Cited by 590Gut microbiota and healthGastrointestinal motility and disordersMicrobial Metabolites in Food Biotechnology

The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.

Dietary emulsifiers directly alter human microbiota composition and gene expression ex vivo potentiating intestinal inflammation

Open access

Chassaing, Benoit, Van de Wiele, Tom, De Bodt, Jana, Marzorati, Massimo, Gewirtz, Andrew T·2017·Gut

DOI 10.1136/gutjnl-2016-313099PMC PMC5940336

Open this paper in CoChat — free account Open PDF

Abstract

Objective: The intestinal microbiota plays a central role in the development of many chronic inflammatory diseases including IBD and metabolic syndrome. Administration of substances that alter microbiota composition, including the synthetic dietary emulsifiers polysorbate 80 (P80) and carboxymethylcellulose (CMC), can promote such inflammatory disorders. However, that inflammation itself impacts microbiota composition has obfuscated defining the extent to which these compounds or other substances act directly upon the microbiota versus acting on host parameters that promote inflammation, which subsequently reshapes the microbiota. Design: We examined the direct impact of CMC and P80 on the microbiota using the mucosal simulator of the human intestinal microbial ecosystem (M-SHIME) model that maintains a complex stable human microbiota in the absence of a live host. Results: This approach revealed that both P80 and CMC acted directly upon human microbiota to increase its proinflammatory potential, as revealed by increased levels of bioactive flagellin. The CMC-induced increase in flagellin was rapid (1 day) and driven by altered microbiota gene expression. In contrast, the P80-induced flagellin increase occurred more slowly and was closely associated with altered species composition. Transfer of both emulsifier-treated M-SHIME microbiotas to germ-free recipient mice recapitulated many of the host and microbial alterations observed in mice directly treated with emulsifiers. Conclusions: These results demonstrate a novel paradigm of deconstructing host–microbiota interactions and indicate that the microbiota can be directly impacted by these commonly used food additives, in a manner that subsequently drives intestinal inflammation.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1136/gutjnl-2016-313099

Cites

40 of 40 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

KEGG: Kyoto Encyclopedia of Genes and Genomes
Kanehisa, M. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.1.27 · Cited by 37,077
KEGG: Kyoto Encyclopedia of Genes and Genomes
Ogata, H., Goto, S., Sato, K., Fujibuchi, W., Bono, H., & Kanehisa, M. (1999) · Nucleic Acids Research · doi:10.1093/nar/27.1.29 · Cited by 31,232
An obesity-associated gut microbiome with increased capacity for energy harvest
Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444
Predictive functional profiling of microbial communities using 16S rRNA marker gene sequences
Langille, M. G. I., Zaneveld, J., Caporaso, J. G., McDonald, D., Knights, D., Reyes, J. A., Clemente, J. C., Burkepile, D. E., Vega Thurber, R. L., Knight, R., et al. (2013) · Nature Biotechnology · doi:10.1038/nbt.2676 · Cited by 9,116
KEGG as a reference resource for gene and protein annotation
Kanehisa, M., Sato, Y., Kawashima, M., Furumichi, M., & Tanabe, M. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkv1070 · Cited by 7,387
The gut microbiota as an environmental factor that regulates fat storage
Bäckhed, F., Ding, H., Wang, T., Hooper, L. V., Koh, G. Y., Nagy, A., Semenkovich, C. F., & Gordon, J. I. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407076101 · Cited by 6,245
The COG database: a tool for genome-scale analysis of protein functions and evolution
Tatusov, R. L. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.1.33 · Cited by 4,480
Inflammatory Mechanisms in Obesity
Gregor, M. F., & Hotamisligil, G. S. (2011) · Annual Review of Immunology · doi:10.1146/annurev-immunol-031210-101322 · Cited by 3,754
The metagenomics RAST server – a public resource for the automatic phylogenetic and functional analysis of metagenomes
Meyer, F., Paarmann, D., D'Souza, M., Olson, R., Glass, E., Kubal, M., Paczian, T., Rodriguez, A., Stevens, R. L., Wilke, A., et al. (2008) · BMC Bioinformatics · doi:10.1186/1471-2105-9-386 · Cited by 3,565
Gut microbiota, metabolites and host immunity
Rooks, M. G., & Garrett, W. S. (2016) · Nature reviews. Immunology · doi:10.1038/nri.2016.42 · Cited by 3,409

Show all 40 references

Sorted by citations

Items 301–400 of 590

Food-triad: An index for sustainable consumption
Guido, Y. D. A. S., Fonseca, G., Soares, A. D. F., da Silva, E. C. N., Ostanik, P. A. G., & Perobelli, J. E. (2020) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2020.140027 · Cited by 14
Associations of the Fecal Microbial Proteome Composition and Proneness to Diet-induced Obesity
Tran, H. Q., Mills, R. H., Peters, N. V., Holder, M. K., Vries, G. J. D., Knight, R. D., Chassaing, B., Gonzalez, D. J., & Gewirtz, A. T. (2019) · Molecular & Cellular Proteomics · doi:10.1074/mcp.ra119.001623 · Cited by 15
Self-citation
Dietary content and eating behavior in ulcerative colitis: a narrative review and future perspective
Qin, L., & Lv, W. (2025) · Nutrition Journal · doi:10.1186/s12937-025-01075-y · Cited by 17
Sustainable production of bioemulsifiers, a critical overview from microorganisms to promising applications
Ribeaux, D. R., da Costa, R. A. M., Rodríguez, D. M., Marques, N. S. A. D. A., Puerta-Díaz, M., Mendonça, R. D. S., Franco, P. M., Santos, J. C. F. S., & da Silva, S. S. (2023) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-023-03611-6 · Cited by 15
Environmental and Microbial Factors in Inflammatory Bowel Disease Model Establishment: A Review Partly through Mendelian Randomization
Lin, Z., Luo, W. T., Zhang, K., & Dai, S. (2023) · Gut and Liver · doi:10.5009/gnl230179 · Cited by 14
Stability in fecal metabolites amid a diverse gut microbiome composition: a one-month longitudinal study of variability in healthy individuals
Sangermani, M., Desiati, I., Jørgensen, S. M., Li, J. V., Andreassen, T., Bathen, T. F., & Giskeødegård, G. F. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2427878 · Cited by 15
Rapeseed Lecithin Increases Lymphatic Lipid Output and α-Linolenic Acid Bioavailability in Rats
Robert, C., Couëdelo, L., Knibbe, C., Fonseca, L., Buisson, C., Errazuriz-Cerda, E., Meugnier, E., Loizon, E., Vaysse, C., & Michalski, M. (2020) · Journal of Nutrition · doi:10.1093/jn/nxaa244 · Cited by 17
Dietary emulsifier consumption alters gene expression in the amygdala and paraventricular nucleus of the hypothalamus in mice
Arnold, A. R., Chassaing, B., Pearce, B. D., & Huhman, K. L. (2022) · Scientific Reports · doi:10.1038/s41598-022-13021-7 · Cited by 14
Self-citation
Food supply toxicants and additives alter the gut microbiota and risk of metabolic disease
Barra, N. G., Fang, H., Bhatwa, A., Schmidt, A., Syed, S. A., Steinberg, G. R., Morrison, K. M., Surette, M. G., Wade, M. G., Holloway, A. C., et al. (2025) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00364.2024 · Cited by 13
Modulation of intestinal signal transduction pathways: Implications on gut health and disease
Verma, M., Garg, M., Yadav, P., Khan, A. S., Rahman, S. S., Ali, A., & Kamthan, M. (2025) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2025.177531 · Cited by 14
Dietary exposure to emulsifiers and detergents and the prevalence of cardiovascular disease
Rhodes, J. M. (2017) · QJM · doi:10.1093/qjmed/hcx087 · Cited by 13
Novel foods in the European framework: benefits and risks
Miazzi, M. M., Dellino, M., Fanelli, V., Mascio, I., Nigro, D., Giovanni, C. D., & Montemurro, C. (2024) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2024.2442062 · Cited by 14
Review: Human Intestinal Barrier—Optimal Measurement and Effects of Diet in the Absence of Overt Inflammation or Ulceration
Camilleri, M. (2025) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.70225 · Cited by 14
Gut microbiota perturbation and systemic inflammation are associated with salcaprozate sodium (SNAC)-enabled oral semaglutide delivery
Ariaee, A., Noueihad, K., Hunter, A., Wignall, A. D., Wardill, H. R., Davies, M. R., Prestidge, C. A., & Joyce, P. (2026) · Journal of Controlled Release · doi:10.1016/j.jconrel.2026.114711 · Cited by 13
Maternal emulsifier consumption programs offspring metabolic and neuropsychological health in mice
Milà‐Guasch, M., Ramírez, S., Llana, S. R., Fos-Domènech, J., Dropmann, L. M., Pozo, M., Eyre, E., Gómez-Valadés, A. G., Obri, A., Haddad-Tóvolli, R., et al. (2023) · PLoS Biology · doi:10.1371/journal.pbio.3002171 · Cited by 14
Long-term exposure to dietary emulsifier Tween 80 promotes liver lipid accumulation and induces different-grade inflammation in young and aged mice
Xie, E., Chen, Y., Yang, W., Pan, Q., Shen, Z., Zhou, F., Shen, J., Li, T., Li, Q., & Li, X. (2024) · Food Research International · doi:10.1016/j.foodres.2024.114205 · Cited by 12
The effect of solid food diet therapies on the induction and maintenance of remission in Crohn’s disease: a systematic review
Zhang, J. L., Vootukuru, N., & Niewiadomski, O. (2024) · BMC Gastroenterology · doi:10.1186/s12876-024-03315-7 · Cited by 12
Consumption of Ultra-Processed Foods and Semen Quality in Healthy Young Men Living in Italy
Ceretti, E., Bonaccio, M., Iacoviello, L., Castelnuovo, A. F. D., Ruggiero, E., Donato, F., Lorenzetti, S., Zani, D., & Montano, L. (2024) · Nutrients · doi:10.3390/nu16234129 · Cited by 12
Diet–pathobiont interplay in health and inflammatory bowel disease
Rytter, H., Sturgeon, H., & Chassaing, B. (2025) · Trends in Microbiology · doi:10.1016/j.tim.2025.04.003 · Cited by 12
Self-citation
Maternal emulsifier consumption alters the offspring early-life microbiota and goblet cell function leading to long-lasting diseases susceptibility
Delaroque, C., Rytter, H., Bonazzi, E., Huillet, M., Ellero‐Simatos, S., Chatonnat, E., Hao, F., Patterson, A. D., & Chassaing, B. (2025) · Nature Communications · doi:10.1038/s41467-025-62397-3 · Cited by 16
Self-citation
Impact of PepT1 deletion on microbiota composition and colitis requires multiple generations
Viennois, É., Pujada, A., Sung, J. J., Yang, C., Gewirtz, A. T., Chassaing, B., & Merlin, D. (2020) · npj Biofilms and Microbiomes · doi:10.1038/s41522-020-0137-y · Cited by 12
Self-citation
Diet and acute and chronic, systemic, low-grade inflammation
Hofseth, L. J., & Hébert, J. R. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-822130-3.00011-9 · Cited by 15
An Alternative Oat–Containing, Ready-To-Use, Therapeutic Food Does Not Alter Intestinal Permeability or the 16S Ribosomal RNA Fecal Microbiome Configuration Among Children With Severe Malnutrition in Sierra Leone: A Randomized Controlled Trial
Hendrixson, D. T., Naskidashvili, N., Stephenson, K. B., Laury, M. L., Koroma, A. S., & MANARY, M. J. (2022) · Journal of Nutrition · doi:10.1093/jn/nxac207 · Cited by 11
Insights on the impact of diet-mediated microbiota alterations on immunity and diseases
Harusato, A., & Chassaing, B. (2017) · American Journal of Transplantation · doi:10.1111/ajt.14477 · Cited by 14
Self-citation
Mucus reduction promotes acetyl salicylic acid-induced small intestinal mucosal injury in rats
Suyama, Y., Handa, O., Naito, Y., Takayama, S., Mukai, R., Ushiroda, C., Majima, A., Onozawa, Y., Higashimura, Y., Fukui, A., et al. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.02.202 · Cited by 11
Unraveling the Evolutionary Diet Mismatch and Its Contribution to the Deterioration of Body Composition
Assaf, S., Park, J., Chowdhry, N., Ganapuram, M., Mattathil, S., Alakeel, R., & Kelly, O. J. (2024) · Metabolites · doi:10.3390/metabo14070379 · Cited by 13
Per- and polyfluoroalkyl substances (PFAS) disrupt gut microbiome composition and metabolism in metabolic syndrome: Evidence from a host-free in vitro colonic model
Guo, C., Zhang, S., Zhang, H., Chen, L., Gao, S., Xu, M., Shi, H., & Zhu, J. (2025) · Environmental Pollution · doi:10.1016/j.envpol.2025.127189 · Cited by 11
Distinct diet-microbiome associations in autism spectrum disorder
Wu, Y., Wong, O. W. H., Chen, S., Wang, Y., Lu, W. W., Cheung, C. P., Ching, J. Y. L., Cheong, P. K., Chan, S., Leung, P. W. L., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-67711-7 · Cited by 11
Natural emulsifiers lecithins preserve gut microbiota diversity in relation with specific faecal lipids in high fat-fed mice
Robert, C., Penhoat, A., Couëdelo, L., Monnoye, M., Rainteau, D. P., Meugnier, E., Bary, S., Abrous, H., Loizon, E., Krasniqi, P., et al. (2023) · Journal of Functional Foods · doi:10.1016/j.jff.2023.105540 · Cited by 11
Comparative study of the gut microbiomes between Western and Indigenous cultures – Implications for health and disease
Sreenikitha, K., Das, S., Andrighetti, T., & Sudhakar, P. (2025) · The Microbe · doi:10.1016/j.microb.2025.100310 · Cited by 13
Consumption of Ultra‐Processed Food and Risk of Non‐Alcoholic Fatty Liver Disease: A Prospective Analysis of the Korean Genome and Epidemiology Study
Fu, J., Tan, L., & Shin, S. (2025) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.70099 · Cited by 11
Inflammation: A multifaceted and omnipresent phenomenon
Tyszkowski, R., & Mehrzad, R. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-90960-0.00009-6 · Cited by 15
Development of Novel High and Low Emulsifier Diets Based upon Emulsifier Distribution in the Australian Food Supply for Intervention Studies in Crohn’s Disease
Fitzpatrick, J., Gibson, P., Taylor, K. M., & Halmos, E. (2024) · Nutrients · doi:10.3390/nu16121922 · Cited by 11
Immunomodulatory Effects of Food Additives
Srivastava Rupesh, K. (2017) · International Journal of Immunotherapy and Cancer Research · doi:10.17352/2455-8591.000015 · Cited by 11
Fermented Vegetables and Legumes vs. Lifestyle Diseases: Microbiota and More
Knez, E., Kadac-Czapska, K., & Grembecka, M. (2023) · Life · doi:10.3390/life13041044 · Cited by 11
Ultra-processed foods in a rural Ecuadorian community: associations with child anthropometry and bone maturation
Gyimah, E. A., Nicholas, J. L., Waters, W. F., Gallegos-Riofrío, C. A., Chapnick, M., Blackmore, I., Douglas, K., & Iannotti, L. L. (2023) · British Journal Of Nutrition · doi:10.1017/s0007114523000624 · Cited by 12
Ultra-processed food intake, gut microbiome, and glucose homeostasis in mid-life adults: Background, design, and methods of a controlled feeding trial
Capra, B. T., Hudson, S., Helder, M., Laskaridou, E., Johnson, A. L., Gilmore, C., Marinik, E. L., Hedrick, V. E., Savla, J. T., David, L. A., et al. (2024) · Contemporary Clinical Trials · doi:10.1016/j.cct.2024.107427 · Cited by 10
Associations between Gut Microbiota Dysbiosis and Other Risk Factors in Women with a History of Urinary Tract Infections
Ruţă, F. D., Pribac, M., Mardale, E., Suciu, S., Maior, R., Bogdan, S., & Avram, C. (2024) · Nutrients · doi:10.3390/nu16111753 · Cited by 10
Contrasting the pharmacokinetic performance and gut microbiota effects of an amorphous solid dispersion and lipid nanoemulsion for a poorly water-soluble anti-psychotic
Meola, T. R., Kamath, S., Elz, A. S., Prestidge, C. A., Wignall, A., & Joyce, P. (2024) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2024.114453 · Cited by 10
The Western Diet and Atopic Dermatitis: The Potential Role of Nutrients, Contaminants, and Additives in Dysbiosis and Epithelial Barrier Dysfunction
Boggio, C. M. T., Veronese, F., Armari, M., Zavattaro, E., Esposto, E., Savoia, P., & Azzimonti, B. (2025) · Antioxidants · doi:10.3390/antiox14040386 · Cited by 10
GIDA KATKI MADDELERİNİN MİKROBİYOTA ÜZERİNE ETKİSİ
Bayram, H. M., & Öztürkcan, A. (2020) · GIDA / THE JOURNAL OF FOOD · doi:10.15237/gida.gd20070 · Cited by 10
Impact of Dietary Patterns in Inflammatory Bowel Disease Subtypes
Preda, C. M., Istrătescu, D., Nițescu, M., Manuc, T. E., Mănuc, M., Stroie, T. G., Catrinoiu, M., Ţieranu, C. G., Meianu, C., Tugui, L., et al. (2023) · MAEDICA – a Journal of Clinical Medicine · doi:10.26574/maedica.2023.18.2.174 · Cited by 10
Dietary Inflammatory Potential in Pediatric Diseases: A Narrative Review
Tosi, M., Montanari, C., Bona, F., Tricella, C., Agostinelli, M., Dolor, J., Chillemi, C., Profio, E. D., Tagi, V. M., Vizzuso, S., et al. (2023) · Nutrients · doi:10.3390/nu15245095 · Cited by 16
Changes in Intestinal Permeability Ex Vivo and Immune Cell Activation by Three Commonly Used Emulsifiers
Oscarsson, E., Lindberg, T., Zeller, K. S., Lindstedt, M., Agardh, D., Håkansson, Å., & Östbring, K. (2020) · Molecules · doi:10.3390/molecules25245943 · Cited by 10
Food obesogens as emerging metabolic disruptors; A toxicological insight
Ravichandran, G., Kumar, D., Arunachalam, A., & Thilagar, S. (2021) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2021.106042 · Cited by 13
In vitro models of the canine digestive tract as an alternative to in vivo assays: Advances and current challenges
Deschamps, C. (2022) · ALTEX · doi:10.14573/altex.2109011 · Cited by 10
Nutritional regulators of intestinal inflammation
Shaoul, R. R., & Day, A. S. (2019) · Current Opinion in Gastroenterology · doi:10.1097/mog.0000000000000585 · Cited by 10
Nutritional Therapy in Pediatric Crohn’s Disease—Are We Going to Change the Guidelines?
Matuszczyk, M., & Kierkuś, J. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10143027 · Cited by 10
Vaccination against microbiota motility protects mice from the detrimental impact of dietary emulsifier consumption
Kordahi, M. C., Delaroque, C., Bredèche, M.-F., Gewirtz, A. T., & Chassaing, B. (2023) · PLoS Biology · doi:10.1371/journal.pbio.3002289 · Cited by 9
Self-citation
Upcycling of melon seed (Cucumis melo L.) oil processing by-product: evaluation of functional properties and nutritional components as novel ingredient
Zhang, G., Li, Z., & Charalampopoulos, D. (2024) · Chemical and Biological Technologies in Agriculture · doi:10.1186/s40538-024-00633-6 · Cited by 9
Could the gut microbiota be capable of making individuals more or less susceptible to environmental toxicants?
Santiago, M. D. S. A., Avellar, M. C. W., & Perobelli, J. E. (2024) · Toxicology · doi:10.1016/j.tox.2024.153751 · Cited by 11
LC / MS analysis of mushrooms provided new insights into dietary management of diabetes mellitus in rats
Hussein, A., Ghonimy, A., Jiang, H., Qin, G., El-Ashram, S. A., Hussein, S., el-razek, I. A., El-Afifi, T., & Farouk, M. H. (2023) · Food Science & Nutrition · doi:10.1002/fsn3.3236 · Cited by 9
Modulation of gut microbiota impacts diet-induced and drug-induced alopecia in mice
Lam, S., Zhang, J., Yang, K., Chu, L. C., Zhu, W., Tang, W., Chan, F. K. L., Chan, P. K. S., Wu, W. K. K., & Ng, S. C. (2022) · Gut · doi:10.1136/gutjnl-2021-326320 · Cited by 9
Casein-phosphatidylcholine emulsifier remodels LPS-induced intestinal barrier disfunction via regulating ferroptosis and lipid metabolism
Lin, X., Li, Y., Qi, B., Zhang, S., & Li, X. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.127595 · Cited by 8
High precision acoustofluidic synthesis of stable, biocompatible water-in-water emulsions
Sharma, K., Deng, H., Banerjee, P., Peng, Z., Gum, J., Baldelli, A., Jasieniak, J. J., Meagher, L., Martino, M. M., Gundabala, V., et al. (2024) · Ultrasonics Sonochemistry · doi:10.1016/j.ultsonch.2024.107120 · Cited by 7
Polysorbate 80 and carboxymethylcellulose: A different impact on epithelial integrity when interacting with the microbiome
Bellanco, A., Requena, T., & Martínez‐Cuesta, M. C. (2025) · Food and Chemical Toxicology · doi:10.1016/j.fct.2025.115236 · Cited by 8
Effect of bioactive Rosa roxburghii Tratt fruit polysaccharide on the structure and emulsifying property of lactoferrin protein
Pingping, W., Yu-Tong, D., Xianghua, C., Chen, C., Wu, K., & Fu, X. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.140016 · Cited by 8
Industrial Bread Composition: Potential Implications for Patients with Inflammatory Bowel Disease
Shakhman, S. R., Pfeffer‐Gik, T., Elial-Fatal, S., Broitman, Y., Yanai, H. A., Gophna, U., Dotan, I., & Godny, L. (2025) · Nutrients · doi:10.3390/nu17132120 · Cited by 8
The potential influence of food additives and contaminants on the gut microbiota: A comprehensive review
Ullah, S., Ali, S., Atif, M., Ullah, M., Nabi, G., Freire, L. G. D., Kamimura, E. S., Nejad, A. S. M., & de Oliveira, C. A. F. (2025) · Food and Chemical Toxicology · doi:10.1016/j.fct.2025.115768 · Cited by 9
The impact of selected food additives on the gastrointestinal tract in the example of nonspecific inflammatory bowel diseases
Jarmakiewicz-Czaja, S., Piątek, D., & Filip, R. (2021) · Archives of Medical Science · doi:10.5114/aoms/125001 · Cited by 11
Reducing Oil Separation in Ready-to-Use Therapeutic Food
Zuzarte, A., Mui, M., Ordiz, M. I., Weber, J., Ryan, K. N., & MANARY, M. J. (2020) · Foods · doi:10.3390/foods9060706 · Cited by 8
Bioavailability and metabolism of dietary lipids
Michalski, M., Couëdelo, L., Penhoat, A., Vaysse, C., & Vors, C. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-817105-9.00002-1 · Cited by 10
The Role of Epidemiological Evidence from Prospective Population Studies in Shaping Dietary Approaches to Therapy in Crohn's Disease
Wood, J. A., Halmos, E. P., Taylor, K. M., & Gibson, P. R. (2020) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202000294 · Cited by 8
Metabolic impact of dietary lipids: towards a role of unabsorbed lipid residues?
Michalski, M., Barz, M. L., & Vors, C. (2021) · OCL · doi:10.1051/ocl/2020058 · Cited by 9
Diet-Induced Alterations in Gut Microbiota Composition and Function
Rinninella, E., Cintoni, M., Raoul, P. C., Ianiro, G., Laterza, L., Ponziani, F. R., Pulcini, G., Gasbarrini, A., & Mele, M. C. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-819265-8.00035-8 · Cited by 9
Differences in the Intestinal Flora of Patients with Inflammatory Bowel Disease in Southwest China
Wang, T., Yu, R., Zhu, L., Wang, X., & Yang, B. (2022) · Indian Journal of Microbiology · doi:10.1007/s12088-022-01014-z · Cited by 8
Association between ultra-processed foods frequency of intake and sarcopenia in older adults: a cross-sectional study
de Almeida, H. C., Lage, V. K. D. S., de Paula, F. A., Freitas, J. D. P. C., Moreno, L. G., Oliveira, V. C., Bastone, A. D. C., Santos, J. N. V., Lima, L. P., Fernandes, A. C., et al. (2022) · Research Society and Development · doi:10.33448/rsd-v11i11.33129 · Cited by 9
Etiology of Ulcerative Colitis
Preda, C.-M., & Istrătescu, D. (2022) · IntechOpen eBooks · doi:10.5772/intechopen.106842 · Cited by 10
Biosurfactants for Enhanced Bioavailability of Micronutrients in Soil
Borah, S. N., Sen, S., & Pakshirajan, K. (2021) · doi:10.1002/9781119671022.ch8 · Cited by 8
Treating chronic stress and chronic pain by manipulating gut microbiota with diet: can we kill two birds with one stone?
Costa, A., & Lucarini, E. (2024) · Nutritional Neuroscience · doi:10.1080/1028415x.2024.2365021 · Cited by 8
Deciphering the microbial map and its implications in the therapeutics of neurodegenerative disorder
Vashishth, S., Ambasta, R. K., & Kumar, P. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102466 · Cited by 8
Effects of diet containing germinated faba bean (Vicia faba L.) on the intestinal health and gut microbial communities of Nile tilapia (Oreochromis niloticus)
Chen, M., Li, Q., Yang, L., Lin, W., Qin, Z., Liang, S., Lin, L., & Xie, X. (2024) · Aquaculture Reports · doi:10.1016/j.aqrep.2024.102053 · Cited by 7
Re‐evaluation of propane‐1,2‐diol esters of fatty acids (E 477) as a food additive
(FAF), E. P. O. F. A. A. F., Younes, M., Aquilina, G., Castle, L., Engel, K., Fowler, P., Fernández, M. J. F., Fürst, P., Gürtler, R., Gundert‐Remy, U., et al. (2018) · EFSA Journal · doi:10.2903/j.efsa.2018.5497 · Cited by 7
The Role of Diet in Inflammatory Bowel Disease Onset, Disease Management, and Surgical Optimization
Issokson, K., Lee, D. Y., Yarur, A. J., Lewis, J. D., & Suskind, D. L. (2024) · The American Journal of Gastroenterology · doi:10.14309/ajg.0000000000003085 · Cited by 7
Practical Application of Evidence-Based Dietary Therapy in Inflammatory Bowel Disease: The DELECTABLE Program
Trakman, G., Russell, E., Hamilton, A. L., Wilson-O'Brien, A. L., Thompson, E., Simmance, N., Niewiadomski, O., & Kamm, M. A. (2025) · Nutrients · doi:10.3390/nu17091592 · Cited by 6
A closer look at the role of nutrition in children and adults with ADHD and neurodivergence
Hunter, C., Smith, C., Davies, E., Dyall, S. C., & Gow, R. V. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1586925 · Cited by 9
Dietary Sucralose Exacerbates Ovalbumin-Induced Food Allergy via Dendritic Cells Modulation: In Vitro and In Vivo Studies
Li, Y., Xu, Z., Madjirebaye, P., Xiang, Z., Tang, Z., Deng, X., Fan, Y., Feng, X., Yang, Z., & Wu, X. (2025) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5c08929 · Cited by 8
Intestinal Microplastic Retention Reshapes Gut Microbial Ecology through Surface-Associated Colonization and Additive Leaching
Yan, Z., Liu, R., Zhang, Z., Dai, T., Zhu, D., & Zhang, Y. (2026) · Environmental Science & Technology · doi:10.1021/acs.est.5c16988 · Cited by 7
Microbiota-derived metabolites and cardiovascular implications in Inflammatory Bowel Disease (IBD)
Olic, I. A., Pavlović, N., Kumrić, M., Šantić, R., Bratanić, A., & Božić, J. (2026) · Molecular Medicine · doi:10.1186/s10020-026-01493-6 · Cited by 7
Substitution of polysorbates by plant-based emulsifiers: impact on vitamin D bioavailability and gut health in mice
Bravo‐Núñez, Á., Berthomé, A., Sabran, C., Vairo, D., Martin, J., Alvarado‐Ramos, K., Chassaing, B., Tomas, J., & Reboul, E. (2025) · Communications Biology · doi:10.1038/s42003-025-08293-4 · Cited by 5
Self-citation
Aliments ultra-transformés, maladies chroniques, et mortalité : résultats de la cohorte prospective NutriNet-Santé
Debras, C., Srour, B., Chazelas, E., Julia, C., Kesse‐Guyot, E., Allès, B., Fezeu, L., Galan, P., Herçberg, S., Deschasaux, M., et al. (2021) · Cahiers de Nutrition et de Diététique · doi:10.1016/j.cnd.2021.08.004 · Cited by 11
The Gut Microbiome in Inflammatory Bowel Disease
Lavelle, A., & Sokol, H. (2019) · Springer eBooks · doi:10.1007/978-3-030-28703-0_16 · Cited by 6
Genetic diversity and spatial genetic structure in fragmented populations of Solanum spp. from the Brazilian savannah, based on microsatellite loci
de Moura, T. M., Sebbenn, A. M., Chaves, L. J., Coelho, A. S. G., Oliveira, G. C. X., & Kageyama, P. Y. (2009) · Scientia Forestalis · Cited by 6
Probing the potential microbiota-mediated effects of sodium dehydroacetate on hyperphagia and inflammation in mice
Mo, Q., Shen, F., Ruan, S., Zhang, J., Zhao, M., Feng, F., & Liu, T. (2025) · Food Bioscience · doi:10.1016/j.fbio.2025.105879 · Cited by 5
Quinazolinone Derivative MR2938 Protects DSS-Induced Barrier Dysfunction in Mice Through Regulating Gut Microbiota
Lv, L., Maimaitiming, M., Yang, J., Xia, S., Li, X., Wang, P., Liu, Z., & Wang, C. (2025) · Pharmaceuticals · doi:10.3390/ph18010123 · Cited by 5
Excessive ultra-processed foods exposure aggravates ulcerative colitis via macrophage ferroptosis
Pang, X., Yan, J., Lv, X., Wang, J., Chen, Q., Qi, Y., Xu, X., Wang, B., & Cao, H. (2025) · Environment International · doi:10.1016/j.envint.2025.109706 · Cited by 5
Ultra-processed foods: Implications for gastrointestinal health
Singh, A. K., Gandotra, A., Kumar, S., Singh, A., Kochhar, R. K., & Manrai, M. (2025) · World Journal of Gastroenterology · doi:10.3748/wjg.v31.i36.109143 · Cited by 8
Association of ultra-processed food patterns with overweight and obesity in the German health interview and examination survey for children and adolescents (KiGGS): a longitudinal study
Barata, M. F., Mensink, G., Schienkiewitz, A., Richter, A., & Levy, R. B. (2025) · BMC Public Health · doi:10.1186/s12889-025-25181-y · Cited by 7
Highly Processed Food and Functional Gastrointestinal Disorders in Children and Adolescents with Obesity: The Preventive Challenge—A Narrative Review
Calcaterra, V., Cena, H., Ferrara, C., Magenes, V. C., Boussetta, S., Zambon, I., & Zuccotti, G. (2025) · Nutrients · doi:10.3390/nu17233744 · Cited by 7
Gut microbiota at the crossroads of food additives, pollutants, and chronic disease risk
Alum, E. U., Nwali, B. U., Aniokete, U. C., Emeruwa, A. C., Obasi, D. C., Okoroh, P. N., Akwari, A. A., Nwuruku, O. A., Nzubechukwu, E., & Aja, P. M. (2025) · Toxicology and Environmental Health Sciences · doi:10.1007/s13530-025-00295-3 · Cited by 6
Tween 80 Exposure Induces Colitis by Disrupting Intestinal Tryptophan Metabolism
Zhang, J., Zhang, S., Xu, X., Kuang, H., Xu, C., & Wu, X. (2026) · Environmental Science & Technology · doi:10.1021/acs.est.5c14176 · Cited by 5
Road to IBD prevention in the Global South: a conceptual framework modelling from non-communicable diseases
Birda, C. L., Jena, A., Torres, J., Ng, S. C., Kotze, P. G., Sebastian, S., & Sharma, V. (2026) · Gut · doi:10.1136/gutjnl-2025-337298 · Cited by 5
MBRA 3.0: integrating the mucus environment for advanced high-throughput in vitro intestinal microbiome modeling
Duquesnoy, M., & Chassaing, B. (2026) · Gut Microbes · doi:10.1080/19490976.2026.2612804 · Cited by 6
Self-citation
A Microbiota-Dependent Response to Anticancer Treatment in an In Vitro Human Microbiota Model: A Pilot Study With Hydroxycarbamide and Daunorubicin
Hobson, C. A., Vigué, L., Magnan, M., Chassaing, B., Naimi, S., Gachet, B., Claraz, P., Storme, T., Bonacorsi, S., Tenaillon, O., et al. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.886447 · Cited by 5
Self-citation
Influence of food emulsifiers on cellular function and inflammation, a preliminary study
Dufrusine, B., Lisio, C. D., Maurizio, A., Sallese, M., Laurenzi, V. D., & Dainese, E. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1197686 · Cited by 5
Food emulsifiers aggravate inflammation and oxidative stress induced by food contaminants in zebrafish
Wu, M., Zhang, H., Yang, Y., Wang, Y., Luk, P. K., Xia, I. F., Wong, K., & Kwok, K. W. H. (2024) · Food and Chemical Toxicology · doi:10.1016/j.fct.2024.114850 · Cited by 5
Association of added sugar intake and its forms and sources with handgrip strength decline among middle-aged and older adults: A prospective cohort study
Zhu, L., Gu, Y., Li, J., Yu, S., Wang, J., Wu, H., Meng, G., Wang, X., Zhang, Q., Liu, L., et al. (2024) · Clinical Nutrition · doi:10.1016/j.clnu.2024.04.003 · Cited by 5
An effect of food additives on microbiome
Kornienko, V. Y., & Minaev, M. Y. (2021) · Theory and practice of meat processing · doi:10.21323/2414-438x-2021-6-3-259-268 · Cited by 5
A Review on Dietary Additive, Food Supplement and Exercise Effects on the Prevention of Covid-19
Abedini, A., Mahdavi, A. M., Alizadeh, A. M., Hejazi, E., & Hosseini, H. (2022) · Nutrition and Food Sciences Research · doi:10.52547/nfsr.9.1.1 · Cited by 5
Microbiome Product Toxicology: Regulatory View on Translational Challenges
Rousseau, C. F., Desvignes, C., Kling, F., Voisin, E., & Ruthsatz, M. (2021) · Springer eBooks · doi:10.1007/978-3-030-57499-4_140 · Cited by 5

Authors: Chassaing, B., Van de Wiele, T., De Bodt, J., Marzorati, M., & Gewirtz, A. T.
Affiliations: Center for Inflammation, Immunity and Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, Georgia, USA
Center of Microbial Ecology and Technology (CMET), Faculty of Bioscience Engineering, Ghent University, Ghent, Belgium
Ghent University (BE)
Georgia State University (US)
ORCID: Marzorati, Massimo
Gewirtz, Andrew T
Venue: Gut
Publisher: BMJ
Published: 2017-03-21
Volume: 66
Issue: 8
Pages: 1414-1427
ISSN: 0017-5749 (ISSN-L)
1468-3288
DOI: 10.1136/gutjnl-2016-313099
PMC: PMC5940336
OpenAlex: W2603041755
Cited by: 590
References: 40
Citations by year: 2026: 63 · 2025: 78 · 2024: 71 · 2023: 60 · 2022: 68 · 2021: 70 · 2020: 63 · 2019: 53 · 2018: 45 · 2017: 18
FWCI: 19.99
Type: journal article
Language: en
Update notices: addendum (2018-02-13)
Open access: bronze
doi.org
Locations: Gut (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Ghent University Academic Bibliography (Ghent University) (submittedVersion)
HighWire Press Open Archive (submittedVersion)
Funders: Crohn's and Colitis Foundation of America (DK083890, DK099071)
Crohn's and Colitis Foundation (276509)
Fonds Wetenschappelijk Onderzoek
Universiteit Gent
Vlaamse regering
National Institutes of Health
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK099071, R01DK083890)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
Keywords: food emulsifiers, Tween 80, carboxymethyl cellulose, gut microbiota, flagellin, intestinal inflammation, food additives, germ-free mice, host-microbiota interactions, inflammatory bowel disease, metabolic syndrome
MeSH terms: Gastrointestinal Microbiome, Animals, Carboxymethylcellulose Sodium, Diet, Enteritis, Female, Flagellin, Food Additives, Germ-Free Life, Humans, Male, Mice, Inbred C57BL, Models, Biological, Polysorbates, Gene Expression, Emulsifying Agents, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Dietary emulsifiers directly alter human microbiota composition and gene expression ex vivo potentiating intestinal inflammation

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks