The effects of acute branched-chain amino acid supplementation on recovery from a single bout of hypertrophy exercise in resistance-trained athletes
Open accessAbstract
This study investigated the effects of acute branched-chain amino acid (BCAA) supplementation on recovery from exercise-induced muscle damage among experienced resistance-trained athletes. In a double-blind matched-pairs design, 16 resistance-trained participants, routinely performing hypertrophy training, were randomly assigned to a BCAA (n = 8) or placebo (n = 8) group. The BCAAs were administered at a dosage of 0.087 g/kg body mass, with a 2:1:1 ratio of leucine, isoleucine, and valine. The participants performed 6 sets of 10 full-squats at 70% 1-repetition maximum to induce muscle damage. All participants were diet-controlled across the study. Creatine kinase, peak isometric knee-extensor force, perceived muscle soreness, and countermovement jump (CMJ) height were measured immediately before (baseline) and at 1 h, 24 h, and 48 h postexercise. There were large to very large time effects for all measurements between baseline and 24-48 h. Between-group comparisons, expressed as a percentage of baseline, revealed differences in isometric strength at 24-h (placebo ∼87% vs. BCAA ∼92%; moderate, likely), CMJ at 24 h (placebo ∼93% vs. BCAA ∼96%; small, likely), and muscle soreness at both 24 h (placebo ∼685% vs. BCAA ∼531%; small, likely) and 48 h (placebo ∼468% vs. BCAA ∼350%; small, likely). Acute supplementation of BCAAs (0.087 g/kg) increased the rate of recovery in isometric strength, CMJ height, and perceived muscle soreness compared with placebo after a hypertrophy-based training session among diet-controlled, resistance-trained athletes. These findings question the need for longer BCAA loading phases and highlight the importance of dietary control in studies of this type.
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In studies including resistance participants, BCAAs attenuated muscle soreness after exercise.
“On the other hand, studies that included resistance participants showed that BCAAs attenuated muscle soreness after exercise, while in endurance sports the findings were inconsistent.”
From Oral Branched-Chain Amino Acids Supplementation in Athletes: A Systematic Review (2022) · cites this paper as [36]
Two studies reported that BCAA supplementation attenuated decrements in performance.
“Two studies reported that the consumption of BCAA supplementation attenuated the decrements in performance [36,37].”
From Oral Branched-Chain Amino Acids Supplementation in Athletes: A Systematic Review (2022) · cites this paper as [36]
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- Authors
- Waldron, M., Whelan, K., Jeffries, O., Burt, D., Howe, L., & Patterson, S. D.
- Affiliations
- St Mary's University Twickenham London (GB)
- University of Staffordshire (GB)
- Venue
- Applied Physiology Nutrition and Metabolism
- Publisher
- Canadian Science Publishing
- Published
- 2017-06
- Volume
- 42
- Issue
- 6
- Pages
- 630-636
- ISSN
- 1715-5312 (ISSN-L)
- 1715-5320
- OpenAlex
- W2580627102
- Cited by
- 43
- References
- 48
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 6 · 2022: 5 · 2021: 8 · 2020: 6 · 2019: 5 · 2018: 5 · 2017: 2
- FWCI
- 2.63
- Type
- journal article
- Language
- en
- Open access
- Locations
- Applied Physiology, Nutrition, and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Insight (University of Cumbria) (acceptedVersion)
- St Mary's University Repository (St Mary's University Twickenham London) (acceptedVersion)
- Edge Hill University Research Information Repository (Edge Hill University) (submittedVersion, cc-by-nc)
- Newcastle University ePrints (Newcastle Univesity)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
- Keywords
- branched-chain amino acids, acute supplementation, exercise-induced muscle damage, recovery, resistance-trained athletes, hypertrophy training, squatting, creatine kinase, isometric strength, countermovement jump, perceived muscle soreness, leucine, isoleucine, valine, dietary management
- MeSH terms
- Amino Acids, Branched-Chain, Creatine Kinase, Double-Blind Method, Female, Humans, Hypertrophy, Male, Physical Endurance, Body Mass Index, Dietary Supplements, Muscle Strength, Resistance Training, Young Adult, Athletes, Myalgia
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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