Eukaryotic Translesion Polymerases and Their Roles and Regulation in DNA Damage Tolerance

DNA Repair and Mutagenesis

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The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase η

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EUKARYOTIC TRANSLESION SYNTHESIS DNA POLYMERASES: Specificity of Structure and Function

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The Relevance of G-Quadruplexes for DNA Repair

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APC/CCdh1-dependent proteolysis of USP1 regulates the response to UV-mediated DNA damage

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Structural basis of DNA lesion recognition for eukaryotic transcription-coupled nucleotide excision repair

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Rescue from replication stress during mitosis

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Interaction between the Rev1 C-Terminal Domain and the PolD3 Subunit of Polζ Suggests a Mechanism of Polymerase Exchange upon Rev1/Polζ-Dependent Translesion Synthesis

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Novel Enzymatic Function of DNA Polymerase ν in Translesion DNA Synthesis Past Major Groove DNA−Peptide and DNA−DNA Cross-Links

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DNA Polymerase ζ Is a Major Determinant of Resistance to Platinum-Based Chemotherapeutic Agents

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Mammalian polymerase ζ is essential for post-replication repair of UV-induced DNA lesions

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Translesion DNA synthesis in the context of cancer research

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Synthesis of Site-Specific DNA–Protein Conjugates and Their Effects on DNA Replication

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NBS1 Recruits RAD18 via a RAD6-like Domain and Regulates Pol η-Dependent Translesion DNA Synthesis

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Human REV3 DNA Polymerase Zeta Localizes to Mitochondria and Protects the Mitochondrial Genome

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HUWE1 interacts with PCNA to alleviate replication stress

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Rev7 dimerization is important for assembly and function of the Rev1/Polζ translesion synthesis complex

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PRIMPOL ready, set, reprime!

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DNA replication and repair bypass machines

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Inhibition of REV3 Expression Induces Persistent DNA Damage and Growth Arrest in Cancer Cells

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The endonuclease IV family of apurinic/apyrimidinic endonucleases

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Genetic instability in budding and fission yeast—sources and mechanisms

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Targeting the Translesion Synthesis Pathway for the Development of Anti-Cancer Chemotherapeutics

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G4-Interacting DNA Helicases and Polymerases: Potential Therapeutic Targets

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Structure of monoubiquitinated PCNA

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Predisposition for TMPRSS2-ERG Fusion in Prostate Cancer by Variants in DNA Repair Genes

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PPL2 Translesion Polymerase Is Essential for the Completion of Chromosomal DNA Replication in the African Trypanosome

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REV1 and DNA polymerase zeta in DNA interstrand crosslink repair

Sharma, S., & Canman, C. E. (2012) · Environmental and Molecular Mutagenesis · doi:10.1002/em.21736 · Cited by 56

DNA polymerase zeta generates clustered mutations during bypass of endogenous DNA lesions in Saccharomyces cerevisiae

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The REV7 Subunit of DNA Polymerase ζ Is Essential for Primordial Germ Cell Maintenance in the Mouse

Watanabe, N., Mii, S., Asai, N., Asai, M., Niimi, K., Ushida, K., Kato, T., Enomoto, A., Ishii, H., Takahashi, M., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.421966 · Cited by 55

Inhibition of DNA Repair in Cancer Therapy: Toward a Multi-Target Approach

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Postreplication gaps at UV lesions are signals for checkpoint activation

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Association of ABCC2 polymorphisms with platinum-based chemotherapy response and severe toxicity in non-small cell lung cancer patients

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Crosstalk between BRCA‐Fanconi anemia and mismatch repair pathways prevents MSH2‐dependent aberrant DNA damage responses

Peng, M., Xie, J., Ucher, A. J., Stavnezer, J., & Cantor, S. B. (2014) · The EMBO Journal · doi:10.15252/embj.201387530 · Cited by 54

A PolH Transcript with a Short 3′UTR Enhances PolH Expression and Mediates Cisplatin Resistance

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A Broad Requirement for TLS Polymerases η and κ, and Interacting Sumoylation and Nuclear Pore Proteins, in Lesion Bypass during C. elegans Embryogenesis

Roerink, S. F., Koole, W., Stapel, L. C., Romeijn, R. J., & Tijsterman, M. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002800 · Cited by 53

Recruitment of DNA polymerase eta by FANCD2 in the early response to DNA damage

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The DNA Polymerase Activity ofSaccharomyces cerevisiaeRev1 is Biologically Significant

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Periodic Oxaliplatin Administration in Synergy with PER2‐Mediated PCNA Transcription Repression Promotes Chronochemotherapeutic Efficacy of OSCC

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Identification of Small Molecule Translesion Synthesis Inhibitors That Target the Rev1-CT/RIR Protein-Protein Interaction

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The C‐terminal domain of human Rev1 contains independent binding sites for DNA polymerase η and Rev7 subunit of polymerase ζ

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Use of high-throughput RT-qPCR to assess modulations of gene expression profiles related to genomic stability and interactions by cadmium

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The dCMP transferase activity of yeast Rev1 is biologically relevant during the bypass of endogenously generated AP sites

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NMR Mapping of PCNA Interaction with Translesion Synthesis DNA Polymerase Rev1 Mediated by Rev1-BRCT Domain

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Strategies for DNA interstrand crosslink repair: Insights from worms, flies, frogs, and slime molds

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Damage-induced localized hypermutability

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Ancient genes establish stress-induced mutation as a hallmark of cancer

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Control of DNA Damage Bypass by Ubiquitylation of PCNA

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Processivity factor of DNA polymerase and its expanding role in normal and translesion DNA synthesis

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Emergence of DNA Polymerase ε Antimutators That Escape Error-Induced Extinction in Yeast

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Mechanism of RNA polymerase II bypass of oxidative cyclopurine DNA lesions

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Mechanism of error-free and semitargeted mutagenic bypass of an aromatic amine lesion by Y-family polymerase Dpo4

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Beyond translesion synthesis: polymerase κ fidelity as a potential determinant of microsatellite stability

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Modulation of mutagenesis in eukaryotes by DNA replication fork dynamics and quality of nucleotide pools

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FANCD2 and REV1 cooperate in the protection of nascent DNA strands in response to replication stress

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Filling gaps in translesion DNA synthesis in human cells

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Translesion Synthesis Polymerases in the Prevention and Promotion of Carcinogenesis

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The Rev1 translesion synthesis polymerase has multiple distinct DNA binding modes

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Specialised DNA polymerases in Escherichia coli: roles within multiple pathways

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DNA Polymerase ζ-Dependent Lesion Bypass in Saccharomyces cerevisiae Is Accompanied by Error-Prone Copying of Long Stretches of Adjacent DNA

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Rare Genetic Diseases with Defects in DNA Repair: Opportunities and Challenges in Orphan Drug Development for Targeted Cancer Therapy

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Genomic analysis finds no evidence of canonical eukaryotic DNA processing complexes in a free-living protist

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Next-generation sequencing reveals the biological significance of the N 2,3-ethenoguanine lesion in vivo

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Regulation of translesion DNA synthesis: Posttranslational modification of lysine residues in key proteins

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Human Translesion Polymerase κ Exhibits Enhanced Activity and Reduced Fidelity Two Nucleotides from G-Quadruplex DNA

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Regulation and Modulation of Human DNA Polymerase δ Activity and Function

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The Role of Dynamic m6A RNA Methylation in Photobiology

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The Fanconi anemia pathway and DNA interstrand cross-link repair

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Temporally distinct translesion synthesis pathways for ultraviolet light-induced photoproducts in the mammalian genome

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The Non-canonical Protein Binding Site at the Monomer-Monomer Interface of Yeast Proliferating Cell Nuclear Antigen (PCNA) Regulates the Rev1-PCNA Interaction and Polζ/Rev1-dependent Translesion DNA Synthesis

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Small molecule inhibitors of PCNA/PIP-box interaction suppress translesion DNA synthesis

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Structural Analysis of the Conserved Ubiquitin-binding Motifs (UBMs) of the Translesion Polymerase iota in Complex with Ubiquitin

Burschowsky, D., Rudolf, F., Rabut, G. E. E., Herrmann, T., Peter, M., & Wider, G. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.135038 · Cited by 41

Perturbations in the Replication Program Contribute to Genomic Instability in Cancer

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DNA polymerase eta: A potential pharmacological target for cancer therapy

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Structural and Molecular Kinetic Features of Activities of DNA Polymerases

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Translesion synthesis inhibitors as a new class of cancer chemotherapeutics

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Tolerating DNA damage during eukaryotic chromosome replication

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Roles of mutagenic translesion synthesis in mammalian genome stability, health and disease

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Bypass of DNA-Protein Cross-links Conjugated to the 7-Deazaguanine Position of DNA by Translesion Synthesis Polymerases

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p15PAF binding to PCNA modulates the DNA sliding surface

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Regulation of tolerance to DNA alkylating damage by Dot1 and Rad53 in Saccharomyces cerevisiae

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Identification of RNF8 as a Ubiquitin Ligase Involved in Targeting the p12 Subunit of DNA Polymerase δ for Degradation in Response to DNA Damage

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REV7 is required for anaphase-promoting complex-dependent ubiquitination and degradation of translesion DNA polymerase REV1

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The Rev1-Polζ translesion synthesis mutasome: Structure, interactions and inhibition

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Error-prone Translesion Synthesis Past DNA-Peptide Cross-links Conjugated to the Major Groove of DNA via C5 of Thymidine

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Human Variation in DNA Repair, Immune Function, and Cancer Risk

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Ribonucleotide discrimination by translesion synthesis DNA polymerases

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CpG promoter methylation of the ALKBH3 alkylation repair gene in breast cancer

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