Eukaryotic Translesion Polymerases and Their Roles and Regulation in DNA Damage Tolerance

DNA Repair and Mutagenesis

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DNA damage response, a double-edged sword for vascular aging

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Replication of the 2,6-Diamino-4-hydroxy-N5-(methyl)-formamidopyrimidine (MeFapy-dGuo) Adduct by Eukaryotic DNA Polymerases

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Biochemical Characterization of Eight Genetic Variants of Human DNA Polymerase κ Involved in Error-Free Bypass across Bulky N2-Guanyl DNA Adducts

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High Risk α-HPV E6 Impairs Translesion Synthesis by Blocking POLη Induction

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Genetic instability is prevented by Mrc1‐dependent spatio‐temporal separation of replicative and repair activities of homologous recombination

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Influence of local sequence context on damaged base conformation in human DNA polymerase ι: molecular dynamics studies of nucleotide incorporation opposite a benzo[a]pyrene-derived adenine lesion

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Roles of SUMO in Replication Initiation, Progression, and Termination

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Both High-Fidelity Replicative and Low-Fidelity Y-Family Polymerases Are Involved in DNA Rereplication

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Exome‐wide single‐base substitutions in tissues and derived cell lines of the constitutive Fhit knockout mouse

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Fanconi anemia pathway and its relationship with cancer

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Frequencies of mutagenic translesion DNA synthesis over cisplatin-guanine intra-strand crosslinks in lacZ plasmids propagated in human cells

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Structure and Functional Analysis of the BRCT Domain of Translesion Synthesis DNA Polymerase Rev1

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Architecture of Y‐Family DNA Polymerases Relevant to Translesion DNA Synthesis as Revealed in Structural and Molecular Modeling Studies

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Regulation of nucleotide excision repair through ubiquitination

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Genetic variation in the DNA repair pathway as a potential determinant of response to platinum‐based chemotherapy in breast cancer

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Precision cancer therapy: profiting from tumor specific defects in the DNA damage tolerance system

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Phosphorylation Alters the Properties of Pol η: Implications for Translesion Synthesis

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Effects of polymorphisms in translesion DNA synthesis genes on lung cancer risk and prognosis in Chinese men

Xu, H., Gao, X., Zhang, W. Y., Cheng, J., Tan, Y., Zheng, W., Shu, X., & Xiang, Y. (2013) · Cancer Epidemiology · doi:10.1016/j.canep.2013.08.003 · Cited by 16

Parental histone deposition on the replicated strands promotes error-free DNA damage tolerance and regulates drug resistancePreprint

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Pol kappa partially rescues MMR-dependent cytotoxicity of O6-methylguanine

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Virtual Pharmacophore Screening Identifies Small‐Molecule Inhibitors of the Rev1‐CT/RIR Protein–Protein Interaction

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Recent Advances in Understanding the Structures of Translesion Synthesis DNA Polymerases

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The amino-terminal tails of histones H2A and H3 coordinate efficient base excision repair, DNA damage signaling and postreplication repair in Saccharomyces cerevisiae

Meas, R., Smerdon, M. J., & Wyrick, J. J. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv372 · Cited by 15

Increased dietary cholesterol promotes enhanced mutagenesis in DNA polymerase kappa-deficient mice

Singer, W. D., Osimiri, L. C., & Friedberg, E. C. (2013) · DNA repair · doi:10.1016/j.dnarep.2013.07.010 · Cited by 15

Ubiquitin-dependent regulation of translesion polymerases

Chun, A. C. S., & Jin, D. (2010) · Biochemical Society Transactions · doi:10.1042/bst0380110 · Cited by 15

Clinical importance of DNA repair in sporadic colorectal cancer

Laporte, G. A., Leguisamo, N. M., Kalil, A. N., & Saffi, J. (2018) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2018.03.017 · Cited by 15

Translesion synthesis polymerases are dispensable for C. elegans reproduction but suppress genome scarring by polymerase theta-mediated end joining

van Bostelen, I., van Schendel, R., Romeijn, R. J., & Tijsterman, M. (2020) · PLoS Genetics · doi:10.1371/journal.pgen.1008759 · Cited by 15

Effects of Twelve Germline Missense Variations on DNA Lesion and G-Quadruplex Bypass Activities of Human DNA Polymerase REV1

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Divalent Cations Alter the Rate-Limiting Step of PrimPol-Catalyzed DNA Elongation

Xu, W., Zhao, W., Morehouse, N., Tree, M. O., & Zhao, L. (2019) · Journal of Molecular Biology · doi:10.1016/j.jmb.2019.01.002 · Cited by 15

Personalized Assessment of Normal Tissue Radiosensitivity via Transcriptome Response to Photon, Proton and Carbon Irradiation in Patient-Derived Human Intestinal Organoids

Nowrouzi, A., Sertorio, M. G., Akbarpour, M., Knoll, M., Krunic, D., Kuhar, M., Schwager, C., Brons, S., Debus, J., Wells, S. I., et al. (2020) · Cancers · doi:10.3390/cancers12020469 · Cited by 14

Budding yeast Mph1 promotes sister chromatid interactions by a mechanism involving strand invasion

Ede, C., Rudolph, C. J., Lehmann, S., Schürer, K. A., & Kramer, W. (2010) · DNA repair · doi:10.1016/j.dnarep.2010.09.009 · Cited by 14

Selective disruption of the DNA polymerase III - complex by the umuD gene products

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Minor Groove 3‐Deaza‐Adenosine Analogues: Synthesis and Bypass in Translesion DNA Synthesis

Malvezzi, S., Angelov, T., & Sturla, S. J. (2016) · Chemistry - A European Journal · doi:10.1002/chem.201604289 · Cited by 14

Analyzing the Catalytic Activities and Interactions of Eukaryotic Translesion Synthesis Polymerases

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Genome‐wide expression profiling analysis to identify key genes in the anti‐HIV mechanism of CD4+and CD8+T cells

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Plastid Genome Stability and Repair

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Cryo-EM reveals conformational flexibility in apo DNA polymerase ζ

Truong, C. D., Craig, T. A., Cui, G., Botuyan, M. V., Serkasevich, R. A., Chan, K.-Y., Mer, G., Chiu, P., & Kumar, R. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.100912 · Cited by 13

A Blm-Recql5 partnership in replication stress response

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An archaeal family-B DNA polymerase variant able to replicate past DNA damage: occurrence of replicative and translesion synthesis polymerases within the B family

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Chronic low-dose ultraviolet-induced mutagenesis in nucleotide excision repair-deficient cells

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DNA Damage Response Pathways in Dinoflagellates

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Analysis of CPD Ultraviolet Lesion Bypass in Chicken DT40 Cells: Polymerase η and PCNA Ubiquitylation Play Identical Roles

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Influence of a pre-stimulation with chronic low-dose UVB on stress response mechanisms in human skin fibroblasts

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Papel das proteínas XPD e DNA polimerase eta nas respostas de células humanas a danos no genoma

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Caracterização genotípica de pacientes brasileiros com deficiência em processos de reparo de DNA.

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Efeitos da luz UVA em células de pacientes com Xeroderma Pigmentosum Variante

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A single hydrophobic cleft in the Escherichia coli processivity clamp is sufficient to support cell viability and DNA damage-induced mutagenesis in vivo

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Non-Canonical CRL4A/4BCDT2 Interacts with RAD18 to Modulate Post Replication Repair and Cell Survival

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Cell-Cycle Control and DNA-Damage Signaling in Mammals

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RAD18 polymorphisms are associated with platinum-based chemotherapy toxicity in Chinese patients with non-small cell lung cancer

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Small molecule scaffolds that disrupt the Rev1-CT/RIR protein-protein interaction

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Modeling the action of environment on proton tunneling in the adenine–thymine base pair

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Large deletions in immunoglobulin genes are associated with a sustained absence of DNA Polymerase η

Lerner, L. K., Nguyen, V., Castro, L. P., Vilar, J. B., Munford, V., Guillou, M. L., Mohammad, M. M., Vergé, V., Rosselli, F., Menck, C. F. M., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-58180-7 · Cited by 12

Multiple Machine Learning Methods Reveal Key Biomarkers of Obstructive Sleep Apnea and Continuous Positive Airway Pressure Treatment

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iDamage: a method to integrate modified DNA into the yeast genome

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Rad51 filaments assembled in the absence of the complex formed by the Rad51 paralogs Rad55 and Rad57 are outcompeted by translesion DNA polymerases on UV-induced ssDNA gaps

Maloisel, L., Ma, É., Phipps, J., Deshayes, A., Mattarocci, S., Marcand, S., Dubrana, K., & Coı̈c, E. (2023) · PLoS Genetics · doi:10.1371/journal.pgen.1010639 · Cited by 11

Glycidamide-induced hypermutation in yeast single-stranded DNA reveals a ubiquitous clock-like mutational motif in humans

Hudson, K. M., Klimczak, L. J., Sterling, J. F., Burkholder, A., Kazanov, M. D., Saini, N., Mieczkowski, P. A., & Gordenin, D. A. (2023) · Nucleic Acids Research · doi:10.1093/nar/gkad611 · Cited by 11

Polymerase iota (POLI) confers radioresistance of esophageal squamous cell carcinoma by regulating RAD51 stability and facilitating homologous recombination

Li, X., Gao, D., Shen, F., Chen, H., Zhang, Z., He, C. S., Gao, A., Lang, Y., Zhu, X., Zhou, J., et al. (2023) · Cell Death Discovery · doi:10.1038/s41420-023-01541-8 · Cited by 11

NGS-based analysis of base-substitution signatures created by yeast DNA polymerase eta and zeta on undamaged and abasic DNA templates in vitro

Chen, Y., & Sugiyama, T. (2017) · DNA repair · doi:10.1016/j.dnarep.2017.08.011 · Cited by 11

Absence of REV3L promotes p53-regulated cancer cell metabolism in cisplatin-treated lung carcinoma cells

Kong, L., Murata, M. M., & Digman, M. A. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.01.026 · Cited by 11

Unscheduled DNA synthesis leads to elevated uracil residues at highly transcribed genomic loci in Saccharomyces cerevisiae

Owiti, N. A., Wei, S., Bhagwat, A. S., & Kim, N. (2018) · PLoS Genetics · doi:10.1371/journal.pgen.1007516 · Cited by 11

The roles of polymerases ν and θ in replicative bypass of O6- and N2-alkyl-2′-deoxyguanosine lesions in human cells

Du, H., Wang, P., Wu, J., He, X., & Wang, Y. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra120.012830 · Cited by 11

Design of amino acid- and carbohydrate-based anticancer drugs to inhibit polymerase η

Kalhor, S., & Fattahi, A. (2022) · Scientific Reports · doi:10.1038/s41598-022-22810-z · Cited by 11

Does evening sun increase the risk of skin cancer?

MITRA, S. P. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1116516108 · Cited by 11

Quantification of pyrophosphate as a universal approach to determine polymerase activity and assay polymerase inhibitors

Malvezzi, S., Sturla, S. J., & Tanasova, M. (2015) · Analytical Biochemistry · doi:10.1016/j.ab.2015.03.002 · Cited by 11

Coordination and Substitution of DNA Polymerases in Response to Genomic Obstacles

Trakselis, M. A., Cranford, M. T., & Chu, A. M. (2017) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.7b00190 · Cited by 11

DNA Adduct-Directed Synthetic Nucleosides

Räz, M. H., Aloisi, C. M. N., Gahlon, H. L., & Sturla, S. J. (2019) · Accounts of Chemical Research · doi:10.1021/acs.accounts.9b00054 · Cited by 11

Conformational flexibility of fork-remodeling helicase Rad5 shown by full-ensemble hybrid methods

Gildenberg, M. S., & Washington, M. T. (2019) · PLoS ONE · doi:10.1371/journal.pone.0223875 · Cited by 11

Implications for Damage Recognition during Dpo4-Mediated Mutagenic Bypass of m1G and m3C Lesions

Rechkoblit, O., Delaney, J. C., Essigmann, J. M., & Patel, D. J. (2011) · Structure · doi:10.1016/j.str.2011.03.020 · Cited by 10

Mutagenic Bypass of an Oxidized Abasic Lesion-Induced DNA Interstrand Cross-Link Analogue by Human Translesion Synthesis DNA Polymerases

Xu, W., Ouellette, A. M., Ghosh, S., O’Neill, T. C., Greenberg, M. M., & Zhao, L. (2015) · Biochemistry · doi:10.1021/acs.biochem.5b01027 · Cited by 10

Elevated MSH2 MSH3 expression interferes with DNA metabolism in vivo

Medina‐Rivera, M., Phelps, S. E., Sridharan, M., Becker, J. T., Lamb, N. A., Kumar, C., Sutton, M. D., Bielinsky, A., Balakrishnan, L., & Surtees, J. A. (2023) · Nucleic Acids Research · doi:10.1093/nar/gkad934 · Cited by 10

Protein Assemblies in Translesion Synthesis

Arianna, G. A., & Korzhnev, D. M. (2024) · Genes · doi:10.3390/genes15070832 · Cited by 10

UV Damaged DNA Repair & Tolerance in Plants

Ashwin, L., & Dana, F. E. (2011) · InTech eBooks · doi:10.5772/22138 · Cited by 10

Comparison of the in Vitro Replication of the 7-(2-Oxoheptyl)-1,N2-etheno-2′-deoxyguanosine and 1,N2-Etheno-2′-deoxyguanosine Lesions by Sulfolobus solfataricus P2 DNA Polymerase IV (Dpo4)

Christov, P. P., Petrova, K. V., Shanmugam, G., Kozekov, I. D., Kozekova, A., Guengerich, F. P., Stone, M. P., & Rizzo, C. J. (2010) · Chemical Research in Toxicology · doi:10.1021/tx100082e · Cited by 10

Participation of translesion synthesis DNA polymerases in the maintenance of chromosome integrity in yeast Saccharomyces cerevisiae

Kochenova, O. V., Soshkina, J. V., Stepchenkova, E. I., Inge-Vechtomov, S. G., & Shcherbakova, P. V. (2011) · Biochemistry (Moscow) · doi:10.1134/s000629791101007x · Cited by 10

Concurrent Nucleotide Substitution Mutations in the Human Genome Are Characterized by a Significantly Decreased Transition/Transversion Ratio

Zhu, W., Cooper, D. N., Zhao, Q., Wang, Y., Liu, R., Li, Q., Férec, C., Wang, Y., & Chen, J. (2014) · Human Mutation · doi:10.1002/humu.22749 · Cited by 10

Identification of New Mutations at the PCNA Subunit Interface that Block Translesion Synthesis

Kondratick, C. M., Boehm, E. M., Dieckman, L. M., Powers, K. T., Sanchez, J. C., Mueting, S. R., & Washington, M. T. (2016) · PLoS ONE · doi:10.1371/journal.pone.0157023 · Cited by 10

Elevated Hedgehog activity contributes to attenuated DNA damage responses in aged hematopoietic cells

Scheffold, A., Baig, A. H., Chen, Z., von Löhneysen, S., Becker, F. R., Morita, Y., Avila, A. I., Groth, M., Lechel, A., Schmid, F. T., et al. (2019) · Leukemia · doi:10.1038/s41375-019-0641-3 · Cited by 10

Yeast DNA polymerase η possesses two PIP-like motifs that bind PCNA and Rad6-Rad18 with different specificities

Ripley, B. M., Reusch, D. T., & Washington, M. T. (2020) · DNA repair · doi:10.1016/j.dnarep.2020.102968 · Cited by 10

Ubiquitin and Ubiquitin-Like Proteins Are Essential Regulators of DNA Damage Bypass

Wilkinson, N. A., Mnuskin, K. S., Ashton, N. W., & Woodgate, R. (2020) · Cancers · doi:10.3390/cancers12102848 · Cited by 10

Effects of in vivo treatment of mice with sulforaphane on repair of DNA pyridyloxylbutylation

Harris, C. M., Zamperoni, K. E., Sernoskie, S. C., Chow, N., & Massey, T. E. (2021) · Toxicology · doi:10.1016/j.tox.2021.152753 · Cited by 10

Eukaryotic stress–induced mutagenesis is limited by a local control of translesion synthesis

Masłowska, K. H., Villafañez, F., Laureti, L., Iwai, S., & Pagès, V. (2022) · Nucleic Acids Research · doi:10.1093/nar/gkac044 · Cited by 10

Pol ζ polymorphisms are associated with platinum based chemotherapy response and side effects among non-small cell lung cancer patients

YE, J., CHU, T., LI, R., Niu, Y., JIN, B., XIA, J., Shao, T. M., & Han, B. (2015) · Neoplasma · doi:10.4149/neo_2015_101 · Cited by 10

Molecular Dynamics Simulations of Mismatched DNA Duplexes Associated with the Major C8-Linked 2′-Deoxyguanosine Adduct of the Food Mutagen Ochratoxin A: Influence of Opposing Base, Adduct Ionization State, and Sequence on the Structure of Damaged DNA

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Replication, Repair, and Translesion Polymerase Bypass of N6-Oxopropenyl-2′-deoxyadenosine

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