Lactobacillus helveticus Lafti L10 supplementation reduces respiratory infection duration in a cohort of elite athletes: a randomized, double-blind, placebo-controlled trial
Open accessAbstract
A randomized, double-blind, placebo-controlled study was conducted to evaluate if Lactobacillus helveticus Lafti L10 (Lallemand Health Solutions, Montreal, Que., Canada) supplementation during 14 weeks in winter can influence the duration, severity, and incidence of upper respiratory tract illness (URTI), as well as to monitor different immune parameters in the population of elite athletes. Before and after the treatment, cardiopulmonary testing and self-rated state of moods evaluation (by Profile of Mood States questionnaire) were performed and blood samples were collected. Thirty-nine elite athletes were randomized either to the placebo (n = 19) or the probiotic (n = 20) group. The probiotic group received L. helveticus Lafti L10, 2 × 10 10 Colony Forming Units. Lafti L10 significantly shortened the URTI episode duration (7.25 ± 2.90 vs. 10.64 ± 4.67 days, p = 0.047) and decreased the number of symptoms in the probiotic group (4.92 ± 1.96 vs. 6.91 ± 1.22, p = 0.035). Severity and incidence of URTI did not differ between the treatments. There were no significant changes in leukocyte subpopulation abundance, transforming growth factor-β serum levels, level of interleukin-10 secreted from peptidoglican stimulated peripheral blood mononuclear cells (PBMCs), interferon-γ level secreted from concanavalin A-stimulated PBMCs or viability/proliferation of PBMCs upon antigen stimulation. Group effect for CD4+/CD8+ ratio was significant (F [1,37] = 6.99, p = 0.020, η 2 = 0.350); this difference was not significant at baseline, but was evident after 14 weeks (p = 0.02). A significant interaction effect was noted for self-rated sense of vigor (F [1,37] = 11.76, p = 0.009, η 2 = 0.595). Self-rated sense of vigor increased in the probiotic group (18.5 ± 4.1 vs. 21.0 ± 2.6, p = 0.012). Probiotic strain Lafti L10 can be a beneficial nutritional supplement for the reduction of URTI length in elite athletes.
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“Some positive effects on various groups of adults from recent studies include significantly fewer community-acquired colds [97], significantly decreased URTI symptoms [98], significantly reduced URTI [99] and significantly fewer number of days with URTI symptoms [100].”
BackgroundHeimer, M., Teschler, M., Schmitz, B., & Mooren, F. C. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.804046 · Cited by 18 · see citing works
“In elite athletes from several different sports ( n = 39, single strain probiotic, 14 weeks) increased self-rated sense of vigor and improved CD4 + /CD8 + ratio (ratio of T helper cells) was demonstrated (53).”
Kaulback, K., Pyne, D. B., Hull, J. H., Snyders, C., Sewry, N. A., & Schwellnus, M. P. (2022) · European Journal of Sport Science · doi:10.1080/17461391.2022.2089914 · Cited by 20 · see citing works
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“Marinkovic et al.(69) Athletes (n 1⁄4 50) Lactobacillus helveticus Lafti® L10 14 weeks Long-term supplementation of probiotics shortened the duration of”
BackgroundMechanism of Action and Beneficial Effects of Probiotics in Amateur and Professional Athletes
Nami, Y., Barghi, A., Shahgolzari, M., Salehian, M., & Haghshenas, B. (2024) · Food Science & Nutrition · doi:10.1002/fsn3.4658 · Cited by 14 · see citing works
“Notably, Lactobacillus helveticus Lafti L10 has demonstrated significant enhancement of immune status in elite athletes when administered at a dosage of 2 × 10 10 CFU daily for a period of 14 weeks (Michalickova et al. 2016).”
Mohr, A., Pyne, D., Leite, G., Akins, D., & Pugh, J. (2022) · Journal of Sport and Health Science · doi:10.1016/j.jshs.2022.12.012 · Cited by 12 · see citing works
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“The MET-h was calculated by selecting METs from the standard METs table for each exercise and multiplying them by the exercise time [26,27].”
MethodEffect of Probiotic Consumption on Immune Response in Athletes: A Meta-analysis
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“Some elite athletes who routinely train and perform at intensities near maximum V̇O2 max value may experience less ergogenic effect on time-to-exhaustion with probiotics compared to non-elite athletes [11, 16].”
BackgroundProbiotic consumption and inflammatory markers in athletes: a systematic review and meta-analysis
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“NK cell count From 14 clinical trials reported cell count, one was excluded since data was reported as the geometric mean([16]), so 13 studies (healthy: 12 studies([19,20,27,35,38,72,95,99,100,111,112,122]), surgery: one([77])) with 2395 participants were included.”
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Regular Physical Activity Influences Gut Microbiota with Positive Health Effects
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Salivary Immunoglobulin A Secretion Rate During Peak Period Conditioning Regimens in Triathletes
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“In addition, the risk of URTIs in athletes is decreased by long-term consumption of a lactic acid bacteria-containing drink (15).”
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SPORCULARDA PROBİYOTİK TAKVİYESİ VE MİKROBİYATANIN PERFORMANSA ETKİSİ
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THE INFLUENCE OF GUT MICROBIOTA ON PERFORMANCE IN ATHLETES
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“In this sense, previous studies have observed reductions in the prevalence or duration of infectious diseases in high-performance athletes after consumption of probiotics [85–87], even in a heat-treated form [88], possibly related to their immunomodulatory potential.”
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“According to Michalickova et al. (56), professional athletes who took Lactobacillus helveticus Lafti L10 supplements for 14 weeks saw a reduction in the number of symptoms and shorter course of URTIs, as well as an improvement in their self-rated vigor.”
- Authors
- Michalickova, D., Minic, R., Dikic, N., Andjelkovic, M., Kostic-Vucicevic, M., Stojmenovic, T., Nikolic, I., & Djordjevic, B.
- Affiliations
- Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, 11152 Belgrade, Serbia.
- Department of Research and Development, Institute of Virology, Vaccines and Sera, Torlak, Vojvode Stepe 458, 11152 Beograd Belgrade, Serbia.
- Sports Medicine Association of Serbia, Marsala Tolbuhina 8, 11000 Belgrade.
- University of Belgrade (RS)
- Venue
- Applied Physiology, Nutrition, and Metabolism
- Publisher
- Canadian Science Publishing
- Published
- 2016-07
- Volume
- 41
- Issue
- 7
- Pages
- 782-789
- ISSN
- 1715-5312 (ISSN-L)
- 1715-5320
- OpenAlex
- W2297270625
- Cited by
- 74
- References
- 42
- Citations by year
- 2026: 7 · 2025: 3 · 2024: 6 · 2023: 5 · 2022: 17 · 2021: 9 · 2020: 5 · 2019: 10 · 2018: 8 · 2017: 2 · 2016: 1
- FWCI
- 8.81
- Type
- journal article
- Language
- en
- Open access
- Licence
- Locations
- Applied Physiology, Nutrition, and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- InTOR – Repository of the Institute "Torlak" (Institute of Virology, Vaccines and Sera “Torlak”, Belgrade, Serbia) (acceptedVersion, cc-by-nc-nd)
- FarFar (University of Belgrade, Faculty of Chemistry (Belgrade, Serbia)) (submittedVersion)
- FarFar (University of Belgrade, Faculty of Chemistry (Belgrade, Serbia)) (submittedVersion, cc-by-nc-nd)
- InTOR – Repository of the Institute "Torlak" (Institute of Virology, Vaccines and Sera “Torlak”, Belgrade, Serbia) (submittedVersion, other-oa)
- Funders
- Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja (46,009, 172049, III46009, OI 172049)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Health Sciences › Health Professions › Emergency Medical Services › Pediatric health and respiratory diseases
- Keywords
- probiotic supplementation, upper respiratory tract infection, elite athletes, immune function, CD4/CD8 ratio, mood states, interferon-gamma, IL-10, TGF-beta, leukocyte subpopulations
- MeSH terms
- Adolescent, Adult, Body Weight, Cell Survival, Concanavalin A, Double-Blind Method, Female, Humans, Interferon-gamma, Leukocytes, Mononuclear, Male, Oxygen Consumption, Respiratory Tract Infections, Exercise, Body Mass Index, Interleukin-10, Probiotics, Cell Proliferation, Lactobacillus helveticus, Young Adult, Athletes
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