Vitamin E supplementation and macular degeneration: randomised controlled trial
Open accessAbstract
OBJECTIVE: To determine whether vitamin E supplementation influences the incidence or rate of progression of age related maculopathy (AMD). DESIGN: Prospective randomised placebo controlled clinical trial. SETTING: An urban study centre in a residential area supervised by university research staff. PARTICIPANTS: 1193 healthy volunteers aged between 55 and 80 years; 73% completed the trial on full protocol. INTERVENTIONS: Vitamin E 500 IU or placebo daily for four years. PRIMARY OUTCOME: development of early age related macular degeneration in retinal photographs. Other measures included alternative definitions of age related macular degeneration, progression, changes in component features, visual acuity, and visual function RESULTS: The incidence of early age related macular degeneration (early AMD 3) was 8.6% in those receiving vitamin E versus 8.1% in those on placebo (relative risk 1.05, 95% confidence interval 0.69 to 1.61). For late disease the incidence was 0.8% versus 0.6% (1.36, 0.67 to 2.77). Further analysis showed no consistent differences in secondary outcomes. CONCLUSION: Daily supplement with vitamin E supplement does not prevent the development or progression of early or later stages of age related macular degeneration.
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A trial of vitamin E in an Australian population with lower risk of developing advanced age-related macular degeneration failed to find a beneficial effect.
“By contrast, a trial of vitamin E in an Australian population with lower risk of developing advanced age-related macular degeneration failed to find a beneficial effect.97”
From Age-related macular degeneration (2008) · cites this paper as [97]
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Cites
(2001) · Archives of Ophthalmology · doi:10.1001/archopht.119.10.1417 · Cited by 3,285 · see citing works
Vitamin E Supplementation and Cardiovascular Events in High-Risk Patients
(2000) · New England Journal of Medicine · doi:10.1056/nejm200001203420302 · Cited by 1,957 · see citing works
Bird, A. C., Bressler, N. M., Bressler, S. B., Chisholm, I. H., Coscas, G., Davis, M. D., de Jong, P. T. V. M., Klaver, C. C. W., Klein, B. E. K., Klein, R., et al. (1995) · Survey of Ophthalmology · doi:10.1016/s0039-6257(05)80092-x · Cited by 1,926 · see citing works
Self-citationThe Five-year Incidence and Progression of Age-related Maculopathy
Klein, R., Klein, R., Jensen, S. C., & Meuer, S. M. (1997) · Ophthalmology · doi:10.1016/s0161-6420(97)30368-6 · Cited by 1,148 · see citing works
Risk factors for age-related macular degeneration
Smith, W., Assink, J., Klein, R., Mitchell, P., Klaver, C. C. W., Klein, B. E. K., Hofman, A., Jensen, S., Wang, J. J., & de Jong, P. T. V. M. (2001) · Ophthalmology · doi:10.1016/s0161-6420(00)00580-7 · Cited by 1,071 · see citing works
Mutation of the Stargardt Disease Gene ( ABCR ) in Age-Related Macular Degeneration
Allikmets, R. L., Shroyer, N. F., Singh, N., Seddon, J. M., Lewis, R. A., Bernstein, P. S., Peiffer, A. P., Zabriskie, N. A., Li, Y., Hutchinson, A. A., et al. (1997) · Science · doi:10.1126/science.277.5333.1805 · Cited by 879 · see citing works
UPTON, G. J. G. (1992) · Journal of the Royal Statistical Society Series A (Statistics in Society) · doi:10.2307/2982890 · Cited by 636 · see citing works
Senile macular degeneration: a case-control study
HYMAN, L. G., LILIENFELD, A. M., FERRIS, F. L., & FINE, S. L. (1983) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a113629 · Cited by 587 · see citing works
The Long-term Effects of Visible Light on the Eye
Taylor, H. R. (1992) · Archives of Ophthalmology · doi:10.1001/archopht.1992.01080130101035 · Cited by 568 · see citing works
Self-citation(2001) · Archives of Ophthalmology · doi:10.1001/archopht.119.10.1439 · Cited by 547 · see citing works
Stone, E. M., Lotery, A. J., Munier, F. L., Héon, E., Piguet, B., Guymer, R. H., Vandenburgh, K., Cousin, P., Nishimura, D. Y., Swiderski, R. E., et al. (1999) · Nature Genetics · doi:10.1038/9722 · Cited by 488 · see citing works
Age-related Macular Degeneration Is Associated with Atherosclerosis
Vingerling, J. R., Dielemans, I., Bots, M. L., Albert Hofman, D., Grobbee, D. E., & de Jong, P. T. V. M. (1995) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a117648 · Cited by 351 · see citing works
Effects of Vitamin E on Lipid Peroxidation in Healthy Persons
Meagher, E. A. (2001) · JAMA · doi:10.1001/jama.285.9.1178 · Cited by 269 · see citing works
Antioxidant vitamin and mineral supplements for preventing age-related macular degeneration
Evans, J. R., & Lawrenson, J. G. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000253.pub4 · Cited by 266 · see citing works
Sibling correlations and segregation analysis of age‐related maculopathy: The beaver dam eye study
Heiba, I. M., Elston, R. C., Klein, B. E. K., & Klein, R. (1994) · Genetic Epidemiology · doi:10.1002/gepi.1370110106 · Cited by 259 · see citing works
Five-Year Incidence and Disappearance of Drusen and Retinal Pigment Epithelial Abnormalities
Bressler, N. M. (1995) · Archives of Ophthalmology · doi:10.1001/archopht.1995.01100030055022 · Cited by 213 · see citing works
Cause-specific prevalence of bilateral visual impairment in Victoria, Australia
VanNewkirk, M. R., Weih, L. M., McCarty, C. A., & Taylor, H. R. (2001) · Ophthalmology · doi:10.1016/s0161-6420(01)00554-1 · Cited by 210 · see citing works
Self-citationIs the incidence of registrable age-related macular degeneration increasing?
Evans, J., & Wormald, R. (1996) · British Journal of Ophthalmology · doi:10.1136/bjo.80.1.9 · Cited by 197 · see citing works
Are Antioxidants or Supplements Protective for Age-Related Macular Degeneration?
West, S. K. (1994) · Archives of Ophthalmology · doi:10.1001/archopht.1994.01090140098031 · Cited by 170 · see citing works
Iris color, skin sun sensitivity, and age-related maculopathy
Mitchell, P., Smith, W. H., & Wang, J. J. (1998) · Ophthalmology · doi:10.1016/s0161-6420(98)98013-7 · Cited by 162 · see citing works
Age-related Macular Degeneration and Antioxidant Status in the POLA Study
Delcourt, C. (1999) · Archives of Ophthalmology · doi:10.1001/archopht.117.10.1384 · Cited by 158 · see citing works
Are Antioxidants or Supplements Protective for Age-Related Macular Degeneration?
Newsome, D. A. (1994) · Archives of Ophthalmology · doi:10.1001/archopht.1994.01090180027007 · Cited by 141 · see citing works
Mutation of the Stargardt Disease Gene (ABCR) in Age-related Macular Degeneration
Allikmets, R. L., Shroyer, N. F., Singh, N. V., Seddon, J. M., Lewis, R. A., Bernstein, P. S., Peiffer, A. P., Zabriskie, N. A., Li, Y., Hutchinson, A., et al. (1998) · Retina · doi:10.1097/00006982-199818020-00027 · Cited by 88 · see citing works
Christen, W. G., Ajani, U. A., Glynn, R., Manson, J. E., Schaumberg, D. A., Chew, E. C., Buring, J. E., & Hennekens, C. H. (1999) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a009836 · Cited by 76 · see citing works
Cigarette Smoking and Risk for Progression of Nuclear Opacities
West, S. K. (1995) · Archives of Ophthalmology · doi:10.1001/archopht.1995.01100110037022 · Cited by 73 · see citing works
Risk factors for agerelated macular degeneration: Pooled findings from three continents
Smith, W., Assink, J. (., Klein, R., Mitchell, P., Klaver, C., Klein, B., Albert Hofman, D., Jensen, S., Wang, J., & Jong, P. D. (2001) · KNAW research portal (Royal Academy of Art and Sciences (KNAW)) · Cited by 70 · see citing works
Community-based recruitment strategies for a longitudinal interventional study
Garrett, S. K. M., Thomas, A. P., Cicuttini, F., Silagy, C. A., Taylor, H. R., & McNeil, J. J. (2000) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(99)00153-5 · Cited by 50 · see citing works
Self-citationAge related macular degeneration
Bressler, N. M., & Gills, J. P. (2000) · BMJ · doi:10.1136/bmj.321.7274.1425 · Cited by 33 · see citing works
Baseline ophthalmic findings in the Vitamin E, Cataract and Age‐Related Maculopathy (VECAT) study
Robman, L. D., GradDip, G. T., Garrett, S. K. M., Harper, C. A., McNeil, J. J., Fraco, H. R. T., & McCarty, C. A. (1999) · Australian and New Zealand Journal of Ophthalmology · doi:10.1046/j.1440-1606.1999.00240.x · Cited by 23 · see citing works
Self-citationRisk factors for age-related maculopathy: the Visual Impairment Project
McCarty, C. A., Mukesh, B. N., Fu, C. L. H., MITCHELL, P., Wang, J. J., & Taylor, H. R. (2001) · Minerva Access (University of Melbourne) · Cited by 18 · see citing works
Self-citationTikellis, G., Robman, L. D., Harper, A., et al. (2000) · Clinical and Experimental Ophthalmology · doi:10.1046/j.1442-9071.2000.00336.x · Cited by 17 · see citing works
Self-citationRisk Factors for Age-Related Maculopathy: The Visual Impairment Project
McCarty, C. A. (2001) · Archives of Ophthalmology · doi:10.1001/archopht.119.10.1455 · Cited by 12 · see citing works
Self-citationVan Newkirk, M. R., Weih, L. M., McCarty, C. A., et al. (2001) · Minerva Access (University of Melbourne) · Cited by 12 · see citing works
Self-citationAge-related macular degeneration is associated with atherosclerosis. The Rotterdam Study
Vingerling, J. R., Dielemans, I., Bots, M. L., Hofman, A., Grobbee, D. E., & de Jong, P. T. V. M. (1995) · Data Archiving and Networked Services (DANS) · Cited by 6 · see citing works
Community based recruitment strategies for a longitudinal interventional study: The VECAT experience
Garrett, S. K. M., Thomas, A. P., McNeil, J. J., et al. (1996) · Investigative Ophthalmology & Visual Science · Cited by 2 · see citing works
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Age-related macular degeneration: etiology, pathogenesis, and therapeutic strategies
Ambati, J., Ambati, B. K., Yoo, S. H., Ianchulev, S., & Adamis, A. P. (2003) · Survey of Ophthalmology · doi:10.1016/s0039-6257(03)00030-4 · Cited by 959 · see citing works
Bjelakovic, G., Nikolova, D., Gluud, L. L., Simonetti, R. G., & Gluud, C. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007176.pub2 · Cited by 924 · see citing works
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Cho, E. (2004) · Archives of Ophthalmology · doi:10.1001/archopht.122.6.883 · Cited by 266 · see citing works
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Self-citation
- Authors
- Taylor, H. R., Tikellis, G., Robman, L. D., McCarty, C. A., & McNeil, J. J.
- Affiliations
- The University of Melbourne (AU)
- Corresponding author
- Taylor, Hugh R
- ORCID
- Taylor, Hugh R
- Venue
- BMJ
- Publisher
- BMJ
- Published
- 2002-07-06
- Volume
- 325
- Issue
- 7354
- Pages
- 11
- ISSN
- 0007-1447 (ISSN-L)
- 0959-8138
- 1468-5833
- PMC
- PMC116664
- OpenAlex
- W2139029875
- Cited by
- 165
- References
- 35
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 5 · 2023: 2 · 2022: 9 · 2021: 6 · 2020: 3 · 2019: 3 · 2018: 1 · 2017: 7 · 2016: 1 · 2015: 5 · 2014: 5 · 2013: 7 · 2012: 17
- FWCI
- 12.76
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.bmj.com/company/legal-information/terms-conditions/legal-information/tdm-licencepolicy (tdm)
- Locations
- BMJ (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Health and Medical Research Council
- Topics
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Retinal Imaging and Analysis
- Keywords
- vitamin E supplementation, age-related macular degeneration, disease progression, early AMD, late AMD, fundus images, visual acuity, visual function, older adults
- MeSH terms
- Aged, Aged, 80 and over, Antioxidants, Follow-Up Studies, Humans, Macular Degeneration, Middle Aged, Prospective Studies, Victoria, Vitamin E, Incidence, Prevalence, Disease Progression
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