Cited by 1,017Biofuel production and bioconversionCatalysis for Biomass ConversionLignin and Wood Chemistry

Deconstruction of Lignocellulosic Biomass to Fuels and Chemicals

Chundawat, Shishir P.S., Beckham, Gregg T., Himmel, Michael E., Dale, Bruce E.·2011·Annual Review of Chemical and Biomolecular Engineering

Abstract

Plants represent a vast, renewable resource and are well suited to provide sustainably for humankind's transportation fuel needs. To produce infrastructure-compatible fuels from biomass, two challenges remain: overcoming plant cell wall recalcitrance to extract sugar and phenolic intermediates, and reduction of oxygenated intermediates to fuel molecules. To compete with fossil-based fuels, two primary routes to deconstruct cell walls are under development, namely biochemical and thermochemical conversion. Here, we focus on overcoming recalcitrance with biochemical conversion, which uses low-severity thermochemical pretreatment followed by enzymatic hydrolysis to produce soluble sugars. Many challenges remain, including understanding how pretreatments affect the physicochemical nature of heterogeneous cell walls; determination of how enzymes deconstruct the cell wall effectively with the aim of designing superior catalysts; and resolution of issues associated with the co-optimization of pretreatment, enzymatic hydrolysis, and fermentation. Here, we highlight some of the scientific challenges and open questions with a particular focus on problems across multiple length scales.

Integrity signals

Registry

Crossref · 10.1146/annurev-chembioeng-061010-114205

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170 of 170 references verified0 citation errors · 0 not checkable

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  • Saccharification can be catalysed by chemicals or enzymes; enzymes are usually preferred due to their higher selectivity.

    “The saccharification can be catalysed by chemicals 41 or enzymes; enzymes are usually preferred due to their higher selectivity.17”

    From Deconstruction of lignocellulosic biomass with ionic liquids (2013) · cites this paper as [41]

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Authors
Chundawat, S. P. S., Beckham, G. T., Himmel, M. E., & Dale, B. E.
Affiliations
  • Great Lakes Bioenergy Research Center (US)
  • National Laboratory of the Rockies (US)
  • Oak Ridge National Laboratory (US)
Venue
Annual Review of Chemical and Biomolecular Engineering
Published
2011-07-15
Volume
2
Issue
1
Pages
121-145
ISSN
  • 1947-5438 (ISSN-L)
  • 1947-5446
OpenAlex
W2098319201
Cited by
1,017
References
170
Citations by year
2026: 22 · 2025: 40 · 2024: 46 · 2023: 42 · 2022: 63 · 2021: 89 · 2020: 88 · 2019: 67 · 2018: 85 · 2017: 73 · 2016: 98 · 2015: 83 · 2014: 86 · 2013: 76 · 2012: 40
FWCI
5.65
Type
journal article
Language
en
Open access
closed
Locations
  • Annual Review of Chemical and Biomolecular Engineering (publishedVersion)
  • PubMed (publishedVersion)
  • Rutgers University Community Repository (Rutgers University) (submittedVersion)
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Biofuel production and bioconversion
  • Physical Sciences › Engineering › Biomedical Engineering › Catalysis for Biomass Conversion
  • Physical Sciences › Engineering › Biomedical Engineering › Lignin and Wood Chemistry
Keywords
lignocellulosic biomass, biomass deconstruction, cell wall recalcitrance, enzymatic hydrolysis, thermochemical pretreatment, biochemical conversion, thermochemical conversion, sugar production, phenolic intermediates, biofuels, bio-based chemicals, enzyme design, fermentation
MeSH terms
Catalysis, Cell Wall, Cellulose, Fungal Proteins, Hydrolysis, Lignin, Models, Molecular, Organic Chemicals, Plants, Trichoderma, Molecular Structure, Protein Structure, Tertiary, Biomass, Cellulases, Biofuels

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