts. The species-specific function of AP-1 in TERT expression may in part help explain the difference in telomerase activity between normal human and mouse cells.

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Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
Livak, K. J., & Schmittgen, T. D. (2001) · Methods · doi:10.1006/meth.2001.1262 · Cited by 180,860
Specific Association of Human Telomerase Activity with Immortal Cells and Cancer
Kim, N. W., Piatyszek, M. A., Prowse, K. R., Harley, C. B., West, M. D., Ho, P. L. C., Coviello, G. M., Wright, W. E., Weinrich, S. L., & Shay, J. W. (1994) · Science · doi:10.1126/science.7605428 · Cited by 7,091 · cited 1×
“Detectable telomerase activity is observed only in some highly regenerative tissues such as hematopoietic progenitor, intestinal crypt, skin basal layer, cervical keratinocyte, endometrium, and germ line cells; however, 75 to 85% of cancer cells show telomerase activity (9, 13, 16, 21 , 23, 25, 37, 43).”
BackgroundSelf-citation
Telomeres shorten during ageing of human fibroblasts
Harley, C. B., Futcher, A. B., & Greider, C. W. (1990) · Nature · doi:10.1038/345458a0 · Cited by 5,750
Extension of Life-Span by Introduction of Telomerase into Normal Human Cells
Bodnar, A. G., Ouellette, M., Frolkis, M., Holt, S. E., Chiu, C.-P., Morin, G. B., Harley, C. B., Shay, J. W., Lichtsteiner, S., & Wright, W. E. (1998) · Science · doi:10.1126/science.279.5349.349 · Cited by 4,975
Self-citation
Rapid detection of octamer binding proteins with ‘mini extracts’, prepared from a small number of cells
Schreiber, E. H., Matthias, P., Müller, M. M., & Schaffner, W. (1989) · Nucleic Acids Research · doi:10.1093/nar/17.15.6419 · Cited by 4,179
Mutation of the mouse klotho gene leads to a syndrome resembling ageing
Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., et al. (1997) · Nature · doi:10.1038/36285 · Cited by 3,837
AP-1 as a regulator of cell life and death
Shaulian, E., & Karin, M. (2002) · Nature Cell Biology · doi:10.1038/ncb0502-e131 · Cited by 2,961
A survey of telomerase activity in human cancer
Shay, J. W., & Bacchetti, S. (1997) · European Journal of Cancer · doi:10.1016/s0959-8049(97)00062-2 · Cited by 2,794
Self-citation
Telomerase Catalytic Subunit Homologs from Fission Yeast and Human
Nakamura, T. M., Morin, G. B., Chapman, K. B., Weinrich, S. L., Andrews, W. H., Lingner, J., Harley, C. B., & Cech, T. R. (1997) · Science · doi:10.1126/science.277.5328.955 · Cited by 2,256
The RNA Component of Human Telomerase
Feng, J., Funk, W. D., Wang, S.-S., Weinrich, S. L., Avilion, A. A., Chiu, C.-P., Adams, R. R., Chang, E., Allsopp, R. C., Yu, J., et al. (1995) · Science · doi:10.1126/science.7544491 · Cited by 2,227

Show all 47 references

Research works printed but not linked: 10

Alfonso-De Matte M. Y., 2002, Cancer Res., 62, 4575
Bushel P., 1995, Oncogene, 10, 1361
Devereux T. R., 1999, Cancer Res., 59, 6087
Hirai S., 1990, Oncogene, 5, 39
Horikawa I., 1999, Cancer Res., 59, 826
Ito H., 1998, Clin. Cancer Res., 4, 1603
Kyo S., 1997, Cancer Res., 57, 610
Takakura M., 1999, Cancer Res., 59, 551
Takakura M., 1998, Cancer Res., 58, 1558
Yasumoto S., 1996, Oncogene, 13, 433

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Regulation of Telomerase Through Transcriptional and Posttranslational Mechanisms
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Cloning and molecular characterization of telomerase reverse transcriptase (TERT) and telomere length analysis of Peromyscus leucopus
Zhao, X., Ueda, Y., Kajigaya, S., Alaks, G., Desierto, M. J., Townsley, D. M., Dumitriu, B., Chen, J., Lacy, R. C., & Young, N. S. (2015) · Gene · doi:10.1016/j.gene.2015.05.013 · Cited by 1

Authors: Takakura, M., Kyo, S., Inoue, M., Wright, W. E., & Shay, J. W.
Affiliations: Kanazawa University (JP)
The University of Texas Southwestern Medical Center (US)
Corresponding author: Shay, Jerry W.
ORCID: Takakura, Masahiro
Kyo, Satoru
Wright, Woodring E.
Shay, Jerry W.
Venue: Molecular and Cellular Biology
Publisher: Informa UK Limited
Published: 2005-09-01
Volume: 25
Issue: 18
Pages: 8037-8043
ISSN: 0270-7306 (ISSN-L)
1098-5549
DOI: 10.1128/mcb.25.18.8037-8043.2005
PMC: PMC1234330
OpenAlex: W2114840351
Cited by: 107
References: 47
Citations by year: 2025: 2 · 2024: 2 · 2023: 2 · 2021: 5 · 2020: 1 · 2019: 4 · 2018: 6 · 2017: 6 · 2016: 5 · 2015: 6 · 2014: 7 · 2013: 7 · 2012: 7
FWCI: 4.20
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Molecular and Cellular Biology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Aging (AG07992, R01AG007992)
National Cancer Institute (CA 70907, R01CA085363, P50CA070907, CA 85363)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Keywords: activator protein-1, telomerase reverse transcriptase, c-fos, c-Jun, JunD, AP-1 binding site, telomerase regulation, species-specific gene regulation, cancer cells, transcriptional repression
MeSH terms: Animals, Base Sequence, Binding Sites, DNA-Binding Proteins, HeLa Cells, Humans, Molecular Sequence Data, Mutation, Promoter Regions, Genetic, Transcription, Genetic, Transcriptional Activation, Gene Expression Regulation, Enzymologic, Proto-Oncogene Proteins c-jun, Proto-Oncogene Proteins c-fos, Transcription Factor AP-1, Telomerase, NIH 3T3 Cells, Mice

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Function of AP-1 in Transcription of the Telomerase Reverse Transcriptase Gene (TERT) in Human and Mouse Cells

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