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What can mendelian randomisation tell us about modifiable behavioural and environmental exposures?
Open accessAbstract
Using genetic variants as a proxy for modifiable environmental factors that are associated with disease can circumvent some of the problems of observational studies
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“The MR methodology used is less vulnerable to environmental confounding and reverse causation than traditional observational research strategies [6,7].”
From Associations of genetically determined iron status across the phenome: A mendelian randomization study (2019) · cites this paper as [6]
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Metadata
- Authors
- Smith, G. D., & Ebrahim, S.
- Affiliations
- University of Bristol (GB)
- Venue
- BMJ
- Publisher
- BMJ
- Published
- 2005-05-05
- Volume
- 330
- Issue
- 7499
- Pages
- 1076-1079
- ISSN
- 0007-1447 (ISSN-L)
- 0959-8138
- 1468-5833
- PMC
- PMC557238
- OpenAlex
- W2096940418
- Cited by
- 545
- References
- 22
- Citations by year
- 2026: 13 · 2025: 33 · 2024: 66 · 2023: 37 · 2022: 29 · 2021: 39 · 2020: 61 · 2019: 15 · 2018: 31 · 2017: 19 · 2016: 14 · 2015: 14 · 2014: 18 · 2013: 22 · 2012: 23
- FWCI
- 10.78
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- BMJ (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- LSHTM Research Online (London School of Hygiene and Tropical Medicine) (acceptedVersion)
- Bristol Research (University of Bristol) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Physical Sciences › Mathematics › Statistics and Probability › Advanced Causal Inference Techniques
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Health, Environment, Cognitive Aging
- Keywords
- Mendelian randomization, environmental exposure, causal inference, observational study limitations
- MeSH terms
- Environmental Exposure, Humans, Polymorphism, Genetic, Recombination, Genetic, Genetic Variation, Health Behavior, Occupational Exposure, Genetic Predisposition to Disease
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