The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Morphogen Gradients: From Generation to Interpretation
Abstract
Morphogens are long-range signaling molecules that pattern developing tissues in a concentration-dependent manner. The graded activity of morphogens within tissues exposes cells to different signal levels and leads to region-specific transcriptional responses and cell fates. In its simplest incarnation, a morphogen signal forms a gradient by diffusion from a local source and clearance in surrounding tissues. Responding cells often transduce morphogen levels in a linear fashion, which results in the graded activation of transcriptional effectors. The concentration-dependent expression of morphogen target genes is achieved by their different binding affinities for transcriptional effectors as well as inputs from other transcriptional regulators. Morphogen distribution and interpretation are the result of complex interactions between the morphogen and responding tissues. The response to a morphogen is dependent not simply on morphogen concentration but also on the duration of morphogen exposure and the state of the target cells. In this review, we describe the morphogen concept and discuss the mechanisms that underlie the generation, modulation, and interpretation of morphogen gradients.
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Citations
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Park, S. E., Georgescu, A., & Huh, D. (2019) · Science · doi:10.1126/science.aaw7894 · Cited by 847
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Derynck, R., & Budi, E. H. (2019) · Science Signaling · doi:10.1126/scisignal.aav5183 · Cited by 785
Positional Information and Pattern Formation
Wolpert, L. (2016) · Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2015.11.008 · Cited by 649
Morphogen rules: design principles of gradient-mediated embryo patterning
Briscoe, J., & Small, S. (2015) · Development · doi:10.1242/dev.129452 · Cited by 490
Horstman, A., Li, M., Heidmann, I., Weemen, M., Chen, B., Muino, J. M., Angenent, G. C., & Boutilier, K. (2017) · Plant Physiology · doi:10.1104/pp.17.00232 · Cited by 361
Metadata
- Authors
- Rogers, K. W., & Schier, A. F.
- Venue
- Annual Review of Cell and Developmental Biology
- Publisher
- Annual Reviews
- Published
- 2011-11-10
- Volume
- 27
- Issue
- 1
- Pages
- 377-407
- ISSN
- 1081-0706 (ISSN-L)
- 1530-8995
- OpenAlex
- W2097901077
- Cited by
- 626
- References
- 10
- FWCI
- 2.09
- Type
- journal article
- Language
- en
- Open access
- closed
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