Comparison of three ways to determine and deliver pressure during nasal CPAP therapy for obstructive sleep apnoea

West, S D

doi:10.1136/thx.2005.046300

Cited by 93Obstructive Sleep Apnea ResearchRespiratory Support and MechanismsSleep and related disorders

Comparison of three ways to determine and deliver pressure during nasal CPAP therapy for obstructive sleep apnoea

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West, S D·2006·Thorax

DOI 10.1136/thx.2005.046300PMC PMC2080742

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Abstract

BACKGROUND: The simplest method of initiating and maintaining therapeutic continuous positive airways pressure (CPAP) therapy for obstructive sleep apnoea (OSA) has not been established. METHODS: Ninety eight subjects with OSA requiring CPAP treatment (more than 10 dips in oxygen desaturation of >4% per hour of sleep study and Epworth Sleepiness Score (ESS) >9) were randomised prospectively to three different methods of CPAP delivery for 6 months: (1) autotitration pressure throughout; (2) autotitration pressure for 1 week followed by fixed pressure (95th centile) thereafter; and (3) fixed pressure determined by algorithm (based on neck size and dip rate). Patients and investigators were blind to group allocation. One week after initiation the patients were routinely reviewed by sleep nurses. Study assessments took place before starting CPAP treatment and 1 and 6 months after to assess ESS, maintenance of wakefulness test, 24 hour blood pressure, general health (SF-36), and sleep apnoea related quality of life. CPAP internal monitoring data were also collected. RESULTS: There were no significant differences in any of the outcome measures or CPAP monitoring data between the three groups. The 95th centile CPAP pressures delivered in the 6 month and 1 week autotitration groups were higher than in the algorithm group, but the median pressures were lowest in the 6 month autotitration group. CONCLUSIONS: The method of determining CPAP pressure for treatment of moderate to severe OSA makes no significant difference to clinical outcome measures. The autotitration CPAP machine used has no advantage in this setting over simpler methods of pressure determination.

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Authors: West, S. D.
Affiliations: Churchill Hospital (GB)
Corresponding author: West, S D
Venue: Thorax
Publisher: BMJ
Published: 2006-03-01
Volume: 61
Issue: 3
Pages: 226-231
ISSN: 0040-6376 (ISSN-L)
DOI: 10.1136/thx.2005.046300
PMC: PMC2080742
OpenAlex: W1980494061
Semantic Scholar: 34eaa99954a8a21e8e1ca8afd501984d4a695f34
Cited by: 93
References: 29
Citations by year: 2025: 1 · 2024: 1 · 2023: 3 · 2022: 1 · 2021: 5 · 2020: 1 · 2019: 5 · 2018: 1 · 2017: 5 · 2016: 6 · 2015: 2 · 2014: 1 · 2013: 3 · 2012: 4
FWCI: 5.79
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Thorax (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
HighWire Press Open Archive (submittedVersion)
Newcastle University ePrints (Newcastle Univesity)
Topics: Health Sciences › Medicine › Physiology › Obstructive Sleep Apnea Research
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory Support and Mechanisms
Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
Keywords: obstructive sleep apnea, CPAP therapy, continuous positive airway pressure, CPAP initiation, daytime sleepiness, blood pressure
MeSH terms: Adolescent, Adult, Aged, Blood Pressure, Female, Health Status, Humans, Male, Middle Aged, Pressure, Treatment Outcome, Sleep Apnea, Obstructive, Continuous Positive Airway Pressure

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Comparison of three ways to determine and deliver pressure during nasal CPAP therapy for obstructive sleep apnoea

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