Regulation Mechanisms and Signaling Pathways of Autophagy

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing.

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p62/SQSTM1 Binds Directly to Atg8/LC3 to Facilitate Degradation of Ubiquitinated Protein Aggregates by Autophagy

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Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

Narendra, D., Tanaka, A., Suen, D.-F., & Youle, R. J. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200809125 · Cited by 4,026

TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival

Inoki, K., Zhu, T., & Guan, K.-L. (2003) · Cell · doi:10.1016/s0092-8674(03)00929-2 · Cited by 3,914

Autophagy as a Regulated Pathway of Cellular Degradation

Klionsky, D. J., & Emr, S. D. (2000) · Science · doi:10.1126/science.290.5497.1717 · Cited by 3,630

Induction of autophagy and inhibition of tumorigenesis by beclin 1

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p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death

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Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

Twig, G., Elorza, A., Molina, A. J. A., Mohamed, H., Wikstrom, J. D., Walzer, G., Stiles, L., Haigh, S. E., Katz, S., Las, G., et al. (2008) · The EMBO Journal · doi:10.1038/sj.emboj.7601963 · Cited by 3,082

Bufalin induces autophagy-mediated cell death in human colon cancer cells through reactive oxygen species generation and JNK activation

Xie, C., Chan, W. Y., Yu, S. S. B., Zhao, J., & Cheng, C. H. K. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.06.016 · Cited by 241

The emerging roles of vacuolar-type ATPase-dependent Lysosomal acidification in neurodegenerative diseases

Song, Q., Meng, B., Xu, H., & Mao, Z. (2020) · Translational Neurodegeneration · doi:10.1186/s40035-020-00196-0 · Cited by 244

Helicobacter pylori and Gastric Cancer: Adaptive Cellular Mechanisms Involved in Disease Progression

Díaz, P., Valenzuela, M., Bravo, J., & Quest, A. F. G. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.00005 · Cited by 237

Mitochondria in the spotlight of aging and idiopathic pulmonary fibrosis

Mora, A. L., Bueno, M., & Rojas, M. M. (2017) · Journal of Clinical Investigation · doi:10.1172/jci87440 · Cited by 236

Autophagy in bone homeostasis and the onset of osteoporosis

Yin, X., Zhou, C., Li, J., Liu, R., Shi, B., Yuan, Q., & Zou, S. (2019) · Bone Research · doi:10.1038/s41413-019-0058-7 · Cited by 235

Pathogenic LRRK2 mutations, through increased kinase activity, produce enlarged lysosomes with reduced degradative capacity and increase ATP13A2 expression

Henry, A. G., Aghamohammadzadeh, S., Samaroo, H., Chen, Y., Mou, K., Needle, E., & Hirst, W. D. (2015) · Human Molecular Genetics · doi:10.1093/hmg/ddv314 · Cited by 235

Regulation of autophagy by phosphatidylinositol 3‐phosphate

Burman, C., & Ktistakis, N. T. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.01.011 · Cited by 234

Regulation of Glutamine Carrier Proteins by RNF5 Determines Breast Cancer Response to ER Stress-Inducing Chemotherapies

Jeon, Y. J., Khelifa, S., Ratnikov, B. I., Scott, D. A., Feng, Y., Parisi, F., Ruller, C. M., Lau, E. K., Kim, H., Brill, L. M., et al. (2015) · Cancer Cell · doi:10.1016/j.ccell.2015.02.006 · Cited by 235

Natural products for treating colorectal cancer: A mechanistic review

Huang, X., Yang, Z., Xie, Q., Zhang, Z., Zhang, H., & Ma, J. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.109142 · Cited by 234

Role and regulation of autophagy in heat stress responses of tomato plants

Zhou, J., Wang, J., Yu, J., & Chen, Z. (2014) · Frontiers in Plant Science · doi:10.3389/fpls.2014.00174 · Cited by 232

Autophagy and tumorigenesis

Chen, N., & Debnath, J. (2009) · FEBS Letters · doi:10.1016/j.febslet.2009.12.034 · Cited by 233

Chloroquine and hydroxychloroquine for cancer therapy

Manic, G., Obrist, F., Kroemer, G., Vitale, I., & Galluzzi, L. (2014) · Molecular & Cellular Oncology · doi:10.4161/mco.29911 · Cited by 231

Curcumin: A naturally occurring autophagy modulator

Shakeri, A., Cicero, A. F. G., Panahi, Y., Mohajeri, M., & Sahebkar, A. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.27404 · Cited by 231

Targeting autophagy in disease: established and new strategies

Koçak, M., Erdi, S. E., Jorba, G., Maestro, I., Farrés, J., Kirkin, V., Martínez, A., & Pleß, O. (2021) · Autophagy · doi:10.1080/15548627.2021.1936359 · Cited by 235

Molecular mechanisms of cell death in intervertebral disc degeneration (Review)

Zhang, F., Zhao, X., Shen, H., & Zhang, C. (2016) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2016.2573 · Cited by 230

Autophagy Signaling Through Reactive Oxygen Species

Huang, J., Lam, G. Y., & Brumell, J. H. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3554 · Cited by 228

Chloroquine Inhibits Autophagy to Potentiate Antiestrogen Responsiveness in ER+ Breast Cancer

Cook, K. L., Wärri, A. M., Soto‐Pantoja, D. R., Clarke, P. A. G., Cruz, M. I., Zwart, A. L., & Clarke, R. C. (2014) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-3227 · Cited by 226

Multiple interacting cell death mechanisms in the mediation of excitotoxicity and ischemic brain damage: A challenge for neuroprotection

Puyal, J., Ginet, V., & Clarke, P. G. H. (2013) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.03.002 · Cited by 224

Zinc oxide nanoparticles induce apoptosis by enhancement of autophagy via PI3K/Akt/mTOR inhibition

Roy, R., Singh, S. K., Chauhan, L. K. S., Das, M., Tripathi, A., & Dwivedi, P. D. (2014) · Toxicology Letters · doi:10.1016/j.toxlet.2014.02.024 · Cited by 222

Autophagy as a modulator of cell death machinery

Noguchi, M., Hirata, N., Tanaka, T., Suizu, F., Nakajima, H., & Chiorini, J. A. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-2724-5 · Cited by 223

Fatty Acids Suppress Autophagic Turnover in β-Cells

Las, G., Serada, S. B., Wikström, J. D., Twig, G., & Shirihai, O. S. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.242412 · Cited by 220

Cordycepin prevents radiation ulcer by inhibiting cell senescence via NRF2 and AMPK in rodents

Wang, Z., Chen, Z., Jiang, Z., Luo, P., Liu, L., Huang, Y., Wang, H., Wang, Y., Long, L., Tan, X., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-10386-8 · Cited by 219

AMPK and autophagy in glucose/glycogen metabolism

Ha, J., Guan, K., & Kim, J. (2015) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2015.08.002 · Cited by 219

Pompe disease: from pathophysiology to therapy and back again

Lim, J., Li, L., & Raben, N. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00177 · Cited by 219

Macrophage autophagy in macrophage polarization, chronic inflammation and organ fibrosis

Wen, J.-H., Li, D.-Y., Liang, S., Yang, C., Tang, J., & Liu, H. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.946832 · Cited by 219

Hyperammonemia-mediated autophagy in skeletal muscle contributes to sarcopenia of cirrhosis

Qiu, J., Tsien, C. D., Thapalaya, S., Narayanan, A. S., Weihl, C. C., Ching, J. K., Eghtesad, B., Singh, K., Fu, X., Dubyak, G., et al. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00183.2012 · Cited by 217

miR-519a enhances chemosensitivity and promotes autophagy in glioblastoma by targeting STAT3/Bcl2 signaling pathway

Li, H., Chen, L., Li, J., Zhou, Q., Huang, A., Liu, W., Wang, K., Gao, L., Qi, S., & Lu, Y. (2018) · Journal of Hematology & Oncology · doi:10.1186/s13045-018-0618-0 · Cited by 216

Autophagy and the Cell Cycle: A Complex Landscape

Mathiassen, S. G., Zio, D. D., & Cecconi, F. (2017) · Frontiers in Oncology · doi:10.3389/fonc.2017.00051 · Cited by 214

Parkinson’s disease as a result of aging

Rodriguez, M., Rodriguez‐Sabate, C., Morales, I., Sanchez, A., & Sabate, M. (2015) · Aging Cell · doi:10.1111/acel.12312 · Cited by 214

mTOR-Dependent Cell Survival MechanismsPreprint

Hung, C., García-Haro, L., Sparks, C. A., & Guertin, D. A. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a008771 · Cited by 215

Autophagy mediates pharmacological lifespan extension by spermidineand resveratrol

Morselli, E., Galluzzi, L., Kepp, O., Criollo, A., Maiuri, M. C., Tavernarakis, N., Madeo, F., & Kroemer, G. (2009) · Aging · doi:10.18632/aging.100110 · Cited by 213

Activation of the PIK3CA/AKT Pathway Suppresses Senescence Induced by an Activated RAS Oncogene to Promote Tumorigenesis

Kennedy, A. L., Morton, J. P., Manoharan, I., Nelson, D. M., Jamieson, N. B., Pawlikowski, J. S., McBryan, T., Doyle, B., McKay, C., Oien, K. A., et al. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.02.020 · Cited by 213

2-Deoxy-d-glucose activates autophagy via endoplasmic reticulum stress rather than ATP depletion

Xi, H., Kurtoğlu, M., Liu, H., Wangpaichitr, M., You, M., Liu, X., Savaraj, N., & Lampidis, T. J. (2010) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-010-1391-0 · Cited by 214

Zinc oxide nanoparticles harness autophagy to induce cell death in lung epithelial cells

Zhang, J., Qin, X., Wang, B., Xu, G., Qin, Z., Wang, J., Wu, L., Ju, X., Bose, D. D., Qiu, F., et al. (2017) · Cell Death and Disease · doi:10.1038/cddis.2017.337 · Cited by 212

Autophagy in health and disease. 1. Regulation and significance of autophagy: an overview

Mehrpour, M., Esclatine, A., Beau, I., & Codogno, P. (2010) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00507.2009 · Cited by 211

Oxidative Stress in Placenta: Health and Diseases

Wu, F., Tian, F., & Lin, Y. (2015) · BioMed Research International · doi:10.1155/2015/293271 · Cited by 214

Autophagy: An Intracellular Degradation Pathway Regulating Plant Survival and Stress Response

Su, T., Li, X., Yang, M., Shao, Q., Zhao, Y., Ma, C., & Wang, P. (2020) · Frontiers in Plant Science · doi:10.3389/fpls.2020.00164 · Cited by 211

Autophagy in aging and longevity

Wong, S. Q., Kumar, A. V., Mills, J., & Lapierre, L. R. (2019) · Human Genetics · doi:10.1007/s00439-019-02031-7 · Cited by 210

Transient Activation of Autophagy via Sox2-Mediated Suppression of mTOR Is an Important Early Step in Reprogramming to Pluripotency

Wang, S., Xia, P., Ye, B., Huang, G., Liu, J., & Fan, Z. (2013) · Cell Stem Cell · doi:10.1016/j.stem.2013.10.005 · Cited by 209

The Dual Role of Autophagy in Cancer Development and a Therapeutic Strategy for Cancer by Targeting Autophagy

Yun, C. W., Jeon, J., Go, G., Lee, J. H., & Lee, S. H. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms22010179 · Cited by 209

Docosahexaenoic acid induces autophagy through p53/AMPK/mTOR signaling and promotes apoptosis in human cancer cells harboring wild-type p53

Jing, K., Song, K., Shin, S., Kim, N., Jeong, S., Oh, H.-R., Park, J.-H., Seo, K.-S., Heo, J. Y., Han, J., et al. (2011) · Autophagy · doi:10.4161/auto.7.11.16658 · Cited by 208

Targeted Protein Degradation by Small Molecules

Bondeson, D. P., & Crews, C. M. (2017) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010715-103507 · Cited by 207

Basic Biology of Skeletal Aging: Role of Stress Response Pathways

Almeida, M., & O’Brien, C. A. (2013) · The Journals of Gerontology Series A · doi:10.1093/gerona/glt079 · Cited by 207

Suppression of Autophagy in Osteocytes Mimics Skeletal Aging

Onal, M., Piemontese, M., Xiong, J., Wang, Y., Han, L., Ye, S., Komatsu, M., Selig, M., Weinstein, R. S., Zhao, H., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.444190 · Cited by 206

Autophagy is a regulator of TGF-β1-induced fibrogenesis in primary human atrial myofibroblasts

Ghavami, S., Cunnington, R. H., Gupta, S., Yeganeh, B., Filomeno, K. L., Freed, D. H., Chen, S., Klonisch, T. C., Halayko, A. J., Ambrose, E., et al. (2015) · Cell Death and Disease · doi:10.1038/cddis.2015.36 · Cited by 206

Activation of MTOR in pulmonary epithelium promotes LPS-induced acute lung injury

Hu, Y., Lou, J., Mao, Y., Lai, T., Liu, L.-Y., Zhu, C., Zhang, C., Liu, J., Li, Y.-Y., Zhang, F., et al. (2016) · Autophagy · doi:10.1080/15548627.2016.1230584 · Cited by 206

Understanding intrinsic hematopoietic stem cell aging

Mejía-Ramírez, E., & Florian, M. C. (2019) · Haematologica · doi:10.3324/haematol.2018.211342 · Cited by 206

Spermidine and spermine delay brain aging by inducing autophagy in SAMP8 mice

Xu, T., Li, H., Dai, Z., Lau, G. K., Li, B., Zhu, W., Liu, X.-Q., Liu, H.-F., Cai, W.-W., Huang, S., et al. (2020) · Aging · doi:10.18632/aging.103035 · Cited by 210

Regulation of YAP by mTOR and autophagy reveals a therapeutic target of tuberous sclerosis complex

Liang, N., Zhang, C., Dill, P., Panasyuk, G., Pion, D., Koka, V., Gallazzini, M., Olson, E. N., Lam, H., Henske, E. P., et al. (2014) · Journal of Experimental Medicine · doi:10.1084/jem.20140341 · Cited by 205

Mutant HTT (huntingtin) impairs mitophagy in a cellular model of Huntington disease

Franco-Iborra, S., Plaza‐Zabala, A., Montpeyó, M., Sebastián, D., Vila, M., & Martínez‐Vicente, M. (2020) · Autophagy · doi:10.1080/15548627.2020.1728096 · Cited by 205

Adipose‐derived mesenchymal stem cells reduce autophagy in stroke mice by extracellular vesicle transfer of miR‐25

Kuang, Y., Zheng, X., Zhang, L., Ai, X., Venkataramani, V., Kılıç, E., Hermann, D. M., Majid, A., Bähr, M., & Doeppner, T. R. (2020) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12024 · Cited by 205

Fipronil insecticide toxicology: oxidative stress and metabolism

Wang, X., Martínez, M., Wu, Q., Arés, I., Martínez-Larrañaga, M. R., Anadón, A., & Yuan, Z. (2016) · Critical Reviews in Toxicology · doi:10.1080/10408444.2016.1223014 · Cited by 204

Targeting toll-like receptor 4 to modulate neuroinflammation in central nervous system disorders

Leitner, G. R., Wenzel, T. J., Marshall, N., Gates, E. J., & Klegeris, A. (2019) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2019.1676416 · Cited by 204

The Role of MicroRNAs in Biological Processes

Tüfekçi, K. U., Meuwissen, R. L. J., & Genç, Ş. (2013) · Methods in molecular biology · doi:10.1007/978-1-62703-748-8_2 · Cited by 201

Histone deacetylase inhibitors induce autophagy through FOXO1-dependent pathways

Zhang, J., Ng, S., Wang, J., Zhou, J., Tan, S.-H., Yang, N., Lin, Q., Xia, D., & Shen, H. (2015) · Autophagy · doi:10.1080/15548627.2015.1023981 · Cited by 199

Neurodegenerative Diseases: Multifactorial Conformational Diseases and Their Therapeutic Interventions

Sheikh, S., Safia, Haque, E., & Mir, S. S. (2012) · Journal of Neurodegenerative Diseases · doi:10.1155/2013/563481 · Cited by 199

Aneuploidy generates proteotoxic stress and DNA damage concurrently with p53-mediated post-mitotic apoptosis in SAC-impaired cells

Ohashi, A., Ohori, M., Iwai, K., Nakayama, Y., Nambu, T., Morishita, D., Kawamoto, T., Miyamoto, M., Hirayama, T., Okaniwa, M., et al. (2015) · Nature Communications · doi:10.1038/ncomms8668 · Cited by 199

Autophagic removal of micronuclei

Rello-Varona, S., Lissa, D., Shen, S., Niso-Santano, M., Senovilla, L., Mariño, G., Vitale, I., Jemaá, M., Harper, F., Pierron, G., et al. (2012) · Cell Cycle · doi:10.4161/cc.11.1.18564 · Cited by 198

Proteostasis and neurodegeneration: The roles of proteasomal degradation and autophagy

Tanaka, K., & Matsuda, N. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2013.03.012 · Cited by 198

Resveratrol-induced autophagy and apoptosis in cisplatin-resistant human oral cancer CAR cells: A key role of AMPK and Akt/mTOR signaling

Chang, C.-H., Lee, C., Lu, C., Tsai, F., Hsu, Y., Tsao, J.-W., Juan, Y., Chiu, H.-Y., Yang, J., & Wang, C. (2017) · International Journal of Oncology · doi:10.3892/ijo.2017.3866 · Cited by 197

The Role of Silver Nanoparticles in the Diagnosis and Treatment of Cancer: Are There Any Perspectives for the Future?

Takáč, P., Michalková, R., Čižmáriková, M., Bedlovičová, Z., Balážová, Ľ., & Takáčová, G. (2023) · Life · doi:10.3390/life13020466 · Cited by 197

Role and regulation of autophagy in cancer

Rakesh, R., Dharshini, L. C. P., Sakthivel, K. M., & Rasmi, R. R. (2022) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2022.166400 · Cited by 198

Autophagy for tissue homeostasis and neuroprotection

Mariño, G., Madeo, F., & Kroemer, G. (2011) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2010.10.001 · Cited by 195

Caspase involvement in autophagy

Tsapras, P., & Nezis, I. P. (2017) · Cell Death and Differentiation · doi:10.1038/cdd.2017.43 · Cited by 197

Oxidation of SQSTM1/p62 mediates the link between redox state and protein homeostasis

Carroll, B., Otten, E. G., Manni, D., Stefanatos, R. K. A., Menzies, F. M., Smith, G. R., Jurk, D., Kenneth, N. S., Wilkinson, S., Passos, J. F., et al. (2018) · Nature Communications · doi:10.1038/s41467-017-02746-z · Cited by 195

Inhibitory effect of mTOR activator MHY1485 on autophagy: suppression of lysosomal fusion

Choi, Y. J., Park, Y. J., Park, J. Y., Jeong, H. O., Kim, D. H., Ha, Y. M., Kim, J. M., Song, Y. M., Heo, H.-S., Yu, B. P., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0043418 · Cited by 192

mTORC 1 activation decreases autophagy in aging and idiopathic pulmonary fibrosis and contributes to apoptosis resistance in IPF fibroblasts

Romero, Y., Bueno, M., Ramírez, R., Álvarez, D., Sembrat, J., Goncharova, E. A., Rojas, M. M., Selman, M., Mora, A. L., & Pardo, A. (2016) · Aging Cell · doi:10.1111/acel.12514 · Cited by 193

Immunogenic cell death in cancer: concept and therapeutic implications

Galluzzi, L., Kepp, O., Hett, E. C., Kroemer, G., & Marincola, F. M. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04017-6 · Cited by 200

Dynamic modelling of oestrogen signalling and cell fate in breast cancer cells

Tyson, J. J., Baumann, W. T., Chen, C., Verdugo, A., Tavassoly, I., Wang, Y., Weiner, L. M., & Clarke, R. C. (2011) · Nature reviews. Cancer · doi:10.1038/nrc3081 · Cited by 190

Targeting Programmed Cell Death Using Small‐Molecule Compounds to Improve Potential Cancer Therapy

Ke, B., Tian, M., Li, J., Liu, B., & He, G. (2016) · Medicinal Research Reviews · doi:10.1002/med.21398 · Cited by 190

The Pan-Bcl-2 Inhibitor (−)-Gossypol Triggers Autophagic Cell Death in Malignant Glioma

Voss, V., Senft, C., Lang, V., Ronellenfitsch, M. W., Steinbach, J. P., Seifert, V., & Kögel, D. (2010) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-09-0562 · Cited by 189

The Amazing Odontoblast

Couve, E., Osorio, R., & Schmachtenberg, O. (2013) · Journal of Dental Research · doi:10.1177/0022034513495874 · Cited by 189

ER stress and the unfolded protein response in intestinal inflammation

McGuckin, M. A., Eri, R. D., Das, I., Lourie, R., & Florin, T. H. (2010) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00063.2010 · Cited by 189

Autophagy contributes to regulation of the hypoxia response during submergence in Arabidopsis thaliana

Chen, L., Liao, B., Qi, H., Xie, L., Huang, L., Tan, W., Zhai, N., Yuan, L., Zhou, Y., Yu, L., et al. (2015) · Autophagy · doi:10.1080/15548627.2015.1112483 · Cited by 188

Age-related macular degeneration: A two-level model hypothesis

Rozing, M. P., Durhuus, J. A., Nielsen, M. K., Subhi, Y., Kirkwood, T. B. L., Westendorp, R. G., & Sørensen, T. L. (2019) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2019.100825 · Cited by 188

Autophagy: a double-edged sword for neuronal survival after cerebral ischemia

Liu, K., Sun, X., Chen, W., & Sun, Y. (2014) · Neural Regeneration Research · doi:10.4103/1673-5374.135329 · Cited by 187

Is Autophagy in Response to Ischemia and Reperfusion Protective or Detrimental for the Heart?

Sciarretta, S., Hariharan, N., Monden, Y., Zablocki, D., & Sadoshima, J. (2010) · Pediatric Cardiology · doi:10.1007/s00246-010-9855-x · Cited by 187

Regulation of Autophagy by Kinases

Sridharan, S., Jain, K., & Basu, A. (2011) · Cancers · doi:10.3390/cancers3022630 · Cited by 189

The interplay between autophagy and ROS in tumorigenesis

Kongara, S., & Karantza, V. (2012) · Frontiers in Oncology · doi:10.3389/fonc.2012.00171 · Cited by 186

Autophagy and Aging

Martínez-López, N., Athonvarangkul, D., & Singh, R. (2015) · Advances in experimental medicine and biology · doi:10.1007/978-1-4939-2404-2_3 · Cited by 185

Small molecules regulating reactive oxygen species homeostasis for cancer therapy

Zhang, J., Duan, D., Song, Z., Liu, T., Hou, Y., & Fang, J. (2021) · Medicinal Research Reviews · doi:10.1002/med.21734 · Cited by 184

Plasticity in the Neonatal Brain following Hypoxic-Ischaemic Injury

Rocha‐Ferreira, E., & Hristova, M. (2016) · Neural Plasticity · doi:10.1155/2016/4901014 · Cited by 184

A Double‐Edged Sword with Therapeutic Potential: An Updated Role of Autophagy in Ischemic Cerebral Injury

Wei, K., Wang, P., & Miao, C. (2012) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12005 · Cited by 183

Mitochondria regulate autophagy by conserved signalling pathways

Graef, M., & Nunnari, J. M. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.104 · Cited by 183

Dysregulation of autophagy as a common mechanism in lysosomal storage diseases

Seranova, E., Connolly, K. J., Zatyka, M., Rosenstock, T. R., Barrett, T. G., Tuxworth, R. I., & Sarkar, S. (2017) · Essays in Biochemistry · doi:10.1042/ebc20170055 · Cited by 183

Dysfunction of Mesenchymal Stem Cells Isolated from Metabolic Syndrome and Type 2 Diabetic Patients as Result of Oxidative Stress and Autophagy may Limit Their Potential Therapeutic Use

Kornicka, K., Houston, J. M. I., & Marycz, K. (2018) · Stem Cell Reviews and Reports · doi:10.1007/s12015-018-9809-x · Cited by 183

Increased expression of lncRNA CASC9 promotes tumor progression by suppressing autophagy-mediated cell apoptosis via the AKT/mTOR pathway in oral squamous cell carcinoma

Yang, Y., Chen, D., Liu, H., & Yang, K. (2019) · Cell Death and Disease · doi:10.1038/s41419-018-1280-8 · Cited by 183

The role of autophagy in resistance to targeted therapies

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Autophagy and Neuronal Cell Death in Neurological DisordersPreprint

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