Eukaryotic Translesion Polymerases and Their Roles and Regulation in DNA Damage Tolerance

DNA Repair and Mutagenesis

Friedberg, E. C., Walker, G. C., Siede, W., Wood, R. D., Schultz, R. A., & Ellenberger, T. (2005) · doi:10.1128/9781555816704 · Cited by 5,683

RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO

Hoege, C., Pfander, B., Moldovan, G., Pyrowolakis, G., & Jentsch, S. (2002) · Nature · doi:10.1038/nature00991 · Cited by 2,202

The Transcriptional Program of Sporulation in Budding Yeast

Chu, S., DeRisi, J. L., Eisen, M. B., Mulholland, J., Botstein, D., Brown, P. O., & Herskowitz, I. (1998) · Science · doi:10.1126/science.282.5389.699 · Cited by 1,860

Cancer Susceptibility and the Functions of BRCA1 and BRCA2

Venkitaraman, A. R. (2002) · Cell · doi:10.1016/s0092-8674(02)00615-3 · Cited by 1,713

The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase η

Masutani, C., Kusumoto, R., Yamada, A., Dohmae, N., Yokoi, M., Yuasa, M., Araki, M., Iwai, S., Takio, K., & Hanaoka, F. (1999) · Nature · doi:10.1038/21447 · Cited by 1,292

Regulation of DNA repair throughout the cell cycle

Branzei, D., & Foiani, M. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2351 · Cited by 1,228

A constant rate of spontaneous mutation in DNA-based microbes.

Drake, J. W. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.16.7160 · Cited by 1,199

Proliferating cell nuclear antigen (PCNA): a dancer with many partners

Maga, G., & Hübscher, U. (2003) · Journal of Cell Science · doi:10.1242/jcs.00653 · Cited by 1,121

Discontinuities in the DNA synthesized in an excision-defective strain of Escherichia coli following ultraviolet irradiation

Rupp, W. D., & Howard-flanders, P. (1968) · Journal of Molecular Biology · doi:10.1016/0022-2836(68)90445-2 · Cited by 1,093

EUKARYOTIC TRANSLESION SYNTHESIS DNA POLYMERASES: Specificity of Structure and Function

Prakash, S., Johnson, R. E., & Prakash, L. (2005) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.74.082803.133250 · Cited by 1,020

DNA polymerases provide a canon of strategies for translesion synthesis past oxidatively generated lesions

Zahn, K. E., Wallace, S. S., & Doublié, S. (2011) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2011.03.008 · Cited by 34

Molecular Chaperone Hsp90 Regulates REV1-Mediated Mutagenesis

Pozo, F. M., Oda, T., Sekimoto, T., Murakumo, Y., Masutani, C., Hanaoka, F., & Yamashita, T. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.05117-11 · Cited by 34

Adeno-Associated Virus Monoinfection Induces a DNA Damage Response and DNA Repair That Contributes to Viral DNA Replication

Ning, K., Kuz, C. A., Cheng, F., Feng, Z., Yan, Z., & Qiu, J. (2023) · mBio · doi:10.1128/mbio.03528-22 · Cited by 33

It takes two to tango: Ubiquitin and SUMO in the DNA damage response

Bologna, S., & Ferrari, S. M. (2013) · Frontiers in Genetics · doi:10.3389/fgene.2013.00106 · Cited by 33

Yeast DNA polymerase ζ maintains consistent activity and mutagenicity across a wide range of physiological dNTP concentrations

Kochenova, O. V., Bezalel‐Buch, R., Tran, P., Makarova, А. V., Chabes, A., Burgers, P., & Shcherbakova, P. V. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw1149 · Cited by 33

Repair and translesion synthesis of O6-alkylguanine DNA lesions in human cells

Du, H., Wang, P., Li, L., & Wang, Y. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.009054 · Cited by 33

In Vivo Bypass of 8-oxodG

Rodriguez, G. P., Song, J. B., & Crouse, G. F. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003682 · Cited by 33

Defect of Dpb2p, a noncatalytic subunit of DNA polymerase ε, promotes error prone replication of undamaged chromosomal DNA in Saccharomyces cerevisiae

Kraszewska, J., Garbacz, M. A., Jonczyk, P., Fijałkowska, I. J., & Jaszczur, M. M. (2012) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2012.06.002 · Cited by 33

Redundancy of mammalian Y family DNA polymerases in cellular responses to genomic DNA lesions induced by ultraviolet light

Jansen, J. G., Temviriyanukul, P., Wit, N., Delbos, F., Reynaud, C., Jacobs, H., & de Wind, N. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku779 · Cited by 33

Anticancer Chemodiversity of Ranunculaceae Medicinal Plants: Molecular Mechanisms and Functions

Hao, D., He, C., Shen, J., & Xiao, P. (2016) · Current Genomics · doi:10.2174/1389202917666160803151752 · Cited by 33

Molecular basis of transcriptional fidelity and DNA lesion-induced transcriptional mutagenesis

Xu, L., Da, L., Plouffe, S. W., Chong, J. P. C., Kool, E. T., & Wang, D. (2014) · DNA repair · doi:10.1016/j.dnarep.2014.03.024 · Cited by 32

PCNA trimer instability inhibits translesion synthesis by DNA polymerase η and by DNA polymerase δ

Dieckman, L. M., & Washington, M. T. (2013) · DNA repair · doi:10.1016/j.dnarep.2013.02.007 · Cited by 32

The Mechanism of Nucleotide Excision Repair-Mediated UV-Induced Mutagenesis in Nonproliferating Cells

Kozmin, S. G., & Jinks-Robertson, S. (2013) · Genetics · doi:10.1534/genetics.112.147421 · Cited by 32

Detours to Replication: Functions of Specialized DNA Polymerases during Oncogene-induced Replication Stress

Tsao, W.-C., & Eckert, K. A. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19103255 · Cited by 32

REV1 promotes PCNA monoubiquitylation through interacting with ubiquitylated RAD18

Wang, Z., Huang, M., Ma, X., Li, H., Tang, T.-S., & Guo, C. (2016) · Journal of Cell Science · doi:10.1242/jcs.179408 · Cited by 31

Inactivation of REV7 enhances chemosensitivity and overcomes acquired chemoresistance in testicular germ cell tumors

Sakurai, Y., Ichinoe, M., Yoshida, K., Nakazato, Y., Saito, S., Satoh, M., Nakada, N., Sanoyama, I., Umezawa, A., Numata, Y., et al. (2020) · Cancer Letters · doi:10.1016/j.canlet.2020.06.001 · Cited by 31

Targeting DNA Repair, Cell Cycle, and Tumor Microenvironment in B Cell Lymphoma

Bröckelmann, P. J., de Jong, M. R. W., & Jachimowicz, R. D. (2020) · Cells · doi:10.3390/cells9102287 · Cited by 31

Pre-Steady-State Kinetic Analysis of the Incorporation of Anti-HIV Nucleotide Analogs Catalyzed by Human X- and Y-Family DNA Polymerases

Brown, J. A., Pack, L. R., Fowler, J. D., & Suo, Z. (2010) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01229-10 · Cited by 31

DNA damage induced Pol η recruitment takes place independently of the cell cycle phase

Soria, G., Belluscio, L. M., van Cappellen, W. A., Kanaar, R., Essers, J., & Gottifredi, V. (2009) · Cell Cycle · doi:10.4161/cc.8.20.9836 · Cited by 31

The identification of translesion DNA synthesis regulators: Inhibitors in the spotlight

Bertolin, A. P., Mansilla, S. F., & Gottifredi, V. (2015) · DNA Repair · doi:10.1016/j.dnarep.2015.04.027 · Cited by 30

Targeting the DNA damage response in cancer

Guffanti, F., Chiappa, M., & Damia, G. L. M. (2024) · MedComm · doi:10.1002/mco2.788 · Cited by 30

A Genetic Selection for dinB Mutants Reveals an Interaction between DNA Polymerase IV and the Replicative Polymerase That Is Required for Translesion Synthesis

Scotland, M. K., Heltzel, J. M. H., Kath, J. E., Choi, J.-S., Berdis, A. J., Loparo, J. J., & Sutton, M. D. (2015) · PLoS Genetics · doi:10.1371/journal.pgen.1005507 · Cited by 30

Persistence and Tolerance of DNA Damage Induced by Chronic UVB Irradiation of the Human Genome

Bérubé, R., Desgarnier, M. D., Douki, T., Lechasseur, A., & Rochette, P. J. (2017) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2017.08.044 · Cited by 30

Exogenous melatonin enhances soybean ( Glycine max (L.) Merr.) seedling tolerance to saline‐alkali stress by regulating antioxidant response and DNA damage repair

Zhao, Q., Chen, S., Wang, G., Du, Y., Zhang, Z., Yu, G., Ren, C., Zhang, Y., & Du, J. (2022) · Physiologia Plantarum · doi:10.1111/ppl.13731 · Cited by 30

In Vitro Gap-directed Translesion DNA Synthesis of an Abasic Site Involving Human DNA Polymerases ϵ, λ, and β

Villani, G., Hübscher, U., Gironis, N., Parkkinen, S., Pospiech, H., Shevelev, I., di Cicco, G., Markkanen, E., Syväoja, J. E., & Gac, N. T. L. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.246611 · Cited by 30

Genome maintenance inSaccharomyces cerevisiae: the role of SUMO and SUMO-targeted ubiquitin ligases

Jalal, D., Chalissery, J., & Hassan, A. H. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkw1369 · Cited by 30

Translesion Synthesis DNA Polymerase Kappa Is Indispensable for DNA Repair Synthesis in Cisplatin Exposed Dorsal Root Ganglion Neurons

Zhuo, M., Gorgun, M. F., & Englander, E. W. (2017) · Molecular Neurobiology · doi:10.1007/s12035-017-0507-5 · Cited by 30

PDIP38/PolDIP2 controls the DNA damage tolerance pathways by increasing the relative usage of translesion DNA synthesis over template switching

Tsuda, M., Ogawa, S., Ooka, M., Kobayashi, K., Hirota, K., Wakasugi, M., Matsunaga, T., Sakuma, T., Yamamoto, T., Chikuma, S., et al. (2019) · PLoS ONE · doi:10.1371/journal.pone.0213383 · Cited by 30

Genetic Interactions Implicating Postreplicative Repair in Okazaki Fragment Processing

Becker, J. R., Pons, C., Nguyen, H. D., Costanzo, M., Boone, C. M., Myers, C. L., & Bielinsky, A. (2015) · PLoS Genetics · doi:10.1371/journal.pgen.1005659 · Cited by 29

Ribonucleotides in bacterial DNA

Schroeder, J. W., Randall, J. R., Matthews, L. A., & Simmons, L. A. (2014) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238.2014.981647 · Cited by 30

The Translesion Polymerase Pol η Is Required for Efficient Epstein-Barr Virus Infectivity and Is Regulated by the Viral Deubiquitinating Enzyme BPLF1

Dyson, O. F., Pagano, J. S., & Whitehurst, C. B. (2017) · Journal of Virology · doi:10.1128/jvi.00600-17 · Cited by 29

The translesion DNA polymerases Pol ζ and Rev1 are activated independently of PCNA ubiquitination upon UV radiation in mutants of DNA polymerase δ

Tellier-Lebègue, C., Dizet, E., Ma, É., Veaute, X., Coı̈c, E., Charbonnier, J., & Maloisel, L. (2017) · PLoS Genetics · doi:10.1371/journal.pgen.1007119 · Cited by 29

DNA-damage tolerance mediated by PCNA•Ub fusions in human cells is dependent on Rev1 but not Polη

Qin, Z., Lu, M., Xu, X., Hanna, M. D., Shiomi, N., & Xiao, W. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt542 · Cited by 29

Persistently stalled replication forks inhibit nucleotide excision repair in trans by sequestering Replication protein A

Tsaalbi-Shtylik, A., Moser, J., Mullenders, L. H. F., Jansen, J. G., & de Wind, N. (2014) · Nucleic Acids Research · doi:10.1093/nar/gkt1412 · Cited by 28

REV3L, the catalytic subunit of DNA polymerase ζ, is involved in the progression and chemoresistance of esophageal squamous cell carcinoma

Zhu, X., Zou, S., Zhou, J., Zhu, H., Zhang, S., Shang, Z., Ding, W., Wu, J., & Chen, Y. (2016) · Oncology Reports · doi:10.3892/or.2016.4549 · Cited by 28

TRIP/NOPO E3 ubiquitin ligase promotes ubiquitylation of DNA polymerase η

Wallace, H. A., Merkle, J. A., Yu, M. C., Berg, T., Lee, E. N., Bosco, G., & Lee, L. A. (2014) · Development · doi:10.1242/dev.101196 · Cited by 28

RNA polymerase II transcriptional fidelity control and its functional interplay with DNA modifications

Xu, L., Wang, W., Chong, J. P. C., Shin, J. H., Xu, J., & Wang, D. (2015) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238.2015.1087960 · Cited by 28

DNA polymerase kappa protects human cells against MMC-induced genotoxicity through error-free translesion DNA synthesis

Kanemaru, Y., Suzuki, T., Sassa, A., Matsumoto, K., Adachi, N., Honma, M., Numazawa, S., & Nohmi, T. (2017) · Genes and Environment · doi:10.1186/s41021-016-0067-3 · Cited by 28

Structural Basis of Ubiquitin Recognition by Translesion Synthesis DNA Polymerase ι

Cui, G., Benirschke, R. C., Tuan, H.-F., Juranić, N., Macura, S. I., Botuyan, M. V., & Mer, G. (2010) · Biochemistry · doi:10.1021/bi101303t · Cited by 28

Synthetic Nucleotides as Probes of DNA Polymerase Specificity

Walsh, J. M., & Beuning, P. J. (2012) · Journal of Nucleic Acids · doi:10.1155/2012/530963 · Cited by 28

Human replicative DNA polymerase δ can bypass T‐T (6‐4) ultraviolet photoproducts on template strands

Narita, T., Tsurimoto, T., Yamamoto, J., Nishihara, K., Ogawa, K., Ohashi, E., Evans, T. J., Iwai, S., Takeda, S., & Hirota, K. (2010) · Genes to Cells · doi:10.1111/j.1365-2443.2010.01457.x · Cited by 29

Total Syntheses and Biological Evaluation of 3‐O‐Methylfunicone and Its Derivatives Prepared by TMPZnCl·LiCl‐Mediated Halogenation and Carbonylative Stille Cross‐Coupling

Ehrlich, M., & Carell, T. (2012) · European Journal of Organic Chemistry · doi:10.1002/ejoc.201201256 · Cited by 27

Mcm10 deficiency causes defective-replisome-induced mutagenesis and a dependency on error-free postreplicative repair

Becker, J. R., Nguyen, H. D., Wang, X., & Bielinsky, A. (2014) · Cell Cycle · doi:10.4161/cc.28652 · Cited by 27

Homologous Recombination Deficiency in Ovarian and Breast Cancers: Biomarkers, Diagnosis, and Treatment

Shah, B. A., Hussain, M. S., & Seth, A. (2025) · Current Issues in Molecular Biology · doi:10.3390/cimb47080638 · Cited by 28

Maintenance of Genome Integrity: How Mammalian Cells Orchestrate Genome Duplication by Coordinating Replicative and Specialized DNA Polymerases

Barnes, R. P., & Eckert, K. A. (2017) · Genes · doi:10.3390/genes8010019 · Cited by 26

Role of specialized DNA polymerases in the limitation of replicative stress and DNA damage transmission

Bournique, E., Dall’Osto, M., Hoffmann, J., & Bergoglio, V. (2017) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2017.08.002 · Cited by 26

The ubiquitous ‘cancer mutational signature’ 5 occurs specifically in cancers with deletedFHITalleles

Volinia, S., Druck, T., Paisie, C. A., Schrock, M. S., & Huebner, K. (2017) · Oncotarget · doi:10.18632/oncotarget.22321 · Cited by 26

Contributions of Nucleotide Excision Repair, DNA Polymerase η, and Homologous Recombination to Replication of UV-irradiated Herpes Simplex Virus Type 1

Muylaert, I., & Elias, P. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.107920 · Cited by 26

Budding Yeast Dbf4 Sequences Required for Cdc7 Kinase Activation and Identification of a Functional Relationship Between the Dbf4 and Rev1 BRCT Domains

Harkins, V., Gabrielse, C., Haste, L., & Weinreich, M. (2009) · Genetics · doi:10.1534/genetics.109.110155 · Cited by 26

The eukaryotic replisome tolerates leading‐strand base damage by replicase switching

Guilliam, T. A., & Yeeles, J. T. P. (2021) · The EMBO Journal · doi:10.15252/embj.2020107037 · Cited by 25

REV1 promotes lung tumorigenesis by activating the Rad18/SERTAD2 axis

Chen, Y., Jie, X., Xing, B., Wu, Z., Yang, X., Rao, X., Xu, Y., Zhou, D., Dong, X., Zhang, T., et al. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-04567-5 · Cited by 25

The Influence of Circadian Rhythms on DNA Damage Repair in Skin Photoaging

Su, Z. G., Hu, Q., Li, X., Wang, Z., & Xie, Y. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252010926 · Cited by 26

Preparation of Site-specific T=mCG cis-syn Cyclobutane Dimer-containing Template and Its Error-free Bypass by Yeast and Human Polymerase η

Song, Q., Sherrer, S. M., Suo, Z., & Taylor, J. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.333591 · Cited by 25

Association of POLK Polymorphisms with Platinum-Based Chemotherapy Response and Severe Toxicity in Non-small Cell Lung Cancer Patients

Shao, M., Jin, B., Niu, Y., Ye, J., Lu, D., & Han, B. (2014) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-014-0046-x · Cited by 25

XRCC1 interaction with the REV1 C-terminal domain suggests a role in post replication repair

Gabel, S. A., DeRose, E. F., & London, R. E. (2013) · DNA repair · doi:10.1016/j.dnarep.2013.08.015 · Cited by 25

The Impact of dUTPase on Ribonucleotide Reductase-Induced Genome Instability in Cancer Cells

Chen, C., Tsao, N., Huang, L.-Y., Yen, Y., Liu, X., Lehman, C. E., Wang, Y.-H., Tseng, M., Chen, Y., Ho, Y.-C., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.06.094 · Cited by 25

The DNA repair protein SHPRH is a nucleosome-stimulated ATPase and a nucleosome-E3 ubiquitin ligase

Brühl, J., Trautwein, J., Schäfer, A., Linne, U., & Bouazoune, K. (2019) · Epigenetics & Chromatin · doi:10.1186/s13072-019-0294-5 · Cited by 25

Human C6orf211 Encodes Armt1, a Protein Carboxyl Methyltransferase that Targets PCNA and Is Linked to the DNA Damage Response

Perry, J. J. P., Ballard, G. D., Albert, A. E., Dobrolecki, L. E., Malkas, L. H., & Hoelz, D. J. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.01.054 · Cited by 25

Detection of Distinct α-Helical Rearrangements of Cyclobutane Pyrimidine Dimer Photolyase upon Substrate Binding by Fourier Transform Infrared Spectroscopy

Wijaya, I. M. M., Zhang, Y., Iwata, T., Yamamoto, J., Hitomi, K., Iwai, S., Getzoff, E. D., & Kandori, H. (2013) · Biochemistry · doi:10.1021/bi3016179 · Cited by 24

Biological and Therapeutic Relevance of Nonreplicative DNA Polymerases to Cancer

Parsons, J. L., Nicolay, N. H., & Sharma, R. A. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4203 · Cited by 24

Importance of Polη for Damage-Induced Cohesion Reveals Differential Regulation of Cohesion Establishment at the Break Site and Genome-Wide

Enervald, E., Lindgren, E. B., Katou, Y., Shirahige, K., & Ström, L. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003158 · Cited by 24

Pre-steady state kinetic studies show that an abasic site is a cognate lesion for the yeast Rev1 protein

Pryor, J. M., & Washington, M. T. (2011) · DNA repair · doi:10.1016/j.dnarep.2011.08.011 · Cited by 24

The contribution of translesion synthesis polymerases on geminiviral replication

Richter, K. S., Götz, M., Winter, S., & Jeske, H. (2015) · Virology · doi:10.1016/j.virol.2015.10.027 · Cited by 24

DNA polymerase θ specializes in incorporating synthetic expanded-size (xDNA) nucleotides

Kent, T., Rusanov, T., Hoàng, T., Velema, W. A., Krueger, A. T., Copeland, W. C., Kool, E. T., & Pomerantz, R. T. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw721 · Cited by 24

Roles of translesion synthesis DNA polymerases in the potent mutagenicity of tobacco-specific nitrosamine-derived O2-alkylthymidines in human cells

Weerasooriya, S., Jasti, V. P., Bose, A., Spratt, T. E., & Basu, A. K. (2015) · DNA repair · doi:10.1016/j.dnarep.2015.09.023 · Cited by 23

Tracing the tracks of genotoxicity by trivalent and hexavalent chromium in Drosophila melanogaster

Mishra, M., Sharma, A., Negi, M. P. S., Dwivedi, U. N., & Chowdhuri, D. K. (2011) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2011.02.010 · Cited by 23

DNA polymerases are error-prone at RecA-mediated recombination intermediates

Pomerantz, R. T., Goodman, M. F., & O’Donnell, M. E. (2013) · Cell Cycle · doi:10.4161/cc.25691 · Cited by 23

Spd1 accumulation causes genome instability independently of ribonucleotide reduction but functions to protect the genome when deoxynucleotide pools are elevated

Fleck, O., Vejrup-Hansen, R., Watson, A. T., Carr, A. M., Nielsen, O., & Holmberg, C. (2013) · Journal of Cell Science · doi:10.1242/jcs.132837 · Cited by 23

DNA Polymerases λ and β: The Double-Edged Swords of DNA Repair

Mentegari, E., Kiššová, M., Bavagnoli, L., Maga, G., & Crespan, E. (2016) · Genes · doi:10.3390/genes7090057 · Cited by 23

The dark side of the ring: role of the DNA sliding surface of PCNA

March, M. D., & Biasio, A. D. (2017) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409238.2017.1364218 · Cited by 23

Host translesion polymerases are required for viral genome integrity

Zeltzer, S., Longmire, P., Svoboda, M., Bosco, G., & Goodrum, F. D. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2203203119 · Cited by 22

Proteasomal regulation of the mutagenic translesion DNA polymerase, Saccharomyces cerevisiae Rev1

Wiltrout, M. E., & Walker, G. C. (2011) · DNA repair · doi:10.1016/j.dnarep.2010.10.008 · Cited by 22

Genotoxicity and Mutagenicity - Mechanisms and Test Methods

Soloneski, S., & Larramendy, M. L. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.84992 · Cited by 22

Transcription-coupled repair and the transcriptional response to UV-Irradiation

Gaul, L., & Svejstrup, J. Q. (2021) · DNA repair · doi:10.1016/j.dnarep.2021.103208 · Cited by 22

Non-Homologous End-Joining Pathway Associated with Occurrence of Myocardial Infarction: Gene Set Analysis of Genome-Wide Association Study Data

Verschuren, J. J. W., Trompet, S., Deelen, J., Stott, D. J., Sattar, N. A., Buckley, B. M., Ford, I., Heijmans, B. T., Guchelaar, H., Houwing‐Duistermaat, J. J., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0056262 · Cited by 22

Different Sets of Translesion Synthesis DNA Polymerases Protect From Genome Instability Induced by Distinct Food-Derived Genotoxins

Temviriyanukul, P., Meijers, M., van Hees‐Stuivenberg, S., Boei, J. J. W. A., Delbos, F., Ohmori, H., de Wind, N., & Jansen, J. G. (2012) · Toxicological Sciences · doi:10.1093/toxsci/kfs074 · Cited by 22

Detection of PCNA Modifications in Saccharomyces cerevisiae

Davies, A. A., & Ulrich, H. D. (2012) · Methods in molecular biology · doi:10.1007/978-1-61779-998-3_36 · Cited by 22

Microenvironmental Niches and Sanctuaries: A Route to Acquired Resistance

Pérez-Velázquez, J., Gevertz, J. L., Karolak, A. M., & Rejniak, K. A. (2016) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-42023-3_8 · Cited by 22

A novel variant of DNA polymerase ζ, Rev3ΔC, highlights differential regulation of Pol32 as a subunit of polymerase δ versus ζ in Saccharomyces cerevisiae

Siebler, H. M., Lada, A. G., Baranovskiy, A. G., Tahirov, T. H., & Pavlov, Y. I. (2014) · DNA repair · doi:10.1016/j.dnarep.2014.04.013 · Cited by 21

The Role of Dbf4-Dependent Protein Kinase in DNA Polymerase ζ-Dependent Mutagenesis in Saccharomyces cerevisiae

Brandão, L., Ferguson, R. L., Santoro, I. Μ., Jinks-Robertson, S., & Sclafani, R. A. (2014) · Genetics · doi:10.1534/genetics.114.165308 · Cited by 21

Bypass of a Psoralen DNA Interstrand Cross-Link by DNA Polymerases β, ι, and κ in Vitro

Smith, L. A., Makarova, А. V., Samson, L., Thiesen, K. E., Dhar, A., & Bessho, T. (2012) · Biochemistry · doi:10.1021/bi3008565 · Cited by 21

Polymerase Bypass of N6-Deoxyadenosine Adducts Derived from Epoxide Metabolites of 1,3-Butadiene

Kotapati, S., Wickramaratne, S., Esades, A., Boldry, E. J., Dorr, D. Q., Pence, M. G., Guengerich, F. P., & Tretyakova, N. Y. (2015) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.5b00166 · Cited by 21

Functional Conversion of CPD and (6–4) Photolyases by Mutation

Yamada, D., Dokainish, H., Iwata, T., Yamamoto, J., Ishikawa, T., Todo, T., Iwai, S., Getzoff, E. D., Kitao, A., & Kandori, H. (2016) · Biochemistry · doi:10.1021/acs.biochem.6b00361 · Cited by 21

The DinB•RecA complex of Escherichia coli mediates an efficient and high‐fidelity response to ubiquitous alkylation lesions

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