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What can mendelian randomisation tell us about modifiable behavioural and environmental exposures?
Open accessAbstract
Using genetic variants as a proxy for modifiable environmental factors that are associated with disease can circumvent some of the problems of observational studies
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“The MR methodology used is less vulnerable to environmental confounding and reverse causation than traditional observational research strategies [6,7].”
From Associations of genetically determined iron status across the phenome: A mendelian randomization study (2019) · cites this paper as [6]
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Metadata
- Authors
- Smith, G. D., & Ebrahim, S.
- Affiliations
- University of Bristol (GB)
- Venue
- BMJ
- Publisher
- BMJ
- Published
- 2005-05-05
- Volume
- 330
- Issue
- 7499
- Pages
- 1076-1079
- ISSN
- 0007-1447 (ISSN-L)
- 0959-8138
- 1468-5833
- PMC
- PMC557238
- OpenAlex
- W2096940418
- Cited by
- 545
- References
- 22
- Citations by year
- 2026: 13 · 2025: 33 · 2024: 66 · 2023: 37 · 2022: 29 · 2021: 39 · 2020: 61 · 2019: 15 · 2018: 31 · 2017: 19 · 2016: 14 · 2015: 14 · 2014: 18 · 2013: 22 · 2012: 23
- FWCI
- 10.78
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- BMJ (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- LSHTM Research Online (London School of Hygiene and Tropical Medicine) (acceptedVersion)
- Bristol Research (University of Bristol) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Physical Sciences › Mathematics › Statistics and Probability › Advanced Causal Inference Techniques
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Health, Environment, Cognitive Aging
- Keywords
- Mendelian randomization, environmental exposure, causal inference, observational study limitations
- MeSH terms
- Environmental Exposure, Humans, Polymorphism, Genetic, Recombination, Genetic, Genetic Variation, Health Behavior, Occupational Exposure, Genetic Predisposition to Disease
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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