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Eukaryotic Translesion Polymerases and Their Roles and Regulation in DNA Damage Tolerance
Open accessAbstract
SUMMARY: DNA repair and DNA damage tolerance machineries are crucial to overcome the vast array of DNA damage that a cell encounters during its lifetime. In this review, we summarize the current state of knowledge about the eukaryotic DNA damage tolerance pathway translesion synthesis (TLS), a process in which specialized DNA polymerases replicate across from DNA lesions. TLS aids in resistance to DNA damage, presumably by restarting stalled replication forks or filling in gaps that remain in the genome due to the presence of DNA lesions. One consequence of this process is the potential risk of introducing mutations. Given the role of these translesion polymerases in mutagenesis, we discuss the significant regulatory mechanisms that control the five known eukaryotic translesion polymerases: Rev1, Pol ζ, Pol κ, Pol η, and Pol ι.
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“Furthermore, it prevents the formation of double strand breaks in response to UV radiation [125,127].”
From Focus on UV-Induced DNA Damage and Repair—Disease Relevance and Protective Strategies (2020) · cites this paper as [127]
In the citing paper
“Moreover, TLS polymerases lack the 3′-5′ exonucleases (proofreading) activity further limiting repair accuracy [125,127].”
From Focus on UV-Induced DNA Damage and Repair—Disease Relevance and Protective Strategies (2020) · cites this paper as [127]
In the citing paper
“In eukaryotic cells interaction of polymerases with PCNA (dependent on its ubiquitination status) seems to be crucial for employment of TLS polymerases for lesion bypass [127,129].”
From Focus on UV-Induced DNA Damage and Repair—Disease Relevance and Protective Strategies (2020) · cites this paper as [127]
In the citing paper
“Moreover, REV1 seems to regulate TLS via recruitment and coordination of other proteins involved in the damage response [127].”
From Focus on UV-Induced DNA Damage and Repair—Disease Relevance and Protective Strategies (2020) · cites this paper as [127]
In the citing paper
“Pol η and Pol ζ can bypass T-T CPDs and were shown to play an important role in TLS of UV damage, while REV1 was shown to be required for bypass of a 6-4 TT dimer in vivo.”
From Focus on UV-Induced DNA Damage and Repair—Disease Relevance and Protective Strategies (2020) · cites this paper as [127]
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Metadata
- Authors
- Waters, L. S., Minesinger, B. K., Wiltrout, M. E., D'Souza, S., Woodruff, R. V., & Walker, G. C.
- Affiliations
- Massachusetts Institute of Technology (US)
- Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 01239
- Venue
- Microbiology and Molecular Biology Reviews
- Publisher
- American Society for Microbiology
- Published
- 2009-03
- Volume
- 73
- Issue
- 1
- Pages
- 134-154
- ISSN
- 1092-2172 (ISSN-L)
- 1098-5557
- PMC
- PMC2650891
- OpenAlex
- W2167668429
- Cited by
- 591
- References
- 286
- Citations by year
- 2026: 11 · 2025: 17 · 2024: 15 · 2023: 23 · 2022: 34 · 2021: 26 · 2020: 35 · 2019: 33 · 2018: 38 · 2017: 45 · 2016: 36 · 2015: 40 · 2014: 42 · 2013: 48 · 2012: 57
- FWCI
- 3.65
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Microbiology and Molecular Biology Reviews (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of General Medical Sciences (F32GM078966)
- National Institute of Environmental Health Sciences (P30ES002109, R01ES015818)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Keywords
- translesion synthesis, DNA damage tolerance, DNA repair, Rev1, Pol eta, mutagenesis, replication fork restart
- MeSH terms
- DNA Damage, DNA-Directed DNA Polymerase, DNA Repair, Eukaryotic Cells, Humans, Models, Molecular, Yeasts
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