Quantitative, High-Resolution Proteomics for Data-Driven Systems Biology

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

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Bioconductor: open software development for computational biology and bioinformatics

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Gene expression profiling predicts clinical outcome of breast cancer

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The language of covalent histone modifications

Strahl, B. D., & Allis, C. D. (2000) · Nature · doi:10.1038/47412 · Cited by 8,679

Universal sample preparation method for proteome analysis

Wiśniewski, J. R., Zougman, A., Nagaraj, N., & Mann, M. (2009) · Nature Methods · doi:10.1038/nmeth.1322 · Cited by 8,352

Probability-based protein identification by searching sequence databases using mass spectrometry data

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Electrospray Ionization for Mass Spectrometry of Large Biomolecules

Fenn, J. B., Mann, M., Meng, C. K., Wong, S. F., & Whitehouse, C. M. (1989) · Science · doi:10.1126/science.2675315 · Cited by 7,634

Mass spectrometry-based proteomics

Aebersold, R., & Mann, M. (2003) · Nature · doi:10.1038/nature01511 · Cited by 6,955

An approach to correlate tandem mass spectral data of peptides with amino acid sequences in a protein database

Eng, J. K., McCormack, A. L., & Yates, J. R. (1994) · Journal of the American Society for Mass Spectrometry · doi:10.1016/1044-0305(94)80016-2 · Cited by 6,484

A Gene-Expression Signature as a Predictor of Survival in Breast Cancer

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Stable isotope labeling by amino acids in cell culture, SILAC, as a simple and accurate approach to expression proteomics

Ong, S.-E., Blagoev, B., Kratchmarova, I., Kristensen, D. B., Steen, H., Pandey, A., & Mann, M. (2002) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m200025-mcp200 · Cited by 5,574

Large-scale analysis of the yeast proteome by multidimensional protein identification technology

Washburn, M. P., Wolters, D. A., & Yates, J. R. (2001) · Nature Biotechnology · doi:10.1038/85686 · Cited by 4,768

Functional organization of the yeast proteome by systematic analysis of protein complexes

Gavin, A., Böesche, M., Krause, R., Grandi, P., Marzioch, M., Bauer, A., Schultz, J., Rick, J. M., Michon, A., Cruciat, C., et al. (2002) · Nature · doi:10.1038/415141a · Cited by 4,729

Multiplexed protein quantitation in Saccharomyces cerevisiae using amine-reactive isobaric tagging reagents

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Global analysis of protein localization in budding yeast

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Lysine acetylation targets protein complexes and co-regulates major cellular functions

Choudhary, C., Kumar, C., Gnad, F., Nielsen, M. L., Rehman, M., Walther, T. C., Olsen, J. V., & Mann, M. (2009) · Science · doi:10.1126/science.1175371 · Cited by 4,040

Target-decoy search strategy for increased confidence in large-scale protein identifications by mass spectrometry

Elias, J. E., & Gygi, S. P. (2007) · Nature Methods · doi:10.1038/nmeth1019 · Cited by 3,925

Global analysis of protein expression in yeast

Ghaemmaghami, S., Huh, W.-K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., & Weissman, J. S. (2003) · Nature · doi:10.1038/nature02046 · Cited by 3,750

Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry

Ho, Y., Gruhler, A., Heilbut, A. M., Bader, G. D., Moore, L., Adams, S., Millar, A., Taylor, P. P., Bennett, K. L., Boutilier, K., et al. (2002) · Nature · doi:10.1038/415180a · Cited by 3,573

Global, In Vivo, and Site-Specific Phosphorylation Dynamics in Signaling Networks

Olsen, J. V., Blagoev, B., Gnad, F., Maček, B., Kumar, C., Mortensen, P., & Mann, M. (2006) · Cell · doi:10.1016/j.cell.2006.09.026 · Cited by 3,562

Global landscape of protein complexes in the yeast Saccharomyces cerevisiae

Krogan, N. J., Cagney, G., Yu, H., Zhong, G., Guo, X., Ignatchenko, A., Li, J., Pu, S., Datta, N., Tikuisis, A., et al. (2006) · Nature · doi:10.1038/nature04670 · Cited by 2,964

Proteome survey reveals modularity of the yeast cell machinery

Gavin, A., Aloy, P., Grandi, P., Krause, R., Böesche, M., Marzioch, M., Rau, C., Jensen, L. J., Bastuck, S., Dümpelfeld, B., et al. (2006) · Nature · doi:10.1038/nature04532 · Cited by 2,570

A Model for Random Sampling and Estimation of Relative Protein Abundance in Shotgun Proteomics

Liu, H., Sadygov, R. G., & Yates, J. R. (2004) · Analytical Chemistry · doi:10.1021/ac0498563 · Cited by 2,533

STRING 8--a global view on proteins and their functional interactions in 630 organisms

Jensen, L. J., Kuhn, M., Stark, M., Chaffron, S., Creevey, C. J., Muller, J., Doerks, T., Julien, P., Roth, A. C., Simonovic, M., et al. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkn760 · Cited by 2,475

Tandem Mass Tags: A Novel Quantification Strategy for Comparative Analysis of Complex Protein Mixtures by MS/MS

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Mass Spectrometry and Protein Analysis

Domon, B., & Aebersold, R. H. (2006) · Science · doi:10.1126/science.1124619 · Cited by 2,257

Direct analysis of protein complexes using mass spectrometry

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Matrix-assisted laser desorption/ionization mass spectrometry of biopolymers.

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Quantitative mass spectrometry in proteomics: a critical review

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Phosphoproteome analysis by mass spectrometry and its application to Saccharomyces cerevisiae

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A quantitative atlas of mitotic phosphorylation

Dephoure, N., Zhou, C., Villén, J., Beausoleil, S. A., Bakalarski, C. E., Elledge, S. J., & Gygi, S. P. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805139105 · Cited by 1,608

A proteomics approach to understanding protein ubiquitination

Peng, J., Schwartz, D., Elias, J. E., Thoreen, C. C., Cheng, D., Marsischky, G., Roelofs, J., Finley, D. J., & Gygi, S. P. (2003) · Nature Biotechnology · doi:10.1038/nbt849 · Cited by 1,601

Mass spectrometry–based proteomics turns quantitative

Ong, S.-E., & Mann, M. (2005) · Nature Chemical Biology · doi:10.1038/nchembio736 · Cited by 1,572

Network organization of the human autophagy system

Behrends, C., Sowa, M. E., Gygi, S. P., & Harper, J. W. (2010) · Nature · doi:10.1038/nature09204 · Cited by 1,554

Defining the Human Deubiquitinating Enzyme Interaction Landscape

Sowa, M. E., Bennett, E. J., Gygi, S. P., & Harper, J. W. (2009) · Cell · doi:10.1016/j.cell.2009.04.042 · Cited by 1,523

Quantitative Phosphoproteomics Reveals Widespread Full Phosphorylation Site Occupancy During Mitosis

Olsen, J. V., Vermeulen, M., Santamaría, A., Kumar, C., Miller, M. L., Jensen, L. J., Gnad, F., Cox, J., Jensen, T. S., Nigg, E. A., et al. (2010) · Science Signaling · doi:10.1126/scisignal.2000475 · Cited by 1,510

Substrate and Functional Diversity of Lysine Acetylation Revealed by a Proteomics Survey

Kim, S. C., Sprung, R., Chen, Y., Xu, Y., Ball, H., Pei, J., Cheng, T., Kho, Y., Xiao, H., Xiao, L., et al. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.06.026 · Cited by 1,487

Highly Selective Enrichment of Phosphorylated Peptides from Peptide Mixtures Using Titanium Dioxide Microcolumns

Larsen, M. R., Thingholm, T. E., Jensen, O. N., Roepstorff, P., & Jørgensen, T. J. D. (2005) · Molecular & Cellular Proteomics · doi:10.1074/mcp.t500007-mcp200 · Cited by 1,478

Error-Tolerant Identification of Peptides in Sequence Databases by Peptide Sequence Tags

Mann, M., & Wilm, M. S. (1994) · Analytical Chemistry · doi:10.1021/ac00096a002 · Cited by 1,473

Large-scale characterization of HeLa cell nuclear phosphoproteins

Beausoleil, S. A., Jedrychowski, M. P., Schwartz, D., Elias, J. E., Villén, J., Li, J., Cohn, M. A., Cantley, L. C., & Gygi, S. P. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0404720101 · Cited by 1,376

Multiplex peptide stable isotope dimethyl labeling for quantitative proteomics

Boersema, P. J., Raijmakers, R., Lemeer, S., Mohammed, S., & Heck, A. J. R. (2009) · Nature Protocols · doi:10.1038/nprot.2009.21 · Cited by 1,359

Proteomic characterization of the human centrosome by protein correlation profiling

Andersen, J. S., Wilkinson, C. J., Mayor, T., Mortensen, P., Nigg, E. A., & Mann, M. (2003) · Nature · doi:10.1038/nature02166 · Cited by 1,319

Quantitative mass spectrometric multiple reaction monitoring assays for major plasma proteins

Anderson, L., & Hunter, C. L. (2006) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m500331-mcp200 · Cited by 1,230

A new logic for DNA engineering using recombination in Escherichia coli

Zhang, Y., Buchholz, F., Muyrers, J. P. P., & Stewart, A. F. (1998) · Nature Genetics · doi:10.1038/2417 · Cited by 1,228

Nucleolar proteome dynamics

Andersen, J., Lam, Y. W., Leung, A. K. L., Ong, S., Lyon, C. E., Lamond, A. I., & Mann, M. (2005) · Nature · doi:10.1038/nature03207 · Cited by 1,173

Multi-site assessment of the precision and reproducibility of multiple reaction monitoring–based measurements of proteins in plasma

Addona, T. A., Abbatiello, S. E., Schilling, B., Skates, S. J., Mani, D. R., Bunk, D. M., Spiegelman, C. H., Zimmerman, L. J., Ham, A.-J. L., Keshishian, H., et al. (2009) · Nature Biotechnology · doi:10.1038/nbt.1546 · Cited by 1,037

Quantitative chemical proteomics reveals mechanisms of action of clinical ABL kinase inhibitors

Bantscheff, M., Eberhard, D., Abraham, Y., Bastuck, S., Böesche, M., Hobson, S., Mathieson, T., Perrin, J., Raida, M., Rau, C., et al. (2007) · Nature Biotechnology · doi:10.1038/nbt1328 · Cited by 1,036

Higher-energy C-trap dissociation for peptide modification analysis

Olsen, J. V., Maček, B., Lange, O., Makarov, A., Horning, S. R., & Mann, M. (2007) · Nature Methods · doi:10.1038/nmeth1060 · Cited by 1,032

A physical and functional map of the human TNF-α/NF-κB signal transduction pathway

Bouwmeester, T., Bauch, A., Ruffner, H., Angrand, P., Bergamini, G., Croughton, K., Cruciat, C., Eberhard, D., Gagneur, J., Ghidelli, S., et al. (2004) · Nature Cell Biology · doi:10.1038/ncb1086 · Cited by 1,030

Interpretation of Shotgun Proteomic Data

Nesvizhskii, A. I., & Aebersold, R. (2005) · Molecular & Cellular Proteomics · doi:10.1074/mcp.r500012-mcp200 · Cited by 1,025

Accurate quantitation of protein expression and site-specific phosphorylation.

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The Age of Crosstalk: Phosphorylation, Ubiquitination, and Beyond

Hunter, T. R. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.11.019 · Cited by 970

A regulatory mutation in IGF2 causes a major QTL effect on muscle growth in the pig

Laere, A.-S. V., Nguyen, M. Q., Braunschweig, M., Nezer, C., Collette, C., Moreau, L., Archibald, A. L., Haley, C., Buys, N., Tally, M., et al. (2003) · Nature · doi:10.1038/nature02064 · Cited by 949

Functional and quantitative proteomics using SILAC

Mann, M. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2067 · Cited by 931

Selective Anchoring of TFIID to Nucleosomes by Trimethylation of Histone H3 Lysine 4

Vermeulen, M., Mulder, K. W., Denissov, S., Pijnappel, W. W. M. P., van Schaik, F. M. A., Varier, R. A., Baltissen, M. P. A., Stunnenberg, H. G., Mann, M., & Timmers, H. T. M. (2007) · Cell · doi:10.1016/j.cell.2007.08.016 · Cited by 930

Precision Mapping of an In Vivo N-Glycoproteome Reveals Rigid Topological and Sequence Constraints

Zielinska, D. F., Gnad, F., Wiśniewski, J. R., & Mann, M. (2010) · Cell · doi:10.1016/j.cell.2010.04.012 · Cited by 905

Origins of Specificity in Protein-DNA Recognition

Rohs, R., Jin, X., West, S. M., Joshi, R., Honig, B. H., & Mann, R. S. (2010) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060408-091030 · Cited by 902

Selective Isolation at the Femtomole Level of Phosphopeptides from Proteolytic Digests Using 2D-NanoLC-ESI-MS/MS and Titanium Oxide Precolumns

Pinkse, M. W. H., Uitto, P. M., Hilhorst, M. J., Ooms, B., & Heck, A. J. R. (2004) · Analytical Chemistry · doi:10.1021/ac0498617 · Cited by 891

Comprehensive mass-spectrometry-based proteome quantification of haploid versus diploid yeast

de Godoy, L. M. F., Olsen, J. V., Cox, J., Nielsen, M. L., Hubner, N. C., Fröhlich, F., Walther, T. C., & Mann, M. (2008) · Nature · doi:10.1038/nature07341 · Cited by 873

From Proteins to Proteomes: Large Scale Protein Identification by Two-Dimensional Electrophoresis and Arnino Acid Analysis

Wilkins, M. R., Pasquali, C., Appel, R. D., Ou, K., Golaz, O., Sanchez, J., Yan, J. X., Gooley, A. A., Hughes, G. J., Humphery‐Smith, I., et al. (1996) · Nature Biotechnology · doi:10.1038/nbt0196-61 · Cited by 836

Quantitative interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers

Vermeulen, M., Eberl, H. C., Matarese, F., Marks, H., Denissov, S., Butter, F., Lee, K. K., Olsen, J. V., Hyman, A. A., Stunnenberg, H. G., et al. (2010) · Cell · doi:10.1016/j.cell.2010.08.020 · Cited by 806

Mass Spectrometric Quantitation of Peptides and Proteins Using Stable Isotope Standards and Capture by Anti-Peptide Antibodies (SISCAPA)

Anderson, N. L., Anderson, N. G., Haines, L. R., Hardie, D. B., Olafson, R. W., & Pearson, T. W. (2004) · Journal of Proteome Research · doi:10.1021/pr034086h · Cited by 806

Full dynamic range proteome analysis of S. cerevisiae by targeted proteomics

Picotti, P., Bodenmiller, B., Mueller, L. N., Domon, B., & Aebersold, R. (2009) · Cell · doi:10.1016/j.cell.2009.05.051 · Cited by 744

Analysis of protein complexes using mass spectrometry

Gingras, A., Gstaiger, M., Raught, B., & Aebersold, R. H. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2208 · Cited by 727

The biological impact of mass-spectrometry-based proteomics

Cravatt, B. F., Simon, G. M., & Yates, J. R. (2007) · Nature · doi:10.1038/nature06525 · Cited by 717

Computational prediction of proteotypic peptides for quantitative proteomics

Mallick, P., Schirle, M., Chen, S. S., Flory, M. R., Lee, H., Martin, D. B., Ranish, J. A., Raught, B., Schmitt, R., Werner, T., et al. (2006) · Nature Biotechnology · doi:10.1038/nbt1275 · Cited by 714

Stable-Isotope Dimethyl Labeling for Quantitative Proteomics

Hsu, J., Huang, S., Chow, N.-H., & Chen, S. (2003) · Analytical Chemistry · doi:10.1021/ac0348625 · Cited by 701

A Global Protein Kinase and Phosphatase Interaction Network in Yeast

Breitkreutz, A., Choi, H., Sharom, J. R., Boucher, L., Neduva, V., Larsen, B. G., Lin, Z., Breitkreutz, B., Stark, C., Liu, G., et al. (2010) · Science · doi:10.1126/science.1176495 · Cited by 684

Temporal analysis of phosphotyrosine-dependent signaling networks by quantitative proteomics

Blagoev, B., Ong, S., Kratchmarova, I., & Mann, M. (2004) · Nature Biotechnology · doi:10.1038/nbt1005 · Cited by 681

SILAC mouse for quantitative proteomics uncovers kindlin-3 as an essential factor for red blood cell function

Krüger, M., Moser, M., Ussar, S., Thievessen, I., Luber, C. A., Forner, F., Schmidt, S., Zanivan, S., Fässler, R., & Mann, M. (2008) · Cell · doi:10.1016/j.cell.2008.05.033 · Cited by 680

A Genecentric Human Protein Atlas for Expression Profiles Based on Antibodies

Berglund, L., Björling, E., Oksvold, P., Fagerberg, L., Asplund, A., Szigyarto, C. A., Persson, A. B., Ottosson, J. E. A., Wernérus, H., Nilsson, P., et al. (2008) · Molecular & Cellular Proteomics · doi:10.1074/mcp.r800013-mcp200 · Cited by 671

Reading protein modifications with interaction domains

Seet, B. T., Đikić, I., Zhou, M., & Pawson, T. J. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1960 · Cited by 665

Proteomics: the move to mixtures

Peng, J., & Gygi, S. P. (2001) · Journal of Mass Spectrometry · doi:10.1002/jms.229 · Cited by 648

Distinguishing protein-coding and noncoding genes in the human genome

Clamp, M., Fry, B., Kamal, M., Xie, X., Cuff, J., Lin, M. F., Kellis, M., Lindblad-Toh, K., & Lander, E. S. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709013104 · Cited by 624

BAC TransgeneOmics: a high-throughput method for exploration of protein function in mammals

Poser, I., Sarov, M., Hutchins, J. R. A., Hèriché, J.-K., Toyoda, Y., Pozniakovsky, A., Weigl, D., Nitzsche, A., Hegemann, B., Bird, A. W., et al. (2008) · Nature Methods · doi:10.1038/nmeth.1199 · Cited by 605

The Language of Histone Crosstalk

Lee, J., Smith, E. R., & Shilatifard, A. (2010) · Cell · doi:10.1016/j.cell.2010.08.011 · Cited by 598

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle

Daub, H., Olsen, J. V., Bairlein, M., Gnad, F., Oppermann, F. S., Körner, R., Greff, Z., Kéri, G., Stemmann, O., & Mann, M. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.07.007 · Cited by 594

Decoding signalling networks by mass spectrometry-based proteomics

Choudhary, C., & Mann, M. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2900 · Cited by 594

A Mammalian Organelle Map by Protein Correlation Profiling

Foster, L. J., de Hoog, C. L., Zhang, Y., Zhang, Y., Xie, X. S., Mootha, V. K., & Mann, M. (2006) · Cell · doi:10.1016/j.cell.2006.03.022 · Cited by 581

Reproducible isolation of distinct, overlapping segments of the phosphoproteome

Bodenmiller, B., Mueller, L. N., Mueller, M., Domon, B., & Aebersold, R. H. (2007) · Nature Methods · doi:10.1038/nmeth1005 · Cited by 564

The molecular sociology of the cell

Robinson, C. V., Šali, A., & Baumeister, W. P. (2007) · Nature · doi:10.1038/nature06523 · Cited by 553

Super-SILAC mix for quantitative proteomics of human tumor tissue

Geiger, T., Cox, J., Ostasiewicz, P., Wisniewski, J. R., & Mann, M. (2010) · Nature Methods · doi:10.1038/nmeth.1446 · Cited by 538

Global analysis of lysine ubiquitination by ubiquitin remnant immunoaffinity profiling

Xu, G., Paige, J. S., & Jaffrey, S. R. (2010) · Nature Biotechnology · doi:10.1038/nbt.1654 · Cited by 537

Signaling networks assembled by oncogenic EGFR and c-Met

Guo, A., Villén, J., Kornhauser, J. M., Lee, K. A., Stokes, M. P., Rikova, K., Possemato, A. P., Nardone, J., Innocenti, G., Wetzel, R. K., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707270105 · Cited by 511

Multiple reaction monitoring for robust quantitative proteomic analysis of cellular signaling networks

Wolf‐Yadlin, A., Hautaniemi, S., Lauffenburger, D. A., & White, F. M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0608638104 · Cited by 494

Lysine Acetylation Is a Highly Abundant and Evolutionarily Conserved Modification in Escherichia Coli

Zhang, J., Sprung, R. W., Pei, J., Tan, X., Kim, S., Zhu, H., Liu, C., Grishin, N. V., & Zhao, Y. (2008) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m800187-mcp200 · Cited by 474

Mass spectrometry in high-throughput proteomics: ready for the big time

Nilsson, T., Mann, M., Aebersold, R., Yates, J. R., Bairoch, A., & Bergeron, J. J. M. (2010) · Nature Methods · doi:10.1038/nmeth0910-681 · Cited by 470

Probing Native Protein Structures by Chemical Cross-linking, Mass Spectrometry, and Bioinformatics

Leitner, A., Walzthoeni, T., Kahraman, A., Herzog, F., Rinner, O., Beck, M., & Aebersold, R. H. (2010) · Molecular & Cellular Proteomics · doi:10.1074/mcp.r000001-mcp201 · Cited by 468

A dual pressure linear ion trap orbitrap instrument with very high sequencing speed

Olsen, J. V., Schwartz, J. C., Griep-Raming, J., Nielsen, M. L., Damoc, E., Denisov, E., Lange, O., Remes, P., Taylor, D., Splendore, M., et al. (2009) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m900375-mcp200 · Cited by 464

Identifying and quantifying in vivo methylation sites by heavy methyl SILAC

Ong, S., Mittler, G., & Mann, M. (2004) · Nature Methods · doi:10.1038/nmeth715 · Cited by 458

Structural characterization of protein tryptic peptides via liquid chromatography/mass spectrometry and collision-induced dissociation of their doubly charged molecular ions

Covey, T. R., Huang, E. C., & Henion, J. D. (1991) · Analytical Chemistry · doi:10.1021/ac00013a003 · Cited by 446

Proteomics: a pragmatic perspective

Mallick, P., & Küster, B. (2010) · Nature Biotechnology · doi:10.1038/nbt.1658 · Cited by 440

Quantitative proteomics combined with BAC TransgeneOmics reveals in vivo protein interactions

Hubner, N. C., Bird, A. W., Cox, J., Splettstoesser, B., Bandilla, P., Poser, I., Hyman, A., & Mann, M. (2010) · Journal of Cell Biology · doi:10.1083/jcb.200911091 · Cited by 440

Mass spectrometry–based proteomics in cell biology

Walther, T. C., & Mann, M. (2010) · The Journal of Cell Biology · doi:10.1083/jcb.201004052 · Cited by 425

Proteome-wide cellular protein concentrations of the human pathogen Leptospira interrogans

Malmström, J., Beck, M., Schmidt, A., Lange, V., Deutsch, E. W., & Aebersold, R. (2009) · Nature · doi:10.1038/nature08184 · Cited by 421

Metabolic labeling of C. elegans and D. melanogaster for quantitative proteomics

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Large-scale database searching using tandem mass spectra: Looking up the answer in the back of the book

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Absolute SILAC for Accurate Quantitation of Proteins in Complex Mixtures Down to the Attomole Level

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Quantitative proteomic analysis of single pancreatic islets

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De Novo Peptide Sequencing and Identification with Precision Mass Spectrometry

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Proteomic Changes Resulting from Gene Copy Number Variations in Cancer Cells

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Identification of SUMO Target Proteins by Quantitative Proteomics

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Deep proteome and transcriptome mapping of a human cancer cell line

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