Cited by 1,066DNA Repair MechanismsFungal and yeast genetics researchGenomics and Chromatin Dynamics

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Regulation of Homologous Recombination in Eukaryotes

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Heyer, Wolf-Dietrich, Ehmsen, Kirk T., Liu, Jie·2010·Annual Review of Genetics

DOI 10.1146/annurev-genet-051710-150955PMC PMC4114321

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Abstract

Homologous recombination (HR) is required for accurate chromosome segregation during the first meiotic division and constitutes a key repair and tolerance pathway for complex DNA damage, including DNA double-strand breaks, interstrand crosslinks, and DNA gaps. In addition, recombination and replication are inextricably linked, as recombination recovers stalled and broken replication forks, enabling the evolution of larger genomes/replicons. Defects in recombination lead to genomic instability and elevated cancer predisposition, demonstrating a clear cellular need for recombination. However, recombination can also lead to genome rearrangements. Unrestrained recombination causes undesired endpoints (translocation, deletion, inversion) and the accumulation of toxic recombination intermediates. Evidently, HR must be carefully regulated to match specific cellular needs. Here, we review the factors and mechanistic stages of recombination that are subject to regulation and suggest that recombination achieves flexibility and robustness by proceeding through metastable, reversible intermediates.

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Authors: Heyer, W.-D., Ehmsen, K. T., & Liu, J.
Affiliations: University of California, Davis (US)
ORCID: Heyer, Wolf-Dietrich
Ehmsen, Kirk T.
Liu, Jie
Venue: Annual Review of Genetics
Publisher: Annual Reviews
Published: 2010-12-01
Volume: 44
Issue: 1
Pages: 113-139
ISSN: 0066-4197 (ISSN-L)
1545-2948
DOI: 10.1146/annurev-genet-051710-150955
PMC: PMC4114321
OpenAlex: W2109879947
Cited by: 1,066
References: 177
Citations by year: 2026: 26 · 2025: 44 · 2024: 54 · 2023: 64 · 2022: 70 · 2021: 91 · 2020: 86 · 2019: 75 · 2018: 79 · 2017: 86 · 2016: 83 · 2015: 71 · 2014: 67 · 2013: 67 · 2012: 62
FWCI: 4.67
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Annual Review of Genetics (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: Tobacco-Related Disease Research Program
National Institutes of Health
National Cancer Institute (CA92776, R01CA092276, R03CA092776)
National Institute of General Medical Sciences (GM58015, R01GM058015)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Keywords: homologous recombination, recombination regulation, DNA double-strand breaks, meiotic chromosome segregation, DNA repair, DNA damage tolerance, replication fork recovery, genomic instability, cancer susceptibility, genome rearrangement, translocation, recombination intermediates, metastable intermediates, eukaryotic cells
MeSH terms: Animals, DNA Repair, Humans, Recombination, Genetic, Yeasts

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Regulation of Homologous Recombination in Eukaryotes

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